Broader Goals Research Articles

Adaptation of Aglycosylated Monoclonal Antibodies for Improved Production in Komagataella phaffii.

Monoclonal antibodies (mAbs) are a major class of biopharmaceuticals manufactured by well-established processes using Chinese Hamster Ovary (CHO) cells. Next-generation biomanufacturing using alternative hosts like Komagataella phaffii could improve the accessibility of these medicines, address broad societal goals for sustainability, and offer financial advantages for accelerated development of new products. Antibodies produced by K. phaffii, however, may manifest unique molecular quality attributes, like host-dependent, product-related variants, that could raise potential concerns for clinical use. We demonstrate here conservative modifications to the amino acid sequence of aglycosylated antibodies based on the human IgG1 isotype that minimize product-related variations when secreted by K. phaffii. A combination of 2-3 changes of amino acids reduced variations across six different aglycosylated versions of commercial mAbs. Expression of a modified sequence of NIST mAb in both K. phaffii and CHO cells showed comparable biophysical properties and molecular variations. These results suggest a path toward the production of high-quality mAbs that could be expressed interchangeably by either yeast or mammalian cells. Improving molecular designs of proteins to enable a range of manufacturing strategies for well-characterized biopharmaceuticals could accelerate global accessibility and innovations.

Article: Is the Privilege Too Privileged? the Orde van de Vlaamse Balies Case Revisited

The objective of this article is to analyse the concept of the legal professional privilege in the field of taxation. First, the Orde van de Vlaamse Balies case is examined in which the CJEU struck down an element of the mandatory disclosure regime contained in the fifth amendment to the Directive on Administrative Cooperation (DAC 6) as it was considered a disproportionate infringement of the legal professional privilege. The article challenges whether the CJEU was correct in simply further developing its own and the ECtHR’s precedence to reach the conclusion that all activities of lawyers as targeted by the DAC 6 fall within the scope of the strengthened protection of legal professional privilege. Additionally, it is concluded that the CJEU insufficiently took into account the DAC 6’s broader goals. Next, the article investigates ethical considerations concerning legal professional privilege, discussing particularly how it should be delineated in the field of taxation. The article concludes that the scope of legal professional privilege should not be expanded to include the activities of lawyers in tax planning.

COVID-19's Effect on Practice Quality Improvement and Transformation Activities: Practice Survey Results.

The Transforming Clinical Practices Initiative (TCPI) was a 4-year, large-scale, collaborative, peer-based learning initiative for physician practices of all specialties with broad goals to improve the quality of patient care, spend health care dollars more wisely, and assist practices in being ready to succeed under value-based payment (VBP). We investigated whether the COVID-19 pandemic had erased or diminished practice transformation progress made during the TCPI program period, through a follow-up survey of participating practices fielded in October 2021. In October 2021 to April 2022, we surveyed a probability sample of 2207 primary care and specialty practices that participated in the TCPI, receiving 610 responses. We asked about practice characteristics, financial and ownership stability, clinical performance, and quality improvement efforts, both now and prior to COVID-19. The COVID-19 content was part of a larger survey. Responses were weighted to account for sample selection, unknown eligibility status, and nonresponse. We generated weighted univariate descriptive statistics representative of practices with clinicians enrolled in TCPI. These estimated percentages have a 95% confidence interval of about ±5%. Multivariate analysis of unweighted data examined associations between practice characteristics and other variables of interest. For all but one of 13 practice transformation activities engaged in prior to the COVID-19 public health emergency, a majority of practices (at least 52%) reported that the progress on these activities were either not hurt or were helped by their COVID-19 experience. Compared to January 2020, only about 7% of practices reported that their quality of care or clinical performance was worse due to COVID-19, and 32% reported that their quality of care was better. More rural than urban practices reported that half or more of their transformation activities were hurt by COVID-19 (29% and 14%, respectively). Physician-owned practices were more likely to report quality is better today than prior to COVID-19 relative to practices with other ownership types such as hospitals or health systems (43% vs 24%). Most practices have been able to recover from the deep stress of the COVID-19 pandemic and continue their efforts to improve patient care and performance to succeed under VBP. These results suggest a high perceived return on investment in value-readiness support along with emergency financial support in times of crisis, as well as room to continue preparation for any future pandemic and the national movement toward increased VBP, especially in rural settings.

