Broad-spectrum UV Research Articles

In situ O2-releasing quantum dot composites with enhanced radical scavenging behaviour, biosafety, and broadband UV shielding applications

Understanding the defect-driven photophysics-surface chemistry interplay at the nanoscale further augments new design considerations for active ingredients used in sun-protection, emphasizing affordability, safety, and multi-functionality. Accelerating it, our study unravelled broad-spectrum UV attenuation (250 nm–400 nm) and long-lasting photostability (>5 h) exhibited by in-house fabricated β-cyclodextrin functionalized, oxygen vacancy (VO●) engineered-CeO2(x)/ZnO(1-x) quantum dot composites (Em-C(x)Z(1-x)). A conceptually different strategy was pursued, involving artificially engineering surface VO● defects to modulate the band structure and enhance the molar absorptivity through photogenerated electron-hole separation. Unlike conventional inorganic UV blockers, these QD composites harnessed surface VO● for a self-cascading antioxidant effect, scavenging 62.8 % ●OH radicals. Results indicated that autocatalytic endogenous O2 generation from H2O2 scavenging, accelerated by Ce3+/Ce4+ couple, begets anti-photoaging and sunburn alleviation. Em-C(x)Z(1-x) demonstrated synergistic suppression of oxidative stress development and remarkable cell viability (≥90 %) even under UV irradiation. These underlying principles can be extended to prevent and treat other ROS-induced skin ailments. Incorporating Em-C0.3Z0.7 in commercial sunscreens unveiled a substantial enhancement in overall sun protection and antioxidative efficacy. Thus, it is envisioned that Em-C(x)Z(1-x) holds promise for developing safe, efficacious, and economical sunscreens.

Hyaluronic acid/polyphenol sunscreens with broad-spectrum UV protection properties from tannic acid and quercetin

Currently, commercial sunscreens cause a number of biotoxicity and environmental issues, making it imperative to develop biocompatible alternatives. In this study, we aimed to develop an alternative sunscreen from two ecofriendly and biocompatible natural polyphenolic compounds, tannic acid (TA) and quercetin (Que). The sunscreen was prepared through a simple process using an oil-in-water emulsion as the medium and hyaluronic acid (HA) as the base polymer to improve biocompatibility. The HA/TA/Que. sunscreen prepared in this study exhibits 0 % transmittance in the UVB region and <15 % transmittance in the UVA region, resulting in excellent sun-protection properties (SPF 30). Remarkably, the as-prepared HA/TA/Que. sunscreen has a suitable viscosity and similar UV protection properties to those of commercial sunscreens. The HA/TA/Que. sunscreen also exhibits 90.4 % antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl, demonstrating an ability to effectively capture reactive oxygen species that directly affect the skin. In addition, the cell viability was >90 % at a concentration of 50 μg/mL after 7 days, indicating excellent cytocompatibility. Owing to its various advantageous features, the HA/TA/Que. sunscreen with excellent sun protection properties and multiple functionalities is expected to resolve many environmental and biological issues caused by commercial sunscreens.

Helosciadium crassipes Koch (Apiaceae) extracts as natural sunscreen and preservative additives

Recently, ingredients derived from natural sources have gained increasing interest in the cosmetic field due to their low toxicity. Therefore, this study was designed to explore the cosmetic potential of Helosciadium crassipes Koch (Apiaceae) species growing in Algeria as a promising natural preservative and broad-spectrum UV protection additive. In our study, the in-vitro antioxidant effect was assessed via DPPH radical scavenging and total antioxidant capacity by phosphomolybdenum method (TAC), while the protection against UVB radiation was evaluated according to the sun protection factor (SPF) by using UV spectroscopic technic at wavelengths ranging from 290 to 320 nm and Mansur’s equation, for the photoprotective effect against long-wavelength UVA, UVA/UVB and critical wavelength (λc) parameters were evaluated. The outcomes showed that among the tested extracts, the methanolic extract (MeOH) contains high levels of phenolics and flavonoids, and possesses a significant antioxidant effect, particularly in DPPH radical scavenging assay. Similarly, this last one exhibited high photoprotective activity in UVB and UVA ranges. The gathered results reveal the possibility of using this extract as a good natural additive to be incorporated into cosmetic formulations as a broad-spectrum UV protection candidate and as a preservative agent.

