Body Systems Research Articles

Potential Therapeutic Targets for the Management of Diabetes Mellitus Type 2

Diabetes is one of the lifelong chronic metabolic diseases which is prevalent globally. There is a continuous rise in the number of people suffering from this disease with time. It is characterized by hyperglycemia, which leads to severe damage to the body's system, such as blood vessels and nerves. Diabetes occurs due to the dysfunction of pancreatic β-cell which leads to the reduction in the production of insulin or body cells unable to use insulin produce efficiently. As per the data shared International diabetes federation (IDF), there are around 415 million affected by this disease worldwide. There are a number of hit targets available that can be focused on treating diabetes. There are many drugs available and still under development for the treatment of type 2 diabetes. Inhibition of gluconeogenesis, lipolysis, fatty acid oxidation, and glucokinase activator is emerging targets for type 2 diabetes treatment. Diabetes management can be supplemented with drug intervention for obesity. The antidiabetic drug sale is the second-largest in the world, trailing only that of cancer. The future of managing diabetes will be guided by research on various novel targets and the development of various therapeutic leads, such as GLP-1 agonists, DPP-IV inhibitors, and SGLT2 inhibitors that have recently completed their different phases of clinical trials. Among these therapeutic targets associated with type 2 diabetes, this review focused on some common therapeutic targets for developing novel drug candidates of the newer generation with better safety and efficacy.

Manifestaciones neurológicas de enfermedades sistémicas: aspectos claves para el clínico

The nervous system interacts with all other systems in the human body on a continuous ba-sis. It’s not uncommon for a disease to exhibit neurological symptoms that are not solely at-tributable to a primary nervous system disorder, but, rather, to the intricate relationships the nervous system has with other organs. This article reviews how diverse gastrointesti-nal, endocrine, rheumatic, kidney, heart, and other affections manifest in the neurological system. Key points, frequent symptoms, and signs are thus summarized to provide a com-prehensive understanding of the relationship between systemic diseases and neurological symptoms. Emphasizing the clinical presentation of a selected group of conditions, it is hoped that clinicians can better recognize the potential for neurological symptoms in pa-tients with systemic diseases, and the potential for systemic diseases in patients exhibiting neurological symptoms, leading to earlier diagnosis and improved outcomes.

FP-GCN: Frequency Pyramid Graph Convolutional Network for Enhancing Pathological Gait Classification

Gait, a manifestation of one’s walking pattern, intricately reflects the harmonious interplay of various bodily systems, offering valuable insights into an individual’s health status. However, the current study has shortcomings in the extraction of temporal and spatial dependencies in joint motion, resulting in inefficiencies in pathological gait classification. In this paper, we propose a Frequency Pyramid Graph Convolutional Network (FP-GCN), advocating to complement temporal analysis and further enhance spatial feature extraction. specifically, a spectral decomposition component is adopted to extract gait data with different time frames, which can enhance the detection of rhythmic patterns and velocity variations in human gait and allow a detailed analysis of the temporal features. Furthermore, a novel pyramidal feature extraction approach is developed to analyze the inter-sensor dependencies, which can integrate features from different pathways, enhancing both temporal and spatial feature extraction. Our experimentation on diverse datasets demonstrates the effectiveness of our approach. Notably, FP-GCN achieves an impressive accuracy of 98.78% on public datasets and 96.54% on proprietary data, surpassing existing methodologies and underscoring its potential for advancing pathological gait classification. In summary, our innovative FP-GCN contributes to advancing feature extraction and pathological gait recognition, which may offer potential advancements in healthcare provisions, especially in regions with limited access to medical resources and in home-care environments. This work lays the foundation for further exploration and underscores the importance of remote health monitoring, diagnosis, and personalized interventions.

