Camera calibration is a key technique in the field of computer vision. The Zhang’s method is currently the most commonly used camera calibration method, but its accuracy is mainly dependent on the image quality, thusly constrained by camera hardware conditions. Considering that high-performance cameras are often expensive, a cost-effective method to improve the quality of calibration images is of great practical value. Without changing the existing hardware conditions, image super-resolution can be considered to enhance the quality of the calibration image. Image super-resolution (SR) is the process of reconstructing an image from low resolution (LR) to high resolution (HR). It can enhance the clarity and detail of the calibration images, which will be beneficial in improving the accuracy of camera calibration. However, there is very little research on the application of image super-resolution to camera calibration. Therefore, this study innovatively proposed a method and process for applying image super-resolution in camera calibration. Firstly, the ESRGAN (Enhanced Super-Resolution Generative Adversarial Networks) was optimized and improved, followed by the proposal of the MMRSRGAN (Multi-scale Multi-adaptive-weights Residual Super-Resolution Generative Adversarial Networks). Two methods for local image super-resolution were also proposed for efficient training and testing of datasets, and two evaluation metrics based on reprojection error were proposed evaluate the effectiveness of the proposed model. Training and testing experiments of image super-resolution for camera calibration were conducted on both virtual and real image datasets. The proposed MMRSRGAN was compared with several advanced image super-resolution networks developed in recent years across multiple dimensions and indicators. The positive results have demonstrated the feasibility of applying image super-resolution to camera calibration and showcased the good performance of the MMRSRGAN.