Calcinosis Circumscripta Research Articles

Severe calcinosis circumscripta in multiple foot pads in a 5- month old pomeranian puppy secondary to renal disease – a case report

A 5-month old Pomeranian puppy with lameness in all four limbs, polydipsia, polyuria, vomiting, and melena observed approximately for one month was presented to the Veterinary Teaching Hospital, University of Peradeniya. The metacarpal and metatarsal foot pads of all four limbs were swollen with chalky white, mottling. The differential diagnoses for the foot pad lesions were fungal granuloma, calcinosis circumscripta, and neoplasia. The fine needle aspirates obtained from the foot pad lesions were chalky white, gritty, and microscopically consistent with mineral deposits. Plain radiographs of the metacarpals revealed deposition of radiopaque material in metacarpal and digital foot pads with normal bones and joints. Based on the gross lesions, radiography, and fine needle aspiration cytology, a tentative diagnosis of calcinosis circumscripta of foot pads was made. Haematology and serum chemistry revealed microcytic hypochromic anaemia and mild azotaemia. Abdominal ultrasonography revealed small right and left kidneys with increased overall echogenicity and poor corticomedullary differentiation. The historical, clinical, radiographic, and ultrasonographic findings were suggestive of calcinosis circumscripta in multiple foot pads with concurrent renal disease. The very young age of the dog was highly suggestive of renal dysplasia as the cause of concurrent renal disease. Despite the supportive and symptomatic treatments, the puppy died five days after the presentation. This appears to be the first report of calcinosis circumscripta of foot pads with evidence of renal disease diagnosed in a dog less than one year old.

Calcinosis circumscripta in a rabbit with recurrent cervical myelopathy.

Journal of Small Animal PracticeEarly View Images in Small Animal Practice Calcinosis circumscripta in a rabbit with recurrent cervical myelopathy C. Abeloos, Corresponding Author C. Abeloos clotilde.abeloos@hotmail.fr Anderson Moores Veterinary Specialists, Bunstead Barns, Poles Lane, Hursley, Winchester, Hampshire, SO21 2LL UK Corresponding author email: edward.ives@andersonmoores.comSearch for more papers by this authorT. Dutton, T. Dutton Great Western Exotics, Units 10 – 16, Berkshire House, County Business Park, Shrivenham Road, Swindon, Wiltshire, SN1 2NR UKSearch for more papers by this authorD. Denk, D. Denk Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, Ludwig Maximilian University of Munich, Munich, GermanySearch for more papers by this authorE. J. Ives, E. J. Ives edward.ives@andersonmoores.com Anderson Moores Veterinary Specialists, Bunstead Barns, Poles Lane, Hursley, Winchester, Hampshire, SO21 2LL UKSearch for more papers by this author C. Abeloos, Corresponding Author C. Abeloos clotilde.abeloos@hotmail.fr Anderson Moores Veterinary Specialists, Bunstead Barns, Poles Lane, Hursley, Winchester, Hampshire, SO21 2LL UK Corresponding author email: edward.ives@andersonmoores.comSearch for more papers by this authorT. Dutton, T. Dutton Great Western Exotics, Units 10 – 16, Berkshire House, County Business Park, Shrivenham Road, Swindon, Wiltshire, SN1 2NR UKSearch for more papers by this authorD. Denk, D. Denk Institute of Veterinary Pathology, Center for Clinical Veterinary Medicine, Ludwig Maximilian University of Munich, Munich, GermanySearch for more papers by this authorE. J. Ives, E. J. Ives edward.ives@andersonmoores.com Anderson Moores Veterinary Specialists, Bunstead Barns, Poles Lane, Hursley, Winchester, Hampshire, SO21 2LL UKSearch for more papers by this author First published: 26 March 2023 https://doi.org/10.1111/jsap.13596Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Early ViewOnline Version of Record before inclusion in an issue RelatedInformation

Single-incision drilling technique to achieve hemiepiphysiodesis of the distal metacarpus - complications and outcome in 207 foals with metacarpophalangeal varus deformities.

To report the outcome of foals treated for metacarpophalangeal varus deformity with a single-incision drilling technique for hemiepiphysiodesis of the distal lateral metacarpal physis. Retrospective case-control cohort study. Thoroughbred foals (n = 207), 171 age- and sex-matched maternal siblings. Medical records (2017-2020) were reviewed for signalment, limb(s) treated, location of the surgery, and any reported complications. Follow-up radiographs obtained for the yearling sale were assessed for abnormalities. Horses were matched to maternal siblings using an online database. Sales and racing performance data were compared between cohorts. The average age at the time of surgery was 97 days. The treated limb was the left front in 52, right front in 31, both fronts in 119, unknown in 5. Three horses developed calcinosis circumscripta lesions adjacent to the physis, which were removed successfully. No radiographic abnormalities associated with the surgery site were detected on yearling prepurchase radiographs. There were no differences in sales and racing performance data between treated horses and maternal controls. Hemiepiphysiodesis is a safe and effective treatment for metacarpophalangeal varus deformities in foals. No negative effect on sales or racing performance was identified. This technique avoids risks, costs, and the need for second surgery associated with an orthopedic implant. The surgeon should be aware of the potential for development of a calcinosis circumscripta lesion with this technique.

