Extraction Of Cadmium Research Articles

Synthesis and Characterization of Mesoporous Materials Functionalized with Phosphinic Acid Ligand and Their Capability to Remove Cd(II).

This article presents a study of cadmium removal from nitrate medium using adsorption in calcined mesoporous silica (MCM-C), mesoporous silica doped (MCM_DIOPA), and calcined and impregnated mesoporous silica (MCM@DIOPA), with diisooctylphosphinic acid (DIOPA). The sorbents were synthesized via a sol-gel method. Several characterization techniques, such as XRD, FTIR spectroscopy, N2 sorption and elemental analysis, have been used to determine the main structural, textural, and chemical properties of prepared sorbents. Batch adsorption and kinetics tests were carried out, where the influence of pH and contact time of the sorbents and their role in cation removal were studied. Experimental results show poor sorption efficiencies with MCM-C and MCM_DIOPA at pH 5.85. At the same pH, better cadmium extraction was attained by MCM@DIOPA and was achieved within 30 min. The pseudo-second-order model is the most appropriate model to describe the elimination mechanism of Cd(II) ions. The Langmuir equation was used to model the sorption isotherm and the maximum sorption capacity of Cd(II) is 22.16 mg/g (200 mmol/kg). The complex type of the probable extracted species isCdL2-HL.

A New Approach to Differentiate the Causes of Excessive Cadmium in Rice: Soil Cadmium Extractability or Rice Variety

In order to effectively decrease cadmium (Cd) in rice grains in contaminated paddy soil and maintain the safe production of rice, identifying excessive Cd in rice caused by rice varieties or soil Cd is critical, but it is currently lacking. In the present study, the soil ethylenediaminetetraacetic acid (EDTA)-extractable Cd (EDTA-Cd) and the bioaccumulation factors of rice based on EDTA-Cd (BCFEDTA-Cd) were used to develop an approach to identify excessive Cd in rice caused by rice varieties or soil Cd. Based on an empirical soil–plant transfer model and species sensitivity distribution (SSD), BCFEDTA-Cd and EDTA-Cd were divided into five grades. The results showed that the five grades of the EDTA-Cd (minimum value less than 0.11 mg/kg and maximum value greater than 2.93 mg/kg) and BCFEDTA-Cd (minimum value less than 0.09 and maximum value greater than 1.40) were classified in the normal soil pH range. Further, the conversion equation between EDTA-Cd and diethylene triamine pentaacetic acid (DTPA)-Cd was obtained through linear regression analysis using 67 sets of soil data from the literature. In addition, the four selected rounding thresholds for the percentage of EDTA-Cd to total soil Cd (EDTA-Cd) (%) were 52.5, 67.5, 82.5, and 97.5%. A selected soil EDTA-Cd (%) (about 75%) can be used to identify the status of soil bioavailability, especially in soil with high background Cd. Finally, a set of 1084 pairs of rice and soil data for Cd-contaminated soils was used to investigate the respective contributions of rice varieties and soil Cd when Cd in rice exceeds the limit (0.2 mg/kg). Based on field experiment data, a systematic identification approach for the causes of rice Cd exceeding the limit, soil Cd or rice variety, was established and applied. In conclusion, under Cd exposure conditions, the importance of the causes of Cd in soil and rice varieties can be identified, and their contributions can be distinguished, thus helping to identify the causes of Cd contamination in rice.

Enhancing the effect of novel cd mobilization bacteria on phytoremediation and microecology of cadmium contaminated soil

The efficacy of phytoextraction for remediating heavy-metal contaminated soil depends on the bioavailability of the heavy metals and plant growth. In this study, we employed a synergistic system comprising water-soluble chitosan and the novel Cd mobilization bacteria, Serratia sp. K6 (hereafter K6), to enhance cadmium (Cd) extraction by Lolium perenne L. (ryegrass). The application of chitosan and K6 resulted in an increase in the biomass of ryegrass by 11.81% and Cd accumulation by 73.99% and effective-state Cd by 43.69% and pH decreased by 4.67%, compared to the control group. Microbiome and metabolomics analyses revealed significant alterations in the inter-root microbial ommunity, with rhizobacteria such as Sphingomonas, Nocardioides, and Bacillus likely contributing to enhanced plant growth and Cd accumulation in response to chitosan and K6 addition. Additionally, the contents of various organic acids, amino acids, lipids, and other metabolites exhibited significant changes under different additive treatments, suggesting that ryegrass can regulate its own metabolites to resist Cd stress. This study provides valuable insights into the effects of additives on phytoextraction efficiency and the soil bacterial community, offering a promising approach for phytoremediation of Cd-contaminated soils.

