This study aimed to evaluate how different tooth substrates affect the survival rate, shear bond strength, fracture strength, and mode of failure of laminate veneers (LVs). This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. In vitro studies comparing the bonding of laminate veneers to different substrates were included. Electronic databases and manual searches were performed to identify relevant studies. Data on survival rate, shear bond strength, fracture strength, and failure modes were extracted and analyzed using Review Manager software. A total of 10 studies were included in the review, comprising 621 laminate veneers. The findings revealed that laminate veneersbonded to enamel substrate had lower failure rates than those bonded to tooth substrate with severely exposed dentin or existing composite restorations (ECRs). The failure modes observed were debonding, chipping, cracks, or fractures. Bonding laminate veneers to enamel substrate showed higher survival rates compared to bonding to tooth substrates with severely exposed dentin or ECRs, underscoring the significance of enamel preservation. When dealing with exposed dentine surfaces or ECRs, it is crucial to perform appropriate surface treatment before luting to improve adhesion. This involves immediate dentine sealing, as well as the use of suitable primers and bonding agents.