C-reactive Protein Levels In Adults Research Articles

C-Reactive Protein Levels in Adults With Sickle Cell Disease Visiting the University College Hospital, Ibadan, Nigeria

Sickle cell anemia is one of the major problem in the society, especially the health-care sector. Millions of people in the world are affected and one of the highest incidence occurred in Nigeria. The situation has been further worsened by the insufficient/ inappropriate genetic counseling and diagnosing procedure for the condition. C-reactive protein is one of the greatest indicators that can prevent patients with sickle cell disease from going into cardiac arrest if its level is determined early. This study aimed at improving knowledge on the significance of C-reactive protein as one of the indicators for a possible cardiac attack on sickle cell patients. 131 persons above 18 years of age were recruited, 95 of which were sicklecelled patients and 36 without sickle-cell used as control. Questionnaires were used to collect demographic information of the participants, while their blood samples were collected into Lithium Heparin bottle (3ml), spunned, and plasma was separated, aliquoted in 2 vials and stored at -80oC. Roche (COBAS 311) was used to analyse for C-reactive protein and data summarized in tables. Mean age was 35.4years ±SD=7.54years which ranges from 19 to 56years for sickle cell subjects, and 36.8years ±SD=9.11years which ranges from 19 to 58years for control. The male to female ratio was approximately 2:1 in control and 2.4:1 in sickle cell subjects. 2(2.1%) sickle cell patients had abnormal C-reactive protein, there is no significant difference in mean C-Reactive protein between Sickle cell patients and non-Sickle cell patients (p=.551) and there is no significant relationship between C-Reactive protein in HBSS and haematological parameters like white blood cell (p=0.622) and platelets (p=0.622). No significant disparity was determined between the sickle cell and non-sickle cell individuals. Hence, further studies are needed to confirm the factor behind the abnormal C-reative protein in the two groups.

The Effects of Zinc Supplementation on C-Reactive Protein and Inflammatory Cytokines: A Meta-Analysis and Systematical Review.

Zinc is known for anti-inflammatory and antioxidant roles. In this meta-analysis, we aim to evaluate the impact of zinc supplementation on inflammatory markers, acute-phase reactants, and serum zinc level during inflammatory and infectious diseases. PubMed, Scopus, and Web of Science databases were screened systematically with the terms "zinc supplementation" AND "CRP" OR "IL-1β" OR "IL-2" OR "IL-6" OR "IL-10" OR "IL-12" OR "TNF-α" OR "TGF-β" OR "IFN-γ" OR "WBC (clinical trial)" OR "macrophage (clinical trial)" OR "lymphocyte (clinical trial)" OR "neutrophil (clinical trial)" OR "virus (clinical trial)" OR "antiviral (clinical trial)" for all databases. A total of 2,258 publications were screened, and 73 articles had suitable data for the meta-analysis. Serum zinc level was significantly higher in supplementation group compared with controls [P = 0.0006, mean difference: 11.35 (4.84, 17.87)] (n = 37). Zinc supplementation downregulates acute-phase reactants, especially serum C-reactive protein (CRP) in adults [P < 0.00001, mean difference: -0.75 (-0.98, -0.52)] (n = 22) and pregnant women [FEM P < 0.00001, mean difference: -1.77 (-2.53, -1.00)] (n = 3) but not in children [REM P = 0.10, mean difference: -0.85 (-1.86, 0.17)] (n = 3). In subgroups analysis of chronic inflammatory diseases, serum CRP [REM P < 0.00001, mean difference: -0.57 (-0.76, -0.38)] were significantly lower in zinc-supplemented patients compared with no intervention group. Zinc supplementation (mg/day) correlated with serum interferon-gamma (IFN-γ) level (P = 0.018, r = 1,000). In the nonsupplemented group, serum zinc correlated with serum interleukin-6 (IL-6) level (P = 0.041, r = -0.829) and serum tumor necrosis factor alpha (TNF-α) level (P = 0.063, r = 0.730). Zinc intake correlated with serum zinc (P = 0.0428, r = 0.5115) and TNF-α (P = 0.0043, r = -0.9461). This meta-analysis shows that zinc supplementation improves CRP levels in adults and pregnant women. It might have modulatory effects on cytokine secretions and blood cells in inflammatory and infectious diseases. For the first time, we investigated the effects of zinc supplementation on inflammatory cytokine.

Effect of Sleep Surgery on C-Reactive Protein Levels in Adults With Obstructive Sleep Apnea: A Meta-Analysis.