Green synthesis of a broad-spectrum UV-blocking bitumen modifier: Investigation of anti-aging performance and mechanism in bitumen

The popularization of inorganic nanomaterials doping, which serves as an effective method to improve the aging resistance of bitumen, is constrained by suboptimal lipophilicity and limited broad-spectrum UV absorption. To overcome this, we synthesized an environmentally-friendly, broad-spectrum UV-blocking nanocomposite by coating nano TiO2–ZnO (Nano-TZ) with sustainable lignin. TEM, T-IR, and photocatalytic activity test results indicate successful lignin coating on the Nano-TZ surface, with the optimal concentration being 15% (Nano-15L@TZ). Rheological test results demonstrated improved UV- and thermal-oxidative aging resistance of the Nano-15L@TZ-modified bitumen compared to those treated with uncoated nanomaterials. The synergistic modification mechanism of the Nano-15L@TZ composite was elucidated by combining the contact angle with UV–Vis and XPS VB tests. Nano-TZ exhibited broad-spectrum UV blocking properties that mitigated the UV aging of bitumen and lignin, while lignin effectively improved its compatibility with bitumen and captured radicals generated by Nano-TZ and aged bitumen.

Proteomics and Lysine Acetylation Modification Reveal the Responses of Pakchoi (Brassica rapa L. ssp. chinensis) to Oxybenzone Stress.

The broad-spectrum UV filter oxybenzone is toxic to plants at environmentally relevant concentrations. Lysine acetylation (LysAc) is one of the essential post-translational modifications (PTMs) in plant signaling responses. The goal of this study was to uncover the LysAc regulatory mechanism in response to toxic exposures to oxybenzone as a first step in elucidating xenobiotic acclimatory reactions by using the model Brassica rapa L. ssp. chinensis. A total of 6124 sites on 2497 proteins were acetylated, 63 proteins were differentially abundant, and 162 proteins were differentially acetylated under oxybenzone treatment. Bioinformatics analysis showed that a large number of antioxidant proteins were significantly acetylated under oxybenzone treatment, implying that LysAc alleviated the adverse effects of reactive oxygen species (ROS) by inducing antioxidant systems and stress-related proteins; the significant changes in acetylation modification of enzymes involved in different branches of carbon metabolism in plants under oxybenzone treatment mean that plants can change the direction of carbon flow allocation by regulating the activities of carbon metabolism-related enzymes. Our results profile the protein LysAc under oxybenzone treatment and propose an adaptive mechanism at the post-translational level of vascular plants in response to pollutants, providing a dataset reference for future related research.

Y2O3 nanoparticles with 2D morphology as reactive oxygen species scavengers under ultraviolet radiation conditions

This study assessed the potential reactive oxygen species (ROS) scavenging activity of Y2O3 nanomaterials with 2D-like morphology in an UV radiation environment and in the Fenton system. The materials were synthesized by a simple chemical precipitation method and annealed in three different environments (air, argon, and hydrogen gas) at 500 °C for 1 h. The materials featured oxygen deficiency and surface defects, and prevented the photodegradation of the dye crystal violet (CV) in presence of TiO2 (P25) under broad-spectrum UV radiation (UVB and UVA). Y2O3 nanoparticles annealed in air prevented ROS-induced dye degradation by 20.5±0.7%, while the prevention rate for the other two particles annealed in Ar and H2 were 19.4±0.7% and 18.1±0.6%, respectively. Similarly, these nanoparticles prevented dye degradation in the Fenton system by 14.5±0.7%, 13.7±0.6%, and 12.0±0.7% for the Y2O3 annealed in Air, Ar, and H2 respectively. Therefore, the use of low atomic number (Z) yttria ceramic nanoparticles could be a promising material to prevent radiation related ROS damage in high-energy ionizing radiation (keV or MeV) conditions.

Single-step laser ablation synthesis of ZnO–Ag nanocomposites for broad-spectrum dye photodegradation and bacterial photoinactivation

We present the single-step production of zinc oxide (ZnO)–silver (Ag) nanocomposites using a second harmonic nanosecond laser. The Ag concentration was controlled using various concentration of AgNO3 solution as the medium. The evaluation of the structural and optical characteristics indicated the formation of ZnO–Ag nanocomposites. The resulting nanocomposites exhibited photocatalytic activity in broad-spectrum light, both UV and visible light, for the degradation of rhodamine 6G. Furthermore, the nanocomposites were assessed as antibacterial agents, and the addition of Ag improved the antibacterial activity of pure ZnO against Escherichia coli and Staphylococcus aureus. Under light exposure, Ag greatly increased S. aureus degradation through a simultaneous antibacterial process. Eventually, the nanocomposites could be anticipated as photoactivation antibacterial agent and water purification nanocatalyst applications.

