Body's Physiological Response Research Articles

Analyzing the Relationship Between Chronic Periodontitis and Psychological Stress in Elderly Patients: A Study Protocol.

Although stress is the body's physiological response to challenging life events, chronic exposure to a stressor may not cause stress. In such cases, stress negatively impacts some physiological functions, which can lead to psychosomatic diseases. According to research, inadequate coping mechanisms and long-term stress are factors that moderate the risk and progression of periodontitis. As a result, theories explaining how stress affects the periodontium have been put forth. The clinical examination comprised measurements of the probing pocket depth (PPD), clinical attachment level, number of teeth present, and plaque index. The current study uses a questionnaire to examine how psychosocial stress affects periodontium. A written consent form will be obtained after each patient has received an extensive description of the study's objectives. The instrument for diagnosis and natural illumination will be used during the patient's examination. PPD and clinical attachment loss will be compared with a questionnaire. Patients who are under stress should receive additional periodontal care to prevent periodontal disease from emerging or, if the issue already exists, from progressing to a more critical stage. Stress here deserves special attention because it is a natural part of people's life experiences with various intensities.Prejudice suggests that psychological stress and anxiety have a role in the advancement of periodontitis, which is consistent with the findings.

Analisis Beban Kerja Mental saat Mengoperasikan Smartphone dengan Memperhatikan Postur Tubuh: Pendekatan Menggunakan Metode NASA-TLX

Work physiology is the study of understanding how the human body adapts and functions in the work environment. Occupational physiology involves the study of the body's physiological responses to work-related demands and stress. This understanding is necessary to protect workers' health and welfare, as well as increase work productivity and efficiency. This research aims to analyze physiological workload by focusing on measuring mental workload, using the NASA-TLX method. Research activities were carried out on 12 students from the Department of Industrial Engineering, Universitas Mataram. Students were divided into 3 groups according to their assigned work posture, namely standing (Group A), sitting (Group B), and lying down (Group C). The results showed that the order of subjects with the highest mental workload was subject 1A (78.97%) with a standing posture, 2B (77.33%) with a sitting posture, and 4A (73.57%) with a standing posture. Based on these results, the final conclusion that can be drawn is that the mental workload in standing and sitting postures is what is most felt by the subject when operating the smartphone. These results conclude that different postures when operating a smartphone can affect the user's mental workload Keywords: Mental, NASA-TLX, Posture, Smartphone, Workload.

Closing the Gap on Addiction Recovery Engagement with an AI-infused Convolutional Neural Network Technology Application—A Design Vision

Currently, real-time detection networks elaborate the technical details of the Faster Regional Convolution Neural Network (R-CNN) recognition pipeline. Within existing R-CNN literature, the evolution exhibited by R-CNN is most profound in terms of computational efficiency integrating each training stage to reduce test time and improvement in mean average precision (mAP), which can be infused into an artificially intelligent (AI), machine learning (ML), real-time, interactive, recovery capital application (app). This article introduces a Region Proposal Network (RPN) that shares full-image convolutional features with a real-time detection AI-ML infused network in an interactive, continuously self-learning wrist-wearable real-time recovery capital app for enabling cost-free region proposals (e.g., instantaneous body physiological responses, mapped connections to emergency services, sponsor, counselor, peer support, links to local and specific recovery capital assets, etc.). A fully merged RPN and Faster R-CNN deep convolutional unified network in the app can simultaneously train to aggregate and predict object bounds and objectness scores for implementing recovery capital real-time solutions (e.g., baseball card scoring dashboards, token-based incentive programs, etc.) A continuous training scheme alternates between fine-tuning RPN tasks (e.g., logging and updating personal client information, gamification orientation) and fine-tuning the detection (e.g., real-time biometric monitoring client’s behavior for self-awareness of when to connect with an addiction specialist or family member, quick response (QR) code registration for a 12-step program, advanced security encryption, etc.) in the interactive app. The very deep VGG-16 model detection system has a frame rate of 5fps within a graphic processing unit (GPU) while accomplishing sophisticated object detection accuracy on PASCAL Visual Object Classification Challenge (PASCAL VOC) and Microsoft Common Objects in Context (MS COCO) datasets. This is achieved with only 300 proposals per real-time retrieved data capture point, information bit or image. The app has real-time, infused cartographic and statistical tracking tools to generate Python Codes, which can enable a gamified addiction recovery-oriented digital conscience. Faster R-CNN and RPN can be the foundations of an interactive real-time recovery capital app that can be adaptable to multiple recovery pathways based on participant recovery plans and actions. This paper discusses some of the critical attributes and features to include in the design of a future app to support and close current gaps in needed recovery capital to help those who are dealing with many different forms of addiction recovery.

