Access to medicines is one of the biggest challenges to health systems, affecting society and individuals. This study aims to explore citizens' opinions, perceptionsand attitudes on the model of medicines' research and development (R&D) and price setting of medicines reimbursed by the Italian National Health Service. We run four online focus groups, analysed through thematic analysis. people aged 30-70 years, who had completed at least compulsory schooling (8-10 years), with no specialised knowledge about the subject. healthcare workers, pharmaceutical and device industry employees, researchersand medicine policy board members. We aimed to include a purposive sample of 20 participants, variable in terms of age, educational leveland place of residence. Eleven women and six men participated. The mean age was 53 years (range: 28-73). Most (n = 15) had a university degree or attended secondary schools. Eight had a job, five were not employed,and four were retired. In general, participants supported the role of the public health service. Almost all had limited knowledge of medicines' R&D and price setting. Most asked for transparency on medicine prices and negotiation criteria. Participants considered revenues of pharmaceutical companies disproportionateand most called for containment measures of profits. Most were in favour of a stronger public intervention in R&D and prices' negotiations. Few were sceptical of the public sector's ability to play this role. Medicines' prices were discussed as a health matter. Increasing citizens' awareness ofthese topics is needed by providing spaces and conditions to participate in the discussion, including different perspectives and interests. Members ofBEUC-the European consumer organisation-proposed the project. Altroconsumo, an independent consumer organisation and OCU, a Spanish consumer organisation, participated in developing the project and the main topics to discuss. The Mario Negri Institute and Aplica cooperative-the Spanish methodological team-were involved by BEUC and their national organisations to define the methodology, organisational aspectsand contentsand conducted the focus groups.