Cape Coloured Research Articles

Indelible apartheid: intergenerational post-colonial narratives of colonial-born coloured females about hair, race and identity in South Africa

ABSTRACT What do the narratives of five Cape Coloured women of three generations reveal about issues of race and identity in post-apartheid South Africa? This question is the essence of this study. Identity in apartheid South Africa was strictly and legislatively framed around race, defined by physical characteristics of skin colour and hair texture. Whiteness was the epitome with socio-economic privileges, which invariably created aspirations for this body or proximity to it among some Coloured South Africans in the pursuit of social-economic upliftment. But in a free, post-apartheid, and multi-racial South Africa, do the colonial constructions of identities still linger? Through a critical theoretical lens of postcolonial discourses about race and identity, this study explores intergenerational phenomenological expressions of five Coloured women between the ages of 48 and 104 born during South Africa’s colonial and apartheid eras. The aim was to explore if colonial narratives of hair still influence hair trends, self-presentation, race and identity. It seems racist ideologies of the past are generational, and still shape the perception of hair amongst this cohort of Coloured females.

Evolution of the Physical Phenotype of Fetal Alcohol Spectrum Disorders from Childhood through Adolescence.

This paper reports findings from the first longitudinal study on the evolution of the physical phenotypes of fetal alcohol syndrome (FAS) and partial FAS (PFAS) from early childhood through adolescence. The sample consisted of 155 children (78 males and 77 females) born to women recruited at an antenatal clinic serving a Cape Coloured (mixed ancestry) population in Cape Town, South Africa. Two expert FASD dysmorphologists, blind regarding prenatal alcohol exposure, independently evaluated each child's growth and dysmorphology at 4 clinics conducted over an 11-year period. Case conferences were held to reach consensus regarding which children had FAS or PFAS growth and physical features using the Revised Institute of Medicine (2005) guidelines. The prevalence of the physical phenotype was stable across the 4 ages for about half of the children with FAS and about one-third of those with PFAS but more variable for the others. Test-retest reliability was substantial for the FAS phenotype, but poorer for PFAS. Two distinct patterns were seen: a "strong phenotype" that was consistently identified and a less consistent one in which dysmorphic features and/or anthropometric deficits fluctuated or diminished with age. The physical phenotype was most apparent during early childhood and least apparent during puberty, due to differences in timing of the growth spurt and the evolving adult face. Short palpebral features and small head circumference diminished with age, flat philtrum fluctuated, while thin vermilion and weight and height restriction were stable. Key facial features that characterize FASD in early childhood diminish or evolve in some individuals, making diagnostic examinations that rely on these characteristics most sensitive during early childhood and school age. Moreover, puberty poses classification problems due to variability in timing of the growth spurt. Given that several features and small head circumference diminished with age, many individuals would be misdiagnosed if only examined at a later age.

Donald William Ebrahim

Donald William Ebrahim (“Don” or “Don Willy”) was born in Cape Town, South Africa. He was one of six children of Florrie, a “Cape Coloured,” and Mohamed Cassim Ebrahim, an...

Cape of Good Hope? Meeting Place of Unwilling Migrants from Africa, Asia and Indigenous People

Abstract The paper mainly deals with the large number of slaves from Asia and Africa imported to the Cape of Good Hope during the period 1658 - 1807. Apart from the (in-)human treatment of people from different continents, and the evils of slavery as a system, the new migrants eventually fused with the indigenous Khoikhoi, San and European population to create a new group of people that would eventually become known as the "Cape Coloured" community (In Afrikaans "kleurlinge" or "bruin mense"). At present this group consists of nearly 5 million people; 10% of the total South African population. Recent research on the ethnic origin of the slave population of the Cape Colony in 1834 undertaken by Stellenbosch Museum and the Department of Economics at the University of Stellenbosch, sheds more light on the ethnic origins of the slave community. This contribution is based on the comprehensive lists of slave-ownership for the period 1816-1834 and also the list of names of slaves that appear on the compensation rolls drawn up in December 1834. (From 1834-1838 the former slaves became known as "apprentices"). For the period directly following the emancipation of slaves in 1834, the ex-slaves, Khoikhoi, San and a number of Europeans gradually intermarried to take on a new "coloured" identity. However, old terminology like Khoikhoi (and the pejorative term "Hottentot") often remained in use into the 20th century and featured in government records and correspondence until the 1930s.

