Micromixers have found extensive applications in various fields such as engineering, biomedicine, medical and chemistry. The utilization of vortex-induced vibration (VIV) of bluff bodies can greatly enhance fluid mixing in micromixers. This study focuses on numerically investigating the interaction between vortex-induced vibration of two cylinders, labeled Cyl-S (stationary cylinder) and Cyl-V (vibrating cylinder), and the mixing performance of micromixers. Specifically, the study examines the effects of spacing ratio (S/D) and vibration system configurations (Cyls-S+S, Cyls-S+V, and Cyls-V+V) on vibration response, near-wake structure, mixing concentration, and mixing index. The results indicate that the spacing ratio directly influences the vibration response of the cylinders, thereby significantly impacting the mixing performance. For the Cyls-V+V configuration, the downstream cylinder exhibits a considerably higher vibration amplitude compared to the upstream cylinder. Increasing the S/D ratio substantially improves the mixing effect in the Cyls-S+S configuration. For the Cyls-S+V and Cyls-V+V configurations, the enhancement of mixing due to VIV is particularly noticeable when S/D ratios of 2 and 3 are employed. The mixing index for Cyls-V+V is higher than that for Cyls-S+V within the range of 3 ≤ U⁎ ≤ 5 (where U* represents the reduced velocity). At a reduced velocity of U⁎ = 4 for Cyls-V+V, the optimal mixing indexs are found to be 0.77 (S/D = 2), 0.76 (S/D = 3), 0.78 (S/D = 4), and 0.77 (S/D = 5), respectively. However, when U⁎ = 6–10, the mixing index decreases due to the vibration of the cylinder is suppressed. Additionally, the Cyls-V+V configuration exhibits a significantly higher pressure drop within the flow channel compared to the Cyls-S+V configuration.
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