Transit Candidates Research Articles

A False Positive Transit Candidate for EPIC 211101996 from K2 and TESS Data Identified as Background Eclipsing Binary Gaia DR3 66767847894609792

Transiting planets around young stars are hard to find due to the enhanced stellar activity. Only a few transiting planets have been detected around stars younger than 100 Myr. We initially detected a transit-like signal in the K2 light curve of a very cool M dwarf star (EPIC 211101996) in the Pleiades open cluster, with an estimated age of about 100 Myr. Our detailed analysis of the per-pixel light curves, detrending with the Wōtan software and transit search with the Transit Least Squares algorithm showed that the source of the signal is a contaminant source (Gaia DR3 66767847894609792) 20″ west of the target. The V-like shape of its phase-folded light curve and eclipse depth of ∼15% suggest that it is a grazing eclipsing binary. The contaminant has hitherto been listed as a single star, which we now identify as an eclipsing stellar binary with a period of about 6 days.

Evaluation of Post-thrombolytic Events to Determine Appropriate ICU Monitoring Duration for Patients with Ischemic Stroke.

Standard treatment for eligible patients presenting with acute ischemic stroke (AIS) is thrombolysis with tissue plasminogen activators alteplase or tenecteplase. Current guidelines recommend monitoring patients in an intensive care unit (ICU) for 24h after thrombolytic therapy. However, recent studies have questioned the need for prolonged ICU monitoring. This retrospective cohort study aims to identify potential candidates for early transition to a lower level of care by assessing risk factors for neurological deterioration, symptomatic intracranial hemorrhage (sICH), or need for ICU intervention within 24h post-thrombolysis. This retrospective cohort study included adult patients 18years and older with AIS who received thrombolysis. Patients were excluded if they were transferred to another facility, if they were transitioned to comfort care or hospice care within 24h, or if they lacked imaging and National Institutes of Health Stroke Scale (NIHSS) score data. The primary end point was incidence of sICH between 0-12 and 12-24h. Secondary end points included the need for ICU intervention and rates of neurological deterioration. The analysis included 204 patients who received the full dose of alteplase. Among them, ten patients (4.9%) developed sICH, with the majority (n = 7) occurring within 12h post-thrombolysis. Sixty-two patients required ICU interventions within 12h compared with four patients after 12h. Twenty-four patients had neurological deterioration within 12h, and seven patients had neurological deterioration after 12h. Multivariable analysis identified mechanical thrombectomy and increased blood pressure at presentation as predictors of ICU need beyond 12h post-thrombolysis. Our study demonstrates that sICH, neurological deterioration, and need for ICU intervention rarely occur beyond 12h after thrombolytic administration. Patients presenting with blood pressures < 140/90mm Hg, NIHSS scores < 10, and not undergoing mechanical thrombectomy may be best candidates for early de-escalation. Larger prospective studies are needed to more fully evaluate the safety, feasibility, and financial impact of early transition out of the ICU.

Electronic Structure Analysis of the A10 Tt2 P6 System (A=Li-Cs; Tt=Si, Ge, Sn) and Synthesis of the Direct Band Gap Semiconductor K10 Sn2 P6.

Investigating the relationship between atomic and electronic structures is a powerful tool to screen the wide variety of Zintl phases for interesting (opto-)electronic properties. To get an insight in such relations, the A10 Tt2 P6 system (A=Li-Cs; Tt=Si-Sn) was picked as model system to analyse the influence of structural motives, combination of elements and their properties on type and width of the band gaps. Those compounds comprise two interesting structural motives of their anions, which are either monomeric trigonal planar TtP3 5- units which are isostructural to CO3 2- or [Tt2 P6 ]10- dimers which correspond to two edge-sharing TtP4 tetrahedra. The A10 Tt2 P6 compounds were structurally optimized for both polymorphs and subsequent frequency analysis, band structure as well as density of states calculations were performed. The Gibbs free energies were compared to determine temperature dependent stability, where Na10 Si2 P6 , Na10 Ge2 P6 and K10 Sn2 P6 were found to be candidates for a high temperature phase transition between the two polymorphs. Additionally, the unknown, but predicted compound K10 Sn2 P6 was synthesized and characterized by single crystal and powder x-ray diffraction. It crystalizes in the monoclinic space group P 21 /n and incorporates [Sn2 P6 ]10- edge sharing double tetrahedra. It was determined to be a direct band gap semiconductor with a band gap of 2.57 eV.

