Leiomyoma Of Breast Research Articles

Breast parenchyma leiomyoma: A diagnostic challenge to treat

Breast leiomyoma is an infrequent entity and accounts for less than 1% of all breast tumors. The disease may affect both sexes with a preference for middle-aged women and its etiology still remains unclear. The nipple and subareolar area harbor the neoplasm in the majority of cases, however the intraparenchymal location, especially in older women has been noted. Histologically, this mesenchymal tumor derives from smooth muscle cells metaplasia or from myofibroblastic cells of the subareolar area. Triple assessment makes up the basic diagnostic tool. Surgical resection in macroscopic clear margins contributes not only to diagnosis but also rules out malignancy. Herein, we present our case of intramammary leiomyoma with a parallel review of world literature.

Intraparenchymal breast leiomyoma and atypical leiomyoma

BackgroundBreast leiomyoma is a rare benign mesenchymal tumor, accounting for less than 1% of all breast neoplasms. Cases of breast atypical leiomyoma is even more rarely reported and its diagnostic criteria together with its clinical courses is not cleared defined.Case presentationWe described two patients with breast leiomyomas. One has unilateral benign breast leiomyoma, the other one has bilateral breast leiomyomas. For the bilateral case, the left-side tumor was diagnosed as benign leiomyoma while the right-side tumor was diagnosed as atypical leiomyoma. The morphological features that lead to the diagnosis of atypical leiomyoma are its invasive growth pattern, mild nuclear atypia, and mitotic figures up to 3mitoses/10HPF.ConclusionsAtypical breast leiomyoma appears to behave like benign leiomyoma without recurrence in our study with nine-year follow-up. Due to the limited experience, cases presented as atypical intraparenchymal breast leiomyoma should be closely followed.

A giant leiomyoma of the breast

Breast leiomyoma is a rare benign tumor arising from the nipple and/or areola or from smooth muscle metaplasia of myoepithelial or myofibroblast cells. Despite its benign morphology, breast leiomyoma can create diagnostic confusion. Here, we report a rare case of a single leiomyoma of the breast in a 52-year-old woman. The patient reported a lump in her right breast for 1 year, and in the past 6 months, it has grown in size. Physical examination showed a dense mass in the right breast, without axillary lymphadenomegaly. Excisional biopsy revealed a well-defined cell tumor by intertwining the spindle cell folds with fibrillar and eosinophilic cytoplasm. Histopathological and immunohistochemical studies help to discriminate between leiomyoma and other benign and malignant breast lesions. Her results are discussed in our report.

Leiomyoma of the Breast- A Rare Case Report

Leiomyoma though a common entity encountered in our daily practise, its occurrence in breast is extremely uncommon. There are a very few reported cases of leiomyomas occurring in breast parenchyma. This tumour clinically simulate commonly occurring tumours of breast. This case report is of such a case of a mesenchymal neoplasm occurring in breast of a woman of child bearing age. The histopathological diagnosis requires careful differentiation from lesions that have smooth muscle proliferation, especially leiomyosarcoma. The most commonly performed treatment is resection of the lesion with free margins. Although breast leiomyoma is rare, it should be considered among the differential diagnoses for breast nodules of benign appearance.

Breast leiomyoma: a case report and review of the literature

Breast leiomyoma is a rare and benign tumor which arises from a smooth muscle in nipple and areola or smooth muscle metaplasia of myoepithelial cells or myofibroblastic cells. Common differential diagnosis of the breast leiomyoma was as follows: fibroadenoma, myoepithelioma, phyllodes tumor, and leiomyosarcoma. We present here a rare case of solitary leiomyoma of the breast. We described a case of breast leiomyoma diagnosed in an otherwise healthy 37-year-old woman at the Rajaee Hospital. The patient presented with a palpable mass in her right breast since 2 years. Physical examination showed a mobile and smooth mass, without any axillary lymphadenopathy. The radiologic examinations revealed a well-circumscribed ovoid mass, 5 cm in diameter. Excisional biopsy disclosed a well-circumscribed cellular tumor by interlacing fascicles of spindle cells with fibrillary and eosinophilic cytoplasm. The tumoral cells were immunoreactive for smooth muscle actin. There were not any evidences of disease recurrence for 20 months of follow up. Histopathological study and immunohistochemical examinations help in the discrimination between leiomyoma and other benign and malignant breast lesions and determination of outcome.

Nipple Inversion Caused by a Breast Leiomyoma

The Breast JournalVolume 18, Issue 4 p. 376-377 BREAST IMAGES Nipple Inversion Caused by a Breast Leiomyoma Huiyuan Wang MD, PhD, Huiyuan Wang MD, PhD Xuanwu Hospital of Capital Medical University—General Surgery, Beijing, ChinaSearch for more papers by this authorBin Luo MD, PhD, Bin Luo MD, PhD Xuanwu Hospital of Capital Medical University—General Surgery, Beijing, ChinaSearch for more papers by this authorFei Li MD, PhD, Fei Li MD, PhD Xuanwu Hospital of Capital Medical University—General Surgery, Beijing, ChinaSearch for more papers by this author Huiyuan Wang MD, PhD, Huiyuan Wang MD, PhD Xuanwu Hospital of Capital Medical University—General Surgery, Beijing, ChinaSearch for more papers by this authorBin Luo MD, PhD, Bin Luo MD, PhD Xuanwu Hospital of Capital Medical University—General Surgery, Beijing, ChinaSearch for more papers by this authorFei Li MD, PhD, Fei Li MD, PhD Xuanwu Hospital of Capital Medical University—General Surgery, Beijing, ChinaSearch for more papers by this author First published: 23 May 2012 https://doi.org/10.1111/j.1524-4741.2012.01262.xCitations: 1 Address correspondence and reprint requests to: Bin Luo, MD, PhD Xuanwu Hospital of Capital Medical University—General Surgery, No. 45 Changchun Street Xicheng District, Beijing, China, or e-mail: luobin@xwh.ccmu.edu.cn. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume18, Issue4July/August 2012Pages 376-377 RelatedInformation

Parenchymal leiomyoma of breast, mimicking cystosarcoma phylloides

Parenchymal leiomyoma of breast, mimicking cystosarcoma phylloides

Parenchymal leiomyoma of the breast. Report of a case and clinicopathological review

We describe a 42-year-old woman with a solid breast mass of smooth muscle cell origin. Breast leiomyoma is an extremely rare benign tumour, with only 11 cases reported thus far. Various explanations have been offered with regard to its origin, such as hamartoma, embryonal migration from the nipple tissue, multipotent mesenchymal cells or the presence of myoepithelial cells originating from the breast ducts. The differential diagnosis for breast leiomyoma usually includes benign fibrous breast lesions, but leiomyosarcoma should definitely be ruled out. Surgical treatment consists of tumour excision with free margins. We discuss the tumour's clinical, pathological and immunohistochemical features, and review the current literature.

Epithelioid leiomyoma of the breast with granular cell change: A case report

A 42-year-old woman with an epithelioid granular cell leiomyoma of the right breast is reported. The cells were spindle to polygonal and displayed finely granular cytoplasm. The smooth muscle differentiation of this tumor was shown by the immunohistochemical positivity of the neoplastic cells with anti-alpha smooth actin and anti-desmin antisera. Microfilaments with focal densities were present in the cytoplasm at an ultrastructural level. The granular cytoplasmic changes are related to a relevant number of lysosomes within the neoplastic cells.