Endosulfan induces reproductive & genotoxic effect in male and female Swiss albino mice

BackgroundToxicity by pesticide has become a global health issue and leaves a harmful impact on human health via various ways. The people exposed to pesticides in the rural population get affected by the harmful effects of it as they enter the human body system through skin, inhalation, oral administration, food chain and many more ways. The present work is designed to study the toxic effect of endosulfan in male (n=30) and female (n=30) Swiss albino mice. Endosulfan was administered by oral gavage (oral administration) method, at the dose of 3.5 mg/Kg body weight daily for period of 3 weeks, 5 weeks and 7 weeks. After the completion of the treatment, the mice were sacrificed and their ovary and testis tissues were dissected out to check the degeneration. The blood was collected for karyotyping, biochemical and hormonal analysis of pesticide induced genotoxicity. After 7 weeks of administration with Endosulfan, various abnormalities were observed in male and female mice.ResultsTreatment with endosulfan at the dose of 3.5 mg/Kg body weight caused a higher degree of degeneration in the reproductive organ of Swiss albino mice . Treatment by this pesticide generated degeneration in long duration of dosage for 3,5 and 7 weeks. Ovaries of endosulfan administered groups showed degenerated germinal epithelium, Graffian follicles and corpus luteum. In testis of endosulfan treated mice, microscopic examination showed that there is significant damage and reduction in the tissue of seminiferous tubules and primordial germ cells. High degree of degeneration caused the disarrangement and deformation of spermatogonia with the decrease in the number of Sertoli cells. Biochemical and hormonal properties was also affected by endosulfan treatment. There was significant 5 folds decrease in the testosterone value of endosulfan in 7 weeks treated mice in comparison to control (p < 0.0001) and similarly there was significant elevation in the estrogen levels found in 7th week endosulfan treated mice. It also influenced the level of free radicals as there was significant decrease (p < 0.0001) in the value in catalase levels in 7 weeks endosulfan treated male and female mice, while significant (p < 0.0001) increase in the values of lipid peroxidation levels as 8 folds and 10 folds in 7 weeks endosulfan treated male and female Swiss albino mice respectively. This study hence speculates that the endosulfan exposed population are at the risk of reproductive health hazards.ConclusionsThe present study thus concludes that, endosulfan after 7 weeks of exposure caused significant reproductive damage to both male and female Swiss albino mice groups. Moreover, the karyotyping study also correlated the genotoxic damage in the mice.

Impact of vitamin D on ultraviolet-induced photoaging and skin diseases

Excessive exposure to ultraviolet (UV) radiation causes premature aging of the skin, known as photoaging. UV radiation induces DNA damage, oxidative stress, inflammatory reactions, and degradation of extracellular matrix (ECM) proteins, contributing to the aged skin phenotype. The skin synthesizes vitamin D upon UVB exposure, which plays a pivotal role in the proper function of multiple body systems. Vitamin D protects skin from photo-damage by repairing cyclobutane pyrimidine dimers, reversing oxidative stress, and reducing chronic inflammation. Moreover, various epidemiological studies have identified vitamin D deficiency as a marker for common dermatological disorders. Improvement of clinical outcomes with vitamin D supplementation further suggests its protective role against skin pathologies. This review comprehensively covers the involvement of vitamin D in combating UV-induced photoaging and various skin disorders, highlighting the significance of maintaining vitamin D adequacy for healthy skin.

LONG-TERM EFFECTS OF COVID-19

The COVID-19 pandemic has been a defining global event, impacting nearly every aspect of life worldwide. This paper presents a review of the long-term effects of COVID-19, focusing on the impacts on people’s physical and mental health. It synthesizes current knowledge from different studies, articles, analyses, and case reports to provide a comprehensive understanding of the prolonged physical, psychological and socioeconomic consequences of COVID-19. The virus has prolonged effects on various organ systems in human body especially in individuals who experienced severe cases or complications, as well as profound psychological impact. Efforts to address the physical and mental consequences of COVID-19 require a comprehensive approach involving healthcare professionals, mental health providers, policymakers, community organizations, and individuals themselves.

A Critical View on Virudha Aahar: Dietic Incompatibility

The three Upstambha (Aahar, Swapna, and Brahmchraya) that describe in the Ayurvedic Samhitas. These three Upstambha hold the body. The body gains strength, firmness, and Varna by carefully using these three pillars. Aahar, the first Upstambha, is helpful for keeping the body in a healthy state. However, people are now consuming improper foods in the wrong combinations. Certain drugs and dietary combinations that have traits in opposition to body elements may decrease the body's immunity. Such types of foods are referred to as Virudha Aahar in old Ayurvedic texts. This article describes how individuals nowadays consume Virudha Aahar and how it has adverse effects on the human health. What impacts do they have on each physiological system of human body?