Development and validation of a quantitative choline food frequency questionnaire for use with drinking and non-drinking pregnant women in Cape Town, South Africa

BackgroundAlthough animal and human studies have demonstrated interactions between dietary choline and fetal alcohol spectrum disorders, dietary choline deficiency in pregnancy is common in the US and worldwide. We sought to develop and validate a quantitative food frequency questionnaire (QFFQ) to estimate usual daily choline intake in pregnant mothers.MethodsA panel of nutrition experts developed a Choline-QFFQ food item list, including sources with high choline content and the most commonly consumed choline-containing foods in the target population. A data base for choline content of each item was compiled. For reliability and validity testing in a prospective longitudinal cohort, 123 heavy drinking Cape Coloured pregnant women and 83 abstaining/light-drinking controls were recruited at their first antenatal clinic visit. At 3 prenatal study visits, each gravida was interviewed about alcohol, smoking, and drug use, and administered a 24-hour recall interview and the Choline-QFFQ.ResultsAcross all visits and assessments, > 78% of heavy drinkers and controls reported choline intake below the Dietary Reference Intakes adequate intake level (450 mg/day). Women reported a decrease in choline intake over time on the QFFQ. Reliability of the QFFQ across visits was good-to-acceptable for 2 of 4 group-level tests and 4 of 5 individual-level tests for both drinkers and controls. When compared with 24-hr recall data, validity of the QFFQ was good-to-acceptable for 3 of 4 individual-level tests and 3 of 5 group-level tests. For controls, validity was good-to-acceptable for all 4 individual-level tests and all 5 group-level tests.ConclusionsTo our knowledge, this is the first quantitative choline food frequency screening questionnaire to be developed and validated for use with both heavy and non-drinking pregnant women and the first to be used in the Cape Coloured community in South Africa. Given the high prevalence of inadequate choline intake and the growing evidence that maternal choline supplementation can mitigate some of the adverse effects of prenatal alcohol exposure, this tool may be useful for both research and future clinical outreach programs.

Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

We recently demonstrated the acceptability and feasibility of a randomized, double-blind choline supplementation intervention for heavy drinking women during pregnancy. In this study, we report our results relating to the efficacy of this intervention in mitigating adverse effects of prenatal alcohol exposure (PAE) on infant growth and cognitive function. Sixty-nine Cape Coloured (mixed ancestry) heavy drinkers in Cape Town, South Africa, recruited in mid-pregnancy, were randomly assigned to receive a daily oral dose of either 2g of choline or placebo from time of enrollment until delivery. Each dose consisted of an individually wrapped packet of powder that, when mixed with water, produced a sweet tasting grape-flavored drink. The primary outcome, eyeblink conditioning (EBC), was assessed at 6.5months. Somatic growth was measured at birth, 6.5, and 12months, recognition memory and processing speed on the Fagan Test of Infant Intelligence, at 6.5 and 12months. Infants born to choline-treated mothers were more likely to meet criterion for conditioning on EBC than the placebo group. Moreover, within the choline arm, degree of maternal adherence to the supplementation protocol strongly predicted EBC performance. Both groups were small at birth, but choline-treated infants showed considerable catch-up growth in weight and head circumference at 6.5 and 12months. At 12months, the infants in the choline treatment arm had higher novelty preference scores, indicating better visual recognition memory. This exploratory study is the first to provide evidence that a high dose of choline administered early in pregnancy can mitigate adverse effects of heavy PAE on EBC, postnatal growth, and cognition in human infants. These findings are consistent with studies of alcohol-exposed animals that have demonstrated beneficial effects of choline supplementation on classical conditioning, learning, and memory.

Facial Curvature Detects and Explicates Ethnic Differences in Effects of Prenatal Alcohol Exposure.