Examining stakeholder attitudes towards tree ecosystem services and disservices in urban environments: insights from Maharshi Dayanand University, Rohtak

ABSTRACT Urbanisation is a growing public health concern worldwide. Green spaces and trees provide critical ecosystem services in urban areas. The perceptions and attitudes of people regarding ecosystem services and disservices of trees were studied in one of the cleanest higher education institutions (HEIs) in India. Based on the Likert scale, this research focused on rating and preferences for ecosystem services and disservices from trees by different stakeholders. The study also aimed to understand the importance of socio-demographic variables on stakeholder’s perceptions towards ecosystem services and disservices. The study attempted to capture specific challenges and suggestions regarding tree management on campus. The survey included 367 people representing administrative staff, faculty members, residents and students from the Maharshi Dayanand University Campus (MDU), Rohtak (Haryana), India. Perceptions of different stakeholders were explored through a semi-structured questionnaire. Respondents rated oxygen (O2) production, medicinal potential and air pollution reduction services of trees as very important. They also highlighted some disservices of the trees on the university campus, such as problems with pollen allergy, litter, blocking of sunshine and monkey menace. Principal component analysis (PCA) identified eight significant varimax factors (VFs) for ecosystem services and disservices, explaining 59.59% of the variance in the data. Ordinal regression analysis indicated a strong correlation between residents on campus, educational background, marital status and ratings of ecosystem services and disservices. Respondents suggested organising more environmental sensitisation programmes, recruiting staff, ensuring strict compliance with rules and establishing tree clubs. The study concludes that people are highly dependent on campus trees, regard ecosystem services and are not significantly concerned about tree disservices. The findings of this study may motivate and guide universities and higher educational institutions across the globe to explore the perceptions of different stakeholders in understanding the ecological significance of trees for achieving their broad goals of campus sustainability.

Power and positionality in the practice of health system responsiveness at sub-national level: insights from the Kenyan coast

BackgroundHealth system responsiveness to public priorities and needs is a broad, multi-faceted and complex health system goal thought to be important in promoting inclusivity and reducing system inequity in participation. Power dynamics underlie the complexity of responsiveness but are rarely considered. This paper presents an analysis of various manifestations of power within the responsiveness practices of Health Facility Committees (HFCs) and Sub-county Health Management Teams (SCHMTs) operating at the subnational level in Kenya. Kenyan policy documents identify responsiveness as an important policy goal.MethodsOur analysis draws on qualitative data (35 interviews with health managers and local politicians, four focus group discussions with HFC members, observations of SCHMT meetings, and document review) from a study conducted at the Kenyan Coast. We applied a combination of two power frameworks to interpret our findings: Gaventa’s power cube and Long’s actor interface analysis.ResultsWe observed a weakly responsive health system in which system-wide and equity in responsiveness were frequently undermined by varied forms and practices of power. The public were commonly dominated in their interactions with other health system actors: invisible and hidden power interacted to limit their sharing of feedback; while the visible power of organisational hierarchy constrained HFCs’ and SCHMTs’ capacity both to support public feedback mechanisms and to respond to concerns raised. These power practices were underpinned by positional power relationships, personal characteristics, and world views. Nonetheless, HFCs, SCHMTs and the public creatively exercised some power to influence responsiveness, for example through collaborations with political actors. However, most resulting responses were unsustainable, and sometimes undermined equity as politicians sought unfair advantage for their constituents.ConclusionOur findings illuminate the structures and mechanisms that contribute to weak health system responsiveness even in contexts where it is prioritised in policy documents. Supporting inclusion and participation of the public in feedback mechanisms can strengthen receipt of public feedback; however, measures to enhance public agency to participate are also needed. In addition, an organisational environment and culture that empowers health managers to respond to public inputs is required.