Oral Calcinosis Circumscripta Associated with Wasp (Hymenoptera vespidae) Sting in a Cat

In veterinary medicine, calcinosis circumscripta is a morphological diagnosis for which the cause may be known or idiopathic. The aetiology of the lesion must be investigated because the nature of the underlying disease process will dictate appropriate treatment. We present a case of oral calcinosis circumscripta in a cat caused by a wasp sting and associated with moderate unilateral facial oedema. Following corticosteroid therapy and oedema resolution, hyperaemic, circular, firm, elevated lesions were observed on the buccal mucosa and evolved into whitish, slightly elevated multifocal plaques with an irregular surface. As antibiotic and corticosteroid therapy was ineffective, an excisional biopsy was performed after 6 months of lesion development and a diagnosis of calcinosis circumscripta of dystrophic aetiology was made. To our knowledge, this is the first report of calcinosis circumscripta in association with an insect sting in an animal. Insect stings should be included in the differential diagnosis of calcinosis circumscripta in cats.

Severe Hydroxyapatite Deposition Disease in Binturongs (Arctictis binturong).

In a collection of 6 young binturongs (Arctictis binturong), 3 presented with anorexia, lethargy, and footpad swelling diagnosed by surgical biopsy as calcinosis circumscripta. Despite supportive care over the next 4 years, affected binturongs had progressive weight loss, hyperphosphatemia, and hyperkalemia and developed large radiodense deposits in tissues adjacent to appendicular joints, thoracolumbar vertebrae, and the sternum. Two binturongs died and necropsies showed severe periarticular mineral deposition with fibrosis and granulomatous inflammation. Additionally, binturongs had mineralization of distal renal tubules, mineralization of the renal interstitium, and marked mineralization of the pulmonary interstitium and peribronchiolar smooth muscle. Foot biopsies from the surviving binturong were evaluated by spectroscopic microanalysis and were positive for hydroxyapatite, Ca10(PO4)6(OH)2. Periarticular and footpad mineralization in these binturongs is consistent with hydroxyapatite deposition disease, which is rarely described in humans and animals as a primary familial condition or a secondary condition often associated with renal injury.

Unusual clinical presentation of dystrophin-deficient feline muscular dystrophy in the UK

An eight-month-old, male, neutered, domestic short hair cat was presented for further investigation of white granuloma-like lesions on the tongue and recent onset regurgitation. The owner reported that the cat...

Case of focal dystrophic calcification in the peritarsal soft tissues of a horse

A 12-year-old Irish sports horse gelding presented with a recently developed oval firm mass at the plantaromedial aspect of right tarsus, located between the gastrocnemius and deep digital flexor tendon....

Co-occurence of calcinosis cutis and calcinosis circumscripta in a young boxer dog

Co-occurence of calcinosis cutis and calcinosis circumscripta in a young boxer dog

Imaging Features of Soft-Tissue Calcifications and Related Diseases: A Systematic Approach

Soft-tissue calcification refers to a broad category of lesions. Calcifications are frequently identified by radiologists in daily practice. Using a simple algorithm based on the distribution pattern of the lesions and detailed clinical information, these calcified lesions can be systematically evaluated. The distribution pattern of the calcific deposits enables initial division into calcinosis circumscripta and calcinosis universalis. Using laboratory test results (serum calcium and phosphate levels) and clinical history, calcinosis circumscripta can be further categorized into four subtypes: dystrophic, iatrogenic, metastatic, and idiopathic calcification. This pictorial essay presents a systematic approach to the imaging features of soft-tissue calcifications and related diseases.

Surgical resection of calcinosis circumscripta in the funicular part of the nuchal ligament in the cranial cervical region of a horse

SummaryThis report describes a 10‐year‐old Welsh Section D gelding presented for signs of neck stiffness that was found to have a mineralised lesion in the funicular part of the nuchal ligament overlying the dorsal aspect of the first cervical vertebra using radiography and ultrasonography. Surgical resection of the mass, including a complete removal of the adjacent nuchal ligament, resulted in improvement in the signs of neck stiffness. Histopathological examination identified the mass as calcinosis circumscripta. These lesions do not appear to have been reported at this site nor has outcome following excision of a complete section of the nuchal ligament.

