Calf Blood Extract Eye Gel Research Articles

Bandage Contact Lenses versus Deproteinized Calf Blood Extract Eye Gel for Recurrent Corneal Erosion Syndrome: A Case-Control Study.

BackgroundThe clinical efficacy of eye drops in the treatment of recurrent corneal erosion syndrome (RCES) is not satisfactory. Many studies have confirmed the positive effect of the bandage contact lens (BCL) in corneal diseases, but not many in patients with RCES. The purpose of this study is to investigate the efficacy of the BCL compared with deproteinized calf blood extract eye gel in the initial treatment of RCES.MethodsForty-seven patients with RCES treated in our hospital from September 2010 to September 2018 were retrospectively analyzed, including 24 cases (26 eyes) in the bandage contact lenses (BCLs) group wearing bandage contact lens and 23 cases (24 eyes) in the drug group treated with deproteinized calf blood extract eye gel. The efficacy was evaluated after 3 months of treatment, with a mean follow-up time of 21.15 ± 1.71 months in the BCL group and 20.87 ± 1.89 months in the drug group. Corneal erosion resolution, pain relief, visual acuity recovery time, recurrence and complications were observed.ResultsAfter 3 months of treatment, 22 eyes (22/26, 84.6%) in the BCLs group achieved complete resolution, compared with 14 eyes (14/24, 58.3%) in the drug group (P <0.05). The corneal healing time in the BCLs group was 4.77 ± 4.51 weeks, which was significantly shorter than that in the drug group (9.83 ± 5.93 weeks (P <0.01)). At 1 and 2 months after treatment, the visual analogue score (VAS) in the BCLs group (3.28 ± 1.15 at 1 month and 1.90 ± 0.77 at 2 months) decreased more significantly than that in the drug group (4.54 ± 0.89 at 1 month and 2.43 ± 0.93 at 2months, P =0.000 at 1 month and P=0.034 at 2 months). At 3 months after treatment, the mean BCVA in the BCL group (logMAR 0.03±0.08) improved more significantly than that in the drug group (logMAR 0.14±0.12,P=0.001). The complete recovery time of visual acuity was 5.46 ± 4.43 weeks in the BCLs group, compared with 10.33 ± 6.12 weeks in the drug group (P =0.003). During further follow-up, recurrence was observed in 2 eyes (2/22, 9.1%) of the BCLs group and 6 eyes (6/14, 42.8%) of the drug group. No patient in both groups developed adverse side effects.ConclusionBandage contact lenses are safe and effective in the initial treatment of RCES. Compared with topical deproteinized calf blood extract eye gel, the use of BCLs can provide a higher cure rate, better pain control, faster visual recovery and lower recurrence rate.Trial RegistrationChinese Clinical Trial Registry, ChiCTR2000031241. Registered 25 March 2020- Retrospectively registered, http://www.chictr.org.cn/edit.aspx?pid=51309andhtm=4.

Comparison of the efficacy of three different drugs on dry eye after cataract surgery

Objective To compare the clinical efficacy of three drugs in the treatment of dry eye after phacoemulsification. Methods A prospective case-control study. A total of 96 eyes of 96 patients with dry eye after phacoemulsification from Jun. 2017 to May 2018 in The First Affiliated Hospital of Zhengzhou University were analyzed. All cases were randomly divided into 3 groups, group A received the deproteinized calf blood extract eye gel, group B received vitamin A palmitate eye gel, and group C received Omega-3 fatty acid drug. Ocular surface disease index questionnaire (OSDI), tear film break-up time (BUT), corneal fluorescence staining (FL) and Schirmer I test (SIt) were performed before and 1 month after operation. Results The OSDI scores of the three groups at 1 month after operation were lower than those before operation.The difference was statistically significant(group A, t=60.012, P=0.001; group B, t=51.114, P=0.001; group C, t=39.427, P=0.001). There was no significant difference among three groups (F=5.684, P=0.051). BUT, SIt and OSDI scores were better in group A and C than those in group B (P<0.05). FL scores of group A were superior to group B and C, and the difference was statistically significant (P<0.05). Conclusion Both deproteinized calf blood extract and Omega-3 fatty acid can extend BUT, and the former has more advantage in repairing corneal epithelium. Key words: Phacoemulsification, cataract; Dry eye; Drugs