To the problem of improving technical skills of ski racers

The article examines the ways of optimizing the educational process and improving the management of motor actions in sports training by using different activity conditions (modes, action tasks) and creating functional systems of the technology of progression of sports skills. It has been established that the regimes of alternating exercises with rest are a means of selective action on indicators of general and special work capacity, coordination structure of movements, reaction of the body’s service systems. The effect of alternating exercise regimes with rest "A" and "B" and action tasks "faster thrust", "wider step" on the change of individual indicators of technique, movements, speed, speed endurance of ski racers when overcoming climbs was established. The practical significance of the obtained data is that they allow building models of directed and previously known action not only for the change of the integral indicator of special performance, but also for the parameters of the coordination structure of movements, as well as to determine the athlete's behavior program depending on the topography of the competition. Research results make it possible to create models of lessons that selectively affect various systems of the athletes' body and contribute to more accurate management of the development of special working capacity, the formation of technical skills. The application of these models in the general structure of the development of special capacity for work creates an opportunity to comprehensively influence a person as a complex organized, self-regulating system. Practical use of research results optimizes the process of managing sports training over a longer period of time.

Impact of Yoga Awareness on Transmission Dynamics of Communicable Diseases: SIR Model Analysis

Communicable diseases are major health problems that affect the whole economy of the na-tion. So it becomes the prime agenda of developed and developing countries to educate peo-ple about disease dynamics and control strategies. Due to changes in people’s living styles, disease treatment modality has been changed. So, we have introduced Yoga awareness as control strategy which includes Ahar, Vihar, Achar and Vichar. They are means for achiev-ing the physical, mental, social and spiritual well-being. Our main aim is to model the role of Yoga awareness in controlling the disease dynamics. It maintains the physical fitness of practitioners and improve the whole metabolism system of the human body. In this work, the previous SIR model is modified by incorporating a new awareness transmission rate β 1 to the existing model. Real life situation data of Yoga aware and aware infected individuals were col-lected from different Yoga centers of Sudurpashchim province, Nepal and analyzed by using mathematical techniques. Stability analysis of governing by ordinary differential equations showed that model is stable. Yoga awareness reproduction number Ra was calculated by next-generation matrix method. Sensitivity analysis of Ra and concerning parameters indicate that Ra decreases with an increase in Yoga awareness coverage level. Also, the recovery rate has the opposite relation with Ra which indicates that the recovery period also decreases with an increase in awareness coverage. Local and global stability analysis showed that disease-free equilibrium exists when Ra &lt; 1 and endemic equilibrium exists when Ra &gt; 1. Numerical simulations also support the analytical results and suggest that Yoga awareness has a positive influence on controlling disease d ynamics. The increase in the coverage of awareness leads to reduced susceptibility and infectivity. So propagation of disease can be controlled by Yoga awareness.

The value of fetal magnetic resonance imaging in diagnosis of congenital anomalies of the fetal body: a systematic review and meta-analysis.

To undertake a systematic review to assess the accuracy of fetal MRI in diagnosis of non-CNS congenital anomalies of the fetal body in comparison with antenatal ultrasound when correlated to postnatal diagnosis. Searches were conducted from electronic databases, key journals and reference lists for eligible papers. Inclusion criteria was original research studies comparing the diagnostic results of antenatal ultrasound, fetal MRI and final postnatal diagnosis via imaging, surgery or post-mortem testing. Studies of CNS anomalies were excluded. Studies were assessed for risk of bias by two reviewers working independently and data was then extracted by a single reviewer. 12 studies were included with a total of 361 eligible patients who underwent USS and MRI and had a postnatal diagnosis. USS alone had a diagnostic accuracy of 60.6% whereas MRI had an improved diagnostic accuracy of 86.4%. The overall odds ratio was 0.86 (CI 0.202-1.519 and p-value < 0.01). Fetal MRI makes a significant contribution to accurate diagnosis of congenital abnormalities of the fetal body; especially in genito-urinary anomalies. More research is needed to improve the evidence base for the role of fetal MRI in diagnosis of congenital anomalies in other body systems.