CALCINOSIS CIRCUMSCRIPTA IN A COHORT OF RELATED JUVENILE AFRICAN LIONS (PANTHERA LEO).

Three juvenile, genetically related African lions (Panthera leo) were evaluated for discrete dome-shaped subcutaneous masses present over the proximal lateral metatarsal-tarsal area. The lesions measured 3-8 cm in diameter, were fluctuant to firm, nonulcerated, and attached to underlying structures. On radiographic evaluation, the lesions were characterized by well-circumscribed punctate mineralizations in the soft tissue surrounded by soft tissue swelling without evidence of adjacent bony involvement. On cut surface, the lesions were made of numerous loculi containing 2-5-mm round-to-ovoid, white-to-gray, firm structures interspersed with fibrous tissue and pockets of serosanguinous fluid. Hematology, serum biochemistry, serum thyroid screening (including total thyroxine, total triiodothyronine, free thyroxine, and free triiodothyronine), and serum vitamin D panels (including parathyroid hormone, ionized calcium, and 25-hydroxyvitamin D) were unremarkable. Histopathologic evaluation of the lesions was consistent with calcinosis circumscripta with fibroplasia, chronic inflammation, and seroma formation. An additional two genetically related lions were considered suspect for calcinosis circumscripta based on presentation, exam findings, and similarity to the confirmed cases. All masses self-regressed and were not associated with additional clinical signs other than initial lameness in two cases.

Calcinosis circumscripta in a captive African cheetah (Acinonyx jubatus)

ABSTRACT This article reports a first case of calcinosis circumscripta in a captive African cheetah ( Acinonyx jubatus ). Histopathology demonstrated well defined multiple cystic structures containing granular, dark basophilic materials with peripheral granulomatous reaction, characterized by presence of multinucleated giant cells surrounded by a varying amounts of fibrous connective tissues. Special staining with von Kossa revealed black stained deposits confirming the presence of calcium salts.

Arthroscopic treatment of chronically painful calcific tendinitis of the rectus femoris

BackgroundRelatively large calcific tendinitis with persistent symptoms after extended periods of conservative treatment is an indication for operative therapy. Arthroscopy, as a treatment for calcific tendinitis of the hip abductors and calcinosis circumscripta, has been described previously; however, to our knowledge, the clinical and radiological response to arthroscopic removal of calcific tendinitis of the rectus femoris tendon has not.MethodsWe present arthroscopic treatment of unusual calcific tendonitis of the origin of the rectus femoris and associated intra-articular lesions in 3 patients with chronic coxa pain.ResultsOur cases show that hip arthroscopy is an effective therapeutic modality for calcific tendinitis of the hip joint with satisfactory short-term outcomes.ConclusionsCalcific tendinitis, although an uncommon clinical entity, should be a part of the differential diagnosis of acute or chronic hip pain.

IMAGING DIAGNOSIS: MULTIPLE CARTILAGINOUS EXOSTOSES AND CALCINOSIS CIRCUMSCRIPTA OCCURRING SIMULTANEOUSLY IN THE CERVICAL SPINE OF A DOG

An 8-month-old female Saint Bernard dog was presented with gait abnormalities consistent with a left-lateralizing cervical myelopathy. Imaging revealed a large, irregular soft tissue and mineral mass at the level of C1 and C2. The lesion was successfully excised, and histopathology was performed, revealing evidence of both multiple cartilaginous exostoses and calcinosis circumscripta. To the authors' knowledge, this is the first report comparing features using magnetic resonance imaging, computed tomography, and radiography. Additionally, multiple cartilaginous exostoses have not previously been reported to occur in combination with calcinosis circumscripta.

Tumoral Calcinosis Form of Hydroxyapatite Deposition Disease in Related Red-Bellied Short-Necked Turtles, Emydura subglobosa

Ten of 12 red-bellied short-necked turtles from a single clutch presented at 9 months of age with multiple white to tan nodules on their feet. Histologically, the nodules were composed of large periarticular deposits of mineralized crystalline material that extended into the joint spaces of interphalangeal joints and was surrounded by granulomatous inflammation and fibrosis. Crystallographic analysis determined the material to be apatite (calcium phosphate hydroxide) consistent with the tumoral calcinosis form of hydroxyapatite deposition disease (HADD). HADD has previously been described in aquatic turtles and rarely lizards and must be differentiated from gout in reptiles. A cause for the tumoral calcinosis lesions in these turtles could not be determined; however, based on previous reports in this species, a species-specific predilection, in conjunction with unknown environmental factors, is suspected. The use of the terms HADD, pseudogout (calcium pyrophosphate crystal deposition disease), and calcinosis circumscripta has been inconsistent, creating confusion in the literature.