The importance of matrix in cardiomyogenesis: Defined substrates for maturation and chamber specificity

Human embryonic stem cell-derived cardiomyocytes (hESC-CM) are a promising source of cardiac cells for disease modelling and regenerative medicine. However, current protocols invariably lead to mixed population of cardiac cell types and often generate cells that resemble embryonic phenotypes. Here we developed a combinatorial approach to assess the importance of extracellular matrix proteins (ECMP) in directing the differentiation of cardiomyocytes from human embryonic stem cells (hESC). We did this by focusing on combinations of ECMP commonly found in the developing heart with a broad goal of identifying combinations that promote maturation and influence chamber specific differentiation. We formulated 63 unique ECMP combinations fabricated from collagen 1, collagen 3, collagen 4, fibronectin, laminin, and vitronectin, presented alone and in combinations, leading to the identification of specific ECMP combinations that promote hESC proliferation, pluripotency, and germ layer specification. When hESC were subjected to a differentiation protocol on the ECMP combinations, it revealed precise protein combinations that enhance differentiation as determined by the expression of cardiac progenitor markers kinase insert domain receptor (KDR) and mesoderm posterior transcription factor 1 (MESP1). High expression of cardiac troponin (cTnT) and the relative expression of myosin light chain isoforms (MLC2a and MLC2v) led to the identification of three surfaces that promote a mature cardiomyocyte phenotype. Action potential morphology was used to assess chamber specificity, which led to the identification of matrices that promote chamber-specific cardiomyocytes. This study provides a matrix-based approach to improve control over cardiomyocyte phenotypes during differentiation, with the scope for translation to cardiac laboratory models and for the generation of functional chamber specific cardiomyocytes for regenerative therapies.

Placebo effect in clinical practice

The term placebo poses challenges in definition, language and use in research and clinical settings. Placebo extends beyond inactive substances, and modern exploration has revealed complex neurobiological, psychological, and social factors influencing placebo mechanisms. With knowledge of the placebo effect, clinicians can assess and enhance the effectiveness of the most optimal treatments. Future research should explore ethical ways of promoting placebo effects, aligning with broader goals in medical practice, as argued in this review.

Ten golden rules for restoration to secure resilient and just seagrass social‐ecological systems

Societal Impact StatementSeagrass meadows are a globally important habitat subject to significant loss. As efforts to restore these sensitive habitats are hampered by their high cost and low levels of reliability, rigorous guidance is required to improve effectiveness and ensure they are cost‐effective. Here, we define 10 golden rules for how we can undertake seagrass restoration. We do this by considering that for seagrass restoration to be successful, it needs to take place with people and not against people. The framework we present aims to direct efforts for seagrass restoration that are holistic and achieve broad goals for people, biodiversity and the planet.SummaryThe world has lost a significant proportion of its seagrass, and although glimmers of hope for its recovery exist, losses and degradations continue. First and foremost, evidence highlights the need to put the world on a global pathway to seagrass net gain. Achieving this outcome requires that conservation of what remains is a priority, but reaching net gain requires seagrass coverage to increase at rates unlikely to be achieved naturally; large‐scale active restoration is required to fill this gap. Novel finance mechanisms aligned to the climate emergency and biodiversity crises are increasingly leading to larger scale restoration projects. However, no clear framework exists for developing or prioritising approaches. With seagrass restoration expensive and unreliable, rigorous guidance is required to improve effectiveness and ensure it is cost‐effective. Building on evidence from terrestrial and marine sources, here, we apply the ‘10 golden rules’ concept, first outlined for reforestation and later applied to coral reefs, to seagrass restoration. In doing so, we follow international standards for ecological restoration and view seagrass restoration in a broad context, whereby regeneration can be achieved either by planting or by enhancing and facilitating natural recovery. These rules somewhat differ from those on reforestation and coral reef restoration, principally due to the relative immaturity of seagrass restoration science. These 10 golden rules for seagrass restoration are placed within a coupled social‐ecological systems context, and we present a framework for conservation more broadly, to achieve multiple goals pertaining to people, biodiversity and the planet.