Electrospray lignin nanoparticles as Pickering emulsions stabilizers with antioxidant activity, UV barrier properties and biological safety

The inherent complexity and large particle size of native-state lignin are the major factors limiting its performance in high value-added materials. To realize the high-value application of lignin, nanotechnology is a promising method. Therefore, we offer a nanomanufacturing approach to produce lignin nanoparticles with uniform size, regular shape and high yield using electrospray. They are efficient in stabilizing oil-in-water (O/W) Pickering emulsions that remain for one month. Lignin has the abilities to demonstrate broad-spectrum UV resistance and green antioxidant properties in advanced materials, taking advantage of its inherent chemical characteristics. In addition, lignin has high safety for topical products according to an in vitro cytotoxicity test. In addition, the nanoparticle concentrations used in the emulsion were as low as 0.1 mg/ml, which maintained UV-resistant ability and overcame traditional lignin-based materials with unfavorable dark colors. Overall, lignin nanoparticles not only act as stabilizers at the water-oil interface but also realize the high functionality of lignin.

From sugarcane to skin: Lignin as a multifunctional ingredient for cosmetic application

Lignin has been suggested as a promising candidate for cosmetic applications due to its remarkable potential to absorb ultraviolet rays and distinctive antioxidant activity. This study aims at evaluating the performance of lignin from sugarcane bagasse (SCB) as natural UV blocker, antioxidant, and pigment. Lignin was extracted from SCB, characterized and incorporated into a blemish balm (BB) cream. The biological potential, concretely, in vitro and in vivo sun protection factor (SPF) and in vitro UVA-PF, and safety were assessed. A high-purity SCB lignin (>92 %) was obtained by a mild alkaline extraction process. The results of cytotoxicity, mutagenicity, skin sensitization and in vivo acute cutaneous irritation demonstrated that SCB lignin is safe for topical applications. Lignin showed capacity to scavenge both ABTS and DPPH radicals, which were preserved after its incorporation into the cosmetic formulation. Notable results were achieved in terms of in vitro and in vivo SPF of 9.5 ± 2.9 and 9.6 ± 0.8, respectively. Furthermore, the tested lignin-based BB cream revealed a broad-spectrum UV protection (critical wavelength of 378 ± 0.5 nm). These results suggest SCB lignin as multifunctional and safe ingredient for use in cosmetic products.

Ultrahigh Detectivity Broad Spectrum UV Photodetector with Rapid Response Speed Based on p-β Ga2 O3 /n-GaN Heterojunction Fabricated by a Reversed Substitution Doping Method.

An excellent broad-spectrum (220-380nm) UV photodetector, covering the UVA-UVC wavelength range, with an ultrahigh detectivity of ≈1015 cm Hz1/2 W-1 , is reported. It is based on a p-β Ga2 O3 /n-GaN heterojunction, in which p-β Ga2 O3 is synthesized by thermal oxidation of GaN and a heterostructure is constructed with the bottom n-GaN. XRD shows the oxide layer is (-201) preferred oriented β-phase Ga2 O3 films. SIMS and XPS indicate that the residual N atoms as dopants remain in β Ga2 O3 . XPS also demonstrates that the Fermi level is 0.2eV lower than the central level of the band gap, indicating that the dominant carriers are holes and the β Ga2 O3 is p-type conductive. Under a bias of -5V, the photoresponsivity is 56 and 22 A W-1 for 255 and 360nm, respectively. Correspondingly, the detectivities reach an ultrahigh value of 2.7 × 1015 cm Hz1/2 W-1 (255nm) and 1.1 × 1015 cm Hz1/2 W-1 (360nm). The high performance of this UV photodetector is attributed mainly to the continuous conduction band of the p-β Ga2 O3 /n-GaN heterojunction without a potential energy barrier, which is more helpful for photogenerated electron transport from the space charge region to the n-type GaN layer.

Health effects of UV nail lamps - is there a risk of cancer?

