Calcified Epithelioma Research Articles

THE PILOMATRICOMA: A CASE REPORT OF PALPEBRAL LOCALIZATION

Pilomatricoma, formerly called calcified epithelioma of Malherbe, is a rare and benign skin tumor occurring during the first two decades of life, generally located in the upper part of the body (neck and head). In its typical form, it manifests clinically as a small, solitary, asymptomatic, sometimes painful subcutaneous nodule. The usual size is less than 3 cm. The diagnosis is made clinically and requires histological confirmation. The prognosis is generally good. Carcinomatous transformation remains controversial. Healing without recurrence is the rule after surgical excision. Ocular or palpebral localization is exceptional. We report the case of Mrs. G.E, 26 years old, without any notable pathological history, who consulted for a mass on the right eyelid that had been developing for 1 year. Objective clinical examination: a polylobed mass, well defined, 3 cm long axis, hard, painless and mobile in relation to the deep plane. The surrounding skin is normal in appearance. In addition, motor skills and ocular mobility remain preserved. A total surgical excision is performed. Histological study of the biopsy specimen reveals the presence of basaloid cells covering layers of mummified cells with eosinophilic cytoplasm, suggestive of a Malherbe Pilomatricoma. No recurrence was detected after a 12-month follow-up.

Isolated Pilomatricoma of the Eyebrow in a Woman

Pilomatricoma, or Malherbe's calcified epithelioma, is a benign adnexal skin tumor, most often seen in children and localized to the upper half of the body. We report a form of pilomatricoma of the eyebrow in a woman. A 56-year-old female patient, with no previous pathological history, presented with a nodular lesion of the right eyebrow that had been evolving for 5 months, indurated, 2 cm long and slow to evolve. This cutaneous tumour is rare in adults, and its diagnosis is often unrecognized preoperatively due to its great clinical polymorphism. Histological examination reveals mummified cells. Treatment is based on complete surgical excision, to reduce the risk of recurrence.

Case of a Calcified Epithelioma with a Suspected Solitary Fibrous Tumor

The patient was a 16-year-old girl. She noticed a gradual increase in the size of a skin mass on the right posterior neck and observed redness 1 month prior to visiting our department. The mass was 4 cm in size, dome-shaped, and on the right side of the neck. Ultrasound images showed a well-defined oval heterogeneous isoechoic mass. The interior was rich in blood flow with some coarse calcifications. Magnetic resonance imaging showed uniform hypointensity on T1-weighted images and variable hypointensity with hyperintensity in some superficial layers on T2-weighted images. On the basis of these findings, a solitary fibrous tumor was suspected. The tumor was resected at the proximal margin under general anesthesia. The mass was erythematous, overlying and partially adherent to the fascia. The mass was diagnosed as a calcified epithelioma.Solitary fibrous tumors are histologically fibroblastic mesenchymal neoplasms, which include hemangiopericytomas. Generally, these tumors arise within the thoracic cavity, but few cases have been reported in the skin and subcutaneous soft tissue. We encountered a calcified epithelioma that we suspected to be a solitary fibrous tumor on imaging. Because similar cases are rare, we report this case along with a literature review.

Giant Sternal Pilomatricoma: An Unusual Tumor at an Uncommon Site

AbstractPilomatricoma, pilomatrixoma, or calcified epithelioma of Malherbe is an uncommon, benign, isolated tumor of hair matrix primarily seen in children and young adults. The most common location is the head and neck region. It usually manifests as a small nodular mass. Here we report a rare case of giant pilomatricoma over the sternum in a 60-year-old male patient with an unusual clinical and radiological presentation mimicking a calcified sebaceous cyst.

Clinicopathological analysis of 719 pediatric and adolescents' ocular tumors and tumor-like lesions: a retrospective study from 2000 to 2018 in China.

