Elastic boundary conditions play an important role in the buckling analysis of cylinders under compressive loading. These structures are used widely in aerospace applications and are highly sensitive to geometrical, material, loading, and boundary imperfections. In fact, the presence of these imperfections can lead to catastrophic failure. In 1968, NASA reported relations for obtaining the Knockdown Factor (KDF) based on an empirical method that is valid for isotropic and orthotropic materials; however, these relations do not consider the effect of elastic boundaries that can lead to highly conservative values of KDF. In design practice, a universal KDF of 0.65 has been used for recent designs by NASA, which may not be applicable to new types of structural configuration with different loading and boundary conditions. Therefore, there is a need for robust design factors for future designs which reduce the dependency on testing during preliminary design phases and speeds up the product development process. The availability of up-to-date and different KDF expressions for different structural configurations would help engineers to design lighter structures with improved load carrying capacity and reliability. The main objective of this work is to identify the buckling load sensitivity of cylindrical shells due to their boundary conditions and develop KDF relations considering elastic boundaries. To achieve this goal, the effect of axial, radial and tangential support stiffness on a quasi-isotropic cylinder under axial compression is investigated. A data-driven design approach is used to develop new KDF empirical relations for a quasi-isotropic cylinder on different elastic foundations. The accuracy of these relations is within 5% for any elastic foundation considered.