Prestressing technology is an effective way to enhance the mechanical properties of space structures. In view of this, a new pentagonal type aluminum alloy suspen-dome structure with large opening is proposed in this paper by introducing the lower cable support system into the aluminium alloy single-layer reticulated shell structure. The seismic performance of this new structure is investigated using time-procedure analysis. Firstly, the effects of rise-span ratio, thickness-span ratio, prestressing level, horizontal radius factor for lower chord nodes and roof loading on the free vibration characteristics of the structure with different supporting stiffness are investigated. The distributions of internal forces and displacements of members of overall structure considering lower support and roof structure only are analyzed. Subsequently, the dynamic response of the structure under seismic combinations of different dimensions and directions is investigated, and reasonable combinations that should be considered for simplified analyses are derived. Furthermore, seismic internal force coefficients are introduced to assess the degree of seismic effects on various types of members. On this basis, parametric analysis of the seismic performance of the structural performance is conducted and quantitative assessment of the sensitivity of the parameters is carried out. Additionally, the free vibration characteristics and dynamic performance of steel and aluminium suspen-dome are compared. The results show that considering the supporting structure weakens the structural stiffness while increasing the structural dynamic response; reasonable values of key parameters in the seismic design of the structure are obtained; and the rise-span ratio and thickness-span ratio are important influencing factors of the seismic performance of the structure. Besides, the internal forces of members in aluminium alloy suspen-dome are less affected by seismic effects than those in steel suspen-dome, and the new structure has good seismic performance.