Assessing prescriber adherence with Global Initiative for Asthma (GINA) guideline-recommended reliever therapy.

In 2019, a landmark change was made to the Global Initiative for Asthma (GINA) guidelines in which an as-needed low-dose inhaled corticosteroid (ICS)-formoterol inhaler was updated to be the preferred reliever therapy for all asthma patients. Use of short-acting beta-agonist monotherapy is no longer recommended. The purpose of this study was to assess provider adherence with the GINA guidelines in regards to reliever therapy. This was a retrospective cohort study of patients presenting with an acute asthma exacerbation from January to May of 2020 and 2021. The primary objective of this study was to quantify provider adherence with the GINA guidelines in terms of reliever therapy. Preferred reliever therapy was defined asuse of an as-needed low-dose ICS-formoterol combination inhaler. Alternative reliever therapy was defined as use of a SABA inhaler with ICS-containing controller therapy. Secondary objectives included the number of patients discharged on any form of corticosteroid and the number of patients who may have been ideal candidates for transition to preferred reliever therapy. A total of 127 patients were included in the analyses. Upon hospital discharge, three patients (2.4%) received preferred reliever therapy and 97 (76.4%) received alternative reliever therapy. Rates of recommended reliever therapy prescription increased from 55 to 79% upon hospital discharge (p < 0.001). Prescription of GINA guideline-recommended reliever therapy was 79% within the patient population evaluated; however, rates significantly improved following hospitalization for asthma exacerbation. Additional studies that assess barriers to guideline adherence may be recommended.

The Perkins INfrared Exosatellite Survey (PINES). II. Transit Candidates and Implications for Planet Occurrence around L and T Dwarfs

We describe a new transit-detection algorithm designed to detect single-transit events in discontinuous Perkins INfrared Exosatellite Survey (PINES) observations of L and T dwarfs. We use this algorithm to search for transits in 131 PINES light curves and identify two transit candidates: 2MASS J18212815+1414010 (2MASS J1821+1414) and 2MASS J08350622+1953050 (2MASS J0835+1953). We disfavor 2MASS J1821+1414 as a genuine transit candidate due to the known variability properties of the source. We cannot rule out the planetary nature of 2MASS J0835+1953's candidate event and perform follow-up observations in an attempt to recover a second transit. A repeat event has yet to be observed, but these observations suggest that target variability is an unlikely cause of the candidate transit. We perform a Markov Chain Monte Carlo simulation of the light curve and estimate a planet radius ranging from to , depending on the host’s age. Finally, we perform an injection and recovery simulation on our light-curve sample. We inject planets into our data using measured M-dwarf planet occurrence rates and attempt to recover them using our transit-search algorithm. Our detection rates suggest that, assuming M-dwarf planet occurrence rates, we should have roughly a 1% chance of detecting a candidate that could cause the transit depth we observe for 2MASS J0835+1953. If 2MASS J0835+1953 b is confirmed, it would suggest an enhancement in the occurrence of short-period planets around L and T dwarfs in comparison to M dwarfs, which would challenge predictions from planet formation models.

Gaia–TESS synergy: improving the identification of transit candidates

Context. The TESS team periodically issues a new list of transiting exoplanet candidates based on the analysis of the accumulating light curves obtained by the satellite. The list includes the estimated epochs, periods, and durations of the potential transits. As the point spread function (PSF) of TESS is relatively wide, follow-up photometric observations at higher spatial resolution are required in order to exclude apparent transits that are actually blended background eclipsing binaries (BEBs). Aims. The Gaia space mission, with its growing database of epoch photometry and high angular resolution, enables the production of distinct light curves for all sources included in the TESS PSF, up to the limiting magnitude of Gaia. This paper reports the results of an ongoing Gaia-TESS collaboration that uses the Gaia photometry to facilitate the identification of BEB candidates and even to confirm on-target candidates in some cases. Methods. We inspected the Gaia photometry of the individual sources included in the TESS PSF, searching for periodic dimming events compatible with their ephemerides and uncertainties, as published by TESS. The performance of the search depends mainly on the number of Gaia measurements during transit and their precision. Results. Since February 2021, the collaboration has been able to confirm 126 on-target candidates and exclude 124 as BEBs. Since June 2021, when our search methodology matured, we have been able to identify on the order of 5% as on-target candidates and another 5% as BEBs. Conclusions. This synergistic approach is combining the complementary capabilities of two of the astronomical space missions of NASA and ESA. It serves to optimize the process of detecting new planets by making better use of the resources of the astronomical community.