Introduction: &#x0D; Every year, more and more people are using manicure and pedicure services performed with UV lamps. As public awareness of the harmfulness of prolonged exposure to UV light increases, there are doubts about the safety of frequent treatments using it.&#x0D; Aim of the study: &#x0D; The aim of the study was to find out whether regular use of UV nail lamps is safe and to educate patients about the prevention of potential cancer. &#x0D; Methods and materials: &#x0D; A literature review was performed in the PubMed database using the keywords: UV; nail lamp; skin cancer; risk.&#x0D; Resulsts: &#x0D; Certain clinical cases indicate that long-term, regular exposure to UVA radiation from nail lamps can increase the risk of squamous cell carcinoma of the skin and actinic keratosis, but other risk factors may overlap. According to a statement by the U.S. Food and Drug Administration (FDA), the use of these devices is safe. Thus, the results of the studies appear to be inconclusive. Both the researchers who prove the safety of lamp use and those who question it unanimously recommend the use of prophylaxis and educating patients about it.&#x0D; Conclusions: &#x0D; The use of UV nail lamps is not associated with significant risks. Single clinical cases describing the development of squamous cell carcinoma of the skin and actinic keratosis appear to be anecdotal. As the low probability of cancer formation is still taken into account, it is worth taking the recommended precautions: using creams with a broad-spectrum UV filter 20 minutes before exposure or manicure gloves. Using LED nail lamps instead of classic UV lamps will also be beneficial. The topic is a developing one and will require more research attention.

Photo-Fenton Degradation of Ciprofloxacin by Novel Graphene Quantum Dots/α-FeOOH Nanocomposites for the Production of Safe Drinking Water from Surface Water

In the current work, novel graphene quantum dots (GQDs)-doped goethite (α-FeOOH) nanocomposites (GQDs/α-FeOOH) were prepared by following a feasible hydrolysis method and applied for ciprofloxacin (CIP) removal. Results showed that the CIP degradation efficiency was significant (93.73%, 0.0566 min−1) in the GQDs/α-FeOOH + H2O2 + Vis system using much lower amounts of H2O2 (0.50 mM), which is 3.9 times the α-FeOOH + H2O2 + Vis system. It was found that •OH, O2•−, and 1O2 were mainly responsible for CIP degradation in the GQDs/α-FeOOH photo-Fenton system. GQDs/α-FeOOH demonstrated broad-spectrum UV–vis-IR responsiveness in the degradation of ciprofloxacin as a function of the doping of GQDs. Additionally, GQDs/α-FeOOH showed outstanding durability (recyclability up to 3 cycles with a lower iron leaking amount, 0.020 mg L−1), a broad range of application pH, and a pretty acceptable catalytic efficacy in a variety of surface water matrices. Overall, GQDs/α-FeOOH have been shown to be an effective photocatalyst for the remediation of emerging contaminants via the workable exploitation of solar energy.

Boosting the photocatalytic performance of Bi2Fe4O9 through formation of Z-scheme heterostructure with In2S3: Applications towards water decontamination

Design of biocompatible nano-heterostructure photocatalyst with broad UV–visible spectrum response and strong redox ability is a promising approach with potential application in micropollutant degradation and pathogen deactivation from aqueous sources. Herein, we have reported the facile fabrication of In2S3/Bi2Fe4O9 (ISxBFO) binary heterostructure by hydrothermally depositing In2S3 nanoparticles (20–40 nm) over Bi2Fe4O9 nanocuboids/nanoplates prepared by combustion synthesis route. In depth characterization study revealed broad spectrum UV–Vis absorption, large interfacial contact, improved charge carrier separation and mobility and a longer excited state life time (4.7 ns) for the ISxBFO heterostructure materials. The integration of In2S3 with Bi2Fe4O9 strongly boosts the optoelectrical and photocatalytic property of pristine Bi2Fe4O9. The ISxBFO heterostructure material exhibited enhanced photocatalytic efficiency for aqueous phase degradation of sulfamethoxazole antibiotics (kapp = 0.06 min−1) and phenyl urea herbicides (kapp = 0.028 min−1) with reaction rates 3–8 times higher than the pure BFO component. The MTT assay experiments confirmed non-cytotoxic nature of treated sulfamethoxazole and diuron solutions. The composite materials also displayed convincing antibacterial behavior towards toxigenic Vibrio cholerae pathogen. Haemagglutination assay study revealed excellent biocompatibility of the binary composite up to 200 mg L−1. Radical trapping study suggested expeditious generation of •OH and •O2− radicals over the ISxBFO surface which is nearly 3.8 and 2.3 times higher than pure BFO and In2S3 respectively. The occurrence of a direct Z-scheme mechanism is inferred from radical trapping and XPS study which accounted for the improved photocatalytic activity and strong radical generation property of the ISxBFO heterostructure material.