Neuroinflammation mechanism underlying neuropathic pain: the role of mesenchymal stem cell in neuroglia.

Pain is an essential aspect of the body's physiological response to unpleasant noxious stimuli from either external sustained injuries or an internal disease condition that occurs within the body. Generally, pain is temporary. However, in patients with neuropathic pain, the experienced pain is persistent and uncontrollable, with an unsatisfactory treatment effectiveness. The activation of the immune system is a crucial factor in both central and peripheral neuropathic pain. The immune response plays an important role in the progression of the stages of neuropathic pain, and acts not only as pain mediators, but also produce analgesic molecules. Neuropathic pain has long been described as a result of dysfunctional nerve activities. However, there is substantial evidence indicating that the regulation of hyperalgesia is mediated by astrocytes and microglia activation. Mesenchymal stem cells currently hold an optimal potential in managing pain, as they can migrate to damaged tissues and have a robust immunosuppressive role for autologous or heterologous transplantation. Moreover, mesenchymal stem cells revealed their immunomodulatory capabilities by secreting growth factors and cytokines through direct cell interactions. The main idea underlying the use of mesenchymal stem cells in pain management is that these cells can replace damaged nerve cells by releasing neurotrophic factors. This property makes them the perfect option to modulate and treat neuropathic pain, which is notoriously difficult to treat.

Analisis Heat Strain Pada Pekerja Pembangunan Kapal PT.IKI (Persero) Makassar

Heat strain is the body's physiological response to heat stress received by a person. This research is a type of quantitative research with a cross-sectional study approach. The sampling technique in this study was random sampling with a total sample of 80 respondents. They are collecting data using questionnaires and interviews. Methods of data analysis using univariate and bivariate analysis with Chi-square test at 95% confidence level (p=0.05). The results showed a significant relationship between drinking water consumption and the heat strain factor (p=0.001); there was no relationship between the length of work and the heat strain factor (p=0.455) for workers in the production division at PT. IKI (Persero) 2023. It can be concluded that there is a relationship between the variable consumption of drinking water and the heat strain factor, and there is no relationship between the length of work and the heat strain factor in workers in the production division of PT. IKI (Persero). Suggested: There is a need for special attention from the agency on the importance of controlling heat stress to reduce the risk of occupational diseases in production workers at PT. IKI (Persero).

Molecular docking analysis of major active compounds of pomegranate peel extract (Punica granatum L.) in inhibiting cyclooxygenase enzyme

Background: Inflammation is the body's physiological response to an injury. Injury that affected the body can be a chemical agent, physical, or biological agent. Nowadays the inflammatory condition treated by eliminating the main etiological factor then prescribing anti-inflammatory drugs such as NSAIDs, but according the data in 2021 shown that 78,8% patients has gastritis side effect. Pomegranate peel extract (PPE) has good anti-inflammatory ability because it containing the highest concentration of flavonoid. Objectives: To predict the molecular inhibition of major active compounds (epigallocatachin gallate, ferulic acid, chlorogenic acid, gallic acid, caffeic acid, cianidanol, epicatechin, and punicalagin) in PPE against cyclooxygenase enzyme (COX-1 & COX-2) using in silico study. Method: Preparation of the active compounds of PPE, prediction of their activity, ADMET predicting test, physicochemical test, and molecular docking simulation. Results and discussions: In silico test showed that all common active compound of PPE that have potential as anti-inflammatory drugs. All of MAC PPE had value of Pa > 0.5. ADMET prediction showed that all common active compounds can distribute systemically because had score of log mucosal permeability < 2.5. All of common active compound in PPE had negative prediction not to toxic or triggering dermatitis contact against oral mucosa through ADMET prediction. The result of molecular docking of chlorogenic acid and punicalagin against protein of COX-2 showed ∆Gbind value more than mefenamic acid and arachidonic acid against COX-1 and COX-2 in range of -3,0 to -9,1 kcal/mol which the most effective as an anti-inflammatory is punicalagin (-4,0 & -9,1 kcal/mol). Conclusion: PPE had potential as anti-inflammatory drugs through COX-1 & COX-2 inhibition with the best anti-inflammation ability is ferrulic acid and punicalagin.

