Despite the importance of seismic design for brick masonry veneer anchored to reinforced concrete (RC) backup walls, the effects of several design parameters on the seismic capacity of such nonstructural component remain unexplored. In this study, material tests and cyclic loading tests were performed to investigate the seismic performance of connection for the brick masonry veneer wall anchored to a RC back-up wall under excitation. To this end, tensile tests were first carried out for each element comprising the unit connection to investigate the basic material strengths. A cyclic loading test was then performed on brick-tie-concrete subassembly to investigate the seismic capacity of the unit connection subjected to seismic loads. The major test parameters included the type and embedded depth of veneer anchor, type of mechanical fastener, compressive strength of concrete, and use of insulation. Based on the material strengths and unit specimen strength, the failure mode and seismic capacity of the unit connection for brick veneer anchored to concrete block were evaluated. The test results showed that the presence of the insulation significantly affected the seismic capacity. Based on the test results, design recommendations were proposed to improve the prescriptive design or general design in current practice for brick masonry veneer walls.