TFAW survey II: six newly validated planets and 13 planet candidates fromK2

ABSTRACTSearching for Earth-sized planets in data from Kepler’s extended mission (K2) is a niche that still remains to be fully exploited. The TFAW survey is an ongoing project that aims to re-analyse all light curves in K2 C1–C8 and C12–C18 campaigns with a wavelet-based detrending and denoising method, and the period search algorithm TLS to search for new transit candidates not detected in previous works. We have analysed a first subset of 24 candidate planetary systems around relatively faint host stars (10.9 &amp;lt; Kp &amp;lt; 15.4) to allow for follow-up speckle imaging observations. Using vespa and TRICERATOPS, we statistically validate six candidates orbiting four unique host stars by obtaining false-positive probabilities smaller than 1 per cent with both methods. We also present 13 vetted planet candidates that might benefit from other, more precise follow-up observations. All of these planets are sub-Neptune-sized with two validated planets and three candidates with sub-Earth sizes, and have orbital periods between 0.81 and 23.98 d. Some interesting systems include two ultra-short-period planets, three multiplanetary systems, three sub-Neptunes that appear to be within the small planet Radius Gap, and two validated and one candidate sub-Earths (EPIC 210706310.01, K2-411 b, and K2-413 b) orbiting metal-poor stars.

Outcomes of Early Transition of Low-Risk Thyroid Cancer Patients from Specialist to Primary Care.

Background: Recently published clinical pathways for management of thyroid cancer outlined the criteria for transitioning low-risk patients to primary care within one to five years from diagnosis. However, discharge patterns among endocrinologists remain heterogeneous as there lacks a consensus regarding post-treatment care for thyroid cancer patients. Objective: This study described general characteristics and outcomes of thyroid cancer patients who were discharged from specialist care and transitioned to a primary care-based follow-up clinic. Methods: Thyroid cancer patients seen in the After Cancer Treatment Transition (ACTT) clinic at Women’s College Hospital (Toronto, Canada) were included in the study. Electronic medical records were reviewed between May and October 2021 to collect patient characteristics and outcomes. Descriptive statistics were calculated. Results: The study cohort included 148 thyroid cancer patients and 76% were female. All cases were papillary thyroid cancer and most diagnoses were classified as T2 (42%), N0 (55%), M0 (91%), and stage 1 (83%). Nearly all patients (n = 147) had complete thyroidectomy. Levels of thyroglobulin and thyroglobulin antibodies (TgAb) were low overall, with only 5% of the study cohort deemed TgAb positive. Mean levels of thyroid stimulating hormone (TSH) measured at 2 time points (1.37 mIU/L, 1.42 mIU/L) were within normal range. About 91% of the study cohort had normal TSH levels and 82% met target TSH levels. There were 2 cases of recurrence; however, investigation determined that they were not initially appropriate candidates for transition to primary care. Nearly 99% (n = 146) of patients had excellent response to therapy, showed no evidence of disease recurrence, and have not required re-referral to specialist care. Conclusions: These findings may reassure specialists that low-risk, stable thyroid cancer patients can be safely transitioned to primary care for post-treatment follow-up.

