Body Area Research Articles

Dynamics of Changes in the Surface Area of Water Bodies in Subsidence Basins in Mining Areas

The Silesian Upland in southern Poland is known as a place where subsidence processes induced by mining activities occur in an area of nearly 1500 square kilometres, with many water bodies that formed in subsidence basins. This study concerned the dynamics of changes in the occurrence, boundaries and area of water bodies in subsidence basins (using orthoimagery from 1996 to 2023), as well as the assessment of the factors underlying the morphogenetic and hydrogenetic transformations of these basins. Within the subsidence basins covered by the study, water bodies occupied a total area that changed from 9.22 hectares in 1996 to 48.43 hectares in 2003, with a maximum of 52.30 hectares in 2009. The obtained figures testify to the extremely dynamic changes taking place in subsidence basins, which are unprecedented within such short time intervals in the case of other morphogenetic types of lakes and anthropogenic water bodies (for instance, from 1996 to 2003, the basin of the Brantka water body in Bytom underwent a more than two-fold change in its area, with RA values in the range of 54.4% to 131.9). A reflection of the dynamics of short-term changes in the water bodies in question in the period from 1996 to 2023 is the increase in the water area of the three studied water bodies, which was projected by linear regression to range from 0.09 hectares/year to 0.56 hectares/year. The area change trends, as determined by polynomial regression, suggest a slight decrease in the water table within the last few years, as well as within the next few years, for each of the studied basins.

Flexible dual-band antenna for ISM/5G enabled MIMO systems with pattern diversity for wireless body area networks

Abstract This paper outlines the design of a six-element multiple-input–multiple-output (MIMO) antenna with pattern diversity for industrial scientific medical (ISM)/5G-enabled wireless body area networks (WBANs). Within the MIMO configuration, each element has a quasi-yagi antenna configuration implemented on an ultrathin microwave laminate. The proposed quasi-yagi antenna has a small form factor of 25 × 25 mm, featuring a dipole-like radiator excited through a microstrip-line to tapered slot-line transition. The antenna’s radiators are patterned to ensure a dual-narrow impedance bandwidth. The conventional strip-line director in the planar yagi is replaced with a semicircular loop-like director, enhancing directional radiation patterns. This proposed flexible antenna offers versatile functionality by operating at both ISM standards of 2.45 GHz and the 5G wireless local area network standard at 3.5 GHz. The quasi-yagi elements are strategically distributed in a hexagonal formation to construct the six-element MIMO scheme with pattern diversity, resulting in a tangential radiation pattern suitable for on-body communication. Following fabrication, the prototype MIMO antenna’s simulation results are validated through real-time measurements. The proposed antenna exhibits an average gain exceeding 3.5 dBi across both operating bands. Furthermore, the proposed MIMO antenna exhibits promising performance metrics suitable for densely cluttered WBAN environments.

Non-Facial Skin Rejuvenation of the Neck, Chest, and Hands. Part One: Using Injections.

The demand for aesthetic procedures aimed at restoring and preserving a youthful appearance is growing. While numerous non-surgical facial rejuvenation techniques are available, there is a need for a comprehensive review of clinic-based procedures targeting non-facial body parts. This review aims to describe and evaluate clinic-based techniques for rejuvenating the neck, chest, and hands, focusing on various types of fillers and other non-invasive procedures. In this first part of this review, we conducted an extensive literature review on PubMed, reporting the effectiveness of different fillers, detailing their preparation, required volume per area, injection methods, durability, and any associated side effects. We also discuss the use of mesotherapy, microneedling, chemical peeling, and Profhilo in these specific body areas. The review synthesizes the latest data on the effectiveness and safety of these procedures, highlighting the advancements in filler technology and the growing popularity of non-invasive techniques for body rejuvenation. This article serves as a valuable resource for practitioners and patients interested in non-surgical body rejuvenation, providing insights into the best practices.

Evaluation of the Social Attention Hypothesis: Do Children with Autism Prefer to See Objects Rather than People?