Toward Efficient Broad-Spectrum Uv Absorption of Carbon Dots: Facile Preparation, Performance Characterization and its Application as Uv Absorbers

Toward Efficient Broad-Spectrum Uv Absorption of Carbon Dots: Facile Preparation, Performance Characterization and its Application as Uv Absorbers

A multifunctional chemical linker in a buried interface for stable and efficient planar perovskite solar cells.

The buried interface between a perovskite (PVK) light absorbing layer and an electron transport layer (ETL) plays an utmost important role in further improving the efficiency and stability of planar perovskite solar cells (PSCs). The interfacial properties greatly affect charge transport, perovskite crystal growth, and device stability. Herein, a variable structure broad-spectrum UV-284 absorber agent 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid (HMBS) is introduced into PSCs based on SnO2 ETLs as an efficient multifunctional chemical linker to modify the buried interface properties. HMBS used to modify SnO2 can simultaneously suppress the surface trap states of ETLs, optimize the ETL/PVK interface energy level arrangement, and improve the crystallization quality of the upper perovskite films. Meanwhile, as an efficient UV absorber, HMBS can also greatly reduce the damage caused by UV light to perovskite films and thus improve the stability of devices. Consequently, HMBS-modified PSCs exhibit champion efficiencies of 23.42% (0.09 cm2) and 20.63% (1.00 cm2) along with remarkably enhanced UV stability. This work emphasizes the importance of appropriate interface treatment strategies for buried interface modification and provides an effective method for fabricating efficient and UV resistant perovskite photovoltaic devices.

Boosting sunscreen stability: New hybrid materials from UV filters encapsulation

Unprotected exposure to solar UV is the main recognized cause of the spreading of skin cancer that has occurred in the last decades. Organic and inorganic UV filters are the main defense against UV exposure and have become ubiquitous in personal-care products, packaging, plastics, dyes, and many other sectors. UV filters still have some stability and efficacy issues making it important to find stable and broad-spectrum UV absorbers, safer for human health and the environment. In this work UV filters octinoxate and avobenzone were encapsulated into zeolites with different chemistry and topology leading to the production of hybrid zeolites/organic filter sunscreens. The obtained materials were deeply characterized and their filtering capacity evaluated. The encapsulation of UV filters in cationic zeolites resulted in an enhanced UV filtering capacity, whereas that in acid zeolites seem less effective in absorbing UV radiation, with emerging visible coloring. The enhancement of UV filtering power is of paramount importance for the future development and exploitation of ZEOfilters, possibly being the key to reduce the quantity of actives, stabilizers, and co-formulants employed, with benefits for humankind and the environment.

Hyaluronic acid/tannic acid hydrogel sunscreen with excellent anti-UV, antioxidant, and cooling effects

Excessive exposure to UV radiation is one of the major factors that causes skin aging, erythema, burns, and skin cancer. Recently, the usage of sunscreens for skin protection has increased because the amount of UV radiation reaching the Earth's surface has increased owing to the destruction of the ozone layer that blocks UV radiation. Hydrogels with a three-dimensional network structure exhibit physical and chemical properties that are similar to those of the extracellular matrix in the human body, a high water content, flexibility, and biocompatibility. Therefore, they are applied in a wide range of fields, such as in cosmetics, medicines, and pharmaceuticals. However, conventional hydrogel-based sunscreens have drawbacks such as complicated process conditions, high cost, and low biocompatibility. In this study, a novel hydrogel-type sunscreen with excellent UV protection and cooling effects was prepared by a very simple process using two natural materials, hyaluronic acid (HA) and tannic acid (TA). The HA/TA hydrogels exhibited broad-spectrum UV protection in the UVA and UVB regions (280-360 nm). In addition, they showed excellent adhesion to the skin surface, antioxidative activity, cooling effect, and high moisture content, demonstrating great application potential as a hydrogel-type sunscreen.

ARTICLE: Alteration to the Skin Barrier Integrity Following Broad-Spectrum UV Exposure in an Ex Vivo Tissue Model.

