Burn injury patients often experience a range of psychological challenges, such as pain, anxiety, and depression. In this context, nurses have a crucial responsibility in caring for clients with mood disorders. In the current study, the authors aim to provide a comprehensive perspective on nursing role during post-burn mood disorders among burn patients by reviewing previous evidence literature. A comprehensive literature search was conducted on PubMed and Scopus databases using the following key terms "burns", "severe burns", "mood disorders", and "nursing". The search desire focused on papers related to burns, mood disorders, and nursing. 20 studies were selected for this review. Nurses play a crucial role in managing post-burn psychological conditions like depression, post-traumatic stress disorder (PTSD), and anxiety. Their responsibilities include early detection, holistic assessment, and intervention in addressing patients' emotional well-being. Educating patients and families, providing emotional support, and creating a therapeutic environment are critical aspects of nursing care. Nurses work to demystify psychological conditions, encourage mental health engagement, and implement personalized care plans. By reducing stress, promoting emotional well-being, and facilitating access to mental health services, nurses contribute significantly to burn survivors' recovery and quality of life. Nursing’s integral role in managing post-burn psychological conditions like depression, PTSD, and anxiety is crucial. Nurses provide compassionate, holistic care that meets the diverse needs of burn survivors, guiding them toward recovery.