Imaging features in calcinosis circumscripta, a rare type of subcutaneous calcification in localized scleroderma

Calcinosis cutis circumscripta is a rare condition in which abnormal deposition of calcium seen in the dermis and subcutaneous tissue, it is associated with localized scleroderma. A 30-year-old female presented with an area of extensive calcification involving the right gluteal region, lateral aspect of right thigh and a small area on left thigh detected on radiograph with atrophy of subcutaneous tissue. Magnetic resonance imaging and computed tomography were done for further evaluation and the findings were of calcification and atrophy involving the skin and subcutaneous tissue.

Digital calcinosis circumscripta

A series of three paediatric cases of digital calcinosis circumscripta is presented. Digital calcinosis circumscripta is an unusual form of calcinosis circumscripta occurring specifically in the digits. The condition is rare among the paediatric population. The cases serve to clarify the clinical and radiographic features of the condition and to discuss suggested treatment options.

Nodular skin problems encountered in a first-opinion equine clinic

Over an eight year period (2004-2011) 68 horses with nodular skin disease were diagnosed with 70 tumour like skin lesions. Diagnoses of the 70 nodular lesions were based on clinical features (5), cytology of fine needle aspirates(4), histological examination of either a biopsy or a complete surgical specimen (59) or on a combination of cytology and histology (2). Fifty-nine (84%) of the nodules proved to be genuine tumour like lesions and eleven (16%) were different forms of localised inflammatory dermatitis. Owners (93%) were very supportive of the need to perform histological or cytological investigations (65/70). Sarcoid was the most common nodular lesion (21) followed in order of occurrence by; melanoma (8), squamous cell carcinoma (8), nodular necrobiosis (7), mastocytoma (3), papilloma (2), maligne lymphoma (2), fibroma (2), naevus (1), botryomycosis (1), calcinosis circumscripta (1), collagen tumour (1), follicular hyperplasia (1) and follicular cyst (1). In the present study there was no breed predilection and the mean age of the group was 10.8 year (range 3-23 years). Melanoma occurred in 62.5% of the grey horses (5/8). Nodular necrobiose was only diagnosed in 10% of the cases , because when the nodule was noticed in the girth or saddle region no therapy was performed. Melanoma, nodular necrobiosis and sarcoids were in this relatively small study found on aspecific locations. In 70% (49/70) the nodules were surgical removed with either sedation and local anaesthesia (38) or general anaesthesia (11). Most patients (60.6%) were surgically treated at the practice (42/70). Of the 70 tumour-like lesions 61 lesions were scored for follow-up (for 8 cases no follow up was possible and one case had just started therapy); 64% (39/61) of the horses had no recurrence of the skin lesion(s) and the owners considerd their horses to be cured. Satisfaction rate as judged by owners was even higher: 80% (49/61).

Calcinosis circumscripta of the both salpinx: A case report

Calcinosis circumscripta is defi ned by calcifi cation in soft tissues. Clinically, calcinosis circumscripta is described as fi rm, white dermal papules, plaques, or subcutaneous nodules found in various sites. They commonly ulcerate, extruding a chalky white material that is frequently identifi ed as hydroxyapatite. Calcinosis circumscripta most commonly involves the hand and wrist of middle-aged woman. The etiology and pathogenesis of calcinosis circumscripta are unknown. We experienced a case of calcinosis circumscrpita of salpinx which was suspected ovarian tumor. Calcinosis circumscripta is extremely rare in gynecologic area. Here we report the case with review of literature.

Endoscopic Treatment of Calcinosis Circumscripta of the Hip Joint: A Report of 2 Cases of Arthroscopic Removal of a Calcific Deposition Between the Labrum and Capsule

We present 2 cases of arthroscopic removal of a calcific deposition in the form of calcinosis circumscripta between the labrum and capsule of the hip joint. Case 1 was a 42-year-old woman who presented with complaints of a 2-year history of right hip pain. Radiographs showed a calcific deposition in the area of the acetabular roof. Arthroscopy showed a calcific deposition between the labrum and capsule in the form of calcinosis circumscripta. At the 4-month follow up, she was symptom free with painless full range of motion. Case 2 was a 48-year-old slim woman who presented with complaints of right hip pain over the last 6 months. Preoperative radiographs showed a hip with a calcific deposition lateral to the pronounced acetabular roof. At the 4-month follow up after removal, she was also symptom free. To our knowledge, these are the first patients with calcinosis circumscripta treated by hip arthroscopy. We recommend the endoscopic approach, which is effective and minimally invasive, for treatment of calcinosis circumscripta and other calcifications in the hip joint. Especially in young patients, with a high activity level and without any symptoms of hip osteoarthritis, hip arthroscopy is the ideal treatment.