Sintered bricks created from solid waste, which have acceptable physical and mechanical qualities, have become a significant trend for green building materials. This article investigated the possibility of using construction spoil, distiller's grains, and seawater to produce sintered brick. The physical and mechanical properties of sintered brick were investigated experimentally and the results were analyzed by Scanning Electron Microscopy (SEM) and Mecury Intrusion Porosimetry (MIP). The test results revealed that the 5% distiller's grain content was relatively appropriate and efficient considering the physical properties like volume shrinkage, water absorption, density, and freeze-thaw performance. The salts in seawater affected not just porosity but also the formation of the glass phase. The density of the crystalline particles was improved when the seawater replacement ratio increased to 50%, enabling the brick to become densified. When the seawater replacement was higher than 50%, the increase in seawater replacement resulted in a decrease in the sintered brick's compressive strength and flexural strength. It was concluded that a 50% replacement seawater ratio is most suitable for improving sintered brick's mechanical properties. • Effects of distiller's grains on physical and mechanical properties of sintered bricks are investigated. • Influence of seawater on mechanical properties of sintered bricks with certain contents of distiller's grains is studied. • Relationship between content of distiller's grains and seawater and mechanical property of sintered brick is established.