Broad Sense Research Articles

Design of SARS-CoV-2 protein S peptides recognized by the most frequent HLA alleles in the Moroccan population using an immunoinformatics approach

Background The coronavirus disease 2019 (COVID-19) is an infectious disease, caused by the new coronavirus known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), and exhibits diverse clinical outcomes and symptoms in infected individuals, emphasizing the need to investigate how human genetic diversity influences the virus’s impact. This study aims to employ in silico methods to identify epitopes capable of eliciting an immune response, focusing on the most prevalent HLA-I and HLA-II alleles in the Moroccan population. Methods Our research consisted in predicting peptide-binding affinities between the most prevalent HLA Class I and Class II alleles in the Moroccan population and SARS-CoV-2 spike glycoprotein (S protein) peptides of variants isolated from strains of Moroccan patients. We performed the same analyses for SARS-CoV-2 wild type S protein to assess the ability of these HLA alleles to interact with peptides in the presence or absence of SARS-CoV-2 mutations. Results In a broader sense, 12 distinct HLA Class I and Class II alleles in the Moroccan population have been identified as possibly interacting with 19 epitopes in the SARS-CoV-2 S protein. Findings of this study must be validated in both in vitro and in vivo models. Conclusions These data may help clarify the issue of host cell susceptibility and the outcome of SARS-CoV-2 infection, and may guide further research to uncover potential targets for the vaccination strategy.

The Fundamental Types of Social Transformations: Evolution and Revolution

The concept of social transformation is of significant importance, as it forms the basis for theories of social development. To comprehensively understand the nature of this phenomenon, it is essential to define its significance. Social transformation, in its broadest sense, refers to the transformation of society's social reality and its ongoing development. However, similar to any socio-cultural phenomenon, transformation exhibits specific characteristics, internal mechanisms, and features that manifest in the interaction between the subject and all aspects of human activity, ranging from economic to social spheres.

Do stories need critics? Environmental storyism and the ends of ecocriticism

ABSTRACT Story, storytelling, and storying are exceptionally privileged concepts in contemporary environmental arts, humanities and social sciences research. This provocation does not set out to exhaustively describe the function of story across so large and diverse a scholarly array. It aims instead to characterise the particular, widespread tendency to posit the making of new stories, or the transforming of extant stories, or the ‘storying’ of a particular issue, place, or dilemma as the ultimate ends of environmental humanities work. We call this tendency ‘storyism’. In its broadest sense, our project attempts to construct a transdisciplinary genealogy of ‘storyism’ in relation to environmental concerns, as well as to comprehend its institutional and disciplinary orientations. For the limited purposes of this paper, we explore how ecocriticism, a field primarily interested in reading, interpreting and critiquing story, relates to the methodological innovation we describe. We hypothesise that ecocritical discourses have ironically undermined their critical values by producing and reproducing a storyist teleology which understands the generation of more, new narratives as ultimately, if not singularly, useful. We conclude by suggesting some ways in which literary ecocriticism can break out of this habit while still participating in the wider interdisciplinary field.

Making robots matter in dementia care: Conceptualising the triadic interaction between caregiver, resident and robot animal.

While previous research studies have focused on either caregivers' or residents' perception and use of social robots, this article offers an empirical and theoretical examination of joint activities in triadic human-robot interaction. The symptomatology of dementia creates an asymmetrical relation wherein the impetus to employ a robot often originates from the caregiver. Drawing on field work and video recorded interactions in dementia care homes, the article investigates how caregivers draw on embodied resources to involve residents and robot animals in interaction. The analysis demonstrates how caregivers promote commitment and encounter resistance with residents. We draw on the theory of sociomaterial interactionism to study situated interaction between bodies in a meaning-generating process. By re-conceptualising the theoretical notions of manipulation and recruitment, the article offers an approach for studying orientations that distinguish between reciprocity of agential objects. We show that caregivers usually distinguish between interactions with people and machines by anticipating a specific response from the robots (manipulation), while they invite participation in a broader sense from residents (recruitment). Social friction arises, however, if caregivers act upon the residents as embodied objects in manipulative ways.