COVID-19: role of resilience on the psychological impact of lockdown in liver transplant transitional candidates and recipients

The coronavirus disease 2019 (COVID-19) pandemic and the necessary spreading control measures implemented by the governments have induced drastic changes in daily life. The reduction in mobility and strict social contact limitations are posing a great challenge, particularly for the adolescents. The purpose of this study is to investigate the psychological and emotional impact of lockdown and their relationship with resilience, on adolescents and young adults listed for liver transplant or liver trans-plant recipient. Social and demographic variables of subjects (n=66) were collected and the analyses were based on the Depression Anxiety and Stress Scales (DASS-21), and Connor-Davidson Resilience Scale (CD-RISC 25), exploring the following areas: emotional states of depression, anxiety and stress; and resilience factors. A correlation between the measured degrees of depression/anxiety and resilience was evaluated by Pearson’s correlation coefficient and linear regression models. The results showed a significant correlation between subscales: DASS depression/anxiety (r2=0.62) depression/stress (r2=0.65) CD-RISC commitment/optimism (r2=0.71). The total score of DAAS depression/anxiety/stress scales significantly diminished at the increasing of CD-RISC total score. The inverse correlation between CD-RISC and DAAS seems to refer to the subscale of the relationship between DAAS depression and CDRISC (β= –0.33, P=0.006). Our findings suggest that resilience can be a protective factor for adolescent liver transplant recipients and liver transplant candidates in mitigating the onset of negative psychological symptoms correlated with the pandemic.

Sub-stellar companions of intermediate-mass stars with CoRoT: CoRoT–34b, CoRoT–35b, and CoRoT–36b

ABSTRACT Theories of planet formation give contradicting results of how frequent close-in giant planets of intermediate mass stars (IMSs; $1.3\le M_{\star }\le 3.2\, \mathrm{M}_{\odot }$) are. Some theories predict a high rate of IMSs with close-in gas giants, while others predict a very low rate. Thus, determining the frequency of close-in giant planets of IMSs is an important test for theories of planet formation. We use the CoRoT survey to determine the absolute frequency of IMSs that harbour at least one close-in giant planet and compare it to that of solar-like stars. The CoRoT transit survey is ideal for this purpose, because of its completeness for gas-giant planets with orbital periods of less than 10 d and its large sample of main-sequence IMSs. We present a high precision radial velocity follow-up programme and conclude on 17 promising transit candidates of IMSs, observed with CoRoT. We report the detection of CoRoT–34b, a brown dwarf close to the hydrogen burning limit, orbiting a 1.1 Gyr A-type main-sequence star. We also confirm two inflated giant planets, CoRoT–35b, part of a possible planetary system around a metal-poor star, and CoRoT–36b on a misaligned orbit. We find that $0.12 \pm 0.10\, {{\ \rm per\ cent}}$ of IMSs between $1.3\le M_{\star }\le 1.6\, \mathrm{M}_{\odot }$ observed by CoRoT do harbour at least one close-in giant planet. This is significantly lower than the frequency ($0.70 \pm 0.16\, {{\ \rm per\ cent}}$) for solar-mass stars, as well as the frequency of IMSs harbouring long-period planets ($\sim 8\, {{\ \rm per\ cent}}$).

New β -decay spectroscopy of the Te137 nucleus

Background: Nuclear spectroscopy of neutron-rich isotopes provides important information on their nuclear structure and has a valuable impact on the modeling of the $r$-process path. Particularly interesting are nuclei close to doubly-magic species, e.g., $^{132}\mathrm{Sn}$, with only several valence particles. Such is the barely explored $^{137}\mathrm{I}$ nucleus, investigated here in detail.Purpose: To establish excited states in $^{137}\mathrm{I}$, $\ensuremath{\beta}$ decay of the $^{137}\mathrm{Te}$ ground state is studied. In addition, the unknown $\ensuremath{\beta}$-delayed neutron-emission channel of $^{137}\mathrm{Te}$ to $^{136}\mathrm{I}$ is inspected. Search for levels and for candidates for Gamow-Teller and first-forbidden transitions between the mother nucleus and excited states in the daughter nucleus is conducted within the experimental observations.Methods: $\ensuremath{\beta}$-delayed $\ensuremath{\gamma}$-ray spectroscopy is employed to study excited states in $^{137}\mathrm{I}$. The nucleus is populated in the decay of a mass-separated beam of $^{137}\mathrm{Te}$, produced in neutron-induced fission of $^{235}\mathrm{U}$.Results: The new level scheme of $^{137}\mathrm{I}$ populated in $\ensuremath{\beta}$ decay is established. The half-life ${T}_{1/2}$ of $^{137}\mathrm{Te}$ is determined to be 2.46(5) s. The $\ensuremath{\beta}$-delayed neutron-emission probability ${P}_{n}$ value of $^{137}\mathrm{Te}$ is deduced as a lower limit to be 2.63(85)%.Conclusions: The experimental results are an important input to the theoretical description of nuclei in the region, being well interpreted within large-scale shell model calculations, and provide essential information on the first-forbidden transitions beyond $N=82$ and $Z=50$.

