Achieving process stability in the thermoforming of fiber reinforced polymer materials (FRPs) for aerospace or automotive manufacturing is usually associated with a costly trial-and-error process, where experimental boundary conditions and other influencing factors, such as, for example, material composition, need to be adjusted over time. This is especially true when material phenomena on the microlevel, such as the crystallization kinetics of the polymer matrix or resulting stresses from temperature gradients, are the cause of the process instability. To reduce the experimental effort and reliably predict the material behavior during thermoforming, finite element simulation tools on multiple scales are a useful solution. Hereby, incorporating micromechanical phenomena into the model approaches is crucial for an accurate prediction by further reducing the deviation between simulation and experiment, in particular with regard to the underlying nonlinear material behavior. In this work, unit cell simulations on the microscale of a unidirectional glass fiber reinforced polymer (UD GFRP) are conducted to predict effective thermomechanical properties of a single material ply and ascertain the effect of individual ply constituents on the homogenized material behavior. The polymeric matrix material model used was identified in a prior publication with experimental data at various temperatures for polyamide 6 blends with varying degrees of crystallinities. Various randomization methods are tested to generate the unit cells and replicate the composites’ random fiber distribution, with a focus on process automation. The simulative results are successfully compared to an experimental study on glass fiber reinforced polyamide 6 tested at various temperatures, demonstrating the potential of the approach to reduce both time and cost required for material characterization. Finally, the unit cells are used to generate a database to predict untested load cases that will be used in future work to characterize a homogenized macroscopic material model.