Measuring water poverty based on SDG 6

AbstractThe United Nations' Sustainable Development Goal (SDG) 6 refers to ensuring access to water and sanitation for all. This study develops alternatives for calculating a water poverty measure based on SDG 6. We use ENEMDU, which is a quarterly labor market survey that only for March 2019 incorporates a Water, Sanitation, and Hygiene (WASH) module. An innovative feature of this survey is that it includes information about water quality at the point of use as well as information about quality at the point of collection. Water poverty is assessed based on four dimensions: (i) safety, (ii) sanitation, (iii) hygiene, and (iv) quality. We use three different approaches to calculate our water poverty measures; the first is a deprivation approach, and the other two incorporate different weighting methods. The results indicate that our water poverty measures are highly correlated with each other (above 0.95); moreover, they are correlated with other poverty measures and social and health variables. People in water poverty are mostly racial minorities, have lower educational attainment, and are more likely to belong to the lower quintiles of income distribution This indicates that our water poverty measures are signs of poverty and deprivation in a broader sense.

A synthesis of Kantian ethics and Rousseauvian General Will in justifying the moral ground of political laws

This article explores the Kantian and Rousseauvian solutions to the conflict between autonomy and authority. First, I discuss how the categorical imperatives (CI) are the supreme source of the legitimate authority of a limited number of political laws. By extending the synthetic a priori nature of the CI, I demonstrate how Rousseau’s General Will (GW) can justify political laws in a broader sense. I also refer to the theory of H.L.A. Hart and John Rawls to show that all political laws are binding if they are within the limits of injustice and have some moral foundation. I discussed the limits of authority of on debatable laws such as banning abortion. I analyzed the possibility of GW by using Condorcet’s theorem. I conclude that GW cannot fully justify political laws based on majoritarian direct democracy, owing to problematic assumptions, although it may be an improvement to the current legislative procedure of the U.S.

Re-Imagining Artistic Research

This special issue explores contemporary efforts in rethinking artistic research, especially in relation to its boundaries, methods, formats, and collaborations across fields of knowledge and practice. As artistic research sets itself firmly on its own scientific grounds, its relational and affective potential expands beyond the fields of visual arts. This potential is explored in this special issue as artist-researchers engage in re-imagining research in arts, architecture, photography, design, craft, and education. Through these collective efforts, we expect to contribute to understanding the impacts of artistic research and emphasize its importance in shaping research in a broader sense.

Hand-to-hand combat in the 21st century-INNOAGON warrior or modern gladiator?-a prospective study.

In being an important lifestyle factor, the physical activity influences people's health status, including life expectancy. Specific forms of physical activity are exercises related to hand-to-hand combat in the broadest sense, often overlapping and containing similar elements associated with combat sports (for Western culture) and martial arts (for Far Eastern culture). There are many types of forms of practising hand-to-hand combat exercises, which can be seen as opposing or in some ways complementary, e.g.: "traditional"-e.g., karate or kung fu, practised for hundreds or even thousands of years, usually adhering to moral codes of conduct, and drawing ideas from philosophy, religion vs. "modern"-e.g., American pro wrestling or mixed martial arts-MMA, suggesting a combination of various traditional forms of martial arts. In terms of shaping a healthy lifestyle with mental health elements based on the implementation of hand-to-hand combat exercises, an analysis of these fundamental insights into physical activity is warranted. This study aims to investigate the development direction of the hand-to-hand exercises in Western culture, opposing the "traditional" and "modern" forms. In this study, INNOAGON theory responds to the overuse of the term "science of martial arts". It is currently being used to promote extreme aggression and violence as an acceptable means of achieving success, and this model is expressively permeating other spheres of social interaction. In INNOAGON's understanding, hand-to-hand combat should be associated with the ancient thought of "doing good" (ancient Greece) or "wisdom" (Far Eastern cultures) including aesthetic and philosophical aspects. This links to numerous psychosocial benefits, self-esteem, discipline, body-mind coordination including breath control and relaxation, respect for others. The modern form of hand-to-hand combat, framed in these discussions as MMA or American pro wrestling, historically refers to the gladiatorial fights held during the Roman Games. The holding of fights in so-called "cages" refers to the arena in which Roman slave fights were held, and the athletes performing there are often referred to as modern-day "gladiators". Proper education, including education in the area of physical culture, leading to the development of a society turned towards values broader than just fun or self-satisfaction should be the basis for the development of the next generations. It actually remains to decide which path of social change we will choose: in the case of INNOAGON a positive one, and in the case of modern gladiator a destructive one. Only a proper education combined with a broad programme of social role modelling, social facilitation-the foundations of which are laid by INNOAGON-including promotion on the Internet and social media can provide the right counterbalance to the pathology increasingly penetrating our lives, leading to the promotion of aggression and threats to physical and mental health.