Comparison between the Hamiltonian Monte Carlo method and the Metropolis–Hastings method for coseismic fault model estimation

A rapid source fault estimation and quantitative assessment of the uncertainty of the estimated model can elucidate the occurrence mechanism of earthquakes and inform disaster damage mitigation. The Bayesian statistical method that addresses the posterior distribution of unknowns using the Markov chain Monte Carlo (MCMC) method is significant for uncertainty assessment. The Metropolis–Hastings method, especially the Random walk Metropolis–Hastings (RWMH), has many applications, including coseismic fault estimation. However, RWMH exhibits a trade-off between the transition distance and the acceptance ratio of parameter transition candidates and requires a long mixing time, particularly in solving high-dimensional problems. This necessitates a more efficient Bayesian method. In this study, we developed a fault estimation algorithm using the Hamiltonian Monte Carlo (HMC) method, which is considered more efficient than the other MCMC method, but its applicability has not been sufficiently validated to estimate the coseismic fault for the first time. HMC can conduct sampling more intelligently with the gradient information of the posterior distribution. We applied our algorithm to the 2016 Kumamoto earthquake (MJMA 7.3), and its sampling converged in 2 × 104 samples, including 1 × 103 burn-in samples. The estimated models satisfactorily accounted for the input data; the variance reduction was approximately 88%, and the estimated fault parameters and event magnitude were consistent with those reported in previous studies. HMC could acquire similar results using only 2% of the RWMH chains. Moreover, the power spectral density (PSD) of each model parameter's Markov chain showed this method exhibited a low correlation with the subsequent sample and a long transition distance between samples. These results indicate HMC has advantages in terms of chain length than RWMH, expecting a more efficient estimation for a high-dimensional problem that requires a long mixing time or a problem using nonlinear Green’s function, which has a large computational cost.Graphical

Even-even Nd isotopes in an SD -pair shell model

Nucleon pair shell model truncated to $SD$ collective pair subspace (SDPSM) was applied to study the properties of the low-lying states of the even-even $^{144--156}\mathrm{Nd}$ isotopes. It is found that, within the $M$ scheme, the systems with the number ${N}_{\ensuremath{\nu}}=7$ of neutron pairs (or the number ${N}_{\ensuremath{\pi}}=7$ of proton pairs) can be studied in the SDPSM for the first time. The results show that the properties of the low-lying states of the even-even Nd isotopes can be reproduced approximately, and the even-even $^{144--156}\mathrm{Nd}$ isotopes may be a good candidate for the first-order shape phase transition.

Impact of a Pharmacist-Led Warfarin to Direct Oral Anticoagulant Conversion Initiative during the COVID-19 Pandemic.

Purpose: To assess the impact of a pharmacist-led warfarin to DOAC conversion initiative during the COVID-19 pandemic. Methods: Patients who were prescribed warfarin and followed with the anticoagulation clinic for INR monitoring were assessed by outpatient clinical pharmacists as potential candidates for transition to DOACs from March-August 2020. Results: 530 patients were assessed for transition to DOACs, of which 373 (70.4%) were deemed by clinical pharmacists to be candidates for DOACs. Of the patients who were candidates for DOACs, 66 (17.7%) were transitioned from warfarin to a DOAC. Of the patients who transitioned to a DOAC, 59 (89.4%) remained on a DOAC after one year. Conclusion: Outpatient clinical pharmacists are an effective resource to help identify patients who are candidates for DOACs and assist with transition from warfarin. Further, high persistence rates with DOAC therapy after one year demonstrate the positive impact of the clinical pharmacist on medication adherence.

Neural Crest Stem Cells in Juvenile Angiofibromas.