Cadmium recovery from acid leachates of Tunisian phosphoric acid purification residues.

The management of cadmium-rich sludges, which are pollutant residues from the phosphorus industry, including the valorization of these sludges through the selective recovery of heavy metals, is a promising prospect. However, there is still a need to develop recovery methods that are both optimized for efficiency, cost-effectiveness, and environmentally friendly. This study aims to enhance cadmium extraction from the polymetallic sludge by optimizing the processes of sulfuric acid (SA) leaching and sodiumsulfide precipitation. Key parameters including SA concentration, temperature, solid/liquid ratio, and stirring velocity were optimized to maximize the heavy metals extraction. Over 90% of the Cd and Zn present in the sludge were successfully extracted. Subsequently, investigates the selective precipitation of metal sulfide from acidic leachates (pH < 2), focusing particularly on cadmium. Through the optimization of chemical precipitation parameters (Na2S concentration, temperature, and reaction time), more than 99% of the cadmium was selectively recovered as CdS. The precipitates underwent analysis for mineralogy, chemistry, purity, and particle size. XRD analyses indicated CdS formation in "Greenockite" and "Hawleyite" forms, confirmed by SEM-EDS data, revealing fine powder consisting of micro and nanoparticles (< 0.5 µm) with varied spherical shapes.

Advances in Sustainable Extraction of Arsenic and Cadmium from Sewage Sludge: Use of Hydrophobic Deep Eutectic Solvent Modified with Magnetic Nanoparticles

Advances in Sustainable Extraction of Arsenic and Cadmium from Sewage Sludge: Use of Hydrophobic Deep Eutectic Solvent Modified with Magnetic Nanoparticles

Effects and mechanisms of microbial ecology and diversity on phytoremediation of cadmium-contaminated soil under the influence of biodegradable organic acids

In recent years, heavy metal pollution has become a global environmental problem and poses a great threat to the health of people and ecosystems. Therefore, strategies for the effective remediation of Cd from contaminated soil are urgently needed. In this study, ryegrass was utilized as a remediation plant, and its remediation potential was enhanced through the application of Citric Acid (CA) in conjunction with Bacillus megaterium (B. megaterium). The P3 treatment (CA + Bacillus megaterium) exhibited a significantly higher efficiency in promoting cadmium extraction by ryegrass, resulting in a 1.79-fold increase in shoot cadmium accumulation compared to the control group (CK) with no Bacillus megaterium or CA. Moreover, the P3 treatment led to an increased abundance of Actinobacteriota, Acidobacteriota, and Patescibacteria in the rhizosphere. The concentration of amino derivatives (such as betaine, sulfolithocholylglycine, N-alpha-acetyl-lysine, glycocholic acid, arginyl-threonine) showed significant upregulation following the P3 treatment. In summary, this study proposes a viable approach for phytoremediation of soil contaminated with cadmium by harnessing the mobilizing abilities of soil bacteria.

Application of a novel deep eutectic solvent as an eco-friendly medium for green extraction of cadmium from herbal medicines

In this research, hydrophobic DESs were successfully prepared using components with hydrophobic and sulfydryl group, which were applied to develop a green and eco-friendly method to extract and detect the cadmium (Cd) in herbal medicine (HM). The basic properties of the DESs were studied, which showed good hydrophobicity, low density and sufficient absorption capacity. In extraction process, the extraction efficiency (EE) of Cd employing proposed process ranged from 89.12 %∼94.59 % and the maximal enrichment factor (EF) was 46.85. The DES based method demonstrated a good linear response in the range of 1 ∼ 50 µg·L-1 with a detection limit (LOD) of 0.29 μg L-1, which was detected by Inductively coupled plasma mass spectrometry (ICP-MS). Additionally, the accuracy of method (as recoveries %) was obtained with the recoveries ranging from 98.38 %∼105.48 %. The extraction process was also compared with microwave digestion (MD) method and showed basically equivalent effect with good propensity to enrichment. The mechanism was explored by DFT calculation to reveal the interaction of extraction process. The greenness of the proposed method was also evaluated using the Green Analytical Procedure Index (GAPI) and Analytical Eco-Scale (AES), which indicated excellent environmental protection. This study successfully prepared novel DESs and established an eco-friendly and effective analytical process integrating adsorption, collection, separation and detection for the detection of heavy metals in HM, and the DESs were contributed to the first three parts as a multifunctional role. The absorption mechanism related to the formation of molecular complexes in quantum chemistry perspective, which were attribute to the electrostatic attraction and H+ exchange between Cd and adsorbent. This method showed vast potential in heavy metal research involving complex matrices such as HM and its processed products, and the proposed process provides the way for a greener alternative for Cd extraction rather than conventional polluting processes.