A growing body of research shows that children with autism exhibit selective limitations in their ability to direct their visual attention to social stimuli. The cause of this selective limitation, however, remains unknown. The main purpose of this study is to determine whether the limitations in social attention are influenced by the objects in the environment. Specifically,the study examines the differences in visual attention between children with autism and typically developing (TD) children as they view videos of social interactions under two conditions, with and without objects. The sample consisted of 53 children with autism and 74 TD children, aged between 18 and 36 months. The findings indicated that young children with autism exhibited differences in their social attention compared to their TD peers. The results revealed that the presence of objects did not affect the visual attention differences between the two groups. However, removing objects from the environment positively impacted the social attention of both groups. In the condition without objects, both groups directed more visual attention more toward the Face and Body Areas of Interests (AoIs), whereas in the condition with objects, both groups prioritized looking at the Toy AoI. These findings have important implications for evidence-based decision-making, especially in designing early intervention environments for children with autism.

Efficacy and Safety Analysis in Chinese Patients with Moderate-to-Severe Psoriasis from a Phase 3 Trial: Impact of Treatment Withdrawal and Retreatment of Ixekizumab.

In China, approximately 2.3 million people have psoriasis. Continuous treatment is recommended for moderate-to-severe psoriasis. This study aimed to evaluate the outcomes of continuous versus interrupted ixekizumab (IXE) treatment and retreatment with IXE after disease worsening in Chinese patients. In this Phase 3, multicenter, randomized, double-blind, placebo-controlled study, patients were randomized to IXE or placebo at Week 0. At Week 12, IXE responders (static Physician's Global Assessment [sPGA] score, 0 or 1 [0,1]) were re-randomized (2:1) to IXE (IXE/IXE, continuous treatment) or placebo (IXE/PBO, interrupted treatment). After re-randomization, treatment in IXE/PBO patients with disease worsening (relapse, sPGA ≥ 3) was switched to IXE every 4weeks (IXE/PBO + IXEQ4W, retreatment). Efficacy was assessed by evaluating the response rates of Psoriasis Area and Severity Index (PASI) 75/90/100, sPGA (0,1), Dermatology Life Quality Index (DLQI) (0,1), mean PASI, and Itch Numerical Rating Scale (NRS) scores and improvements of special body areas. Safety was evaluated by assessing treatment-emergent adverse events (AEs) and serious AEs. At Week 12, 289 IXE responders were re-randomized to the IXE/IXE group (192 patients) and IXE/PBO group (97 patients). High rates of PASI 75 and sPGA (0, 1) responses were maintained in the IXE/IXE group until Week 60. At Week 60, 88 (90.7%) patients in the IXE/PBO group had disease relapse; the median time to relapse was approximately 20weeks. After 24weeks of retreatment, PASI 75 and sPGA (0, 1) were recaptured (97.2% and 74.6%, respectively, in the IXE/PBO + IXEQ4W group). AEs were comparable in patients who received continuous treatment and retreatment. In Chinese patients who received continuous IXE treatment, high response rates were maintained through 60weeks. Most patients had disease relapse after treatment withdrawal. After retreatment, most of these patients had regained and maintained response since Week 12. NCT03364309.

Assessment of Critical Environmental Risk Zones Around Wetlands in Colombo, Sri Lanka, Using Satellite Remote Sensing and Multi-criteria Decision Tools

Colombo, Sri Lanka’s commercial capital, is recognized as one of the first 18 global sites that were awarded the Ramsar Wetland City accreditation, and is a prime example of the intersection between urbanization and wetland conservation. Thus, this study aims to conduct an environmental risk assessment that can provide insights into the changes in biophysical properties driven by urbanization over the 2000–2020 period. The study used Geographical Information Systems and a remote sensing approach to assess critical environmental risk zones around urban freshwater lakes in the Colombo district of Sri Lanka, including Thalangama, an environmental protection area experiencing sub-urbanization. Satellite data (2000–2020) were employed, and spectral indices, including NDVI, NDBI, NDWI, NDMI, RVI and LST, were calculated. Intersecting areas with multiple risk factors were determined, and distances from these zones to lakes were calculated to generate spatially explicit risk maps using inverse distance weighting. The building density has consistently increased from 2000 to 2020 in all three sites, with ‘very high’ density areas expanding notably. NDVI reveals a gradual increase in ‘very high’ categories until 2015. Plant-water stress analysis shows significant water stress in 2015, and water body areas have decreased after 2010 in all the sites. Multi-criteria assessment identifies critical environmental risk zones around urban lakes, indicating high vulnerability to environmental damage and degradation. Overall, the study emphasizes the importance of leveraging data and risk analysis to inform decision-making processes in environmental management. By doing so, policymakers can enhance the effectiveness of conservation measures and promote the long-term sustainability of natural resources.

