Body Filler Research Articles

Nonsurgical Gluteal Volume Correction with Hyaluronic Acid: A Retrospective Study to Assess Long-term Safety and Efficacy

Background: Augmentation and reshaping of body volume, particularly in the gluteal area, presents a significant challenge in aesthetic surgery. Hyaluronic acid (HA) fillers have emerged as an effective and safe tool for such indications, but literature examining nonsurgical gluteal reshaping with HA remains limited. This study aims to evaluate the long-term safety of using recommended volumes of HA body fillers for nonsurgical gluteal augmentation. Methods: A retrospective, observational study was carried out across multiple centers in Italy and the United Arab Emirates. The study involved participants between 22 and 53 years of age who underwent gluteal augmentation using HA body filler (HYAcorp MLF1/2) between 2017 and 2021, with up to 4 years and 7 months of follow-up. Participants and investigators independently evaluated the procedure’s effectiveness by comparing pre- and posttreatment photographs. The Global Aesthetic Improvement Scale was used to assess posttreatment satisfaction by both participants and investigators. All adverse effects (AEs) were recorded. Results: The study included a diverse group of 91 participants. No serious adverse events were reported, with the majority of AE occurring shortly after treatment and resolving in 1 week. AEs were more frequently observed in participants with previous treatments using different substances in the treatment area. Conclusions: The real-world application of HA body filler (HYAcorp MLF1/2) for gluteal augmentation in the participants of this study showed the treatment’s effectiveness, with no severe adverse events reported among the participants. High levels of satisfaction were reported among both participants and investigators.

Photocurable Thiol-yne Alginate Hydrogels for Regenerative Medicine Purposes.

Every year millions of people worldwide undergo surgical interventions, with the occurrence of mild or severe post-treatment consequences meaning that rehabilitation plays a key role in modern medicine. Considering the cases of burns and plastic surgery, the pressing need for new materials that can be used for wound patches or body fillers and are able to sustain tissue regeneration and promote cell adhesion and proliferation is clear. The challenges facing next-generation implant materials also include the need for improved structural properties for cellular organization and morphogenic guidance together with optimal mechanical, rheological, and topographical behavior. Herein, we propose for the first time a sodium alginate hydrogel obtained by a thiol-yne reaction, easily synthesized using carbodiimide chemistry in a two-step reaction. The hydrogels were formed in all cases within a few minutes of light irradiation, showing good self-standing properties under solicitation. The mechanical, rheological, topographical, and swelling properties of the gels were also tested and reported. Lastly, no cytotoxicity was detected among the hydrogels. Soluble extracts in culture media allowed cell proliferation, and no differences between samples were detected in terms of metabolic activity and DNA content. These results suggest the potential use of these cytocompatible hydrogels in tissue engineering and regenerative medicine.

Dynamic ultrasound evaluation of body fillers and biostimulators in the buttocks of fresh-frozen specimen.

Ultrasound imaging is a useful tool to study the injection of fillers and biostimulators in the body. Sonographically evaluate real-time injections of fillers and biostimulators and describe their behavior in the subcutaneous tissue of the buttocks of fresh-frozen specimen. injection of two brands of high-density hyaluronic acid (HA), one brand of calcium hydroxyapatite (CaHA), one brand of hybrid injectable (CaHa + HA), one brand of polycaprolactone (PCL) and three brands of poly-l-lactic acid (PLLA) were performed in the subcutaneous tissue of the gluteal region under ultrasonography visualization on a fresh-frozen specimen. Videos during injection and static images immediately after injection were obtained. The sonographic aspects of the substances and their dispersion and interaction with the surrounding tissues were described. Real-time ultrasound showed different dispersion patterns of the two brands of HA, CaHA, hybrid injectable (CaHa + HA) and the three brands of PLLA. The sonographic aspects among the brands of PLLA were also different. The dynamic ultrasound evaluation of the injection of HA, CaHA, hybrid injectable (CaHa + HA), PCL and PLLA in a fresh-frozen specimen shed some light on their aspects and dispersion pattern in the buttock. If these patterns are confirmed in further studies in vivo, there will be a positive impact on the selection and development of safer and more effective techniques to enhance buttock contour.

