Brazilian Girl Research Articles

Adapted Milwaukee protocol for rabies treatment in a Brazilian indigenous child: case report

BackgroundThis case report describes the treatment of a 12-year-old indigenous Brazilian girl from the Maxakali group with rabies using the adapted Milwaukee Protocol.Case presentationThe patient suffered a superficial bat bite on her right elbow, reported on April 5, 2022. Despite receiving immunoglobulin, a vaccine, and antiviral medications such as amantadine and sapropterin, the patient succumbed to the disease 25 days after hospital admission. The report highlights the inherent challenges in treating rabies due to the virus’s neurotropic nature and the difficulties in delivering antiviral drugs to the central nervous system. The case underscores the need for early antiviral intervention and calls for more studies to validate and improve treatment protocols for rabies in vulnerable populations, particularly those with genetic and immunological susceptibilities like the Maxakali indigenous group.ConclusionThe findings suggest that while the Milwaukee Protocol offers some hope, significant obstacles remain in achieving successful outcomes in rabies cases.

Novel Variant of SLC34A3 in a Compound Heterozygous Brazilian Girl with Hereditary Hypophosphatemic Rickets with Hypercalciuria.

Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) is a rare FGF23-independent disorder caused by biallelic variants in the SLC34A3 gene. The disease severity varies, and patients have an increased risk of developing renal complications. Phosphate supplementation is standard of care and active vitamin D analogs are not indicated as they could worsen the hypercalciuria. We report a Brazilian girl with HHRH who presented with knee pain and progressive genu valgum deformity that became apparent later in childhood (at age 8). Nephrocalcinosis was also identified at age 13. Next-generation sequencing (NGS) target panel directed to inherited forms of rickets detected compound heterozygous pathogenic variants in SLC34A3, including a novel missense variant c.1217G>T (p.Gly406Val). Compliance to oral phosphorus therapy was suboptimal and adjunctive chlorthalidone therapy improved hypercalciuria. Our case highlights the phenotypic variability of patients with HHRH and expands the growing list of SLC34A3 variants associated with this disorder. An accurate diagnosis is crucial for proper treatment, and a thiazide diuretic may be useful as adjunctive therapy for controlling hypercalciuria.

VARICELLA WITH CLINICAL CHARACTERISTICS SIMILAR TO ACUTE HERPETIC GINGIVOSTOMATITIS: A CASE REPORT

A 6-year-old Brazilian girl arrived at our clinic with small vesicles in the body. Her mother reported that 2 days before, the girl mentioned itching on her body. In the intraoral examination, ulcers and vesicles were seen on the hard palate and on the tongue. The diagnosis was varicella. Treatment with analgesics was carried out. On the fifth day, the patient worsened, showing ulcers throughout the oral cavity, lipedema, runny nose, and weakness, clinically resembling a case of herpetic gingivostomatitis. The patient was unable to ingest solid or liquids and was referred to the hospital to received treatment with serum and analgesics. After treatment, there was an improvement in the clinical case, and the patient has not presented recurrence so far.

Legal abortion in childhood: the official discourse and the reality of a Brazilian case.

to identify the ideological perspectives of official discourses in relation to sexual violence, childhood pregnancy and access to legal abortion based on a Brazilian case. a qualitative documentary study. Data collection was carried out in documents published on official Brazilian websites, between August and December 2020. The analytical categories of gender and generation supported data analysis. a total of 39 documents were selected and three empirical categories were identified: Protection against violence in the legislation and the (re)production of injuries in reality; Facing sexual violence against children by the Brazilian State; Being a Brazilian girl: gender and generational oppressions. the ideological perspectives of official discourses in relation to the case showed a lack of compliance with advances in Brazilian legislation on issues related to child violence and adult-centric authoritarianism, with the imposition of gender and generation subalternity.