Our objective is to help clinicians detect the facial effects of prenatal alcohol exposure by developing computer-based tools for screening facial form. All 415 individuals considered were evaluated by expert dysmorphologists and categorized as (i) healthy control (HC), (ii) fetal alcohol syndrome (FAS), or (iii) heavily prenatally alcohol exposed (HE) but not clinically diagnosable as FAS; 3D facial photographs were used to build models of facial form to support discrimination studies. Surface curvature-based delineations of facial form were introduced. (i) Facial growth in FAS, HE, and control subgroups is similar in both cohorts. (ii) Cohort consistency of agreement between clinical diagnosis and HC-FAS facial form classification is lower for midline facial regions and higher for nonmidline regions. (iii) Specific HC-FAS differences within and between the cohorts include: for HC, a smoother philtrum in Cape Coloured individuals; for FAS, a smoother philtrum in Caucasians; for control-FAS philtrum difference, greater homogeneity in Caucasians; for control-FAS face difference, greater homogeneity in Cape Coloured individuals. (iv) Curvature changes in facial profile induced by prenatal alcohol exposure are more homogeneous and greater in Cape Coloureds than in Caucasians. (v) The Caucasian HE subset divides into clusters with control-like and FAS-like facial dysmorphism. The Cape Coloured HE subset is similarly divided for nonmidline facial regions but not clearly for midline structures. (vi) The Cape Coloured HE subset with control-like facial dysmorphism shows orbital hypertelorism. Facial curvature assists the recognition of the effects of prenatal alcohol exposure and helps explain why different facial regions result in inconsistent control-FAS discrimination rates in disparate ethnic groups. Heavy prenatal alcohol exposure can give rise to orbital hypertelorism, supporting a long-standing suggestion that prenatal alcohol exposure at a particular time causes increased separation of the brain hemispheres with a concomitant increase in orbital separation.

Estimating a child's age from an image using whole body proportions.

The use and distribution of child pornography is an increasing problem. Forensic anthropologists are often asked to estimate a child's age from a photograph. Previous studies have attempted to estimate the age of children from photographs using ratios of the face. Here, we propose to include body measurement ratios into age estimates. A total of 1603 boys and 1833 girls aged 5-16years were measured over a 10-year period. They are 'Cape Coloured' children from South Africa. Their age was regressed on ratios derived from anthropometric measurements of the head as well as the body. Multiple regression equations including four ratios for each sex (head height to shoulder and hip width, knee width, leg length and trunk length) have a standard error of 1.6-1.7years. The error is of the same order as variation of differences between biological and chronological ages of the children. Thus, the error cannot be minimised any further as it is a direct reflection of a naturally occurring phenomenon.

O48. On white matter changes in children with HIV infection and exposure

Introduction Although previous MRI studies have consistently shown immunodeficiency-related white matter (WM) alterations in humans and animal models, investigations of early development in childhood have typically included wide age ranges during which both WM volume and fractional anistropy (FA) increase significantly as part of normal development. Here, we use diffusion tensor imaging (DTI) to examine WM alterations in HIV infected children at age 7 years and compare those who initiated Antiretroviral therapy (ART) before and after 12 weeks of age. Methods POPULATION: MRI scanning was performed on 121 Xhosa and Cape Coloured 7 year old children as part of the longitudinal, neurodevelopmental Children with HIV Early Antiretroviral Therapy (CHER) trial in Cape Town, South Africa. The group included HIV-infected children who were stable on ART, and age-matched controls from the same community as part of a parallel vaccine study. After exclusion of subjects (due to motion, artifacts, etc.), we examined data from 64 HIV-infected (HIV) children and 46 uninfected controls (CTRL). SCANNING PROCEDURE: Children in the study were scanned on a 3T Siemens Allegra (Erlangen, Germany) with a single channel head coil. Children were scanned with structural T 1 imaging (MEMPRAGE) followed by 2 DTI acquisitions with opposite phase encoding (AP-PA) directions using a prospectively motion-corrected navigated twice-refocused spin echo sequence with 5 reacquisitions. Acquisition parameters for diffusion were: TR/TE = 10100/86 ms, 72 slices, voxel = 2 × 2 × 2 mm3, FOV = 224 mm, 30 non-collinear diffusion directions with b = 1000 s/mm2, and four non-diffusion-weighted (b0) acquisitions. Results Comparing the HIV group to CTRL, two regions in the left inferior fronto-occipital fasciculus and left inferior longitudinal fasciculus showed lower FA, and 7 bilateral regions throughout the superior longitudinal fasciculus, superior and inferior fronto-occipital fasciculi, and left corticospinal tract showed higher MD. Conclusion Lower FA and higher MD in HIV-infected children were largely attributable to higher radial diffusivity, indicative of poorer myelination in the affected regions. Some regions with increased MD also showed increased axial diffusivity. Both axial and radial diffusivity have been shown to decrease from neonates to 1-year olds and throughout childhood. The higher levels in HIV-infected children seen here could be indicative of altered developmental trajectories.

A South African mixed race lip/philtrum guide for diagnosis of fetal alcohol spectrum disorders.