Learning from therapists about the challenges and opportunities of training in cognitive behavioral therapy for psychosis: qualitative findings from a US-based service evaluation

ABSTRACT Background CBT for psychosis (CBTp) is a care standard for people with psychosis in the United States (US). However, CBTp access is poor. The context differs from the UK, where CBTp was primarily developed. This US-based service evaluation addresses a knowledge gap and forms a pilot study: a broad goal was to learn about CBTp training’s impact on therapists. Specific aims were to: 1) describe the challenges and opportunities of CBTp training by interviewing therapists competent in formulation-driven CBTp; 2) make recommendations for practice and research. Methods Therapists’ experiences of a 3-day CBTp workshop and 12-month consultation period in a US outpatient service were evaluated via focus groups. Participants were eight of ten therapists achieving CBTp competency. Results Thematic analysis of focus group content yielded four themes: 1) Before CBTp: Support and medication; 2) Hope and possibility; 3) A reality check; 4) The future: Ongoing development or “flavor of the week”. Discussion Therapist perspectives help elucidate barriers and facilitators for US CBTp implementation, from the challenge for therapist-case managers of accommodating CBTp, to the potential of shared therapeutic models for team cohesion. Recommendations include clarifying how best to use CBTp within large caseloads, and mixed method longitudinal studies of training.

Interpretation and utility of the Animal Health Loss Envelope as part of the Global Burden of Animal Diseases analytical process.

The Global Burden of Animal Diseases (GBADs) programme follows a multistage process to produce disease burden estimates in livestock and farmed aquatic animal production systems. The GBADs programme has broad goals of inclusivity, transparency and rigour. Meeting those goals means providing users of all levels of technical expertise with a clear explanation of the programme's output. In this way, the meaning and limitations of those results are clearly communicated, minimising the risk of misinterpretation. The first published estimates of disease burden have been calculated at farm level using a new metric called the Animal Health Loss Envelope. This metric estimates the cost of lost productivity and expenditure on disease control for profit-maximising producers by comparing current system performance to a hypothetical ‘ideal health'scenario. This ideal is a farm-specific concept and is critically different from an ideal health state when physiologically defined. The metric and its key concepts are described in this article.

The politics of higher education in China: the signal–response mechanism, downward tiered pressure escalation, and the Double First-Class University Initiative

ABSTRACT This article examines the politics of higher education in China drawing on empirical data collected from three elite universities listed in the ‘Double First-Class University Initiative’. We investigate how a ‘signal – response’ mechanism, in which the country’s top leaders signal broad policy goals and subordinate officials respond, works in China’s higher education arena. To address the uncertainties caused by vague signals and avoid blame for failure to fulfil policy goals, a strategy involving a gradual downward increase of implementation pressure within the bureaucratic hierarchy, termed cengceng jiama (层层加码), has been adopted. Universities and their faculties/departments now establish their own ‘up-or-leave’ systems to remove underperforming researchers, apply more stringent criteria when assessing faculty members’ publication rates, and discriminate against domestically trained PhDs when hiring. Consequently, faculty members, especially those in the younger generation, often experience high levels of anxiety, insecurity and inequality, which can hinder their development as scholars.