The Downside of Beauty: ASIA Syndrome Associated with Local Silicone Injections: A Literature Review

Silicone has been widely used over the last two decades, mainly for aesthetic purposes. Growing data show that local free/liquid silicone injections, used as body filler, are possibly related to the onset of adverse effects, with autoimmune and inflammatory features. Several reactions have been described, some of which can be classified as ASIA-Autoimmune/Inflammatory Syndrome Induced by Adjuvants. Clinical presentations range from local inflammatory reactions to full-blown systemic autoimmune diseases. These cases share the similar chronological, clinical and histopathological features, as well as treatment rationale. The link between silicone breast implants and autoimmune disorders are still under debate, but local liquid silicone injections adverse effects are sporadically reported. The aim of this review is to identify common features of autoimmune and inflammatory adverse effects of local liquid silicone injections.

Fabrication of nanofibrous electrospun scaffolds from a heterogeneous library of co- and self-assembling peptides.

Construction of peptide hydrogels has received considerable attention due to their potential as nanostructures amenable of easy functionalization and capable of creating microenvironments suited for culturing cells and triggering tissue regeneration. They display a superior biocompatibility unmatched by other known synthetic biomaterials so far. However, their applications are confined to body fillers because most of them do spontaneously form hydrogels, while effective tissue regeneration often requires well-defined fibrous scaffolds. In this work, we developed electrospun fibers of various peptides (cross-beta self-assembling, hierarchically assembling, functionalized, co-assembling) and we provided a deep understanding of the crucial phenomena to be taken into account when peptides fibers fabrication. These results open new venues for exploring novel regenerative applications of peptide nanofibrous scaffolds.

Facial rejuvenation: Serial fat graft transfer

Autologous fat transfer is a century-old method for both aesthetic and reconstructive purposes. It is considered by many plastic surgeons the ideal body filler. The only disadvantage is its variable degree of resorption, which ranged from 45% to 80%. Various groups have studied the effects of cryo-preservation for fat storage, the advantage being that fat harvesting need only be performed once, and thereafter fat injections can be performed using stored fat as an outpatient service. This a clinical study carried out to test the aesthetic outcome of serial injection of the cryo-preserved fat cells for both aesthetic and reconstructive purposes. MethodsClinical evaluation was performed under standardized condition for serial lipofilling between October 2003 and May 2012, and 364 autologous fat transfers were performed in 104 patients ranging in age from 18 to 69years (mean age 34years). ResultsThe postoperative clinical results favored the use of serial fat transfer because the aesthetic and structural results were stable up to 90% of the initial volume more than a year after initial transfer. ConclusionOur data suggest that serial transfer of the cryo-preserved fat leads to better cosmetic results on the basis of outpatient service without increasing the financial burden for our patients.

Subacute fat-embolism-like syndrome following high-volume intramuscular and accidental intravascular injection of mineral oil

Objective. We present a rare case of subacute fat-embolism-like syndrome (FES-like) following intravascular injection of mineral oil–steroid solution with delayed diagnosis, acute onset of pulmonary distress, and transient clinical deterioration. Case report. A 40-year-old man was admitted following as a pedestrian being hit by a car. Examinations revealed sternum fracture and lung contusion. The patient was discharged with oral analgesics. Seven days later he returned presenting with coughing, hemoptysis, elevated leucocytes, and increased C-reactive protein. Chest radiograph revealed basal infiltrations. Suspecting pneumonia, the patient was discharged with antibiotics. Unkown to the clinicians, the patient had self-administered a mineral oil with added anabolic steroids by intramuscular injections for cosmetic purposes. The patient had observed blood on aspiration, and then relocated the needle before injecting 140 ml in his biceps muscle. Shortly after, the patient described near fainting and hemoptysis suggesting an accidental intravascular injection. Over the next 3 days the patient experienced increasing shortness of breath and hemoptysis. Examinations confirmed the diagnosis and the patient was treated with organ-specific supportive measures, tranexamic acid, and prednisolone and discharged after 11 days in the hospital. Conclusion. Subacute FES-like was associated with injection of body filler in muscle tissue. FES-like can mimic pneumonia, posttraumatic lung injury, and other more frequent causes to respiratory failure.

Effects of self-assembled fibers on the synthesis, characteristics and biomedical applications of CCAG hydrogels.