ERUPTION MESENCHYMAL CALCIFIED HAMARTOMA: A CASE REPORT

Eruption mesenchymal calcified hamartoma (formerly known as eruption sequestrum) is an uncommon proliferation of odontogenic calcified structures, usually observed in the opercula of lower first molars of delayed eruption. A 6-year-old Brazilian girl was seen for routine dental examination. A fragment of hard whitish tissue was observed in the gingiva overlying the erupting lower first permanent molar, which showed radiographic appearance of a 0.5-cm faint round radiopacity above and separated from the occlusal surface of the related molar. The patient was submitted to an excisional biopsy, and gross examination showed a hardened whitish fragment surrounded by gingival mucosa. Microscopically, limited proliferation of cords of odontogenic epithelium was observed in association with small concentric basophilic calcifications and few large, round osteodentin and pulp-like structures. There were numerous inflammatory cells and small blood vessels in the surrounding connective tissue. The final diagnosis was eruption mesenchymal calcified hamartoma. Eruption mesenchymal calcified hamartoma (formerly known as eruption sequestrum) is an uncommon proliferation of odontogenic calcified structures, usually observed in the opercula of lower first molars of delayed eruption. A 6-year-old Brazilian girl was seen for routine dental examination. A fragment of hard whitish tissue was observed in the gingiva overlying the erupting lower first permanent molar, which showed radiographic appearance of a 0.5-cm faint round radiopacity above and separated from the occlusal surface of the related molar. The patient was submitted to an excisional biopsy, and gross examination showed a hardened whitish fragment surrounded by gingival mucosa. Microscopically, limited proliferation of cords of odontogenic epithelium was observed in association with small concentric basophilic calcifications and few large, round osteodentin and pulp-like structures. There were numerous inflammatory cells and small blood vessels in the surrounding connective tissue. The final diagnosis was eruption mesenchymal calcified hamartoma.

Naxos/Carvajal disease in an 11-year-old Brazilian girl

Naxos/Carvajal disease in an 11-year-old Brazilian girl

Juvenile dermatomyositis after repeated episodes of pharyngotonsilitis: A case report of a 3-year-old Brazilian girl

Juvenile dermatomyositis after repeated episodes of pharyngotonsilitis: A case report of a 3-year-old Brazilian girl

Intravitreal Cysticercosis

PurposeTo describe a very interesting vitrectomy in a case of intravitreal cysticercosis.SettingCysticercosis is the most common ocular helminthic infection in man.MethodsA 14 year old Brazilian girl complained of blurred vision in her right eye over the past 6 months. During this period she had several episodes of hyperaemia. Visual acuity in the right eye was hand motion and in the left eye 20/20. The intraocular pressure was normal. Fundus examination of the left eye was normal. Fundus examination of the right eye showed a floating cyst in the vitreous cavity.ResultsThe patient underwent 23‐gauge vitrectomy without any complications. Perfluorocarbon liquid was used to facilitate the removal of the cyst in the vitreous cavity. Laser photocoagulation was carried out around the retinal break, followed by silicone oil implantation. Light and electron microscopic studies suggested Cysticercus cellulosae as the infecting agent.ConclusionsThe complete and active aspiration of the Cysticercus Cellulosae in the vitreous cavity was very interesting and efficient. We believe that the success of the surgery was due to the fact that the cyst was removed intact by pars plana vitrectomy.

Discrepant outcomes in two Brazilian patients with Bloom syndrome and Wilms’ tumor: two case reports

IntroductionBloom syndrome is a rare, autosomal recessive, chromosomal instability disorder caused by mutations in the BLM gene that increase the risk of developing neoplasias, particularly lymphomas and leukemias, at an early age.Case presentationCase 1 was a 10-year-old Brazilian girl, the third child of a non-consanguineous non-Jewish family, who was born at 36 weeks of gestation and presented with severe intrauterine growth restriction. She had Bloom syndrome and was diagnosed with a unilateral Wilms’ tumor at the age of 3.5 years. She responded well to oncological treatment and has remained disease-free for the last 17 years. Case 2 was a 2-year-old Brazilian girl born to non-Jewish first-degree cousins. Her gestation was marked by intrauterine growth restriction. She had Bloom syndrome; a unilateral stage II Wilms’ tumor was diagnosed at the age of 4 years after the evaluation of a sudden onset abdominal mass. Surgical removal, neoadjuvant chemotherapy and radiotherapy were not sufficient to control the neoplasia. The tumor recurred after 8 months and she died from clinical complications.ConclusionOur study reports the importance of rapid diagnostics and clinical follow-up of these patients.

Representing Objects, Relations, and Sequences

Vector symbolic architectures (VSAs) are high-dimensional vector representations of objects (e.g., words, image parts), relations (e.g., sentence structures), and sequences for use with machine learning algorithms. They consist of a vector addition operator for representing a collection of unordered objects, a binding operator for associating groups of objects, and a methodology for encoding complex structures. We first develop constraints that machine learning imposes on VSAs; for example, similar structures must be represented by similar vectors. The constraints suggest that current VSAs should represent phrases ("The smart Brazilian girl") by binding sums of terms, in addition to simply binding the terms directly. We show that matrix multiplication can be used as the binding operator for a VSA, and that matrix elements can be chosen at random. A consequence for living systems is that binding is mathematically possible without the need to specify, in advance, precise neuron-to-neuron connection properties for large numbers of synapses. A VSA that incorporates these ideas, Matrix Binding of Additive Terms (MBAT), is described that satisfies all constraints. With respect to machine learning, for some types of problems appropriate VSA representations permit us to prove learnability rather than relying on simulations. We also propose dividing machine (and neural) learning and representation into three stages, with differing roles for learning in each stage. For neural modeling, we give representational reasons for nervous systems to have many recurrent connections, as well as for the importance of phrases in language processing. Sizing simulations and analyses suggest that VSAs in general, and MBAT in particular, are ready for real-world applications.

