Bronchial Papilloma Research Articles

Bronchial Basaloid Papillary Tumor of Uncertain Malignant Potential: A Case Report.

Bronchial papillomas are benign tumors, which can be divided into different subtypes based on the cellular features. So far, no bronchial papilloma with basaloid cell features has been reported. We report a bronchial basaloid papillary tumor in a 67-year-old woman. Tumor recurrence and malignant transformation were observed after a long-term follow-up. The clinical, histological, immunohistochemical, and genetic features were reappraised. The primary tumor was characterized by papillary growth pattern and basaloid neoplastic cells, only a small amount of neoplastic cells showed mature characteristics. The tumor originated from respiratory epithelium and had a low proliferation index by Ki-67. Keratin (KRT) 5/6 and KRT7 showed patchy or partial positivity. Myoepithelial markers were negative. P63 was diffusely positive, but it was negative in the small amount of tumor cells with mature characteristics. The common genetic alterations (EGFR, KRAS, BRAF V600E, HER2, and ALK) of lung cancers were not detected. However, tumor recurrence was observed in the mediastinum and esophagus 12 years after surgery. The recurrent tumor had a morphology overlapping with that of the primary tumor; however, it displayed significantly malignant characteristics. The recurrent tumor was not related to high-risk HPV. A high variant allele frequency was observed in tumor suppressor gene BRCA1, TP53, oncogene GNA11, and KIT, which were all missense mutations. Considering the bland features of the primary tumor and the fact of tumor recurrence and undisputed malignant transformation, the basaloid papillary tumor was considered a tumor with uncertain malignant potential.

What's new in benign lung tumours?

While lung cancer is one of the most common malignancies routinely encountered by pathologists, benign pulmonary neoplasms are quite rare. However, it is important for pathologists to be familiar with the typical diagnostic features of benign lung tumors to avoid confusing them with malignant morphological mimics. There have also been intriguing discoveries in the genetics of benign pulmonary neoplasms in the past decade. This review will cover several of the most common benign lung tumors, including the diagnostic categories of pulmonary adenomas, bronchial papillomas, and benign mesenchymal tumors, with discussion of the current classification, differential diagnosis, and current knowledge regarding genetic drivers.

Complicated tracheo-bronchial papillomatosis

Respiratory papillomas are rare benign lesions. They are characterized by the appearance of papillomatous lesions anywhere in the tracheobronchial tree. It affects children and young adults. Although the disease affects mainly the upper airways, it may be aggressive and extends distally to the lower respiratory tract and pulmonary parenchyma. The course of the disease is unpredictable. It may regress spontaneously, but in other instances, it may lead to serious complications ranging from airway obstruction up to malignant transformation. Surgical excision is the mainstay of definitive treatment to prevent recurrence and to exclude malignancy. We have reviewed the literature for this rare type of respiratory disease and present a thirty-five years old; male patient who had chronic cough and was referred to our unit with a CT-chest that revealed left main endo-bronchial lesion. Bronchoscopy and biopsy of the lesion were performed and revealed squamous papilloma. Final treatment introduced to the patient was endoscopic thermal ablation. However, the final pathology revealed complicated squamous bronchial papilloma with infection by aspergillosis and actinomycosis. Key words: HPV; Tracheo-bronchial papilmomatosis; endo-broncial lesion; bronchoscopy

Co-occurrence of bronchial papilloma and pulmonary sclerosing hemangioma in a male

IntroductionBronchial papilloma and pulmonary sclerosing hemangioma (PSH) are rare tumors. The development of PSH combined with bronchial papilloma in lung is extremely rare. We herein presented a case of the co-occurrence of bronchial papilloma and PSH in a male.Case descriptionA 48-year-old man was referred to our department for further treatment of the productive purulent cough and fever. After bronchoscopy, the biopsy of the specimen showed a bronchial papilloma in the lumen of posterior segment of the right upper lobar bronchus. For computed tomography demonstrated a focal lesion with an air bubble in the posterior segment of the right upper lobe, a lobectomy was performed and PSH was diagnosed.DiscussionThe report emphasizes the fact that even though some of bronchial papilloma and PSH may have a low prevalence, nonetheless, the low prevalence of both diseases in a male has meant that it has not been possible to explore the depth of association between them.ConclusionsThe paper reports a case of PSH in a male suffering from bronchial papilloma which is the exceptional concurrence of these two extremely infrequent events.