The adverse effects of maternal alcohol use during pregnancy represent a spectrum of growth restriction, facial dysmorphology, and neurocognitive challenges in the offspring. The continuum of diagnoses is referred to as fetal alcohol spectrum disorders (FASD). Short palpebral fissures, a smooth philtrum, and a thin vermilion border of the upper lip comprise the three cardinal facial features of FASD. Early attempts to define a smooth philtrum and thin vermilion border of the upper lip were subjective. Astley and colleagues introduced a 5-point Likert-scaled lip/philtrum guide based on Caucasian North American subjects as an objective tool for the evaluation of the facial dysmorphology in FASD. This Caucasian guide has been incorporated into all current diagnostic schemes for FASD. However, broad international clinical experience with FASD indicates racial and ethnic differences with respect to the facial morphology. Because of the substantial number of children with FASD in South Africa among the Cape Coloured (mixed race) population in the Western Cape Province, we developed a specific lip/philtrum guide for that population. The guide incorporates a 45-degree view of the philtrum that enables an enhanced 3-dimensional evaluation of philtral height not possible with a frontal view alone. The guide has proven to be a more specific and sensitive tool for evaluation of the facial dysmorphology of FASD in the Cape Coloured population than the use of the previous North American Caucasian guide and points to the utility of racial and ethnic-specific dysmorphology tools in the evaluation of children with suspected FASD.

A complement C5 gene mutation, c.754G>A:p.A252T, is common in the Western Cape, South Africa and found to be homozygous in seven percent of Black African meningococcal disease cases

Patients with genetically determined deficiency of complement component 5 are usually diagnosed because of recurrent invasive Neisseria meningitidis infections. Approximately 40 individual cases have been diagnosed worldwide. Nevertheless, reports of the responsible genetic defects have been sporadic, and we know of no previous reports of C5 deficiency being associated with a number of independent meningococcal disease cases in particular communities. Here we describe C5 deficiency in seven unrelated Western Cape, South African families.Three different C5 mutations c.55C>T:p.Q19X, c.754G>A:p.A252T and c.4426C>T:p.R1476X were diagnosed in index cases from two families who had both presented with recurrent meningococcal disease. p.Q19X and p.R1476X have already been described in North American Black families and more recently p.Q19X in a Saudi family. However, p.A252T was only reported in SNP databases and was not associated with disease until the present study was undertaken in the Western Cape, South Africa.We tested for p.A252T in 140 patients presenting with meningococcal disease in the Cape Town area, and found seven individuals in five families who were homozygous for the mutation p.A252T. Very low serum C5 protein levels (0.1–4%) and correspondingly low in vitro functional activity were found in all homozygous individuals. Allele frequencies of p.A252T in the Black African and Cape Coloured communities were 3% and 0.66% and estimated homozygosities are 1/1100 and 1/22,500 respectively. In 2012 we reported association between p.A252T and meningococcal disease. Molecular modelling of p.A252T has indicated an area of molecular stress in the C5 molecule which may provide a mechanism for the very low level in the circulation. This report includes seven affected families indicating that C5D is not rare in South Africa.

Common mutation causes cystinosis in the majority of black South African patients.

The mutations responsible for cystinosis in South African patients are currently unknown. A pertinent question is whether they are similar to those described elsewhere in the world. Children who were being managed for cystinosis in the Western Cape Province of South Africa between 2002 and 2013 were studied. All underwent molecular analysis to detect sequence variations in the cystinosis gene. This cohort study included 20 patients, 13 of whom were Xhosa-speaking black South Africans and seven were Cape Coloureds (mixed race); none were Caucasian. All had nephropathic infantile-type cystinosis with evidence of proximal tubulopathy, with glycosuria and renal phosphate wasting. Diagnosis was confirmed in 19 cases by demonstrating an elevated cystine concentration in leukocytes. Molecular analysis of the cystinosin gene revealed that 19 patients had a G > A mutation in intron 11 (CTNS-c.971-12G > A p.D324AfsX44) which caused an out-of-frame 10-bp insertion. Of these 19 patients, 16 were homozygous for this mutation, which was the most frequent mutation identified in the alleles of the black South African and Cape Coloured patients (96 and 71 %, respectively). We recommend that black South African and Cape Coloured patients presenting with cystinosis be tested for CTNS-c.971-12G > A in the first instance, with the possibility of prenatal testing being offered to at-risk families.