The Influence of Enlightenment Ideas on Human Progress and Well-Being

The Influence of Enlightenment Ideas on Human Progress and Well-Being

Anti-corruption Law as a Fiction: The Illusion of Serving Morality by Controlling It through Rules and Regulations with an International Reach

According to the Corruption Perception Index of Transparency International, corruption is still far more prevalent in “non-Western” countries. The search for more effective anti-corruption legislation has shifted from preventing and combating bribery to preventing corruption in a broader sense. Consequently, anti-corruption law has obtained a more far-reaching scope. However, this does not work sufficiently. Up till now, we do not know why. This article focuses on why we should consider revising anti-corruption legislation. The research is a qualitative theoretical analysis based on empirical insights from preliminary anthropological fieldwork conducted in Gabon (Feikema 2015). One of the reasons for the challenge seems to be that the implicit institutional setup—namely, of a national state with a rule of law, which forms the point of departure of anti-corruption law—is not self-evident in countries where this democratic rule of law is not an experienced reality. For example, in the so-called hybrid political orders (Boege 2008), these developments of anti-corruption law may have a confusing and alienating impact, as demonstrated by a case study. Therefore, the effectiveness of these laws could be doubted. Even more importantly, respect for human dignity, the rationale of these laws, seems to be seriously at stake. We could understand recent developments in anti-corruption law as an illusion of control. Even more vitally, anti-corruption law could be considered a symptom of derailment. What we experience as evil may occur as the disturbance of the ecological cohesion of society: derailment.

Determining Structures of Layer-by-Layer Spin-Coated Zinc Dicarboxylate-Based Metal-Organic Thin Films.

Thin films of crystalline solids with substantial free volume from organic chromophores and metal secondary building units (SBUs) are promising for engineering new optoelectronic properties through control of interchromophore coupling. Zn-based SBUs are especially relevant in this case because they avoid quenching the chromophore's luminescence. We find that layer-by-layer spin-coating using Zn acetate dihydrate and benzene-1,4-dicarboxylic acid (H2BDC) and biphenyl-4,4'-dicarboxylic acid (H2BPDC) linkers easily produces crystalline thin films. However, analysis of the grazing-incidence wide-angle X-ray scattering (GIWAXS) data reveals the structures of these films vary significantly with the linker, and metal-to-linker molar ratio used for fabrication. Under equimolar conditions, H2BPDC creates a type of structure like that proposed for SURMOF-2, whereas H2BDC generates a different metal-hydroxide-organic framework. Large excess of Zn2+ ions causes the growth of layered zinc hydroxides, irrespective of the linker used. Density functional theory (DFT) calculations provide structural models with minimum total energy that are consistent with the experimentally observed diffractograms. In the broader sense, this work illustrates the importance in this field of careful structural determination, e.g., by utilizing GIWAXS and DFT simulations to determine the structure of the obtained crystalline metal-organic thin films, so properties can be rationally engineered and explained.