孤立性気管支扁平上皮乳頭腫の 1 例

孤立性気管支扁平上皮乳頭腫の 1 例

孤立性気管支乳頭腫の 1 切除例 : 症例報告と本邦報告例の集計

孤立性気管支乳頭腫の 1 切除例 : 症例報告と本邦報告例の集計

孤立性気管支乳頭腫の 1 切除例

孤立性気管支乳頭腫の 1 切除例

Endobronchial Hamartoma

Pulmonary hamartoma is a benign lung neoplasm and it comprises 6% of solitary pulmonary nodules. Two clinical types have been defined according to its location: intraparenchymal (90%) and endobronchial (10%). We report on a case of endobronchial hamartoma resected with electrocautery by a flexible bronchoscope (FB). A 57-year-old male patient was admitted to our clinic because of worsening dyspnea. The patient had been smoking 1 pack per day for 37 years. A solid smooth lesion with calcification, located in the distal part of the left main bronchus and partially obstructing the lumen of bronchus, was detected at computerized tomography. A mass lesion that moved with coughing was observed during FB. The polypoid mass was arising from the anterior wall of the left main bronchus. Punch biopsies were taken from the polypoid lesion and a diagnosis of bronchial papilloma was made after histopathologic examination. The patient underwent endobronchial electrosurgery and the lesion was excised using FB. Pathologic evaluation revealed it to be a cartilagenous hamartoma. In conclusion, endobronchial hamartomas are benign neoplasms of the tracheobronchial tree. Endoscopic treatment with flexible bronchoscopic electrocautery is safe and less invasive in experienced hands. Therefore, it should be considered as the primary treatment approach in selected cases.

A Case of Solitary Bronchial Papilloma of Mixed Squamous Cell and Glandular Type Resected Endoscopically Using an Electrosurgical Snare and Diode Laser

背景．気管支の孤立性乳頭腫は比較的稀な上皮性良性腫瘍であるが，その中で扁平上皮腺上皮性混合型乳頭腫は極めて稀で，これまで文献的に自験例を含めて13例の報告しかみられない．孤立性気管支乳頭腫の治療としては，これまで主に外科的切除術が実施されている．症例．84歳，女性．検診の胸部X線写真で右中肺野に異常陰影を指摘され，当院を受診．胸部CT画像では右肺S3に部分的無気肺と右主気管支内腔に突出する腫瘤陰影が認められた．気管支内視鏡検査では，中間幹の内腔にポリープ状の腫瘍が認められ，生検組織で混合型乳頭腫と診断された．腫瘍内における悪性化の合併の有無を検索するために，高周波スネアと半導体レーザーを用いて内視鏡的に腫瘍を切除した．摘出された腫瘍の病理組織学的検査で悪性化はみられず，孤立性気管支乳頭腫（扁平上皮腺上皮性混合型）と診断が確定できた．なお，免疫染色でヒトパピローマウイルスは陰性であった．内視鏡的治療後，2年6ヶ月の現在再発はみられない．結論．内視鏡的治療により切除された孤立性気管支混合型乳頭腫の1例を報告した．高周波スネアと半導体レーザーを用いての内視鏡的治療は，孤立性気管支乳頭腫に対して有用な治療法の1つと思われる．

Solitary Bronchial Papilloma with Malignant Degeneration Presenting with Bronchiectasis and Hemoptysis

Solitary Bronchial Papilloma with Malignant Degeneration Presenting with Bronchiectasis and Hemoptysis

A solitary bronchial papilloma with unusual endoscopic presentation: case study and literature review

BackgroundSolitary endobronchial papillomas (SEP) are rare tumors and most of them are described by case report. A misdiagnosis is common with viral related papillomas. A histopathological classification has recently permitted a major advancement in the understanding of the disease.Case PresentationWe report a case of a mixed bronchial papilloma with an unusual endoscopic presentation. The literature was extensively reviewed to ascertain the unusual characteristics of the current case. A 39-year of age male was referred to our institution for the investigation of a slight hemoptysis. Routine examination was normal. A fibroscopy revealed an unusual feature of the right main bronchus. The lesion was a plane, non-bleeding, non-glistering sub-mucosal proliferation. No enhanced coloration was noticed. Biopsies revealed a mixed solitary bronchial papilloma. In situ HPV hybridization was negative. Endoscopic treatment (electrocautery) was effective with no relapse.ConclusionThis lesion contrasts with the data of the literature where papilloma were described as wart-like lesions or cauliflower tumors, with symptoms generally related to bronchial obstruction. We advise chest physicians to be cautious with unusually small swollen lesions of the bronchi that may reveal a solitary bronchial papilloma. Endoscopic imaging can significantly contribute to the difficult diagnosis of SEP by pulmonary physicians and endoscopists.

