Background Cerebral palsy (CP) is a group of permanent movement disorders that appear early in life. So, having a child with disability is a major event that negatively affects families and forces families to evaluate their plans, goals, and relationships in light of restrictions and limitations associated with child disability. Aim and objectives The present study aimed to assess the burden and self-efficacy level of family caregivers of children with CP. Patients and methods This study was conducted at the National Institute of Neuro Motor Rehabilitation, Embaba, Giza Governorate. Result Overall, 72% of family caregivers experience moderate to severe burden and 16% experience mild to moderate burden, whereas 12% experience severe burden. Moreover, 94% of family caregivers can control thinking of how unfair they have to put up with taking care of their children with CP and 90% cannot ask a friend or family member to stay with the children with CP, whereas 88% cannot control their anger or answer their children with CP without raising their voice. Conclusion These results suggest caring for a child with CP may put the family caregivers at risk of moderate to severe burden and affect their relationships with other family members or friends in a negative way, and they might feel angry when they are around their relatives.