Appendicitis with Periappendiceal Abscess and Phlegmon in Second Trimester Pregnancy: A Case Report

There is anatomical, physiological and biochemical changes in all body systems in pregnancy and these changes can be often misinterpreted as pathological. The unreliable nature of complaint reports, examination findings, and laboratory parameters in pregnancy appendicitis cases makes it challenging for physicians to diagnose and manage cases effectively. So, we present a case report with presentation dangling between its typical and atypical form.

Ceria nanoparticles: biomedical applications and toxicity.

Ceria nanoparticles (CeO2 NPs) have become popular materials in biomedical and industrial fields due to their potential applications in anti-oxidation, cancer therapy, photocatalytic degradation of pollutants, sensors, etc. Many methods, including gas phase, solid phase, liquid phase, and the newly proposed green synthesis method, have been reported for the synthesis of CeO2 NPs. Due to the wide application of CeO2 NPs, concerns about their adverse impacts on human health have been raised. This review covers recent studies on the biomedical applications of CeO2 NPs, including their use in the treatment of various diseases (e.‍g., Alzheimer's disease, ischemic stroke, retinal damage, chronic inflammation, and cancer). CeO2 NP toxicity is discussed in terms of the different systems of the human body (e.‍g., cytotoxicity, genotoxicity, respiratory toxicity, neurotoxicity, and hepatotoxicity). This comprehensive review covers both fundamental discoveries and exploratory progress in CeO2 NP research that may lead to practical developments in the future.

The effect of alcoholic extract of Citrullus colocynthis on the structural manifestations of the parasite Fasciola gigantica and its comparison with the drug pendazole

The current study aims to find out the effect of alcoholic extracts of the fruit of the Citrullus colocynthis plant, as it was during the current study during the period from 12/2/2022 to 24/4/2023 and by 206 livers for cows, including (31) infected livers and 1348 livers for sheep that did not show infection. In the current study, the incidence of giant liver Fasciola gigantica cows was 15.04%, while sheep hadn't infection during the study period. The results of the current study show that there are different effects in the tissues of the treated worms if compared to the control group, which was showing the integrity of the tissues well after 6 hours, as it is observed the layers of the body wall, spines and muscle layers that cover the wall, as well as the parenchyma tissue in which the body systems are embedded, which did not notice any changes in those tissues and structures, which include (for intestinal backfilling, testicles, mules and uterus). As noted, the damages vary according to the concentration of separation and deformation in the longitudinal and circular muscles, and a few cells are seen in the tenderloin. The thorns are still present in the cover, and the effect of the drug albendazole is little practical Clearly.

Oxidative Stress in Breast Cancer: A Biochemical Map of Reactive Oxygen Species Production.

This review systematizes information about the metabolic features of breast cancer directly related to oxidative stress. It has been shown those redox changes occur at all levels and affect many regulatory systems in the human body. The features of the biochemical processes occurring in breast cancer are described, ranging from nonspecific, at first glance, and strictly biochemical to hormone-induced reactions, genetic and epigenetic regulation, which allows for a broader and deeper understanding of the principles of oncogenesis, as well as maintaining the viability of cancer cells in the mammary gland. Specific pathways of the activation of oxidative stress have been studied as a response to the overproduction of stress hormones and estrogens, and specific ways to reduce its negative impact have been described. The diversity of participants that trigger redox reactions from different sides is considered more fully: glycolytic activity in breast cancer, and the nature of consumption of amino acids and metals. The role of metals in oxidative stress is discussed in detail. They can act as both co-factors and direct participants in oxidative stress, since they are either a trigger mechanism for lipid peroxidation or capable of activating signaling pathways that affect tumorigenesis. Special attention has been paid to the genetic and epigenetic regulation of breast tumors. A complex cascade of mechanisms of epigenetic regulation is explained, which made it possible to reconsider the existing opinion about the triggers and pathways for launching the oncological process, the survival of cancer cells and their ability to localize.