Entrepreneurial migrations and diffusion of innovations: the case of Apulia in the first half of the 19th century

Purpose Through the reconstruction of the events of some foreign entrepreneurs who worked in the territory of the Italian city of Bari in the first half of the 19th century, this paper aims to analyze the role of entrepreneurial migration in the economic development of Apulia land in this period. Design/methodology/approach This study adopts a theoretical framework that combines the concept of mixed embeddedness in a multifocal perspective, with the model of the diffusion of innovation focusing on the role of the so-called agency of actors, and of the network, in the dissemination of innovation. The theoretical framework is applied to multiple case studies to compare the evidence that emerged from the simultaneous analysis of several situations. Findings By analyzing how innovations have spread within the network of entrepreneurs of that time, it is possible to identify some relevant aspects related to the mechanisms of dissemination of innovations in the context of entrepreneurial migration. Specifically, the opportunity structure is intended in an even broader sense than indicated in the classic approach to mixed embeddedness: it is considered as the result of the joint interaction of the political, institutional and economic context of several places, and the behavioral dynamics of several groups. Research limitations/implications Due to the specific method chosen, the outcomes of the research might apply to a narrow context. Therefore, the results need to be tested and confirmed in further empirical studies, and by applying multiple research methods. Practical implications Findings are useful and significant in the analysis of the link that exists between the diffusion of innovations and migrant entrepreneurship, and then the conclusions can be applied and extended to the current phenomenon of migration-related innovations, with specific reference to developing countries. Social implications Findings can be applied and extended to the current phenomenon of migration-related innovations and highly skilled migration, with specific reference to developing countries. Originality/value This paper contributes to shed new light on the contextual and multifocal factors that influence the development of innovations in the networks of migrant entrepreneurship, in a specific historical period and a specific context. Combining social, human and financial capital with the wider opportunity structure, this study also provides a comprehensive understanding of the modalities through which migrant and high-skilled entrepreneurs could innovate.

Wear Behavior Assessment of New Wire-Arc Additively Manufactured Surfaces on AA6061 and AA5086 Alloys through Multi-Walled Carbon Nanotubes and Ni Particles Inducement

This study investigates the new surface development on AA6061 and AA5086 alloys considering the wire-arc additive manufacturing technique as a direct energy deposition (DED) process of wire. Two different quantities of MWCNTs, i.e., 0.01 (low) and 0.02 (high) g, with a constant nickel (Ni) weight (0.2 g) were pre-placed in the created square patterns. ER4043 filler was used as a wire for additive deposition, and an arc was generated through a tungsten inert gas (TIG) welding source. Furthermore, hardness and pin-on-disk wear-testing methods were employed to measure the changes at the surfaces with the abovementioned inducements. This work was designed to illustrate the hardness and the offered wear resistance in terms of mass loss of the AA6061 and AA5086 aluminum alloys with the function of nano-inducements. Two sliding distance values of 500 m and 600 m were selected for the wear analysis of mass loss from tracks. A maximum increase in hardness for AA6061 and AA5086 alloys was observed in the experiments, with average values of 70.76 HRB and 74.86 HRB, respectively, at a high mass content of MWCNTs. Moreover, the tribological performance of the modified surfaces improved with the addition of MWCNTs with Ni particles in a broader sense; the modified surfaces performed exceptionally well for AA5086 compared to AA6061 with 0.02 and 0.01 g additions, respectively. The system reported a maximum of 38.46% improvement in mass loss for the AA5086 alloy with 0.02 g of MWCNTs. Moreover, the morphological analysis of the developed wear tracks and the mechanism involved was carried out using scanning electron microscope (SEM) images.

Experimental and Numerical Evaluations of Dynamic Transfer Matrix for a Three-Dimensional Centrifugal Impeller Based on Unsteady Energy Conservation

Abstract Under unsteady operating conditions in turbomachinery, the performance is unable to respond rapidly enough to follow characteristic curves for the steady condition. To design a reliable turbomachinery under unexpected unsteady conditions, we evaluated the dynamic transfer matrix of a three-dimensional centrifugal impeller. The working fluid is incompressible air. To make the current results more applicable in a broader sense such as pumps, all parameters and results were normalized. The experimental results showed a more significant negative slope in the unsteady performance curve compared to that in the steady performance curve. This was mainly caused by the phase delay of the pressure rise to the pulsating flowrate. We clarified the changes in gain and phase delay under unsteady conditions by conducting numerical simulations. The numerical results showed that the unsteady pressure rise was primarily generated by inertia and power terms in the unsteady energy conservation equation. The power term was predominantly influenced by the angular momentum flowrate difference and the change rate of angular momentum. Each term was quantitatively evaluated, and its contribution to the unsteady pressure rise was discussed. Within the range of frequencies tested in this study, the transfer matrix for the three-dimensional centrifugal impeller could be effectively approximated through a first-order lag approximation considering a series-connected derivative system. We believe that our findings can be extended to centrifugal pumps when disregarding the compressibility effects such as cavitation.

