A flat-type 10 kW-class loop heat pipe (LHP) with a box-type wick was designed and developed to handle the higher heat loads in waste heat recovery applications, such as industrial processing and internal combustion engines. Additionally, a numerical model was developed to predict the overall thermal performance of the LHP. The LHP used a stainless steel wick with a pore diameter of 2.0 µm and pure water as the working fluid. The LHP was tested using two types of cooling for the condenser (forced and natural convection), two types of evaporator orientations (horizontal and vertical), and with and without gravity assist (0.3 m and 0 m). For all the tests, the maximum heat load ranged from 5 kW to 10 kW, with the test with a gravity assist of 0.3 m, vertical evaporator orientation, and natural convection performing the best. This test sustained a 10 kW heat load at a steady-state temperature of 182 °C for the evaporator. During the same test, a maximum evaporative heat transfer coefficient of 92,000 W/m2/K at 4.5 kW and a thermal resistance between the evaporator and condenser value of less than 0.007 K/W was achieved. A numerical model was developed to compare the experimental results with the numerical temperature results for the heater block, evaporator, vapor line, condenser, liquid line, and compensation chamber. Overall, the average temperature difference for all components ranged from 7.1 °C to 10.6 °C, with the horizontal orientation without gravity assist and natural convection test predicting the best. The findings demonstrate that LHPs can handle the higher heat loads that are found in waste heat recovery applications for industrial processing and internal combustion engines.