Blood Transfusion In Clinical Medicine Research Articles

Transfusion Medicine

Transfusion Medicine Cees Th. Smit Sibinga ID Consulting, Zuidhorn, The NetherlandsTransfusion Medicine is a bridging science, spanning the evidence-based practice at the bedside with the social sciences in the community.     Transfusion Medicine starts at the bedside. Surprisingly, only recently that has become rediscovered with the development of ‘patient blood management’ and ‘patient centered’ approaches to allow the growth of an optimal and rational patient care through supportive hemotherapy – safe and effective, affordable and accessible.1    Where transfusion of blood found its origin in the need of a patient, it has drifted away for a long period of time from the bedside and has been dominated for almost a century by laboratory sciences. At least the first ten editions of the famous and well reputed textbook Mollison’s Blood Transfusion in Clinical Medicine contained only a fraction on the actual bedside practice of transfusion medicine and did not focus at all on patient blood management.2    This journal will focus on all aspects of the transfusion chain that immediately relate to the bedside practice and clinical use of blood and its components, and plasma derivatives as integral elements of a human transplant tissue. That includes legal and regulatory aspects, medical, ethical and cultural aspects, pure science and pathophysiology of disease and the impact of transfusion of blood, as well as aspects of the epidemiology of blood transfusion and clinical indications, and cost-effectiveness. Education through timely and continued transfer of up to date knowledge and the application of knowledge in clinical practice to develop and maintain clinical skills and competence, with the extension of current educational approaches through e-learning and accessible ‘apps’ will be given a prominent place.

Patrick Loudon Mollison

Patrick Loudon Mollison

HLA type and risk of alloimmunization in sickle cell disease

Red blood cell (RBC) transfusions are frequently required to treat patients with sickle cell disease (SCD) [1]. One of the most serious complications of repeat transfusion is alloimmunization to RBC antigens [2]. Because human leukocyte antigen (HLA) genes mediate the response to foreign antigens, particular HLA alleles may predispose to the development of alloimmunization in patients with SCD who receive multiple transfusions. We conducted a case-control study to determine if particular HLA alleles are associated with alloimmunization and whether HLA homozygosity influences the risk of developing RBC alloantibodies. High-resolution HLA genotyping was performed on DNA samples from 159 multiply transfused patients with SCD. HLA allele frequencies were compared between alloantibody-positive and alloantibody-negative groups. The HLA-DRB1 * 1503 allele was associated with an increased risk (P = 0.039), while HLA-DRB1 * 0901 conferred protection from alloimmunization (P = 0.008). HLA Class II locus homozygosity was more frequently observed in the alloantibody-negative group (P = 0.01). These preliminary findings suggest that particular HLA-DR81 alleles and overall homozygosity at HLA class II loci are associated with alloimmunization risk in SCD. If confirmed, HLA type may serve as a useful genetic predictor of alloimmunization risk, and permit a targeted approach to the use of phenotypically matched blood.

MOLLISON'S BLOOD TRANSFUSION IN CLINICAL MEDICINE, 11TH ED.

TransfusionVolume 47, Issue 3 p. 551-551 MOLLISON'S BLOOD TRANSFUSION IN CLINICAL MEDICINE, 11TH ED. Paul M. Ness MD, Paul M. Ness MD Editor, TRANSFUSION Search for more papers by this authorR. Sue Shirey MS, MT(ASCP)SBB, R. Sue Shirey MS, MT(ASCP)SBB Assistant Editor Search for more papers by this author Paul M. Ness MD, Paul M. Ness MD Editor, TRANSFUSION Search for more papers by this authorR. Sue Shirey MS, MT(ASCP)SBB, R. Sue Shirey MS, MT(ASCP)SBB Assistant Editor Search for more papers by this author First published: 21 February 2007 https://doi.org/10.1111/j.1537-2995.2007.01153.xRead the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume47, Issue3March 2007Pages 551-551 RelatedInformation

Mollison's Blood Transfusion in Clinical Medicine, 11th edition by Harvey G. Klein and David J. Anstee