Helminths of captive and free-ranging populations of the mountain gazelle (Gazella gazella): Evidence from faecal examination.

Understanding parasite diversity in wild and captive animal populations has critical implications for both individual animal health and ecosystem dynamics in a broader sense. In mountain gazelles (Gazella gazella), the gastrointestinal helminth community is poorly understood, limiting our efforts in the conservation of this endangered bovid species. This species has only two remaining populations in the world, including the isolated northernmost population in Türkiye. To identify and compare the diversity and prevalence of gastrointestinal helminths in captive and free-ranging populations of mountain gazelles in Hatay, Türkiye, and to assess potential zoonotic risks. In total, 105 fresh faecal samples, 45 individual samples and 60 faecal samples, representing 16 pools, from both captive and free-ranging populations were collected and analysed using Fulleborn flotation, Benedek sedimentation and Bearman-Wetzel methods faecal flotation methods, including the McMaster technique to determine the severity of infection. We detected 12 helminth taxa in our examination of faecal samples, including gastrointestinal nematodes, lungworms and trematodes. Parasites from the Trichostrongyloidea family demonstrated variable hatching stages and rates, potentially influenced by ambient conditions. We also detected one protozoan among the samples. Our results revealed a higher diversity of parasites in free-ranging populations compared to captive ones. This study underscores the necessity for regular parasitological surveillance in both captive and free-ranging wildlife populations for effective conservation management. It also contributes to the 'One Health' perspective by highlighting the potential zoonotic risks posed by parasites in wild ruminants. Our results have implications for the conservation and management of the mountain gazelle.

From greenwashing to ESG‐washing: A focus on the circular economy field

AbstractIn the field of Corporate Social Responsibility (CSR) today, Environmental, Social and Governance (ESG) factors play a fundamental and increasingly central role in the evaluation of corporate performance worldwide. The purpose of this paper is to investigate whether the recent phenomenon of ESG issues has given rise to a new form of greenwashing in a broad sense, not limited to the environmental sphere, but also extended to social and governance issues. The paper examines whether companies engaged in the transition to sustainable and in particular to circular models are actually focusing on concrete sustainable actions and less on distorted communication. Specifically, ESG performance measures were collected for 366 companies from the most impactful industries in different countries around the world to test the relationships between ESG performance, adoption of circular economy models and ‘washing’ practices related to stakeholder communication. As the transition to sustainable and circular models requires not only substantive action but also transparency, further research and efforts are needed to better understand the relationship between these elements in corporate behavior.

Social Media and Social Networking

A Social networking service (also social networking site, SNS or social media) is an online platform that is used by people to build social networks or social relations with other people who share similar personal or career interests, activities, backgrounds or real-life connections. The variety of stand-alone and built-in social networking services currently available in the online space introduces challenges of definition; however, there are some common features: (1) social networking services are Web 2.0 internet-based applications, (2) user-generated content (UGC) is the lifeblood of SNS organisms, (3) users create service-specific profiles for the site or app that are designed and maintained by the SNS organization, and (4) social networking services facilitate the development of online social networks by connecting a user's profile with those of other individuals and/or groups. Most social network services are web-based and provide means for users to interact over the Internet, such as by e-mail and instant messaging and online forums. Social networking sites are varied and they incorporate a range of new information and communication tools such as availability on desktop and laptops, mobile devices such as tablet computers and smart phones, digital photo/video/sharing and "web logging" diary entries online (blogging). Online community services are sometimes considered a social network service, though in a broader sense, social network service usually means an individual-centered service whereas online community services are group-centered. Social networking sites allow users to share ideas, digital photos and videos, posts, and inform others about online or real world activities and events with people in their network. While in-person social networking, such as gathering in a village market to talk about events has existed since the earliest developments of towns, the Web enables people to connect with others who live in different locations, ranging from across a city to across the world. Depending on the social media platform, members may be able to contact any other member. Key words : Social Networking, e-mail, Web-based, Social Media, Face Book .