Solvent extraction and trace determination of cadmium(II) by spectrophotometry and ICP‐MS

Solvent extraction and trace determination of cadmium(II) by spectrophotometry and ICP‐MS

Comparative analysis of lead and cadmium extraction capacities of hydrophobic deep eutectic solvents

In this study, a total of eight hydrophobic deep eutectic solvents (HDESs) were prepared and evaluated for their efficacy in extracting lead and cadmium from aqueous solutions. The physical and thermal properties of these HDESs were characterized. Among the HDESs tested, the thymol:decanoic acid system, with a molar ratio of 1:1, exhibited the highest distribution ratios for lead and cadmium, with values of 0.79 and 0.55, respectively. The extraction performance of the thymol:decanoic acid system was further investigated by considering various factors such as contact time, pH, mass ratio of water to HDES, and HDES molar ratio. After optimization, the thymol:decanoic acid HDES demonstrated significantly improved extraction efficiency for lead (up to 93.49 %) and cadmium (up to 76.70 %) at initial concentrations of 1000 ppm and 100 ppm, respectively. The extraction mechanism was found to be primarily driven by the complexation and partitioning effects of thymol:decanoic acid with lead or cadmium, as confirmed by the noticeable changes in harmonic frequencies (730, 1337, and 1515 cm−1) observed in the IR spectra analysis before and after extraction. Additionally, the performance of the thymol:decanoic acid HDES was evaluated through solvent regeneration using a multi-stage extraction and reuse approach.

High cadmium-accumulating Salix ecotype shapes rhizosphere microbiome to facilitate cadmium extraction

Cadmium (Cd) contamination poses a significant threat to agricultural soils and food safety, necessitating effective remediation strategies. Salix species, with their high coverage and Cd accumulating capacity, hold promise for remediation efforts. The rhizosphere microbiome is crucial for enhancing Cd accumulating capacity for Salix. However, the mechanisms by how Salix interacts with its rhizosphere microbiome to enhance Cd extraction remains poorly understood. In this study, we compared the remediation performance of two Salix ecotypes: 51–3 (High Cd-accumulating Ecotype, HAE) and P646 (Low Cd-accumulating Ecotype, LAE). HAE exhibited notable advantages over LAE, with 10.80 % higher plant height, 43.80 % higher biomass, 20.26 % higher Cd accumulation in aboveground tissues (93.09 μg on average), and a superior Cd translocation factor (1.97 on average). Analysis of the rhizosphere bacterial community via 16S rRNA amplicon sequencing revealed that HAE harbored a more diverse bacterial community with a distinct composition compared to LAE. Indicator analysis identified 84 genera specifically enriched in HAE, predominantly belonging to Proteobacteria, Actinobacteria, and Firmicutes, including beneficial microbes such as Streptomyces, Bacillus, and Pseudomonas. Network analysis further elucidated three taxa groups specifically recruited by HAE, which were highly correlated with functional genes that associated with biosynthesis of secondary metabolites, glycan biosynthesis and metabolism, and metabolism of cofactors and vitamins. These functions contribute to enhancing plant growth, Cd uptake, and resistance to Cd in Salix. Overall, our findings highlight the importance of the rhizosphere microbiome in facilitating Cd extraction and provide insights into microbiome-based strategies for sustainable agricultural practices.