Hereditary human diseases with skeletal pathology – molecular pathogenesis and clinical characteristics

Differential diagnosis of hereditary diseases is challenging due to similar clinical manifestations, diversity of nosologies, wide clinical variability and genetic heterogeneity, severity, rare frequency and complex molecular etiology. In some of them, connective tissue as a whole is involved in the pathological process, affecting almost all organs and systems of the human body, and in particular bone tissue, disrupting its remodeling and microarchitecture. The defect can occur at any of the stages of remodeling: during the initiation process, during bone resorption, osteoblast differentiation, osteoid mineralization, etc. Violation of the microarchitecture of bone tissue is accompanied by the development of low-traumatic fractures and deformities, early osteoarthritis, the formation of contractures and chronic pain syndrome. Genetic studies of patients have expanded knowledge about the molecular signaling pathways that coordinate bone development and metabolism, the nature of disease inheritance, clinical features, and specific bone biomarkers. This article provides an overview of key cellular mechanisms, features of diagnosis and treatment of hereditary human diseases that affect the condition of bone tissue and skeleton: osteogenesis imperfecta, EhlersDanlos syndrome, Marfan syndrome, juvenile osteoporosis, hypophosphatasia, osteopetrosis, progressive diaphyseal dysplasia, mucopolysaccharidoses, achondroplasia, multiple hereditary exostoses. Doctors of different specialties can encounter these diseases, and making a correct diagnosis will make it possible to determine the correct algorithm for patient management and begin timely treatment, the ability to prevent the development of severe complications, improve the quality of life of patients, restore maximum working capacity and reduce the percentage of disability.

A 3D In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface

Emerging regenerative cell therapies for alveolar bone loss have begun to explore the use of cell laden hydrogels for minimally invasive surgery to treat small and spatially complex maxilla-oral defects. However, the oral cavity presents a unique and challenging environment for in vivo bone tissue engineering, exhibiting both hard and soft periodontal tissue as well as acting as key biocenosis for many distinct microbial communities that interact with both the external environment and internal body systems, which will impact on cell fate and subsequent treatment efficacy. Herein, we design and bioprint a facile 3D in vitro model of a human dentine interface to probe the effect of the dentine surface on human mesenchymal stem cells (hMSCs) encapsulated in a microporous hydrogel bioink. We demonstrate that the dentine substrate induces osteogenic differentiation of encapsulated hMSCs, and that both dentine and β-tricalcium phosphate substrates stimulate extracellular matrix production and maturation at the gel-media interface, which is distal to the gel-substrate interface. Our findings demonstrate the potential for long-range effects on stem cells by mineralized surfaces during bone tissue engineering and provide a framework for the rapid development of 3D dentine-bone interface models.

Silver nanoparticles forensic uses and toxicity on vital organs and different body systems

This study aimed to investigate the forensic uses and potential toxicity of silver nanoparticles on vital organs and different body systems. A systematic review methodology was used to identify and critically evaluate the literature on the forensic uses of silver nanoparticles in different fields and to assess their potential toxicity on various vital organs and body systems. The study found that silver nanoparticles have potential forensic uses, particularly in forensic biology and forensic toxicology, but there are concerns about their potential toxicity. The study recommends further research on the mechanisms of toxicity of silver nanoparticles and the development of safe and effective strategies for their use in forensic science. The study’s strengths include its systematic review methodology and use of multiple databases, while limitations include a limited time frame and focus on English language publications. Future research should focus on investigating the potential risks of silver nanoparticle exposure for forensic professionals.

Determination of the Energy Eigenvalues of the Varshni-Hellmann Potential

In this paper, we solve the bound state problem for the Varshni-Hellmann potential via a useful technique. In our technique, we obtain the bound state solution of the Schrödinger equation for the Varshni-Hellmann potential via ansatz method. We obtain the energy eigenvalues and the corresponding eigenfunctions. Also, the behavior of the energy spectra for both the ground and the excited state of the two body systems is illustrated graphically. The similarity of our results to the accurate numerical values is indicative of the efficiency of our technique.

Detection of Cadmium in Human Biospecimens by a Cadmium-Selective Whole-Cell Biosensor Based on Deoxyviolacein.

