This research paper presents a comprehensive study focused on optimizing innovative tailplane configurations for transport jet aircraft. This study aims to enhance the aerodynamics of the aircraft's rear end by introducing a novel tail arrangement. The ultimate goal is to reduce the size of the horizontal empennage, which will have a positive impact on aircraft fuel efficiency. To fulfill its objectives, this work develops a systematic approach, integrating advanced methodologies such as the Design of Experiments and Response Surface Models for both aerodynamics and structural disciplines. By levering response surfaces methodology, the aerostructural optimization has been performed towards a size reduction of the horizontal tail. Results indicate a potential 9% reduction in the tailplane reference area, which could result in enhanced aerodynamic performance and weight saving. This target would only be achievable if the innovative design includes a Leading Edge Extension device to maintain the stability and handling characteristics of a conventional reference aircraft. The impact of the innovative optimized tail arrangement developed in this study at the aircraft level resulted in a 1% reduction in block fuel for a mission range of approximately 3,400 nautical miles for a 180-seat capacity jet aircraft (similar to A320neo). Furthermore, from an industrial perspective, this paper also demonstrates how an automated workflow assists with CAD modeling, mesh creation, simulation execution, and surrogate models to accelerate complex multidisciplinary optimization processes, thereby reducing the time and costs associated with the development of a new aircraft configuration.