Aim of the study was to evaluate botanical insecticides to control tomato boll worm and leaf minor in western Tigray, Ethiopia. Field experiment was conducted during 2018/2020 in main crop growing season at Humera. A total of five treatments (Green miracle, Neembicidene, Melatonin, Gm+ Neembicidene and control no sprayed) were used in the field experiment. The experiment was laid out randomized complete block design (RCBD) with three replications. The mean yield had a significant difference at (p<0.001) among the botanical insecticides. The highest mean yield was obtained from Neembicidene (348.8) followed by green miracle (195.8) Malathion (183), Malathion+GM (162.8), and control (84.2) qtha-1 respectively. The highest severity recorded from control was 85.41% for leaf severity and 71.3% for fruit severity. However, lowest recorded severity 18.73% for leaves and 4.55% for fruits were calculated from Neembicidene. The highest percent population reduction after chemical spray was recorded from Neembicidene (85.07%). Therefore, Neembicidene botanical insecticide recommended and promoted to verification trial to control tomato bollworm and leaf minor.