Phytochemical and Anti-Inflammatory Activity of Jatropha multifida L.: A Review

Inflammation is the body's physiological response to infection and injury. Inflammation maintains tissue homeostasis under various hazardous conditions. This review article aims to provide the latest knowledge about the chemical composition and anti-inflammatory activity of Jatropha multifida L. Literature is taken from various online journals search sites such as Google Scholar, PubMed, and Science Direct, which have been published since 2012-2022. Based on 9 articles used, 7 discussed phytochemicals, and 4 discussed anti-inflammatory activity. Jatropha multifida L. contains alkaloids, flavonoids, tannins, saponins, steroids, phenols, and terpenoids, which have anti-inflammatory activity by reducing the volume of edema and the number of PMN leukocytes. This review shows that Jatropha multifida L. has the potential as a natural anti-inflammatory.

Does eating less or exercising more to reduce energy availability produce distinct metabolic responses?

When less energy is available to consume, people often lose weight, which reduces their overall metabolic rate. Their cellular metabolic rate may also decrease (metabolic adaptation), possibly reflected in physiological and/or endocrinological changes. Reduced energy availability can result from calorie restriction or increased activity energy expenditure, raising the following question that our review explores: do the body's metabolic and physiological responses to this reduction differ or not depending on whether they are induced by dietary restriction or increased activity? First, human studies offer indirect, contentious evidence that the body metabolically adapts to reduced energy availability, both in response to either a calorie intake deficit or increased activity (exercise; without a concomitant increase in food intake). Considering individual aspects of the body's physiology as constituents of whole-body metabolic rate, similar responses to reduced energy availability are observed in terms of reproductive capacity, somatic maintenance and hormone levels. By contrast, tissue phenotypic responses differ, most evidently for skeletal tissue, which is preserved in response to exercise but not calorie restriction. Thus, while in many ways 'a calorie deficit is a calorie deficit', certain tissues respond differently depending on the energy deficit intervention. This article is part of a discussion meeting issue 'Causes of obesity: theories, conjectures and evidence (Part I)'.

Asymptomatic Bone Marrow Edema in Weight-bearing Bones in Athletes and Military Trainees: A Systematic Literature Review.

Asymptomatic bone marrow edema (aBME) is a non-specific radiographic finding often found in athletes. Although aBME may represent the body's physiological response to training load, the etiology, MRI characteristics, and natural history of aBME remain unknown. To better characterize aBME in the lower extremities of military trainees and athletes. A systematic literature review in accordance with PRISMA guidelines was performed to identify primary research articles reporting on aBME in the lower extremities of athletes and military trainees. We identified 347 unique articles and after applying inclusion and exclusion criteria, 10 articles were included for qualitative synthesis. There were a total of 444 patients with an average age of 28.4±9.6 included. The most commonly used MRI sequences were proton-density with fat-saturation and T1-weighted imaging. The pattern of BME was inconsistently described, with various classification schemas used. The changes in aBME during longitudinal follow-up were dynamic and demonstrated both radiographic progression and regression. aBME is a highly prevalent and radiographically dynamic entity observed in high-level athletes and military trainees. Although follow-up was limited in the included studies, aBME may represent a natural, non-pathologic, reaction in response to specific biomechanical stressors.

Patterns of energy allocation during energetic scarcity; evolutionary insights from ultra-endurance events