Adiposity is associated with improved neuromuscular reaction time

Many studies have focused on the detrimental effects of malnourishment to the performance of the brain and peripheral nerves. Undernourished children and adults have been studied extensively to establish these consequences. Little attention has been given to the body habitus that affects optimum neurological performance and the implications for individuals on the spectral extremes of the healthy weight range. This paper examines the association between markers of adiposity and neurological performance, inclusive of all body types. The data were obtained from Cape Coloured youths (5–20 years) in South Africa from the rural district of Klein Karoo and the urban population of Cape Town. In all, the sums of skin-folds were measured for almost 4000 students. The neuromuscular reaction time was also calculated using a ruler drop test. This measure may serve as a gross marker of peripheral and central neurological performance as both are needed to execute the reflex command. There was a direct correlation between adiposity and neuromuscular reaction time. Whilst controlling for age, increasing fatness was associated with a decrease in neuromuscular reaction time amongst both sexes. This relationship remained statistically significant, even when removing the thinnest 40% of participants, eliminating the scope of influence exerted by malnourishment on the correlation. The trend appears to be more prominent amongst boys. These findings indicate that body lipid reserves are integral to the development of the nervous system even amongst children within the healthy weight ranges. Our hypothesis is that the myelination of the nerves, both centrally through oligodendrocytes and peripherally by Schwann cells, is integral to this process as they are predominantly lipid. Amongst thin but not clinically undernourished individuals, the somatic lipid reserves are modest. These fats may be minimally sequestered away for the development of myelin nerve sheath at the expense of saltatory conduction. This may account for the slowed neuromuscular reaction time demonstrated.

The association between race and Crohn's disease phenotype in the Western Cape population of South Africa, defined by the Montreal Classification System.

BackgroundInter-racial differences in disease characteristics and in the management of Crohn's disease (CD) have been described in African American and Asian subjects, however for the racial groups in South Africa, no such recent literature exists.MethodsA cross sectional study of all consecutive CD patients seen at 2 large inflammatory bowel disease (IBD) referral centers in the Western Cape, South Africa between September 2011 and January 2013 was performed. Numerous demographic and clinical variables at diagnosis and date of study enrolment were identified using an investigator administered questionnaire as well as clinical examination and patient case notes. Using predefined definitions, disease behavior was stratified as ‘complicated’ or ‘uncomplicated’.ResultsOne hundred and ninety four CD subjects were identified; 35 (18%) were white, 152 (78%) were Cape Coloured and 7(4%) were black. On multiple logistic regression analysis Cape Coloureds were significantly more likely to develop ‘complicated’ CD (60% vs. 9%, p = 0.023) during the disease course when compared to white subjects. In addition, significantly more white subjects had successfully discontinued cigarette smoking at study enrolment (31% vs. 7% reduction, p = 0.02). No additional inter-racial differences were found. A low proportion of IBD family history was observed among the non-white subjects.ConclusionsCape Coloured patients were significantly more likely to develop ‘complicated’ CD over time when compared to whites.

An In Vivo 1H Magnetic Resonance Spectroscopy Study of the Deep Cerebellar Nuclei in Children with Fetal Alcohol Spectrum Disorders

Prenatal alcohol exposure has been linked to impairment in cerebellar structure and function, including eyeblink conditioning. The deep cerebellar nuclei, which play a critical role in cerebellar-mediated learning, receive extensive inputs from brain stem and cerebellar cortex and provide the point of origin for most of the output fibers to other regions of the brain. We used in vivo (1) H magnetic resonance spectroscopy (MRS) to examine effects of prenatal alcohol exposure on neurochemistry in this important cerebellar region. MRS data from the deep cerebellar nuclei were acquired from 37 children with heavy prenatal alcohol exposure and 17 non- or minimally exposed controls from the Cape Coloured (mixed ancestry) community in Cape Town, South Africa. Increased maternal alcohol consumption around time of conception was associated with lower N-Acetylaspartate (NAA) levels in the deep nuclei (r = -0.33, p < 0.05). Higher levels of alcohol consumption during pregnancy were related to lower levels of the choline-containing metabolites (r = -0.37, p < 0.01), glycerophosphocholine plus phosphocholine (Cho). Alcohol consumption levels both at conception (r = 0.35, p < 0.01) and during pregnancy (r = 0.38, p < 0.01) were related to higher levels of glutamate plus glutamine (Glx). All these effects continued to be significant after controlling for potential confounders. The lower NAA levels seen in relation to prenatal alcohol exposure may reflect impaired neuronal integrity in the deep cerebellar nuclei. Our finding of lower Cho points to disrupted Cho metabolism of membrane phospholipids, reflecting altered neuropil development with potentially reduced content of dendrites and synapses. The alcohol-related alterations in Glx may suggest a disruption of the glutamate-glutamine cycling involved in glutamatergic excitatory neurotransmission.