Intra-class switch among interleukin-17 inhibitors for the treatment of plaque psoriasis: a single-center experience

Psoriasis is a chronic immune-mediated disease primarily affecting the skin. The most common subtype is plaque psoriasis, which can affect any body area, with a predilection for the knees, elbows, scalp, lumbosacral region, and genitalia. The European guidelines adopted in Italy recommend systemic therapies for moderate-to-severe psoriasis, defined by a Psoriasis Area and Severity Index (PASI) ≥ 10, Dermatology Life Quality Index (DLQI) ≥ 10, and/or Body Surface Area (BSA) ≥ 10. Over the past two decades, the development of biological agents has revolutionized psoriasis management, targeting specific cytokines such as TNF-α, IL-23, and IL-17. Among these, ixekizumab, secukinumab, brodalumab, and bimekizumab are approved for the treatment of moderate-to-severe plaque psoriasis. However, some patients require switching therapy because of primary/secondary ineffectiveness or side effects. We retrospectively analyzed 20 patients who had switched from one anti-IL-17 drug to another, assessing both safety and effectiveness. 70% of patients was represented by males, with a median age of 49.5 years. The most frequent comorbidities were arterial hypertension and hypercholesterolemia. Effectiveness was evaluated in terms of a 90% (PASI90) and 100% (PASI100) reduction in PASI compared to baseline at 16 and 52 weeks. Before switching to the current IL-17 inhibitor, seven patients had failed at least two biologics. Thirteen patients experienced a loss of effectiveness after more than 6 months (secondary ineffectiveness), whereas the other seven never showed improvement with the previous drug (primary ineffectiveness). Fourteen patients completed at least one year of follow-up. Two patients were lost during the follow-up, while four more are currently still under treatment without having completed the established temporal cut-off. Two patients switched to bimekizumab, nine to brodalumab, and nine to ixekizumab. At baseline, the median PASI was 10 (IQR 4.5). After 16 weeks, the median PASI decreased to 2 (IQR 5.5), and after one year, it was 1 (IQR 2). Eight patients (40%) and six patients (30%) achieved PASI 90 and PASI 100 at 16 weeks, respectively. After one year, sustained effectiveness was observed with PASI 90 (57.1%), PASI 100 (35.7%), and PASI ≤ 2 (78.6%). No serious adverse events or discontinuations due to adverse events were observed during the study period. Our study confirms the safety and effectiveness of intraclass switching among IL-17 antagonists, highlighting that an inter-class switch can be a valid option when patients fail to respond or lose effectiveness with an IL-17 inhibitor. However, further larger and longer studies are needed for a deeper understanding.

Platelet-rich plasma and topical minoxidil 5% in the treatment of severe alopecia areata: Report of two cases

Alopecia areata (AA) is an autoimmune non-scarring hair loss that can affect any hair-baring body area. Corticosteroids are considered first-line treatment, but their long-term use may lead to undesirable side effects. Platelet-rich plasma (PRP) is an autologous product, which includes concentrated platelets that secrete growth factors stimulating hair follicle proliferation. Topical minoxidil has been used for mild cases of AA and other types of alopecia. We report two cases of severe multifocal AA, treated successfully with the combination of topical minoxidil 5% and intralesional PRP. PRP was injected once monthly for a total of six visits. Patients were advised to use 5% topical minoxidil twice daily. Trichoscopy was performed and evaluation of the severity of hair loss was done with Severity of Alopecia Tool (SALT). One month after the final PRP procedure, patients showed significant hair regrowth. Further controlled trials with more subjects are needed to validate the reported results.

Skin ultrasound for rheumatologists: Technical issues and challenges.