Mollison's Blood Transfusion in Clinical Medicine, 11th edition by Harvey G. Klein and David J. Anstee

Improved preservation of human red blood cells by lyophilization

The lyophilization of human red blood cells has important implications for blood transfusion in clinical medicine. In this study, sugars, human serum albumin, polyvinylpyrrolidone, and dimethyl sulfoxide were used as protective reagents for the lyophilization of red blood cells. Freezing temperature, shelf temperature, and the rehydration conditions were optimized. The results showed that extracellular disaccharides, especially trehalose, did not increase the recovery of hemoglobin. However, when the concentration of human serum albumin was higher than 25%, it had a considerable protective effect on the recovery of lyophilized red blood cells; the cellular hemoglobin recovery was over 70%, which was significantly higher than that in the group without human serum albumin ( P < 0.01). As the concentration of polyvinylpyrrolidone was increased, the extent of vitrification also increased. But when the concentration of polyvinylpyrrolidone was over 40%, the resulting concentration of free hemoglobin was over 1 g/L, which was significantly higher than that with 40% ( P < 0.01). When lyophilization was carried out after freezing at different temperatures, the recovery of cells and hemoglobin was 70–80% and there were no significant differences among the five groups. When the shelf temperature was higher than −30 °C, the samples were partly collapsed, but when the shelf temperature was lower than −30 °C, the recovery of cells in the −40 and −45 °C groups was significantly higher than in the −30 and −35 °C groups ( P < 0.05). The recovery of cells and hemoglobin after lyophilization and rehydration in solutions containing low concentrations of polymers was over 80%, which is significantly higher than the other groups ( P < 0.01). In addition, when the temperature was higher than 25 °C, the concentration of free hemoglobin was significantly lower than it was at 4 °C ( P < 0.01). In conclusion, our study showed the lyophilization of red blood cells is feasible. Disaccharides have no protective effect on lyophilized cells when they are only extracellular and extensive vitrification may be not beneficial. Although the recovery of cells after lyophilization and rehydration by our method was over 70%, the ultrastructure of the cells may be compromised and some hemolysis does still exist. Further research is required.

Red cell agglutination: the first description by Creite (1869) and further observations made by Landois (1875) and Landsteiner (1901).

Red cell agglutination: the first description by Creite (1869) and further observations made by Landois (1875) and Landsteiner (1901).

Malaria Screening of Blood Donors in Saudi Arabia

Transfusion-associated malaria is a potentially serious complication that continues to pose risks in blood bank settings. There is a need for effective malaria screening of blood donations to improve on the current exclusion policies of potentially infected carriers on the basis of clinical and travel history. We evaluated the potential usefulness of ELISA screening for malaria antibody and P. falciparum antigen among Saudi blood donors. A total of 1756 donors were studied, 1100 from the malaria endemic Southern Region and 656 donors from the known malaria-free Riyadh area. The overall antibody prevalence for the antibody was 7.6%, in comparison to only 0.17% for the antigen. In the endemic region, the antibody positivity rate of 9.1% was almost double the rate in the non-endemic area (4.8%). There was no difference in the antigen prevalence rates; 0.18% in endemic and 0.15% in nonendemic areas. In malaria endemic countries like Saudi Arabia, excluding antibody-positive donations would result in too much wastage of blood units. However, antigen malaria testing appears to offer a potential utility, as only few donations would be rejected.

