It is known that the Kuramoto-Velarde equation is globally well-posed on Sobolev spaces in the case when the parameters γ1 and γ2 involved in the non-linear terms verify γ2=γ12 or γ2=0. In the complementary case of these parameters, the global existence or blow-up of solutions is a completely open (and hard) problem. Motivated by this fact, in this work we consider a non-local version of the Kuramoto-Velarde equation. This equation allows us to apply a Fourier-based method and, within the framework γ2≠γ12 and γ2≠0, we show that large values of these parameters yield a blow-up in finite time of solutions in the Sobolev norm. As a complement to it, we address an alternative result on the finite-time blow-up of smooth solutions by considering a virial-type estimate.