In several rheumatic diseases, the skin is involved and therefore it is an organ of interest which may be investigated by the rheumatologist. Ultrasound imaging has been proposed for assessing multiple skin conditions providing qualitative and quantitative information about different parameters in distinct skin layers. Our aim was to describe with a pictorial essay the main challenges that the ultrasound imaging may encounter when investigating the healthy skin in different body areas. Fourteen healthy subjects were submitted to skin ultrasound. The body areas that were investigated were decided following the 17 modified Rodnan skin score anatomical areas used in systemic sclerosis. Skin ultrasound was performed with a GE Logiq 10 with two probes (20 and 24 MHz). For an optimal quantification of the skin layers, the dermis interfaces either with the epidermis and hypodermis were investigated. The results of the ultrasound analysis are described and summarized in a pictorial essay which shows that some main factors may significantly influence the quality of the images of the skin layers. Specifically, age, scanning position, probe frequency, and the optimal positioning of some anatomical areas, in particular the hands and digits, emerged as factors that may have a relevance in influencing the quality of the imaging of the skin layers. Moreover, some technical suggestions are proposed to help optimizing and standardizing the performance of skin ultrasound assessment in healthy population. The pictorial essay we performed shows that the performance of skin ultrasound in healthy subjects still presents several issues that need to be addressed. The definition of the interface in different body areas is the first step which should be standardized before any measurement of the thickness of the skin layers is performed in rheumatic diseases.

A flexible wideband wearable CPW antenna for WBAN application

Abstract This article presents a wideband wearable antenna with flexible substrate for Body Area Network application. The designed coplanar antenna has a return loss bandwidth of 3.5 GHz ranging from 5.15 GHz to 8.65 GHz with maximum return loss at 5.8 GHz (45.9 dB) and 7.4 GHz (31.4 dB). The average gain of the antenna is 4.069 dB. The obtained specific absorption rate of the antenna is below the FCC reference limit of 1.6 W/Kg per 1 g of tissue, making it suitable for biomedical application.

Systematic Review and Meta-Analysis of Thermal Stress Assessment in Poultry Using Infrared Thermography in Specific Body Areas

Thermal stress is a health and welfare concern in the poultry industry. Poultry have specific thermoregulation strategies for heat stress (i.e., vasodilatation) or cold stress (i.e., vasoconstriction). Infrared thermal (IRT) analysis is a non-invasive temperature assessment technology with significant benefits compared to conventional temperature measurements, which are invasive and time-consuming. However, a wide range of IRT methodologies and equipment are used for temperature assessment in poultry. The aim of this study was to perform a systematic review and meta-analysis of IRT applications in poultry undergoing thermal stress. The bibliographic search yielded 17 records for qualitative synthesis and 10 for quantitative analysis. The results showed IRT is more commonly studied during heat stress than cold stress, and more research is being conducted on laying hens than other poultry species. Also, four body areas (parts of the head, body, face, and leg) were identified as common areas of interest for body surface temperature measurement. There is a clear thermoregulation response to thermal stress in poultry, with marked differences between featherless and feather-covered areas. IRT in poultry undergoing thermal stress has a good diagnostic value and represents an important welfare assessment tool for future research, particularly when combined with other welfare assessment methods.

Cyclin-Dependent Kinase Inhibitors in the Rare Subtypes of Melanoma Therapy

Melanoma occurs in various forms and body areas, not only in the cutis, but also in mucous membranes and the uvea. Rarer subtypes of that cancer differ in genomic aberrations, which cause their minor sensibility to regular cutaneous melanoma therapies. Therefore, it is essential to discover new strategies for treating rare forms of melanoma. In recent years, interest in applying CDK inhibitors (CDKIs) in cancer therapy has grown, as they are able to arrest the cell cycle and inhibit cell proliferation. Current studies highlight selective CDK4/6 inhibitors, like palbociclib or abemaciclib, as a very promising therapeutic option, since they were accepted by the FDA for advanced breast cancer treatment. However, cells of every subtype of melanoma do not react to CDKIs the same way, which is partly because of the genetic differences between them. Herein, we discuss the past and current research relevant to targeting various CDKs in mucosal, uveal and acral melanomas. We also briefly describe the issue of amelanotic and desmoplastic types of melanoma and the need to do more research to discover cell cycle dysregulations, which cause the growth of the mentioned forms of cancer.

Assessment of early neonatal practices to prevent hypothermia ; A comparative study.