To evaluate associations between sleep surgery and CRP (C-reactive protein) levels in adults with obstructive sleep apnea (OSA). Meta-analysis. Two authors independently searched PubMed, Medline, EMBASE, and Cochrane review databases until July 2019. The keywords used were sleep apnea, OSA, sleep apnea syndromes, surgery, C-reactive protein (CRP), and inflammatory markers. The effects of sleep surgery on CRP levels were examined using a random-effects model. Nine studies with 277 patients were analyzed (mean age: 46.5 years; 92% men; mean sample size: 30.8 patients). The mean change in the apnea-hypopnea index (AHI) after surgery was significantly reduced by -21.1 (95% confidence interval [CI], -28.4 to -13.7) events/hr. Overall, sleep surgery resulted in a significant reduction of CRP levels in patients with OSA (standardized mean difference [SMD] = -0.39, 95% CI, -0.67 to -0.11). Patients with postoperative AHI reduction >20 events/hr achieved a greater reduction in CRP than those with AHI reduction <20 events/hr (SMD: -0.72 vs. -0.14, P for heterogeneity = .007). According to subgroup analysis, differences in the CRP levels after surgery were nonsignificant in the different countries (i.e., United States vs. other countries), CRP types (i.e., CRP vs. high-sensitivity CRP), surgical procedures (i.e., pharyngeal surgery vs. other surgical procedures), and follow-up period (i.e., <6 vs. >6 months). Sleep surgery for OSA resulted in a significant reduction of CRP levels in adults. The beneficial effect of surgery on CRP levels is greater in patients with large improvement in OSA (i.e., AHI reduction >20 events/hr) after sleep surgery. Laryngoscope, 131:1180-1187, 2021.

Association between daily level of objective physical activity and C-Reactive protein in a representative national sample of adults with self-reported diagnosed arthritis or fibromyalgia.

Examine the association between physical activity and sedentary time with high sensitivity C-Reactive protein levels in adults with arthritis and fibromyalgia. We also investigated the dose of physical activity that was associated with lower clinical levels of high sensitivity C-Reactive protein (< 3mg/L). Observational design was used to evaluate the variables of interest-based on the Canadian Health Measures Survey cycle 1-3 (2007-2012). Generalized adjusted additive models were used to explore the shape of the association between high sensitivity C-Reactive protein, daily physical activity, step count and sedentary time. High sensitivity C-Reactive protein was measured with blood samples. Physical activity, number of steps and sedentary time were objectively assessed using an Actical accelerometer. Daily moderate to vigorous physical activity and step count were significantly associated with lower high sensitivity C-Reactive protein levels, but daily light physical activity and sedentary time were not associated with high sensitivity C-Reactive protein levels, even after controlling for age, sex, daily smoking, body mass index, household income, level of education levels, marital status, work year and accelerometer wear time and season of accelerometer. Non-linear dose-response patterns were observed between daily moderate to vigorous physical activity as well as step count with high sensitivity C-Reactive protein levels. Lower high sensitivity C-Reactive protein levels were associated with 1-150min of daily moderate to vigorous physical activity and with daily step count starting at 4000 in people with arthritis. Adults with fibromyalgia had lower levels of high sensitivity C-Reactive protein when engaging in 10-35min of daily moderate to vigorous physical activity and in 5000-9000 daily steps. Optimal and specific doses of daily moderate to vigorous physical activity and steps were independently related to lower high sensitivity C-Reactive protein levels in adults with arthritis and fibromyalgia. Daily moderate to vigorous physical activity and step count were associated with high sensitivity C-Reactive protein levels that were below the clinical threshold. Given the positive outcomes of physical activity on health, adults with arthritis and fibromyalgia may benefit from these specific recommendations.

Association between weekend catch-up sleep and high-sensitivity C-reactive protein levels in adults: a population-based study.

To investigate the association between weekend catch-up sleep (WCS) and the levels of high-sensitivity C-reactive protein (hsCRP)-a serum inflammatory maker-in adults. Data of 5,506 adults aged 19 years or older were obtained from the nationwide cross-sectional Korea National Health and Nutrition Examination Surveys conducted in 2016. Serum hsCRP level, weekday and weekend sleep durations, and sociodemographic and health-related characteristics were assessed. Participants whose weekend sleep duration was more than 1 h longer than their weekday sleep duration were included in the WCS group. hsCRP level was categorized into quartiles (i.e. highest, middle-high, middle-low, and lowest). Obesity was defined by body mass index ≥ 25.0 kg/m2. The WCS group included 1,901 participants (34.5%). In the logistic regression analysis controlling for all variables, adults in the WCS group were significantly less likely to show the highest hsCRP level (versus the lowest level) compared with those without WCS in the complete sample (adjusted odds ratio = 0.795, 95% confidence interval [CI] = 0.662 to 0.955). In a subgroup analysis, this association was significant only for those with weekday sleep duration of 6 h or lower. Longer WCS (≥3 h) was not associated with hsCRP levels. Non-obese people with WCS demonstrated a lower risk for high hsCRP levels, while there was no significant difference in obese people with WCS. Our findings indicate that WCS may be beneficial for low-grade systemic inflammation in adults, particularly among those with shorter weekday sleep durations. WCS may also interact with obesity.

