Hybrid cable-stayed suspension bridges combine the advantages of cable-stayed and suspension bridges, mitigating their deficiencies. Due to its super spanning ability, this novel form of bridge enjoys a bright application prospect as a large-span structure. This study introduces an analytical algorithm to estimate the full-bridge response of a hybrid cable-stayed suspension bridge with a vertical uniformly distributed load applied to the main beam. This method is based on the assumption that all parameters, such as the geometric configuration, internal force distribution, and material properties, of the whole bridge under a dead load are known; then, it analyzes the full-bridge response under a live load. First, the minimum and independent basic unknown parameters of the full-bridge response are determined. Next, the governing equations are derived and solved based on the conservation of unstressed length of each section of cable, closure of span lengths and elevation difference in different spans, and conditions for stress balance of the main beam. Thus, the values of basic unknown parameters are obtained. Finally, they are substituted into the governing equations to estimate the full-bridge response, including each bridge component’s internal forces and deflections. The proposed analytical method involves no iterative procedures when dealing with nonlinear problems but only focuses on the bridge’s state with and without loading. The results are obtained directly by solving the equations, which have the advantages of high efficiency, simplicity, and clear physical meaning. Finally, the feasibility and effectiveness of the proposed method are verified by a finite-element-based calculation of an exemplary asymmetric cable-stayed suspension cooperation system bridge with a main span of 1400 m.