ABSTRACT Major efforts to engage scientists in issues of biosecurity in the United States and internationally began in the early 2000s in response to growing concerns about terrorists using weapons of mass destruction and the mailing of anthrax-laced letters in October 2001. This article draws on the literature about the “science of science communication,” including research on framing, to examine the strategies used to try to raise awareness and create support for policies and practices to address public concerns about biosecurity issues within scientific communities. Engagement strategies framed as an inherent part of the broader social responsibilities of the scientific community have shown the promise of being more effective than those framed in terms of legal and regulatory requirements and an emphasis on security alone. The article draws on the case of the InterAcademy Partnership (IAP), the global network of academies of science and medicine, and its relationship with the 1972 Biological and Toxin Weapons Convention (BWC), with additional examples from other national and international scientific organizations.