Introduction: Ayurveda, the comprehensive Indian system of medicine, has devised a novel approach for boosting overall immunity and thereby assisting the child in resisting and fighting sickness. Administration of processed gold to children is unique practice described as Swarnaprashan in the Kashyap Samhita for improving intellect, digestion, metabolism, physical strength, and immunity. The study was aimed to compare the effect of Swarnaprashan prepared from Brahmi Ghrita and Panchgavya Ghrita on immunomodulation and physical growth in children. Materials and Methods: In total 46 children seeking prevention from recurrent seasonal disorders of 0 to 8 years age of both sexes were randomly selected from OPD & IPD of Hospital of University Postgraduate Institute of Ayurveda Studies & Research, Dr. S.R. Rajasthan Ayurved University, Jodhpur, Rajasthan, India. Out of them, six children were drop out during study. Therefore, study was completed on 40 children. They were divided into two groups of 20 each. Group A: Swarnaprashan prepared from Brahmi Ghrita was given to 20 patients. Group B: Swarnaprashan prepared from Panchgavya Ghrita was given to 20 patients. Dose of Swarna Bhasma and Swarnaprashan in children were calculated according to young formula and administered in drops form for a duration of 45 days. Results: The percentage relief for study group A subjects were 66.65% and the relief for group B was 55.67%. The statistical analysis of the same showed that the improvements in both groups were highly significant. Discussion Swarnaprashan used in the above study was in a modified form that contained Swarna Bhasma, ghrita, and honey, along with some herbs showing nootropic, immune-modulatory, adaptogenic and rejuvenator activity. Conclusion: Swarnaprashan prepared from Brahmi ghrita showed a significant result over Swarnaprashan prepared from Panchgavya ghrita on various assessment parameters. However, Swarnaprashan did not elicit any remarkable changes on anthropometry parameters.