Cadmium poses a severe health risk, impacting various bodily systems. Monitoring human exposure is vital. Urine and blood cadmium serve as critical biomarkers. However, current urine and blood cadmium detection methods are expensive and complex. Being cost-effective, user-friendly, and efficient, visual biosensing offers a promising complement to existing techniques. Therefore, we constructed a cadmium whole-cell biosensor using CadR10 and deoxyviolacein pigment in this study. We assessed the sensor for time-dose response, specific response to cadmium, sensitivity response to cadmium, and stability response to cadmium. The results showed that (1) the sensor had a preferred signal-to-noise ratio when the incubation time was 4 h; (2) the sensor showed excellent specificity for cadmium compared to the group 12 metals and lead; (3) the sensor was responsive to cadmium down to 1.53 nM under experimental conditions and had good linearity over a wide range from 1.53 nM to 100 μM with good linearity (R2 = 0.979); and (4) the sensor had good stability. Based on the excellent results of the performance tests, we developed a cost-effective, high-throughput method for detecting urinary and blood cadmium. Specifically, this was realized by adding the blood or urine samples into the culture system in a particular proportion. Then, the whole-cell biosensor was subjected to culture, n-butanol extraction, and microplate reading. The results showed that (1) at 20% urine addition ratio, the sensor had an excellent curvilinear relationship (R2 = 0.986) in the range of 3.05 nM to 100 μM, and the detection limit could reach 3.05 nM. (2) At a 10% blood addition ratio, the sensor had an excellent nonlinear relationship (R2 = 0.978) in the range of 0.097-50 μM, and the detection limit reached 0.195 μM. Overall, we developed a sensitive and wide-range method based on a whole-cell biosensor for the detection of cadmium in blood and urine, which has the advantages of being cost-effective, ease of operation, fast response, and low dependence on instrumentation and has the potential to be applied in the monitoring of cadmium exposure in humans as a complementary to the mainstream detection techniques.

The relationship between dietary intake of ω-3 and ω-6 fatty acids and frailty risk in middle-aged and elderly individuals: a cross-sectional study from NHANES.

Frailty is a complex clinical syndrome characterized by a decline in the functioning of multiple body systems and reduced adaptability to external stressors. Dietary ω-3 fatty acids are considered beneficial dietary nutrients for preventing frailty due to their anti-inflammatory and immune-regulating properties. However, previous research has yielded conflicting results, and the association between ω-6 fatty acids, the ω-6: ω-3 ratio, and frailty remains unclear. This study aims to explore the relationship between these factors using the National Health and Nutrition Examination Survey (NHANES) database. Specialized weighted complex survey design analysis software was employed to analyze data from the 2005-2014 NHANES, which included 12,315 participants. Multivariate logistic regression models and restricted cubic splines (RCS) were utilized to assess the relationship between omega intake and frailty risk in all participants. Additionally, a nomogram model for predicting frailty risk was developed based on risk factors. The reliability of the clinical model was determined by the area under the receiver operating characteristic (ROC) curve, calibration curves, and decision curve analysis (DCA). In dietary ω-3 intake, compared to the T1 group (≤1.175 g/d), the T3 group's intake level (>2.050 g/d) was associated with approximately 17% reduction in frailty risk in model 3, after rigorous covariate adjustments (odds ratio (OR) = 0.83, 95% confidence interval (CI): (0.70, 0.99)). In dietary ω-6 intake, the T2 group's intake level (>11.423, ≤19.160 g/d) was associated with a 14% reduction in frailty risk compared to the T1 group (≤11.423 g/d) (OR: 0.86, 95% CI: 0.75, 1.00, p = 0.044). RCS results indicated a non-linear association between ω-3 and ω-6 intake and frailty risk. Both ROC and DCA curves demonstrated the stability of the constructed model and the effectiveness of an omega-rich diet in reducing frailty risk. However, we did not find a significant association between the ω-6: ω-3 ratio and frailty. This study provides support for the notion that a high intake of ω-3 and a moderate intake of ω-6 may contribute to reducing frailty risk in middle-aged and elderly individuals.