Saethre–Chotzen phenotype with learning disability and hyper IgE phenotype in a patient due to complex chromosomal rearrangement involving chromosomes 3 and 7

The authors describe on a Brazilian girl with coronal synostosis, facial asymmetry, ptosis, brachydactyly, significant learning difficulties, recurrent scalp infections with marked hair loss, and elevated serum immunoglobulin E. Standard lymphocyte karyotype showed a small additional segment in 7p21[46,XX,add(7)(p21)]. Deletion of the TWIST1 gene, detected by Multiplex Ligation Probe-dependent Amplification (MPLA) and array-CGH, was consistent with phenotype of Saethre-Chotzen syndrome. Array CGH also showed deletion of four other genes at 7p21.1 (SNX13, PRPS1L1, HD9C9, and FERD3L) and the deletion of six genes (CACNA2D2, C3orf18, HEMK1, CISH, MAPKAPK3, and DOCK3) at 3p21.31. Our case reinforces FERD3L as candidate gene for intellectual disability and suggested that genes located in 3p21.3 can be related to hyper IgE phenotype.

A combination of clinical and microbiological management of generalized aggressive periodontitis in primary teeth. A case report

Generalized aggressive periodontitis (GAP) in primary teeth is a rare periodontal disease that occurs during or soon after eruption of the primary teeth. An association with systemic diseases is a possibility. A 4-year-old Brazilian girl presented with GAP involving the entire primary dentition. The patient and her parents and sister were subjected to microbiological testing to identify the microorganisms involved in the disease. The patient underwent tooth extraction to eradicate the disease and received a prosthesis for the restoration of masticatory function. After the permanent teeth erupted, fixed orthodontic appliances were place to restore dental arch form and occlusion. The results show the importance of an early diagnosis of GAP and of a multidisciplinary approach involving laboratory and clinical management to treat the disease and to restore masticatory function, providing a better quality of life for patients.

Anaphylaxis to beetroot (Beta vulgaris): a case report

Results LSJ, a 13-years old Brazilian girl has complained of urticaria and asthma about 40 minutes after ingesting salty boiled beetroot on a meal. She had a previous history of wheezing until she was five years old. Seric-specific IgE to beetroot and other foods were negative, as well as to latex, bee, wasp and ant. She was sensitized only to house dust mite. Boiled and raw beetroot prick to prick were also negative (histamine resulted 4mm) but a food challenge with boiled beetroot resulted positive after 30 minutes with generalized hives, throat tightness and bronchospasm. Symptoms were controlled with intramuscular epinephrine, inhaled beta-2-agonists and intravenous corticosteroids. She was advised for a diet free of beetroot and she has had no symptoms for the last 8 months.

Kala-Azar in a Brazilian Child

We report the case of a six-year-old Brazilian girl referred for splenomegaly who first presented with fever, asthenia, and weight loss. Geographical location, clinical exam, and blood laboratories suggested kala-azar. Serology confirmed kala-azar diagnosis, but direct evidence of the parasites was not made. A treatment by meglumine antimoniate is given under hospital surveillance for two weeks. Thereupon, the patient is asymptomatic and all tests are normal.

Laeliocattleya 'Brazilian Girl Rosa': cultivar de orquídea para cultivo em vaso

A obtenção de cultivares de espécies ornamentais é estratégica para o desenvolvimento do país e possibilita obter plantas adaptadas às condições climáticas de cultivo. Aproximadamente 200 plantas de um cruzamento intergenérico entre um híbrido de Cattleya e outro de Laelia foram submetidos à seleção massal na fase de desenvolvimento vegetativo, selecionado-se aquelas com desenvolvimento mais rápido e sem sintomas de pragas e doenças. Ao final de três anos e meio, uma planta com características de crescimento vegetativo vigoroso, sem sintomas das principais pragas e doenças da cultura e boa qualidade de floração foi selecionada como nova cultivar Laeliocattleya 'Brazilian Girl Rosa'. A primeira floração demonstrou inflorescência longa e boa arquitetura com quatro flores de diâmetro médio de 11,7 cm, pétalas e sépalas firmes e proporcionais ao tamanho das flores. A coloração predominante das flores foi o rosa, com senescência aos 20 dias após a antese.