Healthcare leaders navigating complexity: a scoping review of key trends in future roles and competencies

BackgroundAs healthcare systems rapidly become more complex, healthcare leaders are navigating expanding role scopes and increasingly varied tasks to ensure the provision of high-quality patient care. Despite a range of leadership theories, models, and training curricula to guide leadership development, the roles and competencies required by leaders in the context of emerging healthcare challenges (e.g., disruptive technologies, ageing populations, and burnt-out workforces) have not been sufficiently well conceptualized. This scoping review aimed to examine these roles and competencies through a deep dive into the contemporary academic and targeted gray literature on future trends in healthcare leadership roles and competencies.MethodsThree electronic databases (Business Source Premier, Medline, and Embase) were searched from January 2018 to February 2023 for peer-reviewed literature on key future trends in leadership roles and competencies. Websites of reputable healthcare- and leadership-focused organizations were also searched. Data were analyzed using descriptive statistics and thematic analysis to explore both the range and depth of literature and the key concepts underlying leadership roles and competencies.ResultsFrom an initial 348 articles identified in the literature and screened for relevance, 39 articles were included in data synthesis. Future leadership roles and competencies were related to four key themes: innovation and adaptation (e.g., flexibility and vision setting), collaboration and communication (e.g., relationship and trust building), self-development and self-awareness (e.g., experiential learning and self-examination), and consumer and community focus (e.g., public health messaging). In each of these areas, a broad range of strategies and approaches contributed to effective leadership under conditions of growing complexity, and a diverse array of contexts and situations for which these roles and competencies are applicable.ConclusionsThis research highlights the inherent interdependence of leadership requirements and health system complexity. Rather than as sets of roles and competencies, effective healthcare leadership might be better conceptualized as a set of broad goals to pursue that include fostering collaboration amongst stakeholders, building cultures of capacity, and continuously innovating for improved quality of care.

Questioning the Status of Moral Education in the Context of EFL in Kurdistan: A Critique Review

Language education has a broader goal beyond just developing linguistic competence, yet the primary aim of ELT in Kurdistan is solely to improve linguistic ability. While modern ELT stresses language use rather than language usage. Further, with the advent of a critical orientation, ELT now has a completely new role in facilitating learners’ growth in their sense of identity and character, in conjunction with the development of their language skills. Many countries include the study of foreign languages in their curricula to prepare students for the demands of modern life. In this regard, scholars have advocated for the integration of moral education in English language education, to promote not only language acquisition but also the development of students' moral identities and sense of social and personal responsibility. This paper provides a critical review of the ELT education system in Kurdistan, emphasizing the need to move from mainstream ELT to critical ELT. Particularly, this paper examines the gap between English language education and the needs of Kurdish learners. It underlines the significance of moral education in today's globalized world and proposes integrating it with language skill development to achieve the joint objective of promoting social development and language learning in learners. Further, the goal is to bring attention to the topic of incorporating moral education into EFL and to call the educational policies to take a more proactive stance in promoting it. It is noteworthy that policymakers at the Ministry of Education have begun to change the English curricula concurrently.

What Next for Eating Disorder Genetics? Replacing Myths With Facts to Sharpen Our Understanding.

Substantial progress has been made in the understanding of anorexia nervosa (AN) and eating disorder (ED) genetics through the efforts of large-scale collaborative consortia, yielding the first genome-wide significant loci, AN-associated genes, and insights into metabo-psychiatric underpinnings of the disorders. However, the translatability, generalizability, and reach of these insights are hampered by an overly narrow focus in our research. In particular, stereotypes, myths, assumptions and misconceptions have resulted in incomplete or incorrect understandings of ED presentations and trajectories, and exclusion of certain patient groups from our studies. In this review, we aim to counteract these historical imbalances. Taking as our starting point the Academy for Eating Disorders (AED) Truth #5 "Eating disorders affect people of all genders, ages, races, ethnicities, body shapes and weights, sexual orientations, and socioeconomic statuses", we discuss what we do and do not know about the genetic underpinnings of EDs among people in each of these groups, and suggest strategies to design more inclusive studies. In the second half of our review, we outline broad strategic goals whereby ED researchers can expand the diversity, insights, and clinical translatability of their studies. Appeared originally in Mol Psychiatry 2022; 27:3929-3938.

