This study introduces a global land cover clustering using an unsupervised algorithm, incorporating the novel step of filtering data to retain only temporally stable pixels before applying K-means clustering. Unlike previous approaches that did not assess the pixel-level temporal stability, this method provides more reliable clustering results. The K-means identified 160 distinct clusters, with Cluster 13 Global Temporally Stable (Cluster 13-GTS) showing significant improvements in temporal stability. Compared to Cluster 13 Global (Cluster 13-G) from earlier research, Cluster 13-GTS reduced the coefficient of variation by up to 1% and increased the number of calibration locations from 23 to over 50. This study also validated these clusters using TOA reflectance from ground-truth measurements collected at the Radiometric Calibration Network (RadCalNet) Gobabeb (RCN-GONA) site, incorporating data from Landsat 8, Landsat 9, Sentinel-2A, and Sentinel-2B. The GONA Extended Pseudo Invariant Calibration Sites (EPICS) GONA-EPICS cluster used for the validation provided statistically comparable mean TOA reflectance to RCN-GONA, with a reduced chi-square test indicating minimal differences within the cluster’s uncertainty range. Notably, the difference in reflectance between RCN-GONA and GONA-EPICS was less than 0.023 units across all the bands. Although GONA-EPICS exhibited slightly higher uncertainty (6.4% to 10.3%) compared to RCN-GONA site (<5%), it offered advantages such as 80 potential calibration points per Landsat cycle and reduced temporal instability, and it provided alternatives to reduce the reliance on single sites like traditional PICS or RCN-GONA, making it a valuable tool for calibration efforts. These findings highlight the potential of the newly developed EPICS for radiometric calibration and stability monitoring of optical satellite sensors. Distributed across diverse regions, these global targets increase the number of calibration points available for any sensor in any orbital cycle, reducing the reliance on traditional PICS and offering more robust targets for radiometric calibration efforts.