As a major contributor to global energy consumption and greenhouse gas emissions, the building sector is crucial in shaping energy and climate change policies. Understanding building energy consumption is essential for developing effective policies, and comprehensive datasets and analyses are increasingly important. This paper outlines a structured methodology for developing a sustainability assessment index for building energy efficiency retrofits throughout a building’s life cycle, covering the design, construction, use, and out-of-use phases. It highlights the interdependencies among these phases, with the design plan influencing energy efficiency and material selection, the construction plan ensuring these goals are met, and the plans for energy management, demolition, and resource recovery focusing on sustainable practices. The keys to energy-efficient retrofits are sustainable materials, energy-efficient equipment, and green technologies, which help reduce energy consumption, emissions, and operating costs. Oversight and regulation are necessary to maintain standards. This research combines a literature review, surveys, interviews, the Delphi method, and an analytic hierarchy process (AHP) to develop a comprehensive evaluation system, categorizing 20 factors across a building’s life cycle and assigning weights based on environmental, economic, and social dimensions. The system provides a scientific basis for assessing the sustainability of energy efficiency programs, validated through consistency testing.