Scaffolding geospatial epistemic discomfort: a pedagogical framework for cross-disciplinary landscape research

ABSTRACT Current environmental crises call for an integrated knowledge of landscapes and their ecosystems in a broader sense. This article presents a pedagogical framework for cross-disciplinary landscape research at postgraduate level. The framework is grounded in the use of geospatial epistemic discomfort as a creative force to develop and enhance inquiry skills able to cross and merge disciplinary boundaries. Developed within the Erasmus+ KA2 project “CROSSLAND”, the pedagogical framework is based on the scaffolding of epistemic discomfort through four key didactic elements: 1) cross-disciplinary group work and open-ended assignment, 2) in-field inquiry as pre-training on space-time, 3) replacement of traditional lectures by student-led seminars, 4) GIS labs centred on the exploration of cross-disciplinary portfolios of geospatial approaches and methods given as worked-out examples. Main results from the evaluation of the framework implementation in a Summer School show how learning cross-disciplinarity happened thanks to a scaffolding that allowed, first and foremost, the socialisation of different conceptualisations of space. While students felt at ease with geospatial epistemic discomfort, we can conclude that spatial cognitive processes are powerful in improving abilities beyond the spatial domain.

Assessing the economic feasibility of voluntary carbon markets in land use management scenarios for Scottish saltmarshes

Saltmarshes have been valued for their multiple ecosystem services, including agriculture, recreation, habitats for fish and birds, coastal protection and carbon sequestration and long-term storage. However, because of the many threats faced, including rising sea levels, limited sediment supplies and anthropogenic impacts, saltmarshes require careful restoration and protection management to continue providing these benefits. In this study, we examined the feasibility of land abandonment caused by reinstated tidal flow in Scottish saltmarshes, based on the differential gains in soil carbon stock between natural saltmarshes and those manged for agricultural uses, and suggested considerations for a voluntary carbon market plan. The study's results showed that the proportion of Scottish saltmarshes used for agricultural activities was not very large (2.56 %, equivalent to 179.73 ha). The average net benefit (i.e., after removing the opportunity cost of land) of the new land use is GBP £ 5368.71/ha after a 67-year post-abandonment management program, showing that this model is economically viable to implement a carbon market mechanism. A voluntary carbon market scheme may be easier to implement than a compliance scheme, although the price of carbon credits under the voluntary carbon market is not high to fully compensate for the opportunity costs of land in all the Scottish regions. In effect, the carbon price at the break-even point (e.g., that balances the opportunity cost of land) in the Scottish regions varied widely (range £ 1.06–59.83/tC), which means that for regions with higher opportunity costs there is a need to consider compensating farmers through a blended private-public mechanism. Despite these difficulties, implementing saltmarshes management models for carbon market initiatives can benefit society in a broader sense, not just mitigate climate change.

Fəlsəfi antropologiyanın mahiyyəti: Maks Şelerin fəlsəfi antropologiyanın məktəb kimi formalaşmasında rolu

"Philosophical anthropology" is a special and extremely comprehensive branch of the history of world science and modern philosophical thought in general. Philosophical anthropology is an important branch of Western philosophical and social thought. Philosophical anthropology, which took its historical roots from ancient Greek philosophy, existed in the later periods of the history of philosophy, acquired a new meaning in German classical philosophy, and became a special trend in the history of philosophy starting from the beginning of the 20th century, is also, in general, a new philosophy of man. It is a philosophical teaching that includes the results of various systems of knowledge about the nature and existence of man in the 20th century Western Europe, mainly in German-language philosophy. In a broader sense, philosophical anthropology is a scientific system consisting of a set of philosophical ideas, concepts, and teachings that focus on man and aim to study him. Philosophical anthropology, which emerged in the late 1920s as a result of Max Scheler's philosophical teaching and was considered a new direction in the history of thought, developed as a branch of non-classical philosophy.