Globally, neonatal deaths are significantly attributed to hypothermia. This is mostly because of its co-morbidity with asphyxia, premature birth and severe neonatal infections. Worldwide, neonatal hypothermia case fatality rates (CFRs) range from 8.5% to 52%. This study aimed to assess how well a video-based training intervention on mothers' knowledge and practices in preventing neonatal hypothermia worked. The knowledge and practices of two groups of primi-para mothers-one control group and one intervention group-were compared in order to achieve this. A total of 124 primipara mothers took part in the research. Using a video based tool, the intervention group was educated about preventing hypothermia in newborns. Both control and intervention group mothers were interviewed to compare the knowledge and practices. Sixty-one of the sixty-two mothers in the control group were unsure of which body area to cover in order to preserve the baby's body heat. Following the intervention, 61 out of 62 mothers in the group recognised which body part to cover to protect the baby's body heat. In the post-intervention group, 98.4% of moms wore a cap over their baby's head, compared to just 35.5% in the control group. The results of this study demonstrate the significant improvement in mothers' knowledge and actions about the prevention of neonatal hypothermia resulting from the use of a video-based training tool.

Vegetation and carbon sink response to water level changes in a seasonal lake wetland

Water level fluctuations are among the main factors affecting the development of wetland vegetation communities, carbon sinks, and ecological processes. Hongze Lake is a typical seasonal lake wetland in the Huaihe River Basin. Its water levels have experienced substantial fluctuations because of climate change, as well as gate and dam regulations. In this study, long-term cloud-free remote sensing images of water body area, net plant productivity (NPP), gross primary productivity (GPP), and Fractional vegetation cover (FVC) of the wetlands of Hongze Lake were obtained from multiple satellites by Google Earth Engine (GEE) from 2006 to 2023. The trends in FVC were analyzed using a combined Theil-Sen estimator and Mann-Kendall (MK) test. Linear regression was employed to analyze the correlation between the area of water bodies and that of different degrees of FVC. Additionally, annual frequencies of various water levels were constructed to explore their association with GPP, NPP, and FVC.The results showed that water level fluctuations significantly influence the spatial and temporal patterns of wetland vegetation cover and carbon sinks, with a significant correlation (P<0.05) between water levels and vegetation distribution. Following extensive restoration efforts, the carbon sink capacity of the Hongze Lake wetland has increased. However, it is essential to consider the carbon sink capacity in areas with low vegetation cover, for the lakeshore zone with a higher inundation frequency and low vegetation cover had a lower carbon sink capacity. These findings provide a scientific basis for the establishment of carbon sink enhancement initiatives, restoration programs, and policies to improve the ecological value of wetland ecosystem conservation areas.

Morphometric and Molecular Characterization of Fasciola spp. in Livestock From Northwestern Provinces of Iran.

Liver flukes from the genus Fasciola are the causative agents for human and livestock fascioliasis. Accurate identification of Fasciola spp. is essential to understanding the epidemiology of fascioliasis. This study aimed to determine the morphometric and molecular characterization of Fasciola spp. in livestock from Northwestern provinces of Iran. Five hundred adult Fasciola flukes were obtained from different definitive hosts (cattle, sheep, goats, and buffaloes) in four local abattoirs in the northwestern provinces of Iran (West-Azerbaijan, East-Azerbaijan, Ardabil, and Zanjan) from September 2021 to August 2022. All samples were examined by morphometric criteria; then, 49 samples were identified using PCR-RFLP based on ITS1 region and 23 sequence of isolates analyzed by cox1 marker. PCR-RFLP methods compared morphometric results, and cox1 gene sequences were used to confirm PCR-RFLP results and phylogenetic analysis. The differences between the body length, body width, cephalic cone length, cephalic cone width, body area, and distance between the ventral sucker and posterior end of the body in two species were significant (p < 0.05). Based on the morphometric criteria, 139 samples (27.8%) were identified as Fasciola gigantica and 361 (72.2%) as Fasciola hepatica. Similarly, PCR-RFLP analysis of ITS1 region confirmed morphometric results. No hybrid forms of Fasciola were detected. Partial sequences of cox1 showed 13 variable sites with eight haplotypes in F. hepatica and 12 variable sites with five haplotypes in F. gigantica. Based on the results of this study, the PCR-RFLP method can be used to confirm the morphological method of Fasciola species, but it is insufficient to study their genetic diversity. Also, sequences of cox1 results of the present study showed that F. hepatica and F. gigantica species in the Northern provinces of Iran have different genetic structures and haplotypes.

