To address two main challenges (excessive mid-span deflections and numerous cracks in the main girder) in long-span prestressed concrete (PC) box-girder bridges, this paper proposes a long-span simply-supported UHPC box-girder bridge. In comparison to conventional PC box-girder bridges with three-dimensional prestress, the proposed UHPC box-girder consists only one-dimensional (longitudinal) prestress, and the thickness of the bottom/top plate and web of the UHPC box-girder are relatively thin and are strengthened with dense diaphragms and stiffening ribs. The 4th Beijiang River Bridge adopts this type of bridge with a span of 102 m, which is the longest span simply supported prestressed UHPC box-girder highway bridge in the world. Considering the fact that the thickness of the top plate of the UHPC box-girder is relatively thin (only 20 cm) and the transverse prestress is removed from the top plate, thus, under the direct action of wheel loads, the risk of bridge deck cracking may correspondingly increase. To investigate the mechanical behavior of the deck system of UHPC box-girder bridges, a 1:2 scaled experimental specimen associated with the field bridge is tested. The mechanical behavior of the new deck system is investigated and discussed. It is found that because the support strength of the stiffening rib is significantly weaker than that of the web, the UHPC deck slab should still be regarded as a two-way slab rather than a one-way slab in the elastic stage. In addition, although the test load location is unfavorable to the UHPC deck slab and the first crack appears on the UHPC deck slab, this deck system finally suffers from bending failure of the transverse rib. Furthermore, finite element analysis is carried out to study the mechanical behavior of this new deck system. Parametric analysis considers some factors including the reinforcement ratio in the transverse rib, the height of the transverse rib, and the space between transverse ribs. The results provide a good reference for design and optimization in the new deck system of UHPC box-girder bridges.