Ovarian cancer (OC) is one of the most aggressive tumors in women and has a poor prognosis and the highest mortality rate. Circular RNAs (circRNAs) are a type of endogenous non-coding RNAs that have recently attracted interest in cancer research. Inc... Read More
Cancer Research Research Articles
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New insights into the role of circular RNAs in ovarian cancer
- Pathology - Research and Practice
- VOL. 238
on Oct 1, 2022
Cancer clinical trials in the Philippines.
- Cancer causes & control : CCC
- VOL. 33
on Oct 1, 2022
In this Commentary, we discuss disparities in resources for and access to cancer trials from the perspective of the Philippines, a lower-middle-income country in Southeast Asia, where cancer is the fourth leading cause of death. Geographic disparitie... Read More
Olaparib maintenance versus placebo monotherapy in patients with advanced non-small cell lung cancer (PIN): A multicentre, randomised, controlled, phase 2 trial.
- EClinicalMedicine
- VOL. 52
on Oct 1, 2022
Impaired double strand DNA repair by homologous repair deficiency (HRD) leads to sensitivity to poly ADP ribose polymerase (PARP) inhibition. Poly-ADP ribose polymerase (PARP) inhibitors target HRD to induce synthetic lethality and are used routinely... Read More
Rottlerin promotes anti-metastatic events by ameliorating pharmacological parameters of paclitaxel: An in-vivo investigation in the orthotopic mouse model of breast cancer
- Chemico-Biological Interactions
- VOL. 366
on Oct 1, 2022
Despite substantial breakthroughs in cancer research, there is hardly any specific therapy available to date that can alleviate triple-negative breast cancer (TNBC). Paclitaxel is the first-line chemotherapy option, but its treatment is often associa... Read More
Single cell cancer epigenetics
- Trends in Cancer
- VOL. 8
on Oct 1, 2022
Bulk sequencing methodologies have allowed us to make great progress in cancer research. Unfortunately, these techniques lack the resolution to fully unravel the epigenetic mechanisms that govern tumor heterogeneity. Consequently, many novel single c... Read More
COVID-19 imparted immune manifestation can be combated by NLGP: Lessons from cancer research
- Cytokine
- VOL. 158
on Oct 1, 2022
SARS-CoV-2 easily infects human monocytes, macrophages and possibly dendritic cells (DCs), causing dysfunctions of these important antigen presenting cells (APCs). Observed DC dysfunctions facilitate improper antigen presentation, which obviously res... Read More
Hyaluronic microparticle-based biomimetic artificial neighbors of cells for three-dimensional cell culture
- Carbohydrate polymers
- VOL. 294
on Oct 1, 2022
3D spheroids, which have the potential to bridge the gap between 2D cell culture and native tissue, are used as tissue models in many applications, particularly in cancer, stem cell, and pharmaceutical research. A considerable amount of effort has fo... Read More
Small molecule SJ572946 activates BAK to initiate apoptosis
- iScience
- VOL. 25
on Oct 1, 2022
Poration of the outer mitochondrial membrane by the effector BCL-2 proteins BAK and BAX initiates apoptosis. BH3-only initiators BID and BIM trigger conformational changes in BAK and BAX transforming them from globular dormant proteins to oligomers o... Read More
A diagnostic approach to paratesticular lesions with tubulopapillary architecture: a series of 16 serous borderline tumors/low-grade serous carcinoma and 14 well-differentiated papillary mesothelial tumors and mesothelioma
- Human Pathology
- VOL. 128
on Oct 1, 2022
As there is limited literature on paratesticular tumors of müllerian and mesothelial origin, we reviewed archived cases of serous borderline tumors (n=15), low-grade serous carcinoma (n=1), well-differentiated papillary mesothelial tumors (WDPMTs; n=... Read More
Integrated analysis of the tumor microenvironment using a reconfigurable microfluidic cell culture platform.