Body frame variation and adiposity in development, a mixed‐longitudinal study of “cape coloured” children

The obesity epidemic is impacting both developed and undeveloped countries worldwide. It has only been recently that wide scale public campaigning has focused on prevention rather than intervention. Individual variations in food metabolism and energy expenditure may be responsible for much of the adiposity present amongst individuals. This article studies individual variation in relationship between lean trunk size and adiposity. A mixed longitudinal growth study was conducted between 1986 and 1995 among urban and rural "Cape Coloured" schoolchildren from the Western Cape Province of South Africa. The sample consists of 127 females and 130 males between the ages of 6 and 20 years measured 6-9 times each. Correlations between age-standardized triceps, subscapular and abdominal skinfold thicknesses and quotient indices obtained by expressing trunk length, lower limb, and upper limb lengths and bi-acromial and bi-iliocristal diameters as percentages of body height were explored for each year of growth. Significant correlation coefficients (P < 0.05) between 0.087 and 0.511 were found in both males and females, between bi-acromial and bi-iliocristal indices and three skinfold thicknesses, but not between trunk and limb lengths and skinfolds. Skeletal frame width and amount of adiposity are correlated. The correlation persists longitudinally throughout childhood and adolescence in individuals living in very poor, as well as, in good environmental conditions.

Infant Emotional Withdrawal: A Precursor of Affective and Cognitive Disturbance in Fetal Alcohol Spectrum Disorders

Our aim was to test the hypothesis that emotional withdrawal is an early indicator of affective disorder in infants heavily exposed prenatally to alcohol, which is independent of alcohol-related effects on mother-infant interaction and temperament and discriminated between children later diagnosed with fetal alcohol syndrome (FAS) and partial FAS (PFAS) and predicted cognitive and affective outcomes at 5 and 9years. The sample consisted of Cape Coloured (mixed ancestry) infants, whose mothers were interviewed during pregnancy regarding their alcohol consumption using a timeline follow-back approach. Infant emotional withdrawal (n=85) was assessed on the Alarm Distress Baby Scale at 6.5months. Mother-infant interaction was evaluated from video recordings during free play and infant feeding at 6.5months (n=127). Infant temperament was assessed by maternal report on the EAS Temperament Survey at 13months (n=119). Sociodemographic and psychological correlates of maternal alcohol use and infant iron deficiency were examined as potential confounders. The children were diagnosed for FAS/PFAS by expert dysmorphologists at 5years, cognitive and affective function at 5 and 9years. Prenatal alcohol exposure was associated with increased infant emotional withdrawal and decreased activity, but unrelated to mother-infant interaction or any other temperament measures. Children later diagnosed with FAS and PFAS at 5years exhibited more emotional withdrawal and less responsivity and activity as infants. Infant withdrawal, responsivity, quality of interaction, and maternal sensitivity also predicted poorer IQ and affective response at 5 and 9years. When all 4 infant affective measures were examined simultaneously in a regression analysis, only infant emotional withdrawal persisted as a significant predictor of 9-year IQ. This study is the first to document a direct effect of fetal alcohol exposure on emotional withdrawal in infancy. These data link prenatal alcohol to a specific aspect of infant affective function not attributable to mother-infant interaction, infant temperament, or other socioemotional aspects of the infant's environment and identify infant emotional withdrawal as an early indicator of affective disturbance, particularly in children later diagnosed with FAS and PFAS.

