Body Mass Index In Old Age Research Articles

Body mass index, waist circumference, and mortality risks over 27 years of follow-up in old age

PurposeThis study investigates the predictive effects of body mass index (BMI) and waist circumference (WC) for all-cause mortality in old age over 27 years of follow-up. MethodsParticipants were from the Berlin Aging Study (n = 444, M ± SD = 84.55 ± 8.38 years). Reported significance values for hazard ratios were adjusted for age, sex, socioeconomic status, smokers, depressive illness, functional status, cholesterol, and objectively assessed physical diseases. ResultsBMI emerged as a significant predictor of all-cause mortality after adjustment. WC was not a significant predictor of mortality either within the unadjusted model or when fully adjusted, including BMI. After the introduction of WC alongside all covariates, the effect for BMI remained significant. A significant quadratic effect for BMI and mortality within the fully adjusted model also emerged. ConclusionsOur results suggest that lower BMI in the oldest old is associated with increased mortality hazards, and risks were particularly elevated for people who are underweight. This study found no evidence that higher BMI in old age is associated with increased mortality hazards relative to normal weight ranges.

Adiposity in middle and old age and risk of death from dementia: 40-year follow-up of 19,000 men in the Whitehall study.

to examine the hypothesis that obesity is protective for dementia, we compared the associations of death from dementia with body weight and body mass index (BMI) in both middle and old age. height and weight were measured in a prospective study of 19,019 middle-aged men in the Whitehall study in 1967-70 and in 6,158 surviving participants at resurvey in 1997. Cox regression was used to examine the associations of death from dementia over a 40-year period with weight or BMI measured by health professionals in middle and old age adjusting for age, smoking habits, employment grade and marital status. central government employees in London, UK. death due to dementia in 320 participants. body weight measured in middle age was weakly inversely associated with death from dementia (hazard ratio 0.98 [95%CI: 0.97-0.99] per kg), but neither height nor BMI were related to risk of dementia. In contrast, body weight in old age was more strongly inversely related to deaths from dementia (0.96; [0.95-0.98] per kg) as was BMI (0.92 [0.86-0.97] per kg/m2). Weight loss over the 30 years between baseline and resurvey was associated with a higher risk of death from dementia, with an adjusted HR per kg/30 years of 1.04 [95%CI: 1.02-1.08] and the association with loss of BMI was even stronger (adjusted HR of 1.10 [1.03-1.19]) per kg/m2 decrease. the stronger inverse associations of deaths from dementia with BMI in old age, compared with middle age, together with strong positive associations of loss of BMI or body weight between middle and old age casts doubt on previous suggestions that obesity protects against death from dementia.

Cause-specific mortality in old age in relation to body mass index in middle age and in old age: follow-up of the Whitehall cohort of male civil servants

The relevance of body mass index (BMI) to cause-specific mortality in old age is uncertain. To examine cause-specific 5 year mortality in old age by BMI in old age and middle age (40-69 years). Cox proportional hazards for mortality rates among 4862 former male civil servants in relation to quartiles of BMI measured when screened in 1968-70 and when resurveyed in 1997-98 (median age 76 years). The association between all-cause mortality after resurvey and BMI in old age was U-shaped with hazard ratios (HRs) of 1.3 (95% CI 1.1-1.5) for the lightest and heaviest categories relative to the middle two. Among 'healthy' men the lightest (<22.7 kg/m2) had greatest all-cause mortality. The heaviest men (>26.6 kg/m2) had increased risk of cardiovascular disease (CVD) mortality in the first two years or for the whole period if never-smokers. Respiratory mortality was inversely associated with BMI in old age [adjusted HR for trend per BMI category increase 0.6 (0.5-0.7)] but cancer mortality lacked a clear pattern. Net gain or loss of 10 kg or more between middle and old age was a strong predictor of all-cause and CVD mortality. The shape of the association between BMI in old age and mortality differs by cause of death. Major weight change over time is a warning signal for higher CVD mortality. Having BMI<22.7 kg/m2 in old age is associated with above-average mortality rates even if apparently healthy.