CS-HLC-HA-β-GP (chitosan-human-like collagen-hyaluronic acid-β-sodium glycerophosphate) hydrogels were prepared based on the self-assembly of CS-HLC-HA (CCA) fibers. The effects of the fibers on the synthesis, characteristics and biomedical applications of CS-HLC-HA-β-GP (CCAG) hydrogels were studied for various HA contents. The synthesis mechanism of the novel CCAG hydrogel was explored using Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS). The hydrogels were characterized by a swelling test, gelling time and enzymatic treatments. The results indicated that a new amide bond (-CONH) and -NRH2 + were formed. The gelling time and swelling behaviors were dependent on the intertwining, overlap and adsorption of the polymer chains at various temperatures and pH. Furthermore, biomedical applications were evaluated by transmission electron microscopy (TEM), immunohistochemical analysis and haematoxylin and eosin (H&E) staining. The effect of the fibers on the histocompatibility of the hydrogels revealed that the fibers inside the hydrogel pores reduced the quantity of macrophages, decreased the degree of inflammation, and improved the anti-degradation of the modified hydrogels. This type of new hydrogel emerges as an interesting injectable filling biomaterial for tissue engineering.

Doping cosmético: a problemática das aplicações intramusculares de óleos

O doping no mundo esportivo e na subcultura de atletas profissionais e recreacionais de culturismo já é muito conhecido e estudado pela comunidade acadêmica e científica. Porém, uma nova problemática, que definimos como doping cosmético, inseriu-se há algumas décadas no mundo todo, e tem crescido em importância no Brasil nos últimos anos. Trata-se de injeções sistemáticas de substâncias oleosas por via intramuscular, conhecidas como ADE (vitaminas lipossolúveis A, D e E), com intuito de aumentar volumetricamente o músculo per se, podendo levar a necroses, deformidades físicas ou até mesmo ao óbito. Apresentamos a história do uso cosmético dos preenchedores corporais e revisamos os possíveis efeitos deletérios e fatais que podem resultar do seu abuso, assim como os mecanismos envolvidos na evolução clínica da aplicação destas substâncias. Além disto, apresentamos métodos simples para observação potencial do uso. Pretendemos com este trabalho convocar a classe dos profissionais de saúde para que esta publique relatos de casos quando estes usuários forem atendidos devidos às complicações de tal uso, visto que os casos que até hoje apareceram são apenas o início de uma nova problemática de saúde pública que tende a aumentar consideravelmente.

Comparison of Allograft Bone and Titanium Cages for Vertebral Body Replacement in the Thoracolumbar Spine

When an anterior approach to repair a burst fracture is indicated, several devices can be used to restore spinal stability (eg, bone graft, free-standing titanium cage, and expandable titanium cage). We compare the biomechanical stability and prices of each of these systems. Eight fresh human cadaver T11 through L3 vertebral specimens were harvested and cleaned of soft tissues. T11-T12 and L2-L3 were fixed by screws. The fixed ends were then set in automotive body filler (Bondo). The prepared specimens were tested in the Biaxial Instron tester (8874, Norwood, MA) after a sequence of the following: intact, after the creation of an anterior corpectomy at L1, and after insertion of both of the 2 different titanium cages and the fibular graft. A titanium screw-and-plate anterolateral system was used to secure the construct (VANTAGE, Medtronic Sofamor Danek, Memphis, TN). The conditions of displacement testing were as follows: rotation (+/- 3.5 degrees ), flexion and extension, and left and right bending (+/- 3.5 mm). For each mode of testing, the stiffness was calculated. The stiffness data, when statistically analyzed by repeated-measures analysis of variance (at P = .05 and power > 0.9), indicated no significant differences among these devices. On the basis of this biomechanical study, the stiffness of the fibular graft was similar to that of the other metallic devices in this cadaver model.

The Characterization of Automobile Body Fillers*

Body fillers are sometimes encountered with paint evidence from hit-and-run accidents. Little forensic research has been conducted and published on the subject since 1986. The objective of this study was to determine if chemical and physical differences in body fillers from various manufacturers existed and could be identified. Thirty-three samples of light-weight automobile body fillers and spot putties were obtained. The fillers and putties were compared using light microscopy, infrared spectroscopy, scanning electron microscopy with energy dispersive X-ray spectrometry (SEM-EDX), and pyrolysis gas chromatography (pyGC). Results from fourier transform infrared spectroscopy analysis placed the samples into five groups and differentiated six samples. Light microscopy placed the samples into one of five color groups. PyGC placed the samples into three groups and differentiated one sample. SEM-EDX placed the samples into four groups and differentiated 13 samples. Using these analysis methods, 19 of the 33 samples could be discriminated. The best discriminatory tool was found to be SEM-EDX.