Clinical effect of deproteinized calfblood extract eye gel for corneal epithelial defect

Objective: To observe the clinical effect of 20% deproteinized calfblood extract eye gel on the treatment of mechanical injury to corneal epithelium. Methods: 120 cases of patients with corneal epithelial defect caused by mechanical injury were selected and randomly divided into observation group (60 eyes, deproteinized calfblood extract eye gel in use) and control group (0.3% ofloxacin eye drops in use). Both two groups of patients were given eye gel or eye drops 4 times per day. Moreover, the two groups of eye symptoms and corneal epithelial healing were observed on the 3 rd day and the 7 th day after drug usage respectively. Results: The effective rates of 20% deproteinized calfblood extract eye gel on the treatment of mechanical corneal epithelial defect on the 3 rd day and the 7 th day were 78.33% and 93.33% respectively. Meanwhile, the effective rates of 0.3% ofloxacin eye drops were 55.00% and 71.67%. The difference in the comparison of the effective rate between two groups was of statistical significance ( p &lt; .05). Conclusions: 20% deproteinized calfblood extract eye gel can significantly promote the healing of corneal epithelium in a short time, and it is worthy to be widely applied clinically.

Meta analysis of therapeutic effects of domestic deproteinized calf blood extract eye gel on corneal epithelial repair after laser refractive surgery

Meta analysis of therapeutic effects of domestic deproteinized calf blood extract eye gel on corneal epithelial repair after laser refractive surgery

The effects of protein-free calf blood extract for recovery of corneal nerve after LASEK and LASIK

To evaluate the effects of protein-free calf blood extract for recovery of corneal nerve after LASEK and LSEIK. A prospective, randomized, control and double-blind study was carried out from January through February 2009 at Department of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University. Forty-nine eyes of 25 patients who underwent LASEK were randomly divided into two groups. One group with 16 patients (32 eyes) was treated by protein-free calf blood extract eye gel which was defined as drug treated group and the other group with 9 patients (17 eyes) was not treated by protein-free calf blood extract eye gel which was defined as no drug treated group. Forty-four eyes of 23 patients who underwent LASIK were also randomly divided into two groups. One group with 13 patients (24 eyes) was treated by protein-free calf blood extract eye gel which was defined as drug treated group and the other group with 10 patients (20 eyes) was not treated by protein-free calf blood extract eye gel which was defined as no drug treated group. Protein-free calf blood extract eye gel was delivered in both drug treated groups 3 times per day for three months after surgery. Laser scanning confocal microscopic examinations were performed on 48 eyes in vivo. Central corneal sensitivity and tear break-up time (BUT) were tested on 93 eyes preoperatively and 1, 3, 6 months, and 1 year after surgery. The obtained dates in the study were analyzed using independent samples t-test, paired t-test and Mann-Whitney Test. The morphology observed by confocal microscope of sub-basal nerve fibers was not different between drug treated group and no drug treated group until the last follow up after LASIK or LASEK (Z = 0.0000, P = 1.00) and (Z = 0.0000, P = 1.00). Nerve fibers with interconnections were observed in drug treated group at 3 months after LASEK. The morphology of sub-basal nerve fibers had not recovered completely until 1 year after surgery. The central corneal sensitivity was better in drug treated group than in no drug treated group at 1 month after LASEK [(4.95 ± 0.84) µm, (3.62 ± 1.38) µm; t = 4.23, P < 0.01] and at 1 and 3 months after LASIK [(3.29 ± 1.40)µm, (2.35 ± 1.51) µm; t = 2.10, P < 0.05], [(4.31 ± 1.61) µm, (3.18 ± 1.62) µm; t = 2.31, P < 0.05]. At 6 months postoperatively, the central corneal sensitivity of both drug treated group and no drug treated group which underwent LASEK was not significantly different from pre-operation [(5.81 ± 0.35) µm; t = -1.26, P > 0.05], [(5.79 ± 0.36) µm; t = -0.70, P > 0.05]. At 6 months postoperatively, the central corneal sensitivity of drug treated group which underwent LASIK was not significantly different from pre-operation [(5.25 ± 0.91) µm; t = -1.87, P > 0.05]. No significant difference was seen in BUT between drug treated group and no drug treated group after LASEK or LASIK until 1 year after surgery [(8.13 ± 2.18) µm, (8.76 ± 1.64) µm; t = -0.90, P > 0.05], [(7.71 ± 2.14) µm, (7.45 ± 2.37) µm; t = 0.30, P > 0.05]. Protein-free calf blood extract could significantly promote the recovery of corneal nerve in the early period after LASEK and LASIK.