Influence of high altitude on C-reactive protein levels in adults with abdominal visceral adiposity

Objetivo: Evaluar la influencia de la altura en los niveles de proteina C reactiva (PCR) en adultos con adiposidad visceral abdominal. Materiales y metodos: Se realizo un estudio cuantitativo con diseno cuasi-experimental, que incluyo veinticuatro estudiantes de medicina de la Universidad Nacional de Trujillo, sexo masculino, seleccionados de manera no probabilistica por conveniencia y sujeto participante, que fueron evaluados a 0 y 4386 m s. n. m. y clasificados de acuerdo al grado de adiposidad visceral abdominal: normal (G1) y elevada (G2). Resultados: El nivel de PCR de G1 en relacion a G2 no tuvo diferencia significativa. Respecto a los niveles de PCR de G2 se empleo la prueba no parametrica de Wilcoxon y para G1 se uso la prueba T-student, evidenciandose una significancia en ambos casos. Conclusiones: Las variaciones de los niveles de PCR en altura con respecto al basal de ambos grupos fueron significativos.

Social Inequalities in C-Reactive Protein Levels in Adults from the Brazilian Longitudinal Study of Adult Health (Elsa-Brasil): A Life Course Analysis.

Social Inequalities in C-Reactive Protein Levels in Adults from the Brazilian Longitudinal Study of Adult Health (Elsa-Brasil): A Life Course Analysis.

Effects of aerobic exercise on C-reactive protein, body composition, and maximum oxygen consumption in adults: a meta-analysis of randomized controlled trials

The aim of the study was to use the meta-analytic approach to examine the effects of aerobic exercise on C-reactive protein (CRP) in adults. Secondary outcomes included changes in body weight in kilograms, percentage of body fat, and maximum oxygen consumption (V̇ o 2max) in mL kg −1 min −1. Studies were retrieved using computerized literature searches, cross-referencing, and hand searching. Inclusion criteria were assessment of CRP in randomized controlled trials published in the English language between January 1, 1990, and January 1, 2006. Studies were also limited to aerobic exercise interventions lasting 4 weeks or more in adults 18 years or older. Five studies representing 323 male and female subjects (171 exercise, 152 control) and 6 outcomes for CRP were available for pooling. A nonsignificant reduction of approximately 3% was observed for CRP in the exercise groups (mean ± SEM, −0.11 ± 0.14 mg/L; 95% confidence interval [CI], −0.39 to 0.17 mg/L) using a random-effects model. Statistically significant reductions of approximately 4% were found for body weight (mean ± SEM, −3.4 ± 1.0 kg; 95% CI, −5.3 to −1.5 kg) and percentage of body fat (mean ± SEM, −1.4% ± 0.4%; 95% CI, −2.3% to −0.6%), whereas a statistically significant increase of 12% was found for V̇ o 2max (mean ± SEM, 3.3 ± 0.9 mL kg −1 min −1; 95% CI, 1.5 to 5.1 mL kg −1 min −1). The results of our study suggest that aerobic exercise does not reduce CRP levels in adults, but does improve measures of body composition and physical fitness.

Magnesium supplement intake and C-reactive protein levels in adults

Previous research has indicated that dietary magnesium may be a key component in the association between diet and inflammation; however, the role of intake from magnesium supplements has not been elucidated. The objective of this study was to determine the likelihood of elevated C-reactive protein (CRP) in people taking magnesium-containing supplements of 50 mg/d or more. We examined this issue in a study sample derived from the National Health and Nutrition Examination Survey 1999-2002, a nationally representative, survey of the civilian, noninstitutionalized population of the United States. Among US adults, 25.6% were taking a magnesium supplement of at least 50 mg daily. Only 21.9% of individuals not taking supplemental magnesium met or exceeded the recommended daily allowances (RDA) for magnesium intake compared with 60.2% of adults who were taking magnesium supplements. In adjusted logistic regression analyses, people whose total daily magnesium intake was below the RDA were significantly 40% more likely to have elevated CRP regardless of whether they were taking magnesium supplements ( P < .05). Among people with dietary magnesium intake less than 50% RDA, individuals taking magnesium supplements were 22% less likely to have elevated CRP. Magnesium supplement intake is associated with a lower likelihood of elevated CRP in people with low dietary magnesium intake. Prospective studies are needed to examine whether magnesium supplementation can reduce levels of CRP.