Exercise physiologists and evolutionary biologists share a research interest in determining patterns of energy allocation during times of acute or chronic energetic scarcity. Within sport and exercise science, this information has important implications for athlete health and performance. For evolutionary biologists, this would shed new light on our adaptive capabilities as a phenotypically plastic species.In recent years, evolutionary biologists have begun recruiting athletes as study participants and using contemporary sports as a model for studying evolution. This approach, known as human athletic palaeobiology, has identified ultra-endurance events as a valuable experimental model to investigate patterns of energy allocation during conditions of elevated energy demand, which are generally accompanied by an energy deficit. This energetic stress provokes detectable functional trade-offs in energy allocation between physiological processes. Early results from this modelsuggest thatlimited resources are preferentially allocated to processes which could be considered to confer the greatest immediate survival advantage (including immune and cognitive function). This aligns with evolutionary perspectives regarding energetic trade-offs during periods of acute and chronic energetic scarcity.Here, we discuss energy allocation patterns during periods of energetic stress as an area of shared interest between exercise physiology and evolutionary biology. We propose that, by addressing the ultimate “why” questions, namely why certain traits were selected for during the human evolutionary journey, an evolutionary perspective can complement the exercise physiology literature and provide a deeper insight of the reasons underpinning the body's physiological response to conditions of energetic stress.

The role of stress and its impact on the formation of occupational burnout

The term "stress" is customarily used in connection with environmental pressures and adaptation to changing environmental conditions, but also in reference to the body's psychological and physiological response to them. In the understanding presented, adaptive demands are called stressors, their effects are called stress or stressful situations, and methods and techniques aimed at reducing these effects are called ways of coping with stress. Stress can also be understood as a "product" of inappropriate coping with the challenges of everyday life. The differentiation between stress as a process and stressor as a factor makes it easier to understand the issue and its impact on life and the development of mental illnesses.

Urgent Notification Of High Temperature Induced Mortality of Patients with Diabetes and Hypertension in Hodeidah Governorate ،Yemen

Dear Editor: Many researches and studies have shown a relationship between high and cold air temperature and an increase in mortality, especially for patients with cardiovascular disease.[5,6] Recently, associations between ambient temperature and morbidity have also been reported,[7,8] even though these associations have not always been similar in magnitude to mortality,[8] and null findings have also been reported.[9] Also, while the association between temperature and cardiovascular mortality has been reported to be U- shaped in many studies,[10] the association with cardiovascular hospitalization was reported to be linear in the US [7]. Increased blood pressure (BP) is a risk factor for cardiovascular mortality [14,15] and for coronary heart disease and stroke morbidity [16,17]. Therefore changes in BP might also play a part in the development of cardiovascular events that are associated with changes in temperature. The mechanisms behind temperature-related cardiovascular mortality and morbidity are not fully established. As elevated BP is a known risk factor for cardiovascular disease and stroke events, BP can also be part of the mechanism leading to temperature-related deaths. Epidemiological studies have shown that cardiovascular diseases rank first among the causes of death in China and have become a major disease within the Chinese population [18]. The effects of type 1 and type 2 diabetes on the body's physiological response to thermal stress is a relatively new topic in research. Diabetes tends to place individuals at greater risk for heat- related illness during heat waves and physical activity due to an impaired capacity to dissipate heat. Specifically, individuals with diabetes have been reported to have lower skin blood flow and sweating responses during heat exposure and this can have important consequences on cardiovascular regulation and glycemic control. Those who are particularly vulnerable include individuals with poor glycemic control and who are affected by diabetes-related complications [19]. As a result of the war and the siege on Yemen, the deterioration of living and health conditions, the interruption of electricity, the suspension of salaries for six years, and the arrival of about 80% of the population of Al-Hodeidah Governorate to a level below the poverty line. We have monitored as a result of the high temperature, which reached 48 degrees Celsius in the city of Hodeidah, 28 deaths of people with diabetes and arterial hypertension were monitored for the period from 5-6-2022 to 25-6-2022. This catastrophe occurred due to the government power outage as a result of the war and the siege on Yemen and the inability of people to buy expensive commercial electricity. This is considered a humanitarian disaster that requires a serious stand by the government, international organizations and the international community to save Hodeidah residents from extreme heat and poverty by providing electricity and humanitarian aid to contribute to improving the health and living situation in the governorate and supporting hospitals with fuel by the World Health Organization.

Granulocyte-macrophage colony-stimulating factor: Conductor of the wound healing orchestra?

Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a glycoprotein and is derived from both hemopoietic and nonhemopoietic sources which exert immunomodulatory properties. Various theories have been proposed to explain why some wounds become chronic and non-healing. Generalized suppression of inflammation locally or systemically may impede the body's physiological healing response by crippling the activity of reparative cells within the wound ecosystem. Thus, highlighting the importance of promoting host-directed therapeutics with immunomodulatory properties. The temporal and spatial expression of GM-CSF and GM-CSF receptors in the integumentary system suggests that epithelial-derived GM-CSF functions in an autocrine/paracrine manner. This may positively affect wound healing physiology via local inflammatory regulation promoting macrophage survival. Although diabetes negatively affects multiple aspects of wound healing GM-CSF activation is particularly impacted. Compared to acute/healthy wounds diabetic foot ulcers (DFU) only partially activate GM-CSF activity. There is a deleterious chain of events associated with this unfortunate sequala. DFUs also have a high proportion of monocytes and an absence of activated macrophages which results in an impaired inflammatory response. This may potentially serve as a vital point for GM-CSF to act as a companion diagnostic/theragnostic modality to help modulate the inflammatory response in wound healing. Correcting macrophage immune dysfunction with exogenous GM-CSF may help restore the immune balance in the wound ecosystem and jumpstart the wound healing cascade. Thus, the recognized beneficial role of GM-CSF in immune regulation across many studies provides a rationale for the initiation of the ongoing randomized controlled trials using GM-CSF.

Hubungan Kecerdasan Emosional Dengan Tingkat Kecemasan Dalam Menyusun Tugas Akhir Pada Mahasiswa Tingkat Akhir Institut Kesehatan Dan Bisnis St. Fatimah Mamuju

Anxiety is a sense of worry, nervousness, and even anxiety about something uncertain and can coexist, affect or cause depression. Anxiety experienced by students is related to external factors such as anxiety due to lack of knowledge in preparing the final project, delaying time due to many activities outside the final project so that it disrupts the development of the final project, and so on. The anxiety that students feel when dealing with final assignments can affect performance and graduation rates, because in this condition a person will experience a state of distortion of information processing that can interfere with the ability to be able to focus attention, reduce memory functions and others. Anxiety can arise as one of the body's physiological responses to be able to anticipate a problem that might come as a disturbance if it arises excessively. Until now, anxiety is also still a public disease. This study aims to determine the relationship between emotional intelligence and anxiety levels in preparing final assignments in final year students of St. Fatimah Mamuju Health and Business Institute in 2023. The type of research used in this study is a quantitative approach, using a cross sectional design. Sample 63 using total sampling technique. Data obtained by questionnaire and then analyzed by statistical tests. The results showed that based on the chi square test the p value = .725 <0.05, which means that there is no significant relationship between emotional intelligence in preparing the final project in final year students.

ODP029 Associations between Objective and Subjective Indicators of Stress and Sleep Disturbance in Adolescents and Young Adults from the General Population

Abstract Background Sleep is a complex and dynamic vital state, occupying one third of human's lifetime. Disturbed sleep can be a symptom of and a risk factor for a wide range of mental disorders and somatic diseases. One pathway through which sleep problems may lead to health problems is by dysregulation of the body's physiological stress response system as indicated by aberrant cortisol. Previous findings showed that poor sleep quality and sleep disruption were associated with elevated cortisol levels in adults. Regarding adolescents, there is evidence that sleep problems are linked to hyper-reactivity to stress with effects being stronger in girls than boys. In addition, adolescence itself was associated with decreased sleep quality and an increase in perceived stress dependent on age. However, little evidence is available for the association between objective and subjective stress markers and sleep in the daily life of adolescents from the general population. The aim of this study was to examine the association between 1) cortisol and 2) subjective stress with sleep in adolescents and young adults. Methods We used baseline data (11/2015–12/2016) of the Behavior and Mind Health(BeMIND) study, an epidemiological study based on a random community sample of individuals aged 14 to 21 years (Dresden, Germany, N = 1,180). We assessed sleep disturbance with the short form of the PROMIS Sleep-Disturbance questionnaire (8 items) via Ecological Momentary Assessment, conducted on four days directly after awakening, calculated mean. Cortisol was measured in hair (pg/mg) and saliva (nmol/l). Cortisol awakening response and total cortisol were calculated. Subjective stress was assessed via 1) the Perceived Stress Scale (PSS), 2) the Trier Inventory of the Assessment of Chronic Stress-Screening (TICS), and 3) two items for time urgency (subjective stress in school/at work/university and leisure, self-developed). Weighted linear regressions with robust standard errors were performed after exclusions (n = 1132, 48.4% female). Models were adjusted for sex, age, pubertal development and rerun in sex-specific analyses. Results Mean age was 17.83 (SD 0. 07). Neither hair, nor saliva cortisol was associated with PROMIS Sleep (hair cortisol: unstandardized β-coefficient: -0. 002, 95% confidence interval (CI): -0. 012; 0. 007). All analyzed subjective stress variables were associated with PROMIS Sleep. We found positive associations between PSS (β-coefficient: 0.151, 95% CI: 0.117; 0.183), TICS (β-coefficient: 0. 056, 95% CI: 0. 045; 0. 066), and time urgency (β-coefficient: 0.114, 95% CI: 0. 061; 0.166) with sleep. There was no evidence for sex-specific effects. Conclusion Results confirmed the association between perceived stress and sleep in a population-based study with adolescents and young adults, that was previously shown mainly in adults. No evidence for a link between cortisol and sleep was found. Further analyses would benefit from a longitudinal perspective and consideration of mediating/moderation variables to elucidate the complex interplay between stress and sleep. Presentation: No date and time listed

