Bodily Disorders Research Articles

Revealing the Potency of Growth Factors in Bovine Colostrum.

Colostrum is a nutritious milk synthesized by mammals during the postpartum period, and its rich bioactive components has led to a global increase in the consumption of bovine colostrum as a supplement. Bovine colostrum contains key components such as immunoglobulins, oligosaccharides, lactoferrin and lysozyme. It is a special supplement source due to its natural, high bioavailability and high concentrations of growth factors. Growth factors are critical to many physiological functions, and considering its presence in the colostrum, further research must be conducted on its safe application in many bodily disorders. Growth factors contribute to wound healing, muscle and bone development, and supporting growth in children. Additionally, the molecular mechanisms have been explored, highlighting the growth factors roles in cell proliferation, tissue regeneration, and the regulation of immune responses. These findings are crucial for understanding the potential health effects of bovine colostrum, ensuring its safe use, and forming a basis for future clinical applications. This review article examines the growth factors concentration in bovine colostrum, their benefits, clinical studies, and molecular mechanisms.

Non-Adaptive Defense Mechanisms and Their Relationship to Psychosomatic Disorders among a Sample of University Students

Introduction In the university stage, the student is exposed to many psychological changes, pressures, and conflicts, which makes him resort to many non-consensual psychological defense mechanisms such as (repression, justification, projection, relapse, denial, delusional illness, reverse transference, daydreaming), which causes an imbalance in the personality and its psychological functions. This may lead to cognitive and mental distortions and physiological imbalances, and the appearance of symptoms that cause psychosomatic disorders that are not due to organic physiological imbalances or bacterial diseases, but rather as a result of imbalances in the psychological functions of the ego ,Which increases the symptoms of headache, vomiting, poor digestion, irritable bowel syndrome, shortness of breath, rapid heartbeat, hormonal imbalance, facial redness, and others.Objectives1.Identifying the degree of use of non-consensual psychological defense mechanisms among university students, and the differences in this according to the variable (gender and degree of academic achievement) 1. Revealing the correlation between the degree of use of non-consensual psychological defense mechanisms and the emergence of disturbed psychosomatic symptoms in the functions of (the respiratory system, the digestive system, the cardiac system, the muscular system, sleep disorders, and bodily disorders).MethodsThe correlational analysis approach was used to study the relationship between the variables of the study. The sample consisted of 300 male and female university students. A scale for psychological defense mechanisms was constructed, and a scale for psychosomatic disorders prepared by Diop (2011) was adopted, and its psychometric properties were verified.Results The responses in the degrees of non-consensual psychological defense mechanisms were varied, with a high degree in (justification, projection, repression, and delusional illness) and a moderate degree in (relapse, daydreaming, denial, and reverse transference). Differences appeared between males and females in favor of males, while differences in academic grades were in favor of the lowest grade. The results also showed a statistically significant correlation between psychological defense mechanisms and the appearance of psychosomatic symptoms, as it was high in disorders (respiratory system, cardiac system, muscular system, sleep disorders), and moderate in (emotional disorders and somatic disorders).ConclusionsThere is a positive correlation between the degrees of use of non-consensual psychological defense mechanisms and the emergence of psychosomatic disorders, in the functions of several bodily systems and behavioral and emotional disorders.Disclosure of InterestNone Declared

Pengenalan Senam Lansia untuk Pencegahan Stroke pada Warga Lansia Sumber RW 16 Surakarta Jawa Tengah

Elderly people suffer deterioration in body function that can cause bodily disorders primarily in the brain and may cause strokes. The 2018 data for basic health research explains that the above 75 years of age are the largest scarring of all stroke patients diagnosed by medical personnel and the lowest in age 15-24. Other ailments that can cause strokes are hypertension, heart disease, diabetes mellitus and obesity. Physiotherapy is one of the best nonpharmacological efforts to treat stroke patients and to improve the quality of life of older people such as maintenance, restoration, and restoration of limb. The promotive and preventive effort of people living in villages, source rw 16 surakarta, has been established as part of the preliminary screening of strokes, followed by the correction of strokes, calisthenics and recent evaluations of the post test to assess the knowledge of strokes and the resulting increased knowledge of participants.