To describe the clinicopathologic features and classification of pediatric and adolescent ocular tumors and tumor-like lesions. A total of 719 cases of pathologically confirmed ocular tumors and tumor-like lesions in a pediatric population from two academic institutions over an 18-year period were retrospectively analyzed. The main outcome measures were the clinical and pathological features of the cases. Benign tumors accounted for 92.1% of all cases while malignant tumors accounted for 7.9%. The most common ocular benign tumors were (epi-)dermoid cysts (19.8%), nevi (15.2%), corneal dermoid tumors (9.8%), and calcified epitheliomas (8.8%). The most common ocular malignant tumors were retinoblastoma (80.8%), and rhabdomyosarcoma (3.9%). Eyelid and ocular surface tumors comprised 73.3% of benign tumors while intraocular and orbital cavity comprised 94.2% of malignant tumors. For tumor site, the upper eyelid was up to 1.79 times more than lower eyelid (P<0.05). Age at surgery and sex also had an association with different lesions (P=0.006, P=0.035, respectively). Most ocular tumors and tumor-like lesions in children and adolescents are benign. Pediatric ocular tumors are distinct from those in adults in terms of histological origin. (Epi-)dermoid cysts are the most common benign tumors while retinoblastomas the most common malignant tumors.

Calcifying epithelioma on the face of a middle-aged man.

A 42-year-old man presented with a nodule on the left cheek that had gradually increased in size. Physical examination revealed a yellowish subcutaneous tumor. The biopsy specimen revealed epithelial sheets consisting of anucleate squamous cells, basophilic cells, and foreign body giant cells. These findings confirmed that this tumor was a calcifying epithelioma.

Multiple pilomatrixomas in children: the need for long-term follow-up and aesthetically sensitive incisions.

Pilomatrixomas are benign, calcified epitheliomas of the hair follicle, predominately affecting children and commonly presenting in the head and neck region. The current literature is almost unanimous in recommending surgical excision. Reconstruction of these defects may require the need for a skin graft, resulting in poor cosmetic outcome and donor site morbidity. We present two cases demonstrating the benefits of minimal access incisions for pilomatrixomas in children. We recommend that multiple or recurrent lesions should prompt referral to a specialist for management and long-term follow-up.

A Case of Long-term Calcifying Epithelioma in the Neck Region

Calcifying epithelioma is a benign tumor derived from hair matrix cells. It more commonly involves the face and upper extremities in children and females and rarely occurs in individuals aged > 50 years. It can be detected at an early stage, with a typical clinical presentation of a hard mass under the skin, and can be surgically resected.Here we report the case of a 50-year-old male who presented with a scleroid-like tumor mass that could be palpated in his left neck. He had been aware of the tumor for approximately 30 years, and it had been progressively increasing in size. The tumor was located over the left sternomastoid muscle, was approximately the size of the tip of the fifth finger, and was hard and mobile. Two sharply demarcated oval opacities were demonstrated on computed tomography (CT), with the same CT value as that of bone. We diagnosed neck calcifying epithelioma and resected the tumor under local anesthesia. Histological examination revealed calcified material containing shadow cells with marginal ossification. The surface skin showed no apparent abnormalities. We report this rare case of neck calcifying epithelioma that went undiagnosed for more than 30 years and discuss the relevant literature.

Clinical features and micro-invasive reshaping repair of calcified epithelioma in head and face

Objective Calcified epithelioma is a rare benign tumor in head and face. It is seldomly seen canceration. But it has local invasion behavior. The aim of this study was to explore the methodology in the diagnosis and treatment of calcified epithelioma in head and face, and to improve the accuracy of clinical diagnosis. Methods A retrospective analysis was carried out in 26 patients with calcified epithelioma in head and face. Results 53. 8 % patients with calcified epithelioma were less than 13-year-old. The disease was easily misdiagnozed. In this group of patients the misdiagnosis rate reached to 42. 3 %. Btype ultrasonographic diagnosis possessed a high level of concordance with histological diagnosis. There were three major types of calcified epithelioma: type 1, a mass with internal echoic foci; type 2, a hyperechoic mass with high beam; type 3, no calcification in the parenchyma. Piomatricoma was described as a skin tumour histologically composed of shadowcells, basophillic cells, foreign body giant cells and intracellular and stromal calcification. The treatment was excision and no recurrences were found by followup. Conclusions It is important for clinicians to know the clinical features of calcified epithelioma. Imaging studies including ultrasonography would help establish the diagnosis. Surgical excision with clear margins is recommended for this tumor. Key words: Calcified epithelioma; Clinical analysis; Reshaping repair

