This work presents a techno-economic model based on experimental and market data to provide forecasts of the profitability of vanadium flow batteries (VFBs), which are emerging as a promising technology for specific stationary energy services [1‒2]. Each component affecting the capital and operative costs was analyzed and the impact of side phenomena on capacity losses was considered. Relevant economic parameters were taken from real market data: discount rate was calculated based on the Capital Asset Pricing Model (CAPM) to account for real market conditions; the electricity price follows an arbitrage strategy to profit of the daily price fluctuations taken from the historical data of the Italian energy market [3‒4]. Technical parameters are taken from large-area multi-cell stack, rather than from small single cell experiments, thus allow to characterize the behavior of real industrial reactors [5‒6]. The economic performance indicators obtained are the capital cost, the operative cost, the Levelized Cost of Storage (LCOS) and the Net Present Value (NPV). The resulting values are: a discount rate of 9.12% and electricity prices of 200 € MWh–1 in selling and of 100 € MWh–1 in buying. Capital costs and LCOS were calculated for different system power and energy (E/P) ratings. At E/P = 2 h, the values of capital costs and LCOS were in the range of 800 – 900 € kWh–1 and 0.50 – 0.55 € kWh–1, respectively, whereas at E/P = 10 h they reduced to 350 – 380 € kWh–1 and 0.29 – 0.32 € kWh–1, respectively. In addition, a NPV analysis was carried out in order to evaluate whether these capital costs could provide a profit. The analysis suggests that only at capital cost < 105 € kWh–1 the break-even point (NPV = 0) was reached. The result is that the assumed techno-economic scenario VFBs were not profitable for every considered E/P. A perspective analysis was developed to reveal when VFBs can become profitable. Different screenings were made on both technical and economic parameters. At a technical level, a power density of 0.25 W cm–2, a RTE = 85%, a SOC = 90%, and a reduced number of regenerating processes in the lifespan (Nreg = 4) were considered. Regarding the economic parameters, a discount rate of 7 % was assumed, an electricity selling price of 250 € MWh–1 and a purchasing price of 75 € MWh–1 were used, compatible with a more pronounced Duck Curve of the daily electricity price, induced by the expansion of renewable energy sources expected in the near future. Under this scenario, the system costs decreased considerably: at E/P = 2 h, the Capital Costs and LCOS ranged as 530 – 570 € kWh–1 and 0.25 – 0.27 € kWh–1, respectively, whereas at E/P = 10 h, the Capital Costs and LCOS ranges as 260 – 270 € kWh–1 and around 0.17 € kWh–1, respectively. The latter figures made VFBs profitable for E/P in the range of 4 – 10 hours, as shown in the figure below.