OSTEOPOROSIS is a frequent complication of endstage liver disease that often deteriorates after orthotopic liver transplantation (OLT) due to long-term immunosuppression including corticosteroids and other factors like early immobilization. In advanced cases, bone demineralisation increases the susceptibility of atraumatic fractures. Because there is no broadly accepted therapeutic concept for bone demineralisation after OLT the efficacy of calcitriol [1, 25(OH)D] in comparatively low dosages, either as single treatment or in combination with elemental calcium, as well as with calcium and a low dose of sodium fluoride, was evaluated in this study.