Cutaneous manifestations of Costello syndrome

Cutaneous findings are common in Costello syndrome, but have not been extensively reviewed in the dermatology literature. We present the cutaneous and histopathologic findings from two cases of Costello syndrome and review previously described cutaneous features of this syndrome. Both patients had manifestations of Costello syndrome with thick, lax skin on the dorsal aspects of hands and feet, deep palmar and plantar creases, curly hair, hyperkeratoses, acanthosis nigricans, papillomas, and multiple pigmented lesions. One patient had multiple syringomas on the forearms, a finding not previously reported. Pigmented lesions have previously been reported as nevi in the literature though no biopsies have been reported. We conclude that thick, loose skin on the dorsal aspects of hands and feet and deep palmar and plantar creases are cardinal manifestations of Costello syndrome and benign tumors of ectodermal origin such as papillomas, calcified epitheliomas, dermoid cysts, mammary fibroadenosis, and syringomas are important features of this syndrome.

Le pilomatricome isolé du bras : une localisation rare. À propos d'un cas

Pilomatrixoma also known as calcified epithelioma of Malherbe, is a rare benign cutaneous tumor. It is most commonly seen in the head and neck areas, during the first two decades of life. We report a 30-year-old female patient with a rare localisation of pilomatrixoma in the right arm. The pilomatrixoma was excised and at one year follow-up there has been no evidence of recurrence.

耳介周囲の皮下に発現した石灰化上皮腫の２例

We reported two cases of calcifying epithelioma arising in subcutaneous tissue around the auricle. One case was in a 11-year-old Japanese girl who visited our clinic complaining of a mass at the left preauricular region, which had been present since the age of 3. Radiographic examination revealed the presence of calcification measuring 10×8 mm in diameter. Enucleation was performed, and a histopathological diagnosis of a calcifying epithelioma was made. Histopathologically, the tumor was composed mainly of shadow cells, and bone formation was also observed. The other case was in a 52-year old Japanese man, who visited our clinic complaining of a mass at the left side of the neck. The tumor was located at the subauricular region, and the surface of the tumor had undergone partial necrosis. The tumor was enucleated with the surrounding granulation tissue. The histopathological diagnosis was a calcifying epithelioma. Histopathological examination revealed the tumor to be composed of basophilic cells and shadow cells; calcifications were also observed.The postoperative course of both patients was uneventful, with no evidence of recurrence.

急速に増大した耳下腺こう筋部石灰化上皮腫の１例

Calcifying epithelioma is a tumor originating in hair cortex cells. It tends to occur in the head and neck region.We reported a case of rapidly growing calcifying epithelioma. The patient, a 12-yearold girl, had a bone-like hard tumor in her parotidomasseteric region. The tumor had grown rapidly for the last three months before operation. The tumor was extirpated and histological examination revealed a calcifying epithelioma. An inflammatory stimulus apparently promoted the rapid growth of this tumor. There has been no evidence of recurrence for 8 years after operation.

右頬部に認められた石灰化上皮腫の１症例

A 8-year-old girl developed a calcifying epithelioma in the right cheek. The lesion was noticed as a painless, well-defined and movable mass.The 11×17×13 mm mass with overlying skin was excised under local anesthesia.Histologically the mass consisted of proliferation of shadow cells and a few basophilic cells. Calcification was occasionally seen.Infrared spectrum analysis of calcification revealed that main absorption peaks were given by protein and calcium phosphate.The postoperative course is uneventful with no sign of relapse.

Aplasia of the right lung and calcifying epithelioma in association with Goldenhar's syndrome

Summary A case of Goldenhar's syndrome (oculoauriculovertebral dysplasia) with the rare association of aplasia of one lung is presented with a discussion of the clinical findings and the aetiology. The major abnormalities, pulmonary, renal and the undergrowth of the jaw were all right-sided, confirming previous reports. This child developed a calcifying epithelioma and this is cited as support for the theory of the origin of these lesions from epidermoid cysts.

Calcifying epithelioma (Malherbe) in New South Wales.

Medical Journal of AustraliaVolume 1, Issue 25 p. 1086-1088 Original Article CALCIFYING EPITHELIOMA (MALHERBE) IN NEW SOUTH WALES H. Kramer M.B., Ch.B. (Cape Town), D.Phil. (Oxon), M.C.P.A., F.C.Path., H. Kramer M.B., Ch.B. (Cape Town), D.Phil. (Oxon), M.C.P.A., F.C.Path. The Institute of Clinical Pathology and Medical Research, Lidcombe, New South WalesDirector.Search for more papers by this authorJ. Cooper Booth M.B., B.S. (Sydney), M.C.P.A., M.C.Path., J. Cooper Booth M.B., B.S. (Sydney), M.C.P.A., M.C.Path. The Institute of Clinical Pathology and Medical Research, Lidcombe, New South WalesHistopathologist.Search for more papers by this author H. Kramer M.B., Ch.B. (Cape Town), D.Phil. (Oxon), M.C.P.A., F.C.Path., H. Kramer M.B., Ch.B. (Cape Town), D.Phil. (Oxon), M.C.P.A., F.C.Path. The Institute of Clinical Pathology and Medical Research, Lidcombe, New South WalesDirector.Search for more papers by this authorJ. Cooper Booth M.B., B.S. (Sydney), M.C.P.A., M.C.Path., J. Cooper Booth M.B., B.S. (Sydney), M.C.P.A., M.C.Path. The Institute of Clinical Pathology and Medical Research, Lidcombe, New South WalesHistopathologist.Search for more papers by this author First published: 01 June 1968 https://doi.org/10.5694/j.1326-5377.1968.tb29165.xCitations: 3 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article.Citing Literature Volume1, Issue25June 1968Pages 1086-1088 RelatedInformation

Calcifying Epithelioma of Malherbe: Histochemical and Electron Microscopic Studies

Calcifying epithelioma is a rare, solitary tumor which often occurs in young individuals (1), most frequently on the face and the arms (1, 2). Since Malherbe and Chenantais (3) described “calcified epithelioma of sebaceous glands” in 1880, the histogenesis of this tumor has been attributed to various skin appendages such as sebaceous glands (3, 4) and hair (2, 5, 6, 7). Lever and Griesemer (7) regarded the basophilic cells in calcifying epithelioma as primary epithelial germ cells with a tendency to differentiate into keratotic hair cells. Forbis and Helwig (1), in their recent study on 240 specimens, agreed with the opinion of Lever (2) and Lever and Griesemer (7) that calcifying epithelioma arises from primitive cells of the hair matrix. They pointed out that the broad dense transitional zone from basophilic to shadow cells of this tumor, where sulfhydryl groups are abundant, is analogous to the kera-togenous zone of the hair. They also demonstrated that hyalinized shadow cells in some instances show a brilliant birefringence, as does the keratogenous zone of the hair.

Mummified epidermal cyst: calcified epithelioma of Malherbe; report of a case.

Mummified epidermal cyst: calcified epithelioma of Malherbe; report of a case.

Benign Calcified Epithelioma of Eyelid

Benign Calcified Epithelioma of Eyelid

Calcifying epithelioma; report of thirteen cases.

Five EXAMPLES of a peculiar cutaneous or subcutaneous tumor have been encountered during the past year which have been described in the literature as calcifying or calcified epithelioma When the first of these tumors was seen, a diagnosis of carcinoma arising in an epidermal cyst was considered; Dr. W. Harold Civin, of the Queen's Hospital, Honolulu, T. H., suggested the correct diagnosis. A review of the surgical material at the Straub Clinic from 1945 through 1950 (during which time approximately 9,000 specimens were examined) revealed eight additional cases which had been reported under a variety of names (Table 1). These 13 cases are being presented because the tumor is unusual and little known, and because it may be misdiagnosed as carcinoma. There are, moreover, certain clinical and pathologic features of considerable interest about which there is some controversy. HISTORICAL ASPECTS Malherbe and Chenantais 1 first described this tumor,