Phenanthroindolizidine Alkaloids Secondary Metabolites Diversity in Medicinally Viable Plants of the Genus Tylophora

Plants of the genus Tylophora have commonly been used in traditional medicine in various communities, especially in the tropical and subtropical regions of climatic zones. Of the nearly 300 species reported in the Tylophora genus, eight are primarily used in various forms to treat a variety of bodily disorders based on the symptoms. Certain plants from the genus have found use as anti-inflammatory, anti-tumor, anti-allergic, anti-microbial, hypoglycemic, hypolipidemic, anti-oxidant, smooth muscle relaxant, immunomodulatory, and anti-plasmodium agents, as well as free-radical scavengers. Pharmacologically, a few plant species from the genus have exhibited broad-spectrum anti-microbial and anti-cancer activity, which has been proven through experimental evaluations. Some of the plants in the genus have also helped in alcohol-induced anxiety amelioration and myocardial damage repair. The plants belonging to the genus have also shown diuretic, anti-asthmatic, and hepato-protective activities. Tylophora plants have afforded diverse structural bases for secondary metabolites, mainly belonging to phenanthroindolizidine alkaloids, which have been found to treat several diseases with promising pharmacological activity levels. This review encompasses information on various Tylophora species, their distribution, corresponding plant synonyms, and chemical diversity of the secondary metabolic phytochemicals as reported in the literature, together with their prominent biological activities.

Generation COVID-19 and bodily disorders: Hyperbolic narratives and a developmental psychopathology perspective.

Starting from spring 2020, newspapers headlines and studies have suggested that the COVID-19 pandemics had a negative impact especially on the mental health of children and adolescents, so that terms like “lost generation” or “generation COVID-19” have been used to define youth in time of pandemic crisis. Similarly, international health agencies reported an increase in depression and anxiety among adolescents in COVID-19 time, but also a rise in bodily disorders, such as non-suicidal self-injury and eating disorders. However, scientific data on this matter are not as clear as they seem and theoretical-clinical proposals regarding the processes involved are lacking. Focusing specifically on bodily disorders in adolescents during COVID-19, the aim of this perspective paper is to review this issue and propose a novel viewpoint on it. Firstly, data regarding frequency and phenomenology of bodily disorders in adolescence before and during the pandemic will be presented to underline possible discrepancies, gaps, or hyperbolic descriptions in the literature published after the COVID-19 outbreak. Secondly, a specific theoretical-clinical perspective will be proposed, that is, a developmental psychopathology perspective which attempts to frame these phenomena in a more nuanced and complex way, taking into account the role of developmental processes in adolescence age and its difficulties in the specific, subjective life-context of the individual, when intertwining with vulnerability factors and stressful life events. As such, the function of the body for the adolescent as a primary mean for regulating the self-other relationship and developing a greater sense of self-agency will be highlighted. The final objective is to help the clinician in developing both a critical thinking about the data that are shared in public outlets and an intervention that takes into account the complexity of contemporary psychopathological phenomena.

THE ASSESSMENT OF BLOOD CORTISOL AND CREATINE KINASE CONCENTRATION IN PERSONALIZING THE FOOTBALL PLAYERS TRAINING

Background: Blood tests are a common health assessment for diagnosing diseases and bodily disorders. Aims: The aim of the work was to analyze the suitability of sampling and assessing athletes’ blood-borne biomarkers in a search for ways to optimize their football training. Methods: In the prospective study, the results of 14 football players from a youth football team competing at the highest national level ‘blood tests were evaluated before (P1), immediately after (P2) and 24 hours after (P3) playing a football match. The all players were divided into two groups based on the length of time they were on the field during the game: FMP - (8 players) participation in the match for 90 minutes, and PMP - (6 players) participation in the match for 30-75 minutes. Results: In the FMP group, at P2, the following statistically significant (p<0.001) differences were observed: an increase in the leukocyte count; decreases in erythrocytes (RBC), hemoglobin (HGB), and hematocrit (HCT), and increases in creatine kinase (CK), cortisol and lactates. At P3 when comparing the FMP and PMP group results, we observed an increase in CK (p=0.03) and decrease in cortisol (p=0.02) in the former group. The concentration of cortisol<356.04nm/L at P3 was the most sensitive and specific (PPV=0.83; NPV=0.88) difference characterizing the group of FMP players compared with the players of the PMP group. In the FMP group compared with PMP at P3 we showed a significantly increased levels of CK (p=0.002). Conclusions: The blood cortisol levels below 356.04nm/L and CK concentrations below 500UI/L taken 24 hours after the football game in the players from a youth football team competing at the highest national level are characteristic of players with a greater potential for physical exercise.