RELIABILITY AND FAILURE RESISTANCE OF THE STONE BRIDGE STRUCTURE OF CHARLES BRIDGE DURING FLOODS

The most frequent damage and collapse of some of the spans of Charles Bridge during floods occurred namely in its central part which was exposed to an intense flow of backwater and erosion of the bridge pier footing bottom, which the originally relatively shallow foundations of the piers on boxes were not able to resist for a longer time (the floods of 1432, 1496, 1784, 1890). The stone vault bridge structure was damaged due to scouring of the bridge piers foundations, their successive tilting and settlement accompanied by degradation, and finally collapse of the adjoining bridge vaults. The foundation of piers on caissons and execution of caisson rings in 1892 and 1902 to 1904 in this part of the bridge, together with measures avoiding the piling up of objects in front of the bridge, enabled the bridge to withstand the impact of more than a hundred‐year flood during the events of August 2002. The numerical analysis proved an extreme sensitivity of the stone vault bridge structure to the effects of changes in the footing bottom shape. Due to the changes in the footing bottom (angular rotation, subsidence, shifting), normal and shear stresses arise in the stone vault bridge structure, and exceed the load‐bearing capacity of the masonry causing its disintegration. The fundamental measure to prevent the bridge vaults from failure due to the changes in the footing bottom shape is to secure reliably the bridge piers foundations. The increased rigidity of the stone bridge structure achieved by the interaction with the additionally inserted reinforcing structure and by bracing the bridge body filler does not ensure the reliability and safety of the bridge structure from flood‐related failures.

THE ANALYSIS OF NON‐STRESS EFFECTS ON HISTORICAL STONE BRIDGE STRUCTURES (MONITORING, THEORETICAL ANALYSIS, MAINTENANCE)

Due to non‐stress cyclic effects of temperature and moisture, stone bridge structures are subjected to deformations, a gradual growth of permanent deformations, crack development and subsequent disintegration of the stone masonry of bridge vaults. A theoretical analysis of the stress‐state and deformations of the stone bridge structure caused by non‐stress effects and the in‐situ monitoring of deformation changes of the breast walls and the bridge vaults of the historic structure of Charles Bridge (from the mid‐14th century) manifested a response and a growth in permanent deformations and disintegration of the stone bridge structure due to the effects of temperature and moisture. The behaviour of the bridge structure is significantly affected by the interaction of the vault bridge structure with the bridge body filler when exposed to the above‐mentioned non‐stress effects. Special attention must be paid to the spacing effect of filling layers on the stone bridge structure. When repairing historical stone bridge structures, the rehabilitation methods commonly used increase the total rigidity of the stone bridge structure and thus its sensitivity to non‐stress effects caused by changes in temperature.

THE ANALYSIS OF NON‐STRESS EFFECTS ON HISTORICAL STONE BRIDGE STRUCTURES (MONITORING, THEORETICAL ANALYSIS, MAINTENANCE)

Abstract Due to non‐stress cyclic effects of temperature and moisture, stone bridge structures are subjected to deformations, a gradual growth of permanent deformations, crack development and subsequent disintegration of the stone masonry of bridge vaults. A theoretical analysis of the stress‐state and deformations of the stone bridge structure caused by non‐stress effects and the in‐situ monitoring of deformation changes of the breast walls and the bridge vaults of the historic structure of Charles Bridge (from the mid‐14th century) manifested a response and a growth in permanent deformations and disintegration of the stone bridge structure due to the effects of temperature and moisture. The behaviour of the bridge structure is significantly affected by the interaction of the vault bridge structure with the bridge body filler when exposed to the above‐mentioned non‐stress effects. Special attention must be paid to the spacing effect of filling layers on the stone bridge structure. When repairing historic...

β‐ＴＣＰを用いた椎体形成術の小経験

Usually, osteoporotic spine fracture is treated conservatively. But there are cases which resist conservative treatment.We performed vertebroplasty using β- tricalcium phosphate (β- TCP) on such cases.After the operation, some cases should collapse of the vertebral body and escape of the instrument into the vertebral body, due to failure of the β- TCP to bear load with porosity, and insufficient healing β- TCP was found to be unsuitable as a vertebral body filler.