CT Findings of Bronchial Glandular Papilloma

Solitary pulmonary papillomas are rare benign tumors in adults. Glandular papilloma is the rarest subtype among them. In this report, we describe a case of glandular papilloma that showed unique computed tomography features. It was a round nodule containing air spaces encapsulated with a smooth and thin wall, which suggested its endobronchial origin and a secondary change owing to air trapping.

A Case of Radiolucent Foreign Body (Temporary Resin Bridge) Aspiration Accompanied by Inflammatory Polyps

Summary This case demonstrates the rare occurrence of a radio-lucent temporary resin bridge aspiration in adults while they are in a conscious and awaken state and the re-sultant formation of inflammatory polyps. Although no unique findings were noted in a chest x-ray, careful his-tory taking accompanied by physical examinations can lead to clinical suspicion of foreign body aspiration in an earlier stage. Moreover, flexible bronchoscopy is a tool useful not only for the evaluation process but also for managing the aspirated foreign material.

A Review of the Histopathology of Cigarette Smoke–Induced Lung Cancer in Rats and Mice

In the past several years an increased number of lung tumors has been reported in laboratory studies of rats and mice after lifetime exposure to mainstream cigarette smoke. Proliferative epithelial lesions are present in the lungs of both species and are apparent antecedent lesions to benign and malignant tumors. Both species have alveolar epithelia hyperplasia, alveolar adenomas, and alveolar carcinomas. The incidence of all three are more in the rats. In addition, mice also have bronchiolar epithelial hyperplasia and bronchial papillomas not found in rats. Rats have a low incidence of squamous cyst that is not found in mice. Lung tumors in rats and mice are found at the end of the life span and rarely metastasize. The characteristics of the lung tumors, and the proliferative changes associated with the tumors, are important in helping understand the mechanisms of lung cancer induction. These studies in rats and mice allow new approaches to the study of cigarette smoke-induced changes in the lung.

A Case of Solitary Bronchial Papilloma Resected Endoscopically Using an Electrosurgical Snare and Coagulation Electrode

A Case of Solitary Bronchial Papilloma Resected Endoscopically Using an Electrosurgical Snare and Coagulation Electrode

A Case of Bronchial Papilloma

Bronchial papilloma is a rare disease which most commonly manifests as an epithelial tumor consisting of polypoid interstitial tissues and epithelioid cells. This benign tumor comprises 2-5% of primary lung tumors and papilloma derived from the bronchial epithelium, and is a rare benign tumor in adults. Bronchial papilloma has a poor prognosis with a high risk of developing a malignancy. We report a case of a bronchial papilloma in a 62-year-old female patient, presenting with hemoptysis and an endobronchial lesion with a brief review of the relevant literature.

Solitary columnar bronchial papilloma: a rare endoscopic finding

Solitary columnar bronchial papilloma: a rare endoscopic finding

菌球型肺アスペルギルス症を併発した孤立性気管支乳頭腫の 1 症例

菌球型肺アスペルギルス症を併発した孤立性気管支乳頭腫の 1 症例

Asymptomatic solitary papilloma of the bronchus: review of occurrence in Japan

A case of solitary papilloma of the bronchus is described, and 15 other cases occurring in Japan are reviewed. A 57 year old asymptomatic male was referred to our hospital because many squamous metaplastic cells with moderate atypia were observed in sputum cytology, twice in 3 months. The chest X-ray showed no abnormal findings. Endoscopic examination revealed a polypoid tumour at the bifurcation of the right B6a and B6b. The tumour was removed completely by endoscopic biopsy, and histological findings showed squamous papilloma. There has been no evidence of recurrence for 3 yrs. We are not aware of a previously reported case of bronchial papilloma without symptoms or abnormal shadow on chest X-ray. Considering the fact that malignant change was reported in only one case in Japan, and that there is a possibility of cancer subsequently developing at another location in the lung which might also require resection, lobectomy should be avoided if the tumour can be removed completely through endoscopy. If the lesion is limited to a small area in the bronchus, conservative treatment such as photodynamic therapy and/or yttrium aluminium garnet (YAG) laser vaporization might be sufficient to obtain a complete cure.

孤立性気管支乳頭腫の 2 例

孤立性気管支乳頭腫の 2 例