Real-Time Stress Assessment Using Sliding Window Based Convolutional Neural Network

Mental stress has been identified as a significant cause of several bodily disorders, such as depression, hypertension, neural and cardiovascular abnormalities. Conventional stress assessment methods are highly subjective and tedious and tend to lack accuracy. Machine-learning (ML)-based computer-aided diagnosis systems can be used to assess the mental state with reasonable accuracy, but they require offline processing and feature extraction, rendering them unsuitable for real-time applications. This paper presents a real-time mental stress assessment approach based on convolutional neural networks (CNNs). The CNN-based approach afforded real-time mental stress assessment with an accuracy as high as 96%, the sensitivity of 95%, and specificity of 97%. The proposed approach is compared with state-of-the-art ML techniques in terms of accuracy, time utilisation, and quality of features.

Thermal imaging method in the evaluation of psoriasis in upper limb region

Psoriasis is a dermatological disorder that most often causes scaling, itching and lesions on various regions of the skin. This study aims to focus on just the upper limb region affected by psoriasis and perform image acquisition using thermographic imaging. Each and every bodily disorder has a unique heat signature and respective temperature differences. Similarly, Psoriasis also has a typical heat signature that can be clearly observed on performing automated segmentation of the thermal images. The aim of this study includes automated segmentation and GLCM feature extraction in order to understand the nature of the disorder from the thermal images, and to characterize it in a more precise manner. The segmentation algorithm used for the purpose of this study is the Fuzzy C-Means algorithm. Segmentation is performed in order to clearly characterize the region of interest (ROI). The skin temperature differences in the ROI between normal and psoriasis affected hand are important to evaluate the latter. The segmented images’ features have to be extracted in order to clearly visualize the unique aspects of Psoriasis which may not be understandable upon just clinical trials. The GLCM features are extracted using the respective algorithms. The mean average temperature difference between the normal and psoriasis was found to be 2.91°C. The percentage difference between the normal and psoriasis in measurement of average temperature was found to be 9.57%. Thermographic imaging is a non-contact method of image acquisition and is being extensively used in present day for medical study. This study will help understand Psoriasis in a more elaborate and clarified manner and aims to be used as diagnostic tool in the future.

Cytochrome C-decorated graphene field-effect transistor for highly sensitive hydrogen peroxide detection

High-level in vivo reactive oxygen species (ROS) can damage many biomolecules via oxidative stress and play vital roles in the pathogenesis of several bodily disorders. Therefore, fast and sensitive monitoring strategies for trace ROS, such as hydrogen peroxide (H2O2), are of great significance. Herein, we present a highly sensitive field-effect transistor (FET) sensor based on single-layer graphene for trace hydrogen peroxide (H2O2) detection. Graphene and cytochrome c (Cyt c) were employed as the conductive substrate material and biomolecular receptor for H2O2 detection, respectively. High-efficiency charge transfer can be achieved by reliable electrical contact across the Cyt c/underlying graphene interface. The Cyt c/graphene FET platform exhibited hole-transport behavior with high conductivity and high sensitivity toward H2O2 with a detection limit of 100fM and rapid response time (<1s). Moreover, our sensor platform was able to specifically discriminate H2O2 from a series of interfering substances, such as dopamine, ascorbic acid, glucose, uric acid and glutamate. This result, therefore, demonstrates that the proposed Cyt c/single-layer graphene FET sensor could facilitate the high-efficiency charge transfer between the redox center of the Cyt c/graphene interface, indicating a promising application in future trace H2O2 or free radical biosensors.