Afrikaans as an index of identity among Western Cape Coloured communities

In South Africa, reports on language shift have focused on instances of language shift from indigenous African languages to English. There is, however, also research that suggests that language shift is taking place from Afrikaans to English in the Western Cape. Anthonissen (2009), for example, notes in her research among Coloured communities that a shift has taken place from Afrikaans first language (L1), across three generations, to English L1. Against this backdrop, this paper investigates language shift in two semi-urban Western Cape Coloured communities; in particular, it examines what patterns of language shift/maintenance can be observed, and investigates sociolinguistic factors, such as age, language of schooling, socio-economic status and language attitudes, to which the observed patterns can be ascribed. The aim is to ascertain whether language shift, from Afrikaans to English has taken place, and which factors appear to encourage or discourage language shift in the two communities. Through the administration of a questionnaire to 50 households, 25 in each of the communities, the study this paper reports on examined language use across a number of domains: at home, in the community, in church, and in the workplace. It also explored the language attitudes of the participants (53 in total) towards Afrikaans in order to investigate the possibility that this language might be used for indexing their identity. The collected data does not provide any evidence of language shift from Afrikaans to English. However, there seems to be increased use of English in the public domains (such as the workplace and in the church), with Afrikaans being used almost exclusively in the intimate domains. It appears that Afrikaans remains a strong marker of identity in the two semi-urban Western Cape Coloured communities, despite English largely being regarded as the language of upward socio-economic mobility.

Impaired Delay and Trace Eyeblink Conditioning in School-Age Children With Fetal Alcohol Syndrome

Classical eyeblink conditioning (EBC) involves contingent temporal pairing of a conditioned stimulus (e.g., tone) with an unconditioned stimulus (e.g., air puff). Impairment of EBC has been demonstrated in studies of alcohol-exposed animals and in children exposed prenatally at heavy levels. Fetal alcohol syndrome (FAS) was diagnosed by expert dysmorphologists in a large sample of Cape Coloured, South African children. Delay EBC was examined in a new sample of 63 children at 11.3 years, and trace conditioning in 32 of the same children at 12.8 years. At each age, 2 sessions of 50 trials each were administered on the same day; 2 more sessions the next day, for children not meeting criterion for conditioning. Six of 34 (17.6%) children born to heavy drinkers were diagnosed with FAS, 28 were heavily exposed nonsyndromal (HE), and 29 were nonexposed controls. Only 33.3% with FAS and 42.9% of HE met criterion for delay conditioning, compared with 79.3% of controls. The more difficult trace conditioning task was also highly sensitive to fetal alcohol exposure. Only 16.7% of the FAS and 21.4% of HE met criterion for trace conditioning, compared with 66.7% of controls. The magnitude of the effect of diagnostic group on trace conditioning was not greater than the effect on short delay conditioning, findings consistent with recent rat studies. Longer latency to onset and peak eyeblink CR in exposed children indicated poor timing and failure to blink in anticipation of the puff. Extended training resulted in some but not all of the children reaching criterion. These data showing alcohol-related delay and trace conditioning deficits extend our earlier findings of impaired EBC in 5-year-olds to school-age. Alcohol-related impairment in the cerebellar circuitry required for both forms of conditioning may be sufficient to account for the deficit in both tasks. Extended training was beneficial for some exposed children. EBC provides a well-characterized model system for assessment of degree of cerebellar-related learning and memory dysfunction in fetal alcohol exposed children.

An fMRI Study of Number Processing in Children With Fetal Alcohol Syndrome

Number processing deficits are frequently seen in children exposed to alcohol in utero. Functional magnetic resonance imaging was used to examine the neural correlates of number processing in 15 right-handed, 8- to 12-year-old children diagnosed with fetal alcohol syndrome (FAS) or partial FAS (PFAS) and 18 right-handed, age- and gender-matched controls from the Cape Coloured (mixed ancestry) community in Cape Town, South Africa, using Proximity Judgment and Exact Addition tasks. Control children activated the expected fronto-parietal network during both tasks, including the anterior horizontal intraparietal sulcus (HIPS), left posterior HIPS, left precentral sulcus, and posterior medial frontal cortex. By contrast, on the Proximity Judgment task, the exposed children recruited additional parietal pathways involving the right and left angular gyrus and posterior cingulate/precuneus, which may entail verbally mediated recitation of numbers and/or subtraction to assess relative numerical distances. During Exact Addition, the exposed children exhibited more diffuse and widespread activations, including the cerebellar vermis and cortex, which have been found to be activated in adults engaged in particularly challenging number processing problems. The data suggest that, whereas control children rely primarily on the fronto-parietal network identified in previous studies to mediate number processing, children with FAS/PFAS recruit a broader range of brain regions to perform these relatively simple number processing tasks. Our results are consistent with structural neuroimaging findings indicating that the parietal lobe is relatively more affected by prenatal alcohol exposure and provide the first evidence for brain activation abnormalities during number processing in children with FAS/PFAS, effects that persist even after controlling statistically for group differences in total intracranial volume and IQ.