Direct evidence for the occurrence of indigenous cadmium-based nanoparticles in paddy soils

Speciation of heavy metal-based nanoparticles (NPs) in paddy soils greatly determines their fate and potential risk towards food safety. However, quantitative understanding of such distinctive species remains challenging, because they are commonly presented at trace levels (e.g., sub parts-per-million) and extremely difficult to be fractionated in soil matrices. Herein, we propose a state-of-art non-destructive strategy for effective extraction and quantification of cadmium (Cd)-NPs – the most widespread heavy metal in paddy soils – by employing single particle inductively coupled plasma mass spectrometry (spICP-MS) and tetrasodium pyrophosphate (TSPP) as the extractant. Acceptable extraction efficiencies (64.7–80.4 %) were obtained for spiked cadmium sulfide nanoparticles (CdS-NPs). We demonstrate the presence of indigenous Cd-NPs in all six Cd-contaminated paddy soils tested, with a number concentration ranging from 2.20 × 108 to 3.18 × 109 particles/g, representing 17.0–50.4 % of the total Cd content. Furthermore, semi-spherical and irregular CdS-NPs were directly observed as an important form of the Cd-NPs in paddy soils, as characterized by transmission electron microscopy coupled with energy-dispersive X-ray spectroscopy (TEM-EDX). This research marks a significant step towards directly observing indigenous Cd-NPs at trace levels in paddy soil, offering a useful tool for quantitative understanding of the biogeochemical cycling of heavy metal-based NPs in complex matrices.

Sequential extraction of cadmium, nikel, and lead in soils from Rio Grande do Sul State, Brazil

Sequential extraction of cadmium, nikel, and lead in soils from Rio Grande do Sul State, Brazil

On the Problem of the Distillation Separation of Secondary Alloys of Magnesium with Zinc and Magnesium with Cadmium

An alternative to the existing method of processing secondary magnesium raw materials by remelting in a salt furnace can be distillation separation into volatile metals (Mg, Zn and Cd), low-volatile metals (Al, Mn and Zr) and rare earth elements. The separation of metals may be tracked based on phase diagrams where the field boundaries of the vapor–liquid equilibrium are plotted. Due to the fact that Mg, Zn and Cd have comparable saturated vapor pressures, the possibility of the distillation separation of Mg–Zn and Mg–Cd systems using full state diagrams including the melt–vapor phase transition boundaries were determined in this work. The boundaries of these systems were calculated based on the partial values of saturated vapor, determined by the boiling point method, and presented in the form of temperature–concentration dependencies with the indicated boundaries. The field boundaries were calculated (L + V) at atmospheric pressure (101.33 kPa) and in vacuum (1.33 kPa and 0.7 kPa,) supposing the implementation of the process. The possibility of the separate extraction of zinc and cadmium from magnesium was considered using complete phase diagrams including the boundaries of the melt–steam phase transition. When considering the boundaries of the vapor–liquid equilibrium in the binary systems Mg–Zn and Mg–Cd, it was established that it is impossible to separate metals in one “evaporation–condensation” cycle in a vacuum of 1.33 and 0.7 kPa. The problem is caused by the small size of the fields (L + V) at the temperature, which suggests processes of the re-evaporation of the condensate from the previous distillation stage. The separation of zinc and cadmium from liquid alloys with magnesium under equilibrium conditions requires several repetitions of the condensate distillation process. In non-equilibrium conditions, the real processes will require a larger number of conversions. This implies the expediency of the joint evaporation of magnesium with zinc and cadmium and the use of condensate for additional charging to liquid magnesium, and the remainder of the distillation, where volatile metals such as Al, Mn, Zr and rare earth elements will be concentrated, should be directed to the preparation of ligatures for special magnesium-based alloys.

Synergistic Effects of Exogenous Nutrient Ions on the Real-Time Cadmium Extraction by an Accumulator

Bidens tripartita L. is a cadmium (Cd) accumulator. However, the real-time influx or efflux of Cd2+ around its root apex has not yet been performed. The object of this experiment was to compare the roles of added ions in solution on dynamic Cd extraction by B. tripartita root tip. Quartz sand was used to grow the seedling of B. tripartite. The Cd concentrations of all samples were determined by using ICP-OES after digestion. The Cd2+ influx around the root apex was measured in vivo, i.e., using non-invasive micro-test technology (NMT). The results showed that the Cd2+ influx was found to be decreased by 35.9%, 43.7%, 20.6%, and 57.5% under 10 μM Cd combined with high content Ca2+, Mg2+, Fe3+, or K+ (16 mM, 8 mM, 0.5 mM, 18 mM, respectively), compared to that under 10 μM Cd stress. But Cd treatments with low content ions with 0.05 mM Fe3+ or 0.5 mM S increased the Cd2+ influx in roots by 20.5% and 34.6%, respectively. It was also found that Cd treatment with high concentrations of Ca2+ or K+ increased the shoot biomass of B. tripartita seedlings. Chl a and b contents were significantly decreased in the Cd treatments with low concentrations of Fe3+ or S compared to those under Cd stress alone, and the dehydrogenase activity of the roots decreased in the treatment of Cd with 0.05 mM Fe3+ or 0.5 mM S. Our results indicate that the addition of 0.05 mM Fe3+ or 0.5 mM S promoted Cd2+ influx and Cd uptake by B. tripartita. Unlike traditional measurement, the Cd2+ movements of three-dimensional space around the B. tripartita root tip had been performed by NMT. It was suggested that the effects of S and Fe3+ on the remediation potential of B. tripartita need to be further researched in the future. The results of this study provided a real-time and micro-dynamic theoretical basis for phytoremediation mechanisms.