Transfusion welcomes Blackwell Publishing

Effective with this issue of TRANSFUSION, the production, marketing, and distribution of the journal will be carried out by Blackwell Publishing of Boston, Massachusetts. The AABB will retain ownership of the journal and copyright of all material published in it. The present Editor, Associate Editors, and Editorial Board members will continue, and we expect to function as we have in the past. Thus, the rights to the journal and determination of its contents will continue as they are at present. There are several reasons for entering into this new relationship. Blackwell is the largest publisher for societies, colleges, and associations in the world. They have a major presence in the fields of hematology, transfusion medicine, and oncology, publishing 11 journals directly related to transfusion medicine and blood banking, as well as many books on these same topics. Among the nearly 600 journals that Blackwell publishes are British Journal of Haematology, Vox Sanguinis, Transfusion Medicine, Anesthesia, European Journal of Haematology, and Haemophilia. Their books include Hematopoietic Cell Transplantation by Nobel Prize winner E. D. Thomas, S. J. Forman, and Karl G. Blume; Human Blood Groups by Geoff Daniels; A Practical Guide to Therapeutic Plasma Exchange by A. A. Kaplan; and Blood Transfusion in Clinical Medicine by P. L. Mollison, C. P. Engelfriet, and M. Contreras. Blackwell has 10 offices worldwide and a distribution network that will allow TRANSFUSION to be present at conferences, congresses, and symposia throughout the world. Their sales and marketing teams will help us develop new strategies and explore new relationships to further extend the journal's reach. Blackwell's size and the number of books and journals they produce provide economies of scale that make it possible to negotiate better rates for production and distribution services, such as airmail delivery of issues to all international subscribers. If you live outside of the United States, you should be receiving your journals more quickly from now on! Blackwell operates its own online journals delivery service, Blackwell Synergy, which will include all current and back issues of TRANSFUSION. Via Blackwell Synergy, readers will be able to view articles in full-text HTML or PDF format and make use of state-of-the-art features such as e-mail table of contents alerts; personal homepages; links to and from databases such as PubMed (MEDLINE) and ISI; and powerful Boolean searching across the full text of all journals in Blackwell Synergy. Instructions for activating your Synergy online subscription will be sent to you shortly. In the meanwhile, the journal is still available at www.transfusion.org. In addition to our new publisher, we will also be introducing an online manuscript submission system. For the past year, the Editors of TRANSFUSION have been exploring various electronic manuscript management systems for online submission, tracking, and peer review. Our goal was to expedite the review process and to make it easier for authors to submit manuscripts to the journal. After extensive research, we determined that ScholarOne's Manuscript Central was the best system for TRANSFUSION, and we will be working with Blackwell in the coming year to implement this new service. Thus, we look forward to a substantially more rapid system of receipt, review, decision-making, and publication of manuscripts submitted to TRANSFUSION. We are proud of the quality and effectiveness of the production of TRANSFUSION by a very small group of dedicated people at the AABB offices in Bethesda. Production Manager, Betsy Colgan; Publications Editor, Carolinda Hales; Technical Editor, Dawn Rumsey; and Publications Specialist, Deborah Stultz, have worked with unsurpassed dedication, tirelessness, and commitment to making TRANSFUSION the wonderful publication you see each month. The shift to Blackwell in no way reflects on these individuals. Quite the contrary, we have been fortunate to have had such outstanding people dedicated to the journal, and it has been an honor to work with them. So, as we look ahead, we are embarking on another phase in the long and exciting history of TRANSFUSION. We are convinced that this new relationship will enable us to further enhance the quality, attractiveness, and timeliness of the journal to better serve our readers and authors. Your subscription to TRANSFUSION

Blood Transfusion in Clinical Medicine, 10th edition

Blood Transfusion in Clinical Medicine, 10th edition

Blood Transfusion in Clinical Medicine

British Journal of HaematologyVolume 101, Issue 1 p. 213-213 Free Access Blood Transfusion in Clinical Medicine 10th edn. By P. L. M OLLISON, C. P. E NGELFRIET and M. C ONTRERAS. Blackwell Science, Oxford, 1997. Pp. 754. Cees TH. Smit Sibinga, Cees TH. Smit Sibinga 0Search for more papers by this author Cees TH. Smit Sibinga, Cees TH. Smit Sibinga 0Search for more papers by this author First published: 25 December 2001 https://doi.org/10.1046/j.1365-2141.1998.101001213.xAbout ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume101, Issue1April 1998Pages 213-213 RelatedInformation