Comparing the outcome of septoplasty and septoplasty with turbinectomy in patients with deviated nasal septum

&lt;p class="abstract"&gt;&lt;strong&gt;Background:&lt;/strong&gt; Deviated nasal septum is a bodily disorder results in nasal obstruction. Many surgical procedures are available in correcting the disorder. The present study aimed to compare the surgical outcome of septoplasty alone and septoplasty with turbinectomy in patients with deviated nasal septum.&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Methods:&lt;/strong&gt; This prospective study was done on 50 patients attending to the department of ENT of Dr. D. Y. Patil Medical College and Hospital, DPU with complaints of nasal obstruction due to inferior turbinate hypertrophy with deviated nasal septum. The severity of nasal obstruction was assessed by NOSE (nasal obstruction symptom evaluation) scale. Of them, 25 patients were managed with septoplasty alone and other 25 patients with septoplasty and turbinectomy. The outcome of both the procedures was assessed statistically by using NOSE scale. &lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Results:&lt;/strong&gt; Postoperative symptom improvement was seen in the both groups following surgery (p&amp;lt;0.05). When the NOSE scores are compared between two groups, statistically significant improvement in the symptoms (NOSE score) was seen in the group of patients treated with septoplasty and turbinectomy compared to septoplasty alone (p&amp;lt;0.05).&lt;/p&gt;&lt;p class="abstract"&gt;&lt;strong&gt;Conclusions:&lt;/strong&gt; This study re-iterates both septoplasty and concurrent turbinectomy are established mode of treatment in deviated nasal septum along with hypertrophy of inferior turbinates when the preoperative and postoperative symptoms are compared. However, the symptomatic outcomes and diagnostic nasal endoscopic findings are significantly better in patients who underwent septoplasty with concurrent resection of the inferior turbinate. &lt;/p&gt;

In vitro study of chitosan-based multi-responsive hydrogels as drug release vehicles: a preclinical study.

Systematic administration of painkillers and anti-inflammatory drugs is routinely employed to minimize pain and bodily disorders. Controlled drug delivery has the potential to improve the outcomes of disorders by providing sustained exposure to efficacious drug concentrations. Herein, we report the fabrication of multi-responsive hydrogels using reactive and functional polymers such as chitosan and polyvinyl pyrrolidone by varying the concentration of a cleavable crosslinker, tetraethyl orthosilicate. The swelling indices of the hydrogels were evaluated in distilled water, solutions with different pH values and different electrolytes. FTIR, WAXRD and TGA were conducted to investigate the structures, crystallinities and thermal stabilities of the prepared multi-responsive hydrogels, respectively. The ultimate tensile strength and elongations at break of the fabricated hydrogels were investigated to assess their mechanical stability. Optical microscopy, biodegradation, antimicrobial and cytotoxicity analyses were further carried out to verify the magnified crosslinked and porous structures, biodegradabilities, biocompatibilities and toxic behaviour of the as-prepared hydrogels, respectively. Drug release analysis was conducted to evaluate their release behaviour in PBS, SGF, SIF and electrolyte solutions. The overall results indicate the successful development of novel, non-toxic and sustained drug deliverable hydrogels, which can be considered as a paramount success towards the fabrication of controlled drug delivery systems.

Metabolic and Microbiota Measures as Peripheral Biomarkers in Major Depressive Disorder.

Advances in understanding the role of the microbiome in physical and mental health are at the forefront of medical research and hold potential to have a direct impact on precision medicine approaches. In the past 7 years, we have studied the role of microbiota-brain communication on behavior in mouse models using germ-free mice, mice exposed to antibiotics, and healthy specific pathogen free mice. Through our work and that of others, we have seen an amazing increase in our knowledge of how bacteria signal to the brain and the implications this has for psychiatry. Gut microbiota composition and function are influenced both by genetics, age, sex, diet, life experiences, and many other factors of psychiatric and bodily disorders and thus may act as potential biomarkers of the gut-brain axis that could be used in psychiatry and co-morbid conditions. There is a particular need in major depressive disorder and other mental illness to identify biomarkers that can stratify patients into more homogeneous groups to provide better treatment and for development of new therapeutic approaches. Peripheral outcome measures of host-microbe bidirectional communication have significant translational value as biomarkers. Enabling stratification of clinical populations, based on individual biological differences, to predict treatment response to pharmacological and non-pharmacological interventions. Here we consider the links between co-morbid metabolic syndrome and depression, focusing on biomarkers including leptin and ghrelin in combination with assessing gut microbiota composition, as a potential tool to help identify individual differences in depressed population.

Anti-Inflammatory Activity of Rg3-Enriched Korean Red Ginseng Extract in Murine Model of Sepsis.