Inflammaging and body composition: New insights in diabetic and hypertensive elderly men

Age-related changes in the body's physiological responses play a critical role in systemic arterial hypertension (SAH) and type 2 Diabetes mellitus (T2DM). SAH and T2DM have clinically silent low-grade inflammation as a common risk factor. This inflammation has a relevant element, the excess of fatty tissue. In this scenario, little is known about how inflammatory markers interact with each other. Therefore, this work evaluated the interplay among anthropometric, biochemical, and inflammatory markers in the elderly with SAH and T2DM. Men aged 60–80 years old with SAH and T2DM were classified by body mass index (BMI) as eutrophic elderly (EE, 24 individuals) or overweight elderly (OE, 25 individuals). Body composition analysis was performed using bioimpedance. Blood samples were collected to perform inflammatory and biochemical evaluations. The cytokines IL-17A, IL-1β, IFN-y, TNF-α, and IL-10, were evaluated by ELISA. Triglycerides, total and fractions of cholesterol, and glucose were measured by spectrophotometry. Overweight elderly men had a higher glycemic index and an increase in most anthropometric markers, as well as higher means for all pro-inflammatory cytokines analyzed (IL-17A, IL-1β, IFN-y, and TNF-α) in comparison to their eutrophic elderly counterparts. However, there was a decrease in IL-10 anti-inflammatory cytokine and IL-10/IL-17A ratio compared to their eutrophic elderly counterparts. Although overweight elderly men have worsening inflammatory parameters, the magnitude of their correlations with anthropometric and biochemical parameters becomes less evident. The Bayesian networks highlight that in the eutrophic elderly, IL-17A and TNF-α are the cytokines most associated with interactions, and most of these interactions occur with biochemical parameters. It is worth highlighting the role of IFN-y in overweight elderly men. This cytokine influences IL-10 and TNF-α production, contributing to the inflammatory profile exacerbated in this group.

Body physiological responses of city bus drivers subjected to noise and vibration exposure in working environment

BackgroundThe city bus drivers have critical roles in public transport and are occupationally exposed to different environmental stressors. This study aimed to investigate body physiological responses of city bus drivers subjected to noise and vibration exposure while crossing city routes. MethodsThis cross-sectional study was conducted on 103 city bus drivers working in the governmental transportation system in Hamadan city. The subjects' exposures to noise and body vibration were measured during driving activities. Their blood pressure (BP), as well as heart rate (HR), were measured before and after driving. Multivariate regressions (MLR) were employed to analyze the effect size of the stimulus on body physiological responses using SPSS 22. ResultsExposure levels to noise, whole-body vibration (WBV), and hand-arm vibration among drivers were 79.50 ± 3.51dB, 0.620 ± 0.159 m/s2, and 0.438 ± 0.064 m/s2, respectively which were lower than the exposure limits. Heart rate as main physiological response before and after driving were 74.22 ± 4.11 and 79.23 ± 8.59 bpm, respectively. The developed MLR models statistically showed that noise exposure could only affect the HR (β = 0.193 and p < 0.001); while WBV exposure affected both BP (β = 0.360 and p < 0.001) and HR (β = 0.367 and p = 0.020). The statistical analysis represented that exposure to noise and vibration in the presence of other possible covariates have significant effects on body physiological responses. ConclusionThe study empirically confirmed the possibility of body physiological changes influenced by physical stimulus during real driving activities. It is highly recommended that occupational health surveillance should continuously be implemented to maintain and promote the safety and health of drivers throughout their careers.