The etiology of juvenile angiofibroma (JA) has been a controversial topic for more than 160 years. Numerous theories have been proposed to explain this rare benign neoplasm arising predominately in adolescent males, focusing mainly on either the vascular or fibrous component. To assess our hypothesis of JA’s being a malformation arising from neural crest cells/remnants of the first branchial arch plexus, we performed immunohistochemical analyses of neural crest stem cells (NCSC) and epithelial-mesenchymal transition (EMT) candidates. Immunoexpression of the NCSC marker CD271p75 was observed in all investigated JA’s (n = 22), mainly around the pathological vessels. Close to CD271p75-positive cells, high MMP3-staining was also observed. Additionally, from one JA with sufficient material, RT-qPCR identified differences in the expression pattern of PDGFRβ, MMP2 and MMP3 in MACS®-separated CD271p75positive vs. CD271p75 negative cell fractions. Our results, together with the consideration of the literature, provide evidence that JA’s represent a malformation within the first branchial arch artery/plexus remnants deriving from NCSC. This theory would explain the typical site of tumor origin as well as the characteristic tumor blood supply, whereas the process of EMT provides an explanation for the vascular and fibrous tumor component.

Serum dipeptidyl peptidase-4 and eosinophil cationic protein levels in patients of bronchial asthma

Treprostinil, a prostacyclin analogue used in the treatment of pulmonary arterial hypertension (PAH), is available for administration by parenteral, oral, or inhaled routes. Transitioning between routes may be beneficial for appropriate patients; however, there is little published data on transitions between oral and inhaled treprostinil. We used a modified Delphi process to develop expert consensus recommendations on transitions between these formulations. Three questionnaires were used to develop statements about relevant aspects of transition management, which the panelists rated, using a Likert scale, from −5 (strongly disagree) to +5 (strongly agree). Eleven physicians with expertise in PAH treatment modalities, participated in the panel. Of the 492 statements evaluated, consensus was reached on 215 (43.7%). Key consensus recommendations included (1) accurately defining successful transition, as stable or improved PAH with good tolerability and adherence, and (2) patients with stable, low-risk PAH showing insufficient response or tolerability to their existing treprostinil therapy (and due to restrictions in up titration of dosing), as appropriate candidates for transitions between treprostinil formulations. Panelists did not reach consensus for an overall strategy for performing these transitions, mainly because of variability in their practice parameters. Consensus was also achieved on recommendations for adverse event management, including reassurance, administration of oral treprostinil 3 times daily with food, and dosing inhaled treprostinil at intervals ≥3 hours apart. The Delphi process aided in developing expert consensus recommendations that may provide clinically useful guidance for transitioning between treprostinil formulations. However, additional data from centers with high volumes of PAH patients undergoing treprostinil transitions would be optimal for defining more complete and robust strategies to facilitate successful transition.

Clinical Utility and Cost Effectiveness of Long-Acting Lipoglycopeptides Used in Deep-Seated Infections among Patients with Social and Economic Barriers to Care.

The use of long-acting lipoglycopeptides (LaLGPs) in serious, deep-seated infections is of increasing interest. The purpose of this study is to evaluate the economic and clinical utility of LaLGPs in patients requiring protracted antibiotic courses who are not ideal candidates for oral transition or outpatient parenteral antibiotic therapy (OPAT). This is a retrospective, observational, matched cohort study of adult patients who received a LaLGP. Patients were matched 1:1 to those who received standard of care (SOC). Cost effectiveness was evaluated as total healthcare-related costs between groups. Clinical failure was a composite endpoint of mortality, recurrence, or need for extended antibiotics beyond planned course within 90 days of initial infection. There was no difference in clinical failure between the two cohorts (22% vs. 30%; p = 0.491). Six patients in the SOC cohort left against medical advice (AMA) prior to completing therapy. Among those who did not leave AMA, receipt of LaLGPs resulted in a decreased hospital length of stay by an average of 13.6 days. The average total healthcare-related cost of care was USD 295,589 in the LaLGP cohort compared to USD 326,089 in the SOC cohort (p = 0.282). Receipt of LaLGPs may be a beneficial treatment option for patients with deep-seated infections and socioeconomic factors who are not candidates for oral transition or OPAT.

