Abstract The COVID-19 pandemic significantly increased remote work, raising concerns about its impact on mental health. This study assessed the relationship between the challenges of remote work during the pandemic and mental health outcomes such as anxiety, depression, and sleep disorders. An online survey was conducted among South Korean adults, with data from 507 participants analyzed using the Generalized Anxiety Disorder 7-Item Scale (GAD-7), the Patient Health Questionnaire-9 (PHQ-9), and the Insomnia Severity Index (ISI). Results indicated that participants in the ‘difficult’ remote work category experienced higher rates of anxiety (26.6%), sleep disorders (37.3%), and depressive symptoms (38.4%) compared to the ‘non-difficult’ category (14.1% anxiety, 24.8% sleep disorder, and 24.8% depressive symptoms), with all differences statistically significant (p ≤ 0.005). Logistic regression models adjusted for demographics and socio-economic factors revealed increased odds of mental health issues in the ‘difficult’ group (ORs ranging from 2.241 to 3.210). Sub-group analysis highlighted significant disparities, particularly among blue-collar workers and men. The findings underscore the need for organizational strategies to mitigate the mental health challenges of remote work. Interventions should include improving technological infrastructure, enhancing workspace ergonomics, and fostering robust communication channels to replace in-person interactions. Additionally, policies should address the differential impacts observed between genders and industries, tailoring support to diverse needs. On a personal level, promoting regular indoor exercise could help workers manage stress and enhance their well-being in remote work settings. This study calls for a comprehensive approach to managing the complex impacts of remote work on mental health. Key messages • This study calls for a comprehensive approach to managing the complex impacts of remote work on mental health. • The findings underscore the need for organizational strategies to mitigate the mental health challenges of remote work.