Book reviews

Clinical & Laboratory HaematologyVolume 20, Issue 2 p. 131-132 Book reviews Blood Transfusion in Clinical Medicine, 10th Edition Edited by P.L. Mollison, C.P. Engelfriet and M. Contreras. Blackwell Science, Oxford, 1997. ISBN 0-86542-881-6. pp. 754. £79.50 J.K.M. Duguid, J.K.M. DuguidSearch for more papers by this author J.K.M. Duguid, J.K.M. DuguidSearch for more papers by this author First published: 04 January 2002 https://doi.org/10.1046/j.1365-2257.1998.0860b.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume20, Issue2April 1998Pages 131-132 RelatedInformation

Differences between RhD-negative Africans and RhD-negative Europeans

Despite the use of Rh-immunoglobulin prophylaxis for the past 30 years, anti-RhD in RhD-negative women is still the most common cause of severe haemolytic disease of the newborn and fetus (HDN). 1 Mollison PL Engelfriet CP Contreras M Blood transfusion in clinical medicine, 10th edition. Blackwell Science, Oxford1997 Google Scholar Two genes encode the antigens of the Rh system: RHD encodes the RhD antigen; RHCE encodes the RhCc and RhEe antigens. These two genes are highly homologous, each consisting of 10 exons. It is generally accepted that the RhD-negative phenotype results from an absence of RHD; that is, RhD-negative people are homozygous for a deletion of RHD. 2 Colin Y Chérif-Zahar B Le Van Kim C et al. Genetic basis of the RhD-positive and RhD-negative blood group polymorphism as determined by Southern analysis. Blood. 1991; 78: 2747-2752 Crossref PubMed Google Scholar Several PCR-based techniques have been developed to determine the presence of RHD in genomic DNA in order to predict the RhD type of the red cells (reviewed in ref 3). Such tests are now regularly used to ascertain fetal RhD type from amniocyte DNA obtained by amniocentesis of RhD-negative pregnant women with anti-RhD in their plasma. In such circumstances an RhD-positive fetus would be at risk from HDN, whereas an RhD-negative fetus would not.

Blood Transfusion in Clinical Medicine

This is the ninth edition of a popular and well-read text. The authors note in the new preface that the emphasis of the world of blood transfusion has substantially changed in the 40 years the text has been in use. The newest edition follows the traditions of previous ones, comprehensively updating each topic while preserving continuity with the past. The index is characteristically clear and the bibliography encyclopedic. Classic information, such as the science of the development of A, B, and H red blood cell antigen proteins, or the development of the positive direct antiglobulin test following Rh D immunization, is carefully reviewed with recent references. As the science of red blood cell immunology inches along, the authors have kept the reader abreast, while not neglecting their duty to history. For example, they cite the work of Kemp, who in 1930 found that "A and B can be detected on

Book Reviews

Book Reviewed in this article: THE INVISIBLE INVADERS. THE STORY OF THE EMERGING AGE OE VIRUSES By Peter Radetsky. ORGAN TRANSPLANTATION, LONG‐TERM RESULTS Edited by Leendert C. Paul and Kim Solez. T‐CELL‐DIRECTED IMMUNOINTERVENTION Edited by J‐F. Bach. IL‐6: PHYSIOPATHOLOGY AND CLINICAL POTENTIALS Edited by M. Revel. BLOOD TRANSFUSION IN CLINICAL MEDICINE, 9th edn P. L. Mollison, C P. Engelfriet and M. Contreras. ALLERGY AND IMMUNITY TO HELMINTHS: COMMON MECHANISMS OR DIVERGENT PATHWAYS? Edited by R. Moqbel. THE IMMUNOLOGY OF HUMAN PREGNANCY By Henry N. Claman.

Reviews and Notes: Hematology: Blood Transfusion in Clinical Medicine

Reviews and Notes: Hematology: Blood Transfusion in Clinical Medicine

Reviews and Notes: Hematology: Blood Transfusion in Clinical Medicine

Reviews and Notes: Hematology: Blood Transfusion in Clinical Medicine

Book Reviews