Relationship between periodontal disease and C-reactive protein among adults in the atherosclerosis risk in communities study

Background Moderately elevated serum C-reactive protein (CRP) concentration is a systemic marker of inflammation and a documented risk factor for cardiovascular disease in otherwise healthy persons. Unrecognized infections, such as periodontal disease, may induce an acute-phase response, elevating CRP levels. We evaluated the association between periodontal disease and CRP levels in adults in the Atherosclerosis Risk in Communities study. Methods Oral examinations were conducted between January 1, 1996, and December 31, 1998, on 5552 ARIC participants (aged 52-74 years) from 4 US communities. Periodontal disease was quantified as the percentage of periodontal sites with pocket depth of 4 mm or more. Serum CRP concentration was quantified in milligrams per liter using an enzyme-linked immunosorbent assay. Results Mean (SE) CRP level was 7.6 (0.6) mg/L among people with extensive periodontal pockets (>30% of sites with pocket depth ≥4 mm), approximately one-third greater than that for people with less extensive periodontal pockets (5.7 [0.1] mg/L). In a multivariable linear regression model that controlled for age, sex, diabetes mellitus, cigarette use, and nonsteroidal anti-inflammatory drug use, the association of extensive periodontal pockets with CRP concentration was modified by body mass index (BMI; calculated as weight in kilograms divided by the square of height in meters). For people with a BMI of 20, the model predicted a 2-fold difference in mean CRP concentration between periodontal pocket groups (7.5 vs 3.6 mg/L), but the difference decreased with increasing BMI and was negligible when BMI equaled 35. Conclusions Extensive periodontal disease and BMI are jointly associated with increased CRP levels in otherwise healthy, middle-aged adults, suggesting the need for medical and dental diagnoses when evaluating sources of acute-phase response in some patients.

Relationship between periodontal disease and C-reactive protein among adults in the Atherosclerosis Risk in Communities study.

Moderately elevated serum C-reactive protein (CRP) concentration is a systemic marker of inflammation and a documented risk factor for cardiovascular disease in otherwise healthy persons. Unrecognized infections, such as periodontal disease, may induce an acute-phase response, elevating CRP levels. We evaluated the association between periodontal disease and CRP levels in adults in the Atherosclerosis Risk in Communities study. Oral examinations were conducted between January 1, 1996, and December 31, 1998, on 5552 ARIC participants (aged 52-74 years) from 4 US communities. Periodontal disease was quantified as the percentage of periodontal sites with pocket depth of 4 mm or more. Serum CRP concentration was quantified in milligrams per liter using an enzyme-linked immunosorbent assay. Mean (SE) CRP level was 7.6 (0.6) mg/L among people with extensive periodontal pockets (>30% of sites with pocket depth > or =4 mm), approximately one-third greater than that for people with less extensive periodontal pockets (5.7 [0.1] mg/L). In a multivariable linear regression model that controlled for age, sex, diabetes mellitus, cigarette use, and nonsteroidal anti-inflammatory drug use, the association of extensive periodontal pockets with CRP concentration was modified by body mass index (BMI; calculated as weight in kilograms divided by the square of height in meters). For people with a BMI of 20, the model predicted a 2-fold difference in mean CRP concentration between periodontal pocket groups (7.5 vs 3.6 mg/L), but the difference decreased with increasing BMI and was negligible when BMI equaled 35. Extensive periodontal disease and BMI are jointly associated with increased CRP levels in otherwise healthy, middle-aged adults, suggesting the need for medical and dental diagnoses when evaluating sources of acute-phase response in some patients.

Interpretation of circulating C-reactive protein levels in adults: Body Mass Index and gender are a must

The recently demonstrated association between C-reactive protein (CRP) level and body mass index (BMI) raised the question of the link between CRP and the degree of obesity. In the present study, we measured CRP in a healthy population with a wide range of BMI in order to appreciate the influence of overweight in the interpretation of CRP results in clinical use. Blood donors, aged from 19 to 65 years, were included in the study. According to BMI, subjects were classified into 3 groups: A (BMI<25 kg/m(2), n=611); B (25-30, n=147); C (> 30, n=34). CRP values were different among women and men. CRP progressively increased with BMI in women. These results clearly showed that average level of CRP was quite different according to BMI and gender of the subjects and generated different normal ranges of CRP expressed in mg/L (median, 75(th) percentile): Group A: women: 0.44, 0.93; men: 0.40, 0.79, Group B: women: 1.28, 1.84; men: 0.84, 2.17, Group C: women: 3.61, 7.21; men: 1.16, 3.08. Our results suggest that for an inflammatory disease diagnosis, a CRP concentration of 5 mg/L is normal for obese women but is five times the 75(th) percentile for normal people.