Studi Literatur Penerapan Konsep dan Peran Manajemen pada Organisasi

The concept of management is a crucial element for effective organizational management. This article discusses various management theories and approaches, including basic functions such as planning, organizing, directing, and controlling. This research uses literature studies or literature reviews. The information used in this study comes from previous research written in national and international online publications. The data collection procedure makes use of the standards set by the authors of each magazine. Finding problems for research, gathering relevant data about them, and examining some fundamental hypotheses related to them are the broad goals of literary studies. The results of this study highlight the evolution of management thinking from the classical era to the modern era, including the contributions of important figures and recent advances in management practice. The research also explores the application of management concepts in various industries and organizations, as well as the challenges managers face in a dynamic business environment. In addition, this study emphasizes the importance of adaptation and innovation in management practices to improve organizational performance. Thus, this research provides an in-depth insight into the fundamental concepts of management and their influence on management practices. Modern management is based on principles such as discipline, division of labor, authority and responsibility, unity of command, unity of direction, subordination of personal interests, fair wages, centralization, authority, order, justice, stability of positions, initiative, and the spirit of solidarity. These principles help management actions achieve organizational goals.

Cholinergic modulation in the vertebrate auditory pathway.

Acetylcholine (ACh) is a prevalent neurotransmitter throughout the nervous system. In the brain, ACh is widely regarded as a potent neuromodulator. In neurons, ACh signals are conferred through a variety of receptors that influence a broad range of neurophysiological phenomena such as transmitter release or membrane excitability. In sensory circuitry, ACh modifies neural responses to stimuli and coordinates the activity of neurons across multiple levels of processing. These factors enable individual neurons or entire circuits to rapidly adapt to the dynamics of complex sensory stimuli, underscoring an essential role for ACh in sensory processing. In the auditory system, histological evidence shows that acetylcholine receptors (AChRs) are expressed at virtually every level of the ascending auditory pathway. Despite its apparent ubiquity in auditory circuitry, investigation of the roles of this cholinergic network has been mainly focused on the inner ear or forebrain structures, while less attention has been directed at regions between the cochlear nuclei and midbrain. In this review, we highlight what is known about cholinergic function throughout the auditory system from the ear to the cortex, but with a particular emphasis on brainstem and midbrain auditory centers. We will focus on receptor expression, mechanisms of modulation, and the functional implications of ACh for sound processing, with the broad goal of providing an overview of a newly emerging view of impactful cholinergic modulation throughout the auditory pathway.

Unveiling the impact: A mixed-method inquiry into the impact of leadership development programs

PurposePrior research and theory have shown that transformational leadership can be developed through leader development programs (LDPs). To explain how this happens, research suggests a strong connection between an individual’s leader self-concept and their leadership behavior that can be manipulated through LDPs. The purpose of this article is to delve deeper into this phenomenon to understand how development occurs and to better understand how an LDP can improve leadership behaviors by influencing one’s self-concept and ultimately reduce the training transfer gap. As a broader goal, this article contributes to the existing literature on the value proposition of investing in LDPs.Design/methodology/approachWe conducted an explanatory sequential design mixed-methods study to measure the development of participants and the impact of the program. The quantitative phase of the study used self-report surveys to measure the LDP’s impact on participants’ transformational leader behavior (TLB) and concept of themselves regarding leadership, their leader self-views (LSVs). The study also measured the relationship between LSVs and later enactment of leadership behaviors as the second hypothesis. The subsequent qualitative study was designed to understand the mechanisms that might explain the quantitative results.FindingsThe study’s empirical findings indicate a positive relationship between LSVs (efficacy, self-awareness and identity) and distal leader development outcomes (TBLs). The study’s findings also provide support for the claim that LDPs convert knowledge and skills into TLB, expanding an individual’s capacity to be effective in leadership roles and processes (Day & Dragoni, 2015). Qualitative results also show LDPs improve leader behavior by influencing their self-efficacy via providing tools and knowledge as well as building experimental mindset.Originality/valueBy showing LDPs' long term impacts, this paper demonstrates why short-term leadership development programs are worth investing.

