This research investigates a possible subterranean river capture responsible for the morphogenesis of the Poti RiverCanyon, which crosses the uplifted edge of the Parnaíba Basin, in the northern Northeast of Brazil. Morphological andlithostructural evidence of river captures was analysed using remote sensing products (e.g., drainage network, topography,paleotopography, structural framework) and field expeditions. The results indicated a sudden inflexion of the upper courseof the Poti River, low and anomalous divides in the local geomorphological context, canyon with valley segments exhibitingasynchronous morphologies, and block collapse controlled by dissolution along fracture networks. Given this set of data, wepropose an evolutionary model of subterranean river capture for the formation of the Poti River canyon, which, throughpaleotopographic modelling, was linked to the Pleistocene epoch. This drainage rearrangement would have been influencedby a Neogene-Quaternary morphogenetic framework of structural reactivations, regional uplift, and climatic oscillations. Onthis basis, it was concluded that epigenetic processes were significant for a drainage rearrangement of approximately 10,540km² of areas in a semiarid region with sandstone substrate.