Interfacial solar evaporation driven Cd removal from contaminated sediments

Solar-driven evaporative remediation (SDER) is an emerging low carbon technology suitable for both seawater desalination and wastewater treatment. Herein, we extend the application of the technique to sediment remediation for the first time by fabricating a functional evaporator (AC@HA-C) comprising cotton loaded with activated carbon and hydroxyapatite. This evaporator accelerated the extraction of Cadmium (Cd) from contaminated sediments. After 14 days of SDER, the overall Cd removal efficiency in sediments ranged between 49.2% and 65.7%. Moreover, cultivation of crops in SDER treated sediments showed an average reduction in Cd accumulation in cabbage by 74.1%. Comparing the AC@HA-C evaporator to other similar materials, life cycle assessment (LCA) showed a 94.0% reduction in environmental impacts and an 86.0% reduction in CO2 emissions. These results position AC@HA-C as a low-carbon and sustainable evaporator, offering a more environmentally friendly choice for sediment remediation.

Simultaneous extraction of cadmium, nickel, and cobalt ions from acidic aqueous solutions by emulsion liquid membrane using sunflower-kerosene mixture as a diluent; breakage and mass transfer studies

In this study, a simultaneous removal of cadmium, cobalt, and nickel from an aqueous solution through the Green Emulsion Liquid Membrane (GELM) method was carried out. A 7:3 ratio of sunflower oil to kerosene was utilized as the membrane phase stabilized by Span 80 as the emulsifier. D2EHPA as a carrier and HCl as an inner phase were used. Extraction and stripping efficiencies of 97.45% and 98.42% for Cd2+, 96.82% and 97.84% for Co2+, 89.74% and 92.69% for Ni2+, respectively, with the lowest breakage (0.8%) were obtained under the best operating conditions. An extensive investigation of the influence of homogenizer speed, external and internal phase acidity, the HLB value of the surfactant (Tween 80 and Span 80), surfactant and carrier concentrations, volume ratio of the membrane to internal phase, mixer speed, ratio of external to membrane phase emulsification time and extraction time on the stability of membrane, extraction, and stripping efficiencies were carried out. Kinetic analysis of cadmium, cobalt, and nickel extraction was performed using zero, first, and second-order models at optimum conditions. The experimental data fit well with first-order for three metal ions. The coefficient of the total mass transfer (Ft) of cadmium through the GELM technique was 3.28% higher than that of cobalt and 28.61% higher than that of nickel, while the Ft of cobalt is 25.33% higher than that of nickel. Using the recovered membrane, the extraction of the three metal ions for the initial six cycles was extremely efficient under the best conditions.

5-methyl-salicylaldoxime based ionic liquids for non-destructive separation of protein and cadmium