Designing a multi-purpose network of sustainable and closed-loop renewable energy supply chain, considering reliability and circular economy

Since renewable energy systems have a limited lifespan and cannot be used after a while, it seems imperative to pay attention to recycling and sustainability in the supply chain network design of these systems. Also, modern power systems have high complexity and a large number of problems that affect the reliability of electricity supply to consumers. Therefore, organizations should consider broader goals, including the maximum use of resources and the minimization of waste, which is known as lean economy. In this research, a multi-objective non-linear forward optimization model has been considered for the design of the supply chain network of photovoltaic and wind systems based on the aspects of stability and taking into account the reliability. Also, adding the reverse flow, in addition to the forward flow, is also considered, which, in addition to economic advantages, also pays attention to environmental and social issues. The objective function includes minimizing all costs and negative environmental effects as well as increasing reliability. In order to convert the multi-objective planning model into a single-objective one, the epsilon method of the enhanced constraint is used. Uncertainty has been considered for all variables (except binary variables) and parameters of demand, intensity of sun radiation and amount of wind speed. Then, the efficiency of the model has been investigated through its implementation on a case study and the results have been obtained. Eventually, the model's efficiency is illustrated by discussing a real-world case, through which prominent managerial results are acquired.

Pakistan's path to sustainability: Advancements in cleaner production, a circular economy, and climate-smart solutions

Pakistan is at a critical juncture in its sustainability journey, a moment characterized by diverse land­scapes and resilient communities. This commentary explores the multifaceted approach necessary to tackle the nation’s environmental, economic, and societal challenges within the framework of cleaner production, a circular economy, and climate-smart solutions. Environmental issues loom large, with rising air and water pollution, land degradation, and the increasing threat of climate change. To combat these challenges, adopting cleaner production tech­nologies and circular economy practices across industries is imperative. Pakistan is embracing cir­cular principles to mitigate pollution, reduce waste, and enhance resource efficiency, particularly in the agricultural sector, where circular agriculture prac­tices are ensuring food security and sustainability. The circular economy is an economic model that aims to minimize waste and make the most effi­cient use of resources by keeping products and materials in use for as long as possible through reuse, repair, remanufacturing, and recycling. It seeks to design out waste and pollution, regenerate natural systems, and transition toward renewable energy sources (Bourguignon, 2016). In Pakistan, the nation’s broad aspirations and goals regarding the circular economy are centered around sustaina­ble development and environmental stewardship. The government is committed to promoting prin­ciples of a circular economy to address environ­mental challenges, enhance resource efficiency, and promote economic growth. . . .

Krylov complexity for Jacobi coherent states

We develop computational tools necessary to extend the application of Krylov complexity beyond the simple Hamiltonian systems considered thus far in the literature. As a first step toward this broader goal, we show how the Lanczos algorithm that iteratively generates the Krylov basis can be augmented to treat coherent states associated with the Jacobi group, the semi-direct product of the 3-dimensional real Heisenberg-Weyl group H1, and the symplectic group, Sp(2, ℝ) ≃ SU(1, 1). Such coherent states are physically realized as squeezed states in, for example, quantum optics [1]. With the Krylov basis for both the SU(1, 1) and Heisenberg-Weyl groups being well understood, their semi-direct product is also partially analytically tractable. We exploit this to benchmark a scheme to numerically compute the Lanczos coefficients which, in principle, generalizes to the more general Jacobi group Hn ⋊ Sp(2n, ℝ).