Investigating the influence of land cover on land surface temperature

The increasingly serious urban heat island (UHI) effect is unfavorable to urban development. This study utilized land cover data and land surface temperature (LST) data of China in 2020 by using correlation analysis and spatial regression models to analyze the relationships between LST and two influencing factors (land cover and digital elevation model (DEM)). The results showed the following: (1) The correlation between LST and forest was highest in the Northeast China Plain (NCP), Huang-Huai-Hai Plain (HHP), Qinghai Tibet Plateau (QTP), and Loess Plateau (LP). DEM mean displayed its highest correlation in the Northern arid and semiarid region (NAR), Sichuan Basin and surrounding regions (SCR), Yunnan-Guizhou Plateau (YGP), and Middle-lower Yangtze Plain (MYP). Southern China (SC) had the highest correlation between LST and construction land. (2) There was spatial heterogeneity between land cover and LST. Unused land on LP had larger impact on LST. For every 1% increase in the proportion of unused land area, the LST increased by 0.250 °C. LST in some central and western regions of China (the NAR, the LP, the SCR, and the YGP) was mainly affected by local land cover; LST in eastern coastal regions (the HHP, MYP, NCP, SC) and QTP was not only affected by local land cover, but also by LST or land cover of neighboring regions. The warming effect of construction land on LST was more significant, with LST increasing by 0.079 °C to 0.338 °C for every 1% increase in the proportion of construction land area. Coordination of land use planning and synergistic remediation in different regions and rational planning of construction land are essential to mitigate the UHI effect. (3) Water bodies in the NCP, NAR, and MYP had the greatest cooling impact on LST, with LST decreasing by 0.277 °C, 0.246 °C, and 0.079 °C, respectively, for every 1% increase in the proportion of water bodies area. Forest on the QTP, LP, SC, and YGP had the greatest cooling impact on LST, and for every 1% increase in the proportion of forest area, LST decreased by 0.144 °C, 0.089 °C, 0.086 °C, and 0.038 °C, respectively. Actively planting trees and increasing the area of forests and water bodies are of positive significance in alleviating the UHI effect and improving the ecological environment.

Allergic Contact Dermatitis in Pediatric Practice.

Allergic contact dermatitis (ACD) is prevalent among pediatric population, adolescent and young adults. Patients with ACD experience a lot of sociopsychological and qualityof- life (QoL) difficulties. Children and their caregivers alike are vulnerable to the burden of ACD. We have, in this paper, provided an overview of ACD and discussed common and unusual causes of ACD. We performed an up-to-date literature review in the English language on "allergic contact dermatitis" via PubMed Clinical Queries, using the keywords "allergic contact dermatitis" in August 2022. The search included meta-analyses, randomized controlled trials, clinical trials, casecontrol studies, cohort studies, observational studies, clinical guidelines, case series, case reports, and reviews. The search was restricted to English literature and children. ACD may be acute or chronic and it affects more than 20% of children and adults with significant quality-of-life impairments. ACD is manifested by varying degrees of cutaneous edema, vesiculation, and erythema. The hypersensitivity reaction is one of the most prevalent forms of immunotoxicity in humans. Localized acute ACD lesions can be managed with high-potency topical steroids; if ACD is severe or extensive, systemic corticosteroid therapy is often required to provide relief within 24 hours. In patients with more severe dermatitis, oral prednisone should be tapered over 2-3 weeks. Rapid discontinuation of corticosteroids can result in rebound dermatitis. Patch testing should be performed if treatment fails and the specific allergen or diagnosis remains unknown. ACD is common and can be a physically, psychologically, and economically burdensome disease. Diagnosis of ACD is primarily based on history (exposure to an allergen) and physical examination (morphology and location of the eruption). Skin patch test can help determine the causative allergen. Allergen avoidance is the cornerstone of management. Topical mid- or highpotency corticosteroids are the mainstay of treatment for lesions on less than 20% of the body area. Severe cases of ACD may require treatment with systemic corticosteroids.

Effect of Voluntary Wheel Running on Anxiety- and Depression-Like Behaviors in Fluoride-Exposed Mice.