Comparison of antipyretic activities of ethanol and ethyl acetate extracts of Bandotan herb (Ageratum conyzoides L.) in hyperpyrexia mice

Background: Fever is one of the body's physiological responses to metabolic stress, characterised by increasing body temperature. Based on its phytochemical content, Bandotan (tropical whiteweed) is an alternative antipyretic therapeutic agent. Flavonoids are potential chemical contents that can be extracted with various solvents, including ethanol and ethyl acetate. So far, research on its antipyretic potential is limited. Aim: To compare the antipyretic activity of ethanol extract to ethyl acetate extract of Bandotan herb in hyperpyrexia mice. Methods: Bandotan herb extracts were prepared by maceration, followed by phytochemical screening and determining total flavonoid content. Hyperpyrexia mice were made by induction of baker's yeast. Four hours after injection, mice were treated with Bandotan herb extracts, a dose of 100, 200, and 400 mg/kg body weight (BW), then the rectal temperature was observed for four hours. Results: Both extracts contained flavonoid, alkaloid, saponin, tannin, and steroid, while terpenoid was only found in ethanol preparation. The total flavonoid content of ethyl acetate extract was higher than that of ethanol extract. The best antipyretic activity was a dose of 400 mg/kg BW, but there was no significant difference in the percentage of pyrexia inhibition. Conclusion: Both extracts have the same ability to be developed as an alternative antipyretic agent.

Sauna use as a lifestyle practice to extend healthspan.

Sauna use, sometimes referred to as "sauna bathing," is characterized by short-term passive exposure to high temperatures, typically ranging from 45°C to 100°C (113°F to 212°F), depending on modality. This exposure elicits mild hyperthermia, inducing a thermoregulatory response involving neuroendocrine, cardiovascular, and cytoprotective mechanisms that work in a synergistic fashion in an attempt to maintain homeostasis. Repeated sauna use acclimates the body to heat and optimizes the body's response to future exposures, likely due to the biological phenomenon known as hormesis. In recent decades, sauna bathing has emerged as a probable means to extend healthspan, based on compelling data from observational, interventional, and mechanistic studies. Of particular interest are the findings from large, prospective, population-based cohort studies of health outcomes among sauna users that identified strong dose-dependent links between sauna use and reduced morbidity and mortality. This review presents an overview of sauna practices; elucidates the body's physiological response to heat stress and the molecular mechanisms that drive the response; enumerates the myriad health benefits associated with sauna use; and describes sauna use concerns.

Temporal stability and effect dynamics between executive functions, perceived chronic stress, and hair cortisol concentrations.

Accidents caused by human errors illustrate the fragility of cognitive processing and its coordination by executive functions against stress. To better understand how core executive functions change over time, influence each other, and are affected by chronic stress exposure, a prospective cohort study was conducted from 2016 to 2019. Five hundred sixteen German adults aged 25-55 years (mean age/education age: 38.0/11.3 years, 67% females, 94% occupied, 20% smokers) completed at least one internet-based biannual assessment of response inhibition, updating, and set shifting using a Go/NoGo, spatial 2-Back, and Number-Letter task, respectively. Chronic stress exposure was indicated by self-reports on the Perceived Stress Scale (PSS) and hair cortisol concentrations (HCC). Statistical analyses were performed by multivariate stochastic differential equation modeling. All indicators of executive functions (task-specific RTs in target trials or their contrast to nontarget trials) and chronic stress showed intraindividual stability over time (12% to 63% of their variance was attributable to trait influences). With respect to lagged mutual associations, faster Go/NoGo target RTs predicted faster Number-Letter target RTs later in time, while faster Number-Letter target RTs predicted higher HCC later in time (both with maximum effect sizes of d ≈ 0.1 standard deviations). However, PSS was not predictive of later HCC and vice versa. None of the chronic stress indicators significantly predicted indicators of executive functions at subsequent time points. These findings suggest that set shifting is capable of modulating the body's physiological response to chronic stress exposure, whereas executive functions appear comparably robust against chronic stress exposure. (PsycInfo Database Record (c) 2021 APA, all rights reserved).