The emerging experimental program with brilliant gamma beams at the Extreme Light Infrastructure – Nuclear Physics (ELI-NP) facility is presented with emphasis on the day-one experiments which are under preparation. Experiments at ELI-NP will cover nuclear resonance fluorescence (NRF) measurements, studies of large-amplitude motions in nuclei, photo-fission and photonuclear reactions of astrophysics interest, and measurements of photonuclear reaction cross-sections. The physics cases of the flagship experiments at ELI-NP and the performance of the related instruments, which are under construction for their realization, are discussed.
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