Fluoride, an environmental toxicant, could induce endoplasmic reticulum stress (ERS) in neuronal cells ultimately leading to apoptosis and emotional dysfunction. Meanwhile, voluntary wheel running contributes to mitigate anxiety and depression. Our investigation aimed to study the effect of voluntary wheel running on anxiety- and depression-like behaviors in fluoride-exposure mice. The results showed that exposure to 100 mg/L sodium fluoride (NaF) for 6 months can induce anxiety- and depression-like behavior in mice. Fluorosis mice subjected to voluntary wheel running have less anxiety- and depression-like behaviors. Nissl and TUNEL staining demonstrated that fluoride led to a reduced proportion of Nissl body area in the cerebral cortex and an increased apoptotic ratio of nerve cells in the cerebral cortex. In contrast, these pathologic damages were improved in voluntary wheel running mice exposed to NaF. Moreover, the expressions of mRNA in the cerebral cortex GABA, GAD65, GAD67, DR, vGLU, 5-HT1A, BDNF, NMDAR1, and Bcl2 were downregulated and the levels of c-fos, GRP78, PERK, eIF2α, CHOP, Caspase-12, and Caspase-3 mRNA were upregulated in mice exposed to fluoride. NaF treatment had increased the PERK, ATF6, IRE1, p-eIF2α, and Caspase-3 protein levels and reduced the expressions of proteins, including GAD67, VGAT, BDNF, NMDAR1, PSD95, and SYN. By contrast, fluorosis mice subjected to voluntary wheel running enhanced the expression of GAD65, GAD67, VGAT, and neuroplasticity-related proteins in mice and inhibited the PERK-CHOP pathway. It is worth noting that the correlation between the amount of exercise and the behavioral indicators as well as neurotransmitter levels was found. In conclusion, voluntary wheel running inhibits the fluoride-induced ERS and GRP78 expression through the PERK-CHOP pathway and plays an anti-apoptotic role, ultimately ameliorating emotional dysfunction in NaF-exposed mice.

OS BENEFÍCIOS DA REALIDADE VIRTUAL NA SÍNDROME DE DOWN

Introduction: Down syndrome is the most common known genetic cause of intellectual disability. People with DS have multiple deficits, both cognitive and motor development disorders, and associated diseases. The use of virtual reality in treatment is a strategy with a positive impact on the evolution of patients, making individuals interact by moving with images and objects, while motivating and stimulating the patient’s interest in continuing treatment. Objective: To research and seek the benefits of virtual reality in individuals with Down syndrome, based on the reviewed literature. Method: The study consisted of researching and seeking the benefits of virtual reality in individuals with Down syndrome based on scientific studies. The search was carried out in the Pubmed and Scielo databases. The descriptors: virtual reality and Down syndrome were used, and studies in Portuguese and English that proposed to investigate virtual reality in individuals with Down syndrome were included. Results: Of the 24 studies found, 6 that met the inclusion criteria were selected. Conclusion: The importance of virtual reality for people with Down syndrome is highlighted, as it has been shown to be beneficial in several areas of the human body, consequently improving quality of life, considering that the patient’s gains are greater, as the therapy is carried out through games, stimulating the patient’s interest in participating and continuing with the treatment.

Threat Modeling for Enhanced Security in the Healthcare Industry with a Focus on Mobile Health and IoT

The advancement of mobile health and the Internet of Things (IoT) promises to enhance healthcare quality while reducing costs, particularly with the transition from inpatient to home and ambulatory care. This shift, driven by an aging population, financial pressures, and a shortage of skilled healthcare professionals, presents significant opportunities and challenges. While mobile health improves access and encourages self-management, it also raises serious concerns regarding security and interoperability, especially with wearable devices equipped with sensors in a patient's Body Area Network (BAN). This paper critically analyzes the security and interoperability risks associated with these technologies, emphasizing the need for robust measures such as configuration and asset management. Utilizing recommendations from ENISA (2016) and conducting a risk and vulnerability assessment, this study develops a comprehensive security model tailored for healthcare architectures. Additionally, it applies the STRIDE threat modeling approach to identify and mitigate potential threats, providing valuable insights for securing healthcare systems and prioritizing critical assets vital to organizational operations.