44. Cost Effectiveness and Clinical Outcomes of Long Acting Lipoglycopeptides Used in Transitions of Care for Deep-Seated Infections

BackgroundDalbavancin and oritavancin are long-acting lipoglycopeptides (LaLGPs) FDA-approved for one-time only dosing for skin and skin structure infections. The use of these agents in serious, deep-seated infections requiring protracted antibiotic courses is of increasing interest. The purpose of this study is to evaluate the economic and clinical utility of LaLGPs in patients requiring protracted antibiotic courses who are not ideal candidates for oral transition or outpatient parenteral antibiotic therapy (OPAT).MethodsThis is a retrospective, observational, matched cohort study of adult patients who received a LaLGP. Patients who received a LaLGP were matched 1:1 to those who received standard of care (SOC) therapy by age (+/- 10 years), infection type, microorganism, and socioeconomic factor (e.g. persons who inject drugs, homelessness). Cost effectiveness was evaluated as total healthcare-related costs between groups. Clinical failure was a composite endpoint of mortality, recurrence, or need for extended antibiotics beyond planned course within 90 days of initial infection. Secondary outcomes included hospital length of stay and proportion of patients who left against medical advice (AMA).ResultsA total of 46 patients were included (23 per group). The most frequent indication was endovascular infection and the most common organism methicillin-resistant Staphylococcus aureus. The average length of stay was 22.9 days vs. 31.9 days in the LaLGP and SOC cohorts, respectively (p=0.153). The average total healthcare-related cost of care was USD &295,589 in the LaLGP cohort compared to &326,089 in the SOC cohort (p=0.282). LaLGPs were associated with a mean savings of &30,500 - &55,831 per patient (cumulative cost savings of &701,510). There was no difference in clinical failure between the two cohorts (22% vs. 30%; p=0.491). Nearly 26% of patients in the SOC cohort left AMA compared to 0% in the LaLGP cohort (p=0.022). ConclusionReceipt of LaLGPs may be a beneficial treatment option for patients with socioeconomic factors and deep-seated infections who are not candidates for oral transition or OPAT.Disclosures Julie Ann Justo, PharmD, MS, BCPS-AQ ID, bioMerieux (Speaker’s Bureau)Merck & Co. (Advisor or Review Panel member)Therapeutic Research Center (Speaker’s Bureau)Vaxart (Shareholder) P. Brandon Bookstaver, Pharm D, ALK Abello, Inc. (Grant/Research Support, Advisor or Review Panel member)Biomerieux (Speaker’s Bureau)Kedrion Biopharma (Grant/Research Support, Advisor or Review Panel member)

Spatial scenarios of potential electric vehicle adopters in Ireland

Transition to electric vehicles (EVs) is among public policy measures to reduce carbon emissions from the transport sector in Ireland. While EV adoption rates are increasing there is broad scepticism about achieving ambitious national policy targets. We employ microdata on commuting behaviour and different assumptions on the profile of adopters and purpose of vehicle use, based on existing literature, to identify clusters of candidates for transition to EV in Ireland. We estimate that depending on the assumption 17% to 42% of vehicle owners could comfortably switch to EV. High density areas of potential candidates for transition to EVs are identified in specific urban areas such as Cork and Dublin cities. We also find between 2 to 37% reduction in emissions from car owners based on the different set of assumptions we employ. While the per unit emission reduction in rural areas is higher, the aggregate emission reduction that can be achieved is higher in urban areas because of the higher density of candidates for transition in such areas as per our analysis. We show that apart from Dublin, urban areas are lacking when it comes to density of charging infrastructure.

Using optical clock transitions in Cu ii and Yb iii for timekeeping and search for new physics

We study the $^1$S$_0 - ^3$D$_2$ and $^1$S$_0 - ^3$D$_3$ transitions in Cu II and the $^1$S$_0 - ^3$P$^{\rm o}_2$ transition in Yb III as possible candidates for the optical clock transitions. A recently developed version of the configuration (CI) method, designed for a large number of electrons above closed-shell core, is used to carry out the calculation. We calculate excitation energies, transition rates, lifetimes, scalar static polarizabilities of the ground and clock states, and blackbody radiation shift. We demonstrate that the considered transitions have all features of the clock transition leading to prospects of highly accurate measurements. Search for new physics, such as time variation of the fine structure constant, is also investigated.