Effect of lacrimal plugs combined with deproteinized calf blood extract eye gel for filamentary keratitis.

This study aims to investigate the efficacy of lacrimal plugs combined with deproteinized calf blood extract eye gel on the treatment of dry-eye-associated filamentary keratitis. Lacrimal plugs were inserted into both the upper and lower puncta of 15 patients (28 eyes). Deproteinized calf blood cxtract eye gel was applied in two patients who were not cured after this operation. All patients were asked to complete three questionnaires 1day before the surgery and at 1week and 1month after the surgery. Ophthalmologic examinations were carried out and repeated at 1day and at 1week and 1month after plug insertion, which include fluorescein staining, tear break-up time (BUT), Schirmer test I (STI), corneal confocal microscope (HRT-III), and impression cytology (IC). Symptoms were relieved in all patients 1month after the application of lacrimal plugs. Deproteinized calf blood extract eye gel was applied to two patients whose symptoms remained after lacrimal plug implantation for 1week. At 3weeks later, the symptoms disappeared and cornea fluorescein stain was hardly identified. The lacrimal river in all patients became broader after the surgery, 11 of whom reached 0.3mm. Cornea filamentary disappeared in all patients. The average of BUT and ST were increased to 7.50 ± 1.897s (p < 0.001) and 8.12 ± 1.996mm at 1week after the operation and 7.94s and 9.00 ± 1.897mm at 1month later, respectively. Photography from HRT-III suggested that the state of corneal epithelium was markedly improved, including the squamous metaplasia of the epithelial layer of the cornea and the bend of nerve fibers under the corneal epithelium. IC also suggested that the squamous metaplasia of epithelial layer of conjunctiva in these patients was improved. The symptoms of patients suffering from severe filamentary keratitis were remarkably relieved by using lacrimal plugs, which could increase the tear volume of the ocular surface, improve the condition of tear film, and promote the recovery of corneal diseases. For patients with more severe symptoms, additional usage of deproteinized calf blood extract eye gel could assist the treatment. Therefore, lacrimal plugs combined with deproteinized calf blood extract eye gel are suggested to be an effective method to treat severe filamentary keratitis.

Corneal Wound Healing after Superficial Foreign Body Injury: Vitamin A and Dexpanthenol versus a Calf Blood Extract

A prospective randomized double-blind clinical study was performed to investigate corneal wound healing after treatment either with an eye gel containing calf blood extract or an eye ointment containing vitamin A and dexpanthenol. A total of 54 outpatients were included in this study, all treated for corneal foreign body injury. The size of the corneal lesions was measured by planimetry on days 0, 1, and on the following days until complete epithelial healing occurred. Results showed the calf blood extract eye gel to be statistically more effective in promoting corneal wound healing, especially in patients with wound areas larger than 6 mm².