A Brazilian galactosialidosis patient given renal transplantation: A case report

We report a Brazilian girl who was diagnosed as having galactosialidosis (deficiency of protective protein/cathepsin A; PPCA deficiency; GS) at the age of 2 years 6 months during an extensive investigation for renal failure. She was found to have low levels of both β-galactosidase and α-neuraminidase in fibroblasts and to be a carrier of two novel mutations in the PPGB gene (p.G57V and p.R396W). She received a renal allograft at the age of 3 years 4 months. Transplantation was successful and graft function remains excellent after 6 years. However, the patient shows signs of progression of her primary disease. To our knowledge, she is the first GS patient to be given renal transplantation worldwide. We propose that renal transplantation should be considered as a therapeutic option for the treatment of severe renal complications of GS.

Terminal osseous dysplasia and pigmentary defects in a Brazilian girl

Terminal osseous dysplasia and pigmentary defects in a Brazilian girl

Embryonal rhabdomyosarcoma of the uterus associated with uterine inversion in an adolescent: A case report and published work review

AbstractEmbryonal rhabdomyosarcomas of the uterus are extremely rare malignant tumors and their association with uterine inversion is even rarer. The present case report refers to a 15‐year‐old Brazilian girl admitted to hospital with a 3‐month history of transvaginal bleeding and a mass protruding from the vaginal introitus. Following biopsy of the lesion and confirmation of the diagnosis of embryonal rhabdomyosarcoma, the patient was submitted to total abdominal hysterectomy followed by chemotherapy and radiotherapy. The patient died 9 months after surgery. Embryonal rhabdomyosarcoma of the uterus is very rare and extremely aggressive. According to a published work review, there has been only one report to date on the association of embryonal rhabdomyosarcoma of the uterus and uterine inversion.

Van den Ende–Gupta syndrome: Laryngeal abnormalities in two siblings

In 1992, van den Ende et al. first reported an autosomal recessive multiple congenital anomaly syndrome characterized by blepharophimosis, arachnodactyly, and congenital contractures in a Brazilian girl born to consanguineous parents. Since then, nine total patients have been reported with van den Ende-Gupta syndrome (VDEGS), and the syndrome's phenotype has been found to also include additional dysmorphic facial features, palatal abnormalities, and slender skeletal features. We present two African-American sisters born to nonconsanguineous parents who have been diagnosed with VDEGS. Both sisters developed stridor and were found to have an unusual malformation characterized by large, globular cuneiform cartilages, shortened aryepiglottic folds, a tightly coiled epiglottis, and laryngomalacia. Both patients underwent supraglottoplasty with a successful outcome. A review of the literature reveals that airway problems have been reported in a previous patient. However, no specific airway anomaly has been reported. We suggest that all patients with VDEGS and stridor undergo direct laryngoscopy with consideration for surgical correction.

Queilite granulomatosa associada à síndrome de Melkersson-Rosenthal

A síndrome de Melkerson-Rosenthal (SMR) caracteriza-se por edema orofacial, paralisia facial recorrente e língua plicada. A tríade completa é incomum, com freqüência variando de 8 a 25%, sendo que a apresentação mais comum é a presença de somente um sintoma. A queixa mais freqüente é o edema facial e/ou no lábio. No presente relato, descreve-se o caso de uma jovem, 17 anos, com edema no lábio persistente e língua plicada devido à SMR. A paciente informou que o edema e as alterações na língua haviam se iniciado há 2 anos. Tratamentos prévios haviam sido realizados, porém sem sucesso. Propôs-se a injeção intralesional de 20mg de triancinolona a cada 15 dias, associada a 5mg ao dia de clofazimine por três meses. O lábio voltou ao seu aspecto normal após quatro infiltrações da medicação. Estudos recentes têm considerado a SMR como uma doença granulomatosa, sendo a fase inicial da apresentação orofacial da Doença de Crohn em alguns pacientes. Assim, pacientes com SMR deveriam ser avaliados e seguidos quanto à presença de sintomas gastroenterológicos. O tratamento com corticosteróides tem se mostrado efetivo em reduzir a tumefação do lábio associada a essa doença. Discute-se características clínicas, tratamento e importância da terapia com corticosteróides na paralisia facial associada à SMR.