Confronting with explosive cadmium contaminations to environment, non-destructive separation of protein with cadmium for protecting food safety is hardpressed. Ionic liquids (ILs) are benign bio-compatible stabilizer of proteins with considerable metal affinity, while their application in separation of cadmium from protein is limited owing to their comparative metal affinities with protein. Accordingly, we firstly synthesize 1-methyl-3 (salicylaldoxime-5-methyl) imidazole hexafluorophosphate ([Salenmim][PF6]) to enhance cadmium extraction with hydroxyl and oxime groups as ligands of cadmium. Structure of [Salenmim][PF6] is confirmed by 1H NMR, 13C NMR, 31P NMR, 19F NMR, FT-IR, Raman spectra, and theoretical simulations. [Salenmim][PF6] can remove 85.31 % of Cd2+ from bovine serum albumin (BSA) at pH of 2.0. X-ray photoelectron spectroscopy (XPS) of BSA and [Salenmim][PF6] before and after Cd2+ extraction illustrate that Cd2+ generally bonds with C = N and O-H of [Salenmim][PF6] to achieve detachment of Cd2+ from BSA. Molecular docking of BSA and Cd2+ indicates that 4 amino acids residues listed as ASP561, ASP562, LYS563, and GLU564 coordinate with Cd2+ with coordinate number close to 1, further confirmed as 1.48 by isothermal titration calorimetry (ITC) analysis. DFT calculations of [Salenmim][PF6] with Cd2+ demonstrate that energy gap between HOMO orbital localized at benzene ring is 1.6860 eV higher than LUMO orbital, faciliating formation of [Salenmim][PF6]-Cd2+ complex. Finally, there are no changes in secondary and tertiary structure of BSA and no ILs residual observed after [Salenmim][PF6] assisted Cd2+ extraction. This work firstly reports a method for synthesis of [Salenmim][PF6] with high affinity to cadmium and systemically reveals how do structure of [Salenmim][PF6] enhance heavy metal removal from proteins, providing a possible strategy for heavy metal extraction from proteins.

MWCNT@TiSiO4 nanocomposite for dispersive solid phase extraction of traces cadmium in food and environmental samples

Cadmium contamination presents substantial hazards to both human health and the environment due to its persistent presence in ecosystems and toxic characteristics. It accumulates in soil and water, causing chronic renal and respiratory issues, and carcinogenicity. Effective detection for monitoring the environmental and public health effects of Cd is required. This study addresses a new separation and enrichment method with a novel MWCNT@TiSiO4 nanocomposite synthesized via sol-gel and calcination synthesis techniques. A comprehensive characterization of the nanocomposite was conducted utilizing X-ray Diffraction (XRD), Fourier Transform Infrared (FTIR) Spectroscopy, and Field Emission-Scanning Electron Microscopy (FE-SEM) techniques. The nano-sorbent was utilized in conjunction with dispersive solid phase extraction (DSPE) to separate and preconcentrate trace amounts of Cd(II) prior to its determination by using flame atomic absorption spectrometry (FAAS). The optimization of analytical parameters, including pH, sample and eluent volumes, sorbent quantities, and eluent composition, was studied. The effect of matrix components was investigated. The method showed a low limit of detection (LOD), limit of quantification (LOQ), and relative standard deviation (%RSD) of 0.053 ng mL−1, 0.176 ng mL−1, and 4.6%, respectively. The method was validated by analyzing certified reference materials. The developed methodology was applied to determine Cd(II) levels in water, tobacco, and food samples. The recovery values were quantitative (90–101%). The maximum and minimum concentrations of Cd in food samples were in shrimp (47.87 ng g−1) and lentil (11.25 ng g−1), respectively.

Activated nanodiamonds (AND)-MIL-125 (Ti) (AND@MIL-125) nanocomposite for the micro-solid phase extraction of cadmium and lead from water and food samples

Activated nanodiamonds (AND)-MIL-125 (Ti) (AND@MIL-125) nanocomposite for the micro-solid phase extraction of cadmium and lead from water and food samples

Development of a dispersive liquid–liquid microextraction procedure based on a natural deep eutectic solvent for ligand-less preconcentration and determination of heavy metals from water and food samples

In the current study, a ligand-less dispersive liquid–liquid microextraction technique assisted ultrasound and vortex equipment (DLLME-A-US-V) procedure was used for the simultaneous preconcentration and extraction of heavy metal ions. The proposed method was done by a natural hydrophobic deep eutectic solvent for the extraction of arsenic, cadmium, lead, and mercury ions without a complexing agent. The natural deep eutectic solvent was prepared from l-menthol (M) and salicylic acid (SA). The precursor of deep eutectic solvents strongly affects the extraction of metal ions. Among the studied solvents, hydrophobic deep eutectic solvents showed the highest extraction recovery. Under optimal experimental conditions, the method linearity, limits of detection (LOD), limits of quantification (LOQ), relative standard deviations (RSD %), enrichment factors (EF), and extraction recovery (% ER) were equal to 0.005–14 µg/L, 0.0043–0.0088 µg/L, 0.0143–0.0294 µg/L, 1.66–2.83 %, 112–120, and 90–96 %, respectively. The obtained coefficients of determination (r2) were also higher than 0.991. This method was successfully applied to determine some heavy metals in food samples in the ultra-trace range with the recovery values of real samples being 93–108 %.