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- VOL. 36
on Oct 1, 2022
The tumor microenvironment (TME) is a complex network of non-malignant cells and stroma that perform a wide array of vital roles in tumor growth, immune evasion, metastasis, and therapeutic resistance. These highly diverse roles have been shown to be... Read More
Establishment of Four Induced Pluripotent Stem Cell Lines from CD34+ Hematopoietic Stem and Progenitor Cells from a Patient Diagnosed with an Invasive Lobular Mammary Carcinoma
- Stem Cell Research
- VOL. 64
on Oct 1, 2022
CD34+ cells were isolated from peripheral blood of a breast cancer patient. By the introduction of five integration-free episomal vectors, the CD34+ cells were successfully reprogrammed and resulted in four iPSC clones. Flow Cytometry, reverse transc... Read More
Access to urologists for participation in research: An analysis of NCI's Community Oncology Research Program landscape survey.
- Contemporary clinical trials communications
- VOL. 29
on Oct 1, 2022
Urological cancer clinical trials face accrual challenges, which may stem from structural barriers within cancer programs. We sought to describe the extent to which urology cancer care providers are available within community cancer research programs... Read More
AML-072 Myeloid Sarcoma Experience from Tertiary Care Centre of Western India
- Clinical Lymphoma Myeloma and Leukemia
- VOL. 22
on Oct 1, 2022
In rare cases, hematological malignancies can manifest as an extramedullary malignant myeloid precursor cell mass. Myeloid sarcoma (MS) is a type of leukemia that can be acute or chronic. At our institute, we will discuss the clinicopathological feat... Read More
Inferring Cell-type-specific Genes of Lung Cancer Based on Deep Learning
- Current Gene Therapy
- VOL. 22
on Oct 1, 2022
Background: Lung cancer is cancer with the highest incidence in the world, and there is obvious heterogeneity within its tumor. The emergence of single-cell sequencing technology allows researchers to obtain cell-type-specific expression genes at th... Read More
Effects of oral exposure to leachate from boiled-water treated plastic products on gut microbiome and metabolomics
- Journal of Hazardous Materials
- VOL. 439
on Oct 1, 2022
By simulating plastic exposure patterns in modern society, the impact of daily exposure to plastic products on mammals was explored. In this study, Institute for Cancer Research (ICR) mice were used to establish drinking water exposure models of thre... Read More
Repurposed itraconazole for use in the treatment of malignancies as a promising therapeutic strategy
- Biomedicine & Pharmacotherapy
- VOL. 154
on Oct 1, 2022
Understanding cancer biology and the development of novel agents for cancer treatment has always been the goal of cancer researchers. However, the research and development of new drugs is hindered by its long development time, exorbitant cost, high r... Read More
Mortality of early treatment for radiation-induced brain necrosis in head and neck cancer survivors: A multicentre, retrospective, registry-based cohort study.
- EClinicalMedicine
- VOL. 52
on Oct 1, 2022
The evidence of early treatment for radiation-induced brain necrosis (RN) in head and neck cancer survivors remains insufficient. This study aimed to determine whether early anti-RN treatment was associated with lower mortality. In this cohort study,... Read More
Organoids in lung cancer: A teenager with infinite growth potential
- Lung Cancer
- VOL. 172
on Oct 1, 2022
Despite the rapid advancement in lung cancer research, morbidity and mortality remain high in recent years. Therefore, deeper learning of the underlying molecular mechanisms of pathogenesis and discovery of novel effective therapeutic strategies of t... Read More
Effects of general and central adiposity on circulating lipoprotein, lipid, and metabolite levels in UK Biobank: A multivariable Mendelian randomization study
- The Lancet Regional Health - Europe
- VOL. 21
on Oct 1, 2022
The direct effects of general adiposity (body mass index (BMI)) and central adiposity (waist-to-hip-ratio (WHR)) on circulating lipoproteins, lipids, and metabolites are unknown. We used new metabolic data from UK Biobank (N=109,532, a five-fold high... Read More
496 Study of Affinity Tuning in AML-Targeted CAR-NK Cells
- Clinical Lymphoma Myeloma and Leukemia
- VOL. 22
on Oct 1, 2022
CD123 is overexpressed on AML blasts compared to healthy myeloid progenitor cells. There is opportunity to design anti-CD123 therapy to discriminate on antigen density. Our goal is to study affinity modification of the single chain variable fragment ... Read More