Dynamic changes to the skin barrier&rsquo;s molecular structure and ceramide profile are well-documented in skin conditions such as atopic dermatitis and psoriasis. Pathological and environmental factors have been shown to impair barrier integrity and demonstrate shifts in ceramide composition in the skin. However, the relationship between acute and prolonged sun exposure and its effects on skin barrier homeostasis is insufficiently investigated. This study aims to uncover new scientific evidence to elucidate the relationship of UV irradiation with the skin barrier using an ex vivo tissue model following simulated UVA/UVB exposure.&nbsp;Fresh ex vivo human skin pretreated either with or without a broad-spectrum sunscreen was exposed to either a physiological or elevated UV condition. Following eight days in culture, structural and molecular changes were evaluated. UV irradiated skin displayed epidermal cell death and altered expression of key barrier proteins. TEM analysis demonstrated disruption to adherens junctions and dissociation between tissue layers following both physiological and extensive UV exposures. An effective broad-spectrum sunscreen containing essential skin ceramides completely protected the skin from such changes. This is one of the first works demonstrating a clear correlation of altered skin barrier integrity using a physiologically relevant dose in an ex vivo tissue model. Our findings also further support the additional importance and benefits of sun protection among the consumers.&nbsp;J Drugs Dermatol. 20(4 Suppl):s23-28. doi:10.36849/JDD.S589D.

ARTICLE: Alteration to the Skin Barrier Integrity Following Broad-Spectrum UV Exposure in an Ex Vivo Tissue Model

Dynamic changes to the skin barrier’s molecular structure and ceramide profile are well-documented in skin conditions such as atopic dermatitis and psoriasis. Pathological and environmental factors have been shown to impair barrier integrity and demonstrate shifts in ceramide composition in the skin. However, the relationship between acute and prolonged sun exposure and its effects on skin barrier homeostasis is insufficiently investigated. This study aims to uncover new scientific evidence to elucidate the relationship of UV irradiation with the skin barrier using an ex vivo tissue model following simulated UVA/UVB exposure. Fresh ex vivo human skin pretreated either with or without a broad-spectrum sunscreen was exposed to either a physiological or elevated UV condition. Following eight days in culture, structural and molecular changes were evaluated. UV irradiated skin displayed epidermal cell death and altered expression of key barrier proteins. TEM analysis demonstrated disruption to adherens junctions and dissociation between tissue layers following both physiological and extensive UV exposures. An effective broad-spectrum sunscreen containing essential skin ceramides completely protected the skin from such changes. This is one of the first works demonstrating a clear correlation of altered skin barrier integrity using a physiologically relevant dose in an ex vivo tissue model. Our findings also further support the additional importance and benefits of sun protection among the consumers. J Drugs Dermatol. 20(4 Suppl):s23-28. doi:10.36849/JDD.S589D

The Involvement of Xanthone and (E)-Cinnamoyl Chromophores for the Design and Synthesis of Novel Sunscreening Agents.

Excessive UV exposure contributes to several pathological conditions like skin burns, erythema, premature skin aging, photodermatoses, immunosuppression, and skin carcinogenesis. Effective protection from UV radiation may be achieved with the use of sunscreens containing UV filters. Currently used UV filters are characterized by some limitations including systemic absorption, endocrine disruption, skin allergy induction, and cytotoxicity. In the research centers all over the world new molecules are developed to improve the safety, photostability, solubility, and absorption profile of new derivatives. In our study, we designed and synthesized seventeen novel molecules by combining in the structures two chromophores: xanthone and (E)-cinnamoyl moiety. The ultraviolet spectroscopic properties of the tested compounds were confirmed in chloroform solutions. They acted as UVB or UVA/UVB absorbers. The most promising compound 9 (6-methoxy-9-oxo-9H-xanthen-2-yl)methyl (E)-3-(2,4-dimethoxyphenyl)acrylate) absorbed UV radiation in the range 290–369 nm. Its photoprotective activity and functional photostability were further evaluated after wet milling and incorporation in the cream base. This tested formulation with compound 9 possessed very beneficial UV protection parameters (SPFin vitro of 19.69 ± 0.46 and UVA PF of 12.64 ± 0.32) which were similar as broad-spectrum UV filter tris-biphenyl triazine. Additionally, compound 9 was characterized by high values of critical wavelength (381 nm) and UVA/UVB ratio (0.830) thus it was a good candidate for broad-spectrum UV filter and it might protect skin against UVA-induced photoaging. Compound 9 were also shown to be photostable, non-cytotoxic at concentrations up to 50 µM when tested on five cell lines, and non-mutagenic in Ames test. It also possessed no estrogenic activity, according to the results of MCF-7 breast cancer model. Additionally, its favorable lipophilicity (miLogP = 5.62) does not predispose it to penetrate across the skin after topical application.