Chemical characterization of sanding dust and methylene chloride usage in automotive refinishing: implications for occupational and environmental health.

Surface preparation activities conducted during automotive refinishing present several potential human health and environmental risks. This study examines the chemical composition of vehicle sanding dust and the prevalence of methylene chloride use as a basis for evaluating potential chemical exposures in the work environment, fugitive environmental releases, and take-home toxics. This article reports on the findings of (1) a statewide technology and work practices survey of 353 licensed auto body shops and (2) laboratory analyses of sanding dust representing more than 200 vehicles, 10 commercial body filler compounds, and work shirts worn during vehicle sanding while using nonventilated equipment. Survey data revealed that the majority of shops (78%) do not use ventilated sanding equipment, that most workers (55%) take their work clothes and shoes home at the end of the workday, and that 17% of the respondents used a methylene chloride-based paint stripper as an adjunct to mechanical sanding. Laboratory results showed that Pb, As, Cr, Mn, and Ni were present in the sanding dust at every facility tested. Lead concentrations in sanding dust were found to be highest at facilities that performed complete vehicle refinishing (range 770 to 7300 ppm) and at a collision repair shop that used a high-lead content body filler compound (1800 ppm). Hexavalent chromium also was found in two vocational high school paint dust samples at concentrations of 54 and 710 ppm. When total lead and chromium concentrations reached 7300 and 2300 ppm, respectively, facility sanding dust samples failed the U.S. Environmental Protection Agency's Toxicity Characteristic Leaching Procedure for hazardous waste. Metals found in the sanding dust also were present on the work shirts of technicians-ranging from 0.06 (Cd) to 81 (Mg) microg/inch2 of cloth-who sanded on paint without ventilated equipment. Results suggest that sanding dust and methylene chloride paint strippers used in vehicle resurfacing operations pose a potential hazard to human health and the environment.

“New mixers from Kemutec Group”

Kemutec Group Ltd offers a comprehensive range of “Gardner” horizontal mixers. Their whole portfolio has been revised and three new standard ranges, the ‘HE’, ‘PE’ and ‘RE’ Series have just been announced. The company has the expertise and capability to build mixers for products as diverse as dry powders, cream products, meat products through to car body fillers. Working capacities are from ‘Laboratory size’ up to 20,000 litres. Construction can be of epoxy painted mild steel through to 316 grade stainless steel. For applications demanding the most stringent standards of hygiene, stainless steel mixers can be mirror polished both internally and externally if required.

Glasurit 18‐line ‐ two pack system for commercial vehicles

Glasurit 18‐Line, a major new two‐pack top‐coat system, has been developed for refinishing a wide range of commercial vehicles. The 18‐Line system is a complete range of complementary products including: body fillers, primers, primer fillers, hardeners and top‐coat. Glasurit is already an established leader of two‐pack systems for the automotive refinish sector and the new system marks its entry into the commercial vehicle field.

Glasurit launches system for repairing galvanised steel

The first system specifically for repairing galvanised steel has been launched in the UK. The Glasurit Galvanised System (GGS) has been specially developed to overcome the problems of repairing zinc coated steel with traditional products. The system is based on two new products, Glassit Non‐Ferro Polyester Body Filler and Glassofix One‐Pack Red Oxide Primer.

The characterization of motor vehicle body fillers.

The compositions of typical British motor vehicle body fillers are reviewed and a systematic scheme is presented for their characterization, which routinely employs sample colour and analysis by pyrolysis gas chromatography and occasionally employs X-ray fluorescence spectrometry in addition. Eighteen samples obtained from manufacturers were all distinguishable and, from the examination of 121 casework samples, the discriminating power of colour and pyrolysis gas chromatography was estimated to be at least 0·92. Twenty-three samples in the casework collection were all similar in colour and produced similar pyrograms. A brief examination of this large group of samples, by X-ray fluorescence spectrometry, indicated that inorganic analysis provided a useful increase in discrimination. The pyrolysis products of polythene were used to calibrate the retention scale of the gas chromatograms (in methylene units) and peak heights were recorded relative to the height of the largest peak (usually styrene). Using data recorded in this manner a computer based system was developed for the comparison of pyrograms and for establishing the evidential value of a particular analysis. It is suggested that a similar approach could be used for the interpretation of pyrograms from a wide variety of other materials.