Ginseng has therapeutic effects on various bodily disorders ranging from minor inflammation to major cardiovascular diseases. In our study, we explored the anti-inflammatory effects of Rg3-enriched red ginseng extract (Rg3-RGE), a ginsenoside belonging to the panaxadiol group. We employed nitric oxide assay (NO) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR), western blot, and hematoxylin and eosin staining (H&E) to elucidate the anti-inflammatory activity of Rg3-RGE. Rg3-RGE potently suppressed NO production in the murine macrophage cell line, RAW 264.7 cells, without any cytotoxicity across dosages. Additionally, it inhibited the mRNA expression of proinflammatory mediators and cytokines like iNOS, COX-2, IL-1β, IL-6, and TNF-α. Moreover it also inhibited the levels of malondialdehyde levels in serum of septic shock mice. Immunoblot analysis showed that Rg3-RGE induced anti-inflammatory signal transduction via the NF-κB and MAPK pathways. A remarkable attenuation of inflammation by oral treatment with Rg3-RGE in mice was observed in the survival study. The in vivo study using a septic shock mouse model also showed similar results as the in vitro study. Our findings suggest that Rg3-RGE can potentially be a potent anti-inflammatory agent that likely mediates its anti-inflammatory effects via the NF-κB and MAPK pathways.

Glosa do postanowienia Sądu Najwyższego z dnia 28 kwietnia 2016 r. (I KZP 24/15)

The author agrees with the thesis of the verdict according to which, “the legal protection that is due to a public official granted to a physician in Art. 44 of the Act of 5 December 1996 on the Professions of a Physician and a Dentist Physician and in Art. 5 of the Act of 8 September 2006 on National Medical Emergency Service does not cover situations other than providing short-term assistance (i.e. providing first aid and performing emergency medical procedures) or medical assistance where any delay would result in exposing to danger of loss of life, grievous bodily harm or health disorder, and in other urgent cases”.

Diseased Plantations: Law and the political economy of health in Assam, 1860–1920

AbstractThis article argues that ideas of health and disease in the Assam tea plantations of northeastern India exceeded instrumental logics of bodily disorder, medical ‘objectivity’, and preventive cure. It looks at cholera, kala-azar (or black-fever), and malaria—the three main killers in these estates—to show that imperatives of private capital and law conditioned and constrained parameters of well-being, mortality, and morbidity in these plantations. It therefore suggests that epidemiological theories and praxis emerged from a simultaneous—but expedient—reading of three versions of the labour body: the pathological, the productive, and the legal. The overlaps between commerce, law, and pathogens provide for a unique, if not exceptional, social history of health in colonial India.

Exploring the Relationship Between Autistic Traits and Body Image, Body Satisfaction, and Body Competence

ABSTRACTAutism spectrum disorders (ASD) have been linked to bodily disorders (anorexia nervosa, obesity), and individuals with ASD are known to experience unique bodily states (e.g., exaggerated interoceptive sensitivity). Though there is evidence to suggest body variables may significantly impact quality of life in those with ASD, research has yet to examine the potential relationship between ASD and body image variables, that is, the evaluation of one's body. The present study examined 80 healthy college students (40 male, 40 female) who completed an online set of questionnaires regarding body image and satisfaction, body competency, depression, anxiety, and autistic traits (Autism Spectrum Quotient, or AQ) (Baron-Cohen, Wheelwright, Skinner, Martin, & Clubley, 2001). Of primary interest was whether AQ scores, gender, and the interaction between AQ scores and gender could successfully predict participants' scores on body image, satisfaction, and competency scales. Autistic traits were only a significant predictor of scores on one measure of momentary body image and satisfaction (Body Image States Scale: Cash et al., 2002). However, our results did suggest the possibility of an interaction between gender and AQ scores in predicting reports of body image, satisfaction, and competency.

Contradictory individualized self-blaming: a cross-sectional study of associations between expectations to managers, coworkers, one-self and risk factors for musculoskeletal disorders among construction workers

BackgroundWithin work sociology, several studies have addressed construction workers’ practices of masculinity, class, economy, safety risks and production. However, few studies have investigated room for agency in relation to bodily pain or musculoskeletal disorders and even fewer have made a quantitative approach. Accordingly, by means of a questionnaire, we examined the association between construction workers’ room for agency and physical exertion, bodily and mental fatigue, and lower back pain.MethodsA total of 481 Danish construction workers who responded to a multifaceted questionnaire were included. Drawing on previous studies and a Foucauldian inspired concept of agency, agency was quantified through specially crafted questions and examined in relation to established measures on physical exertion, physical and mental fatigue and pain in the lower back. Associations were tested using analyses of variance (general linear models) and controlled for age, gender, job group, lifestyle and depression.ResultsWhen asked about options for agency reducing the burden of work, few workers believed themselves to be prime agents of such practices. When asking about their view on performing alternative agency implying caring for the body, 39–49% expected negative reactions from management, and 20–33% expected negative reactions from colleagues. In contrast, only 13–18% of the participants stated that they would give a negative reception to such alternative practices.Using the expected reception outcomes (positive, neutral, negative) to alternative practices as predictors, the statistical regression analyses showed that negative expectations to management were associated with higher levels of physical exertion 0.62 (95% CI = 0.14–1.09) (scale 0-11), bodily fatigue 0.63 (95% CI = 0.22–1.04), mental fatigue 0.60 (95% CI = 0.07–1.12), and low back pain 0.79 (95% CI = 0.13–1.46) (scales 0-10).ConclusionIn our study, construction workers answered questions about work and MSD. The answers indicated a contradiction between perceived responsibility and room for agency.Based on the study, a number of target areas could fruitfully be addressed in aiming to reduce MSD among construction workers. To change workers’ expectances to the reception of lowering work pace if needed to take care of the body, their expectances to the reception of sickness absence as a result of pain, of discussing physical exertion in work and of demanding appropriate technical assistive devices are such examples. Our results emphasize that management plays an important role in this.

Schizophrenia: a critical psychiatry perspective.

The term 'schizophrenia' has been hotly contested over recent years. The current review explores the meanings of the term, whether it is valid and helpful and how alternative conceptions of severe mental disturbance would shape clinical practice. Schizophrenia is a label that implies the presence of a biological disease, but no specific bodily disorder has been demonstrated, and the language of 'illness' and 'disease' is ill-suited to the complexities of mental health problems. Neither does the concept of schizophrenia delineate a group of people with similar patterns of behaviour and outcome trajectories. This is not to deny that some people show disordered speech and behaviour and associated mental suffering, but more generic terms, such as 'psychosis' or just 'madness', would be preferable because they are less strongly associated with the disease model, and enable the uniqueness of each individual's situation to be recognized. The disease model implicit in current conceptions of schizophrenia obscures the underlying functions of the mental health system: the care and containment of people who behave in distressing and disturbing ways. A new social framework is required that makes mental health services transparent, fair and open to democratic scrutiny.

Association of Auricular Reflective Points and Status of Type 2 Diabetes Mellitus: A Matched Case-Control Study

The reflexive property of the ear can cause various physical attributes to appear on the auricle in the presence of bodily disorders. The association of auricular signals (presence or absence of discoloration, marks after pressing, tenderness, and electrical resistance) and diabetes mellitus (DM) should be further investigated because auricular diagnosis is an objective, painless, and noninvasive method that provides rapid access to information. A matched case-control study on 282 subjects was conducted. Cases (n = 141) were defined as those diagnosed with type 2 DM (T2DM). Every subject in the case group was matched with the control by age and gender. Ear diagnosis was conducted in three aspects: inspection, electrical detection, and tenderness testing. Results suggest that the tenderness and electrical conductivity of some auricular points, including “pancreas and gallbladder,” “endocrine,” “kidney,” “lower tragus,” “heart,” and “eyes,” were associated with T2DM status in Chinese population. In the subgroup analyses, certain auricular signals were also associated with glycemic control, disease duration, and related complications. Auricular diagnosis could be considered as a screening method for vulnerable populations with T2DM risk. Thus, appropriate interventions can be implemented to prevent or delay the progression of T2DM.

IMPORTANCE OF BASTI KARMA IN SWASTHA PURUSHA

Among the shodhana karma, Bastikarma is considered as prime as it is able to provide relief in kostagata, dhatugata, marmagata and sarva shareeragata vikara. As basti is able to pacify vata dosha, it is also considered as complete chikitsa in all types of bodily disorders. Basti karma is not only indicated in vyadhi chikitsa but also in Swastha to prevent the disease occurrence. The multidimensional applicability of basti karma is discussed in this paper.