The present work covers the synthesis of six nanoparticles using a natural reducing agent obtained from tulsi (Ocimum sanctum) leaves. The method comprises boiling tulsi leaves in double distilled water and producing its juice which was used as the green reducing agent. The metal compounds included, gold chloride trihydrate, zinc acetate dihydrate, lithium chloride, silver nitrate, cadmium iodide, and graphene oxide that underwent reduction which was confirmed by color change. The synthesized nanoparticles were analyzed and proven to be successful in formation as it was characterized by scanning electron microscopy (SEM). This green, tulsi leaves-based route demonstrates a feasible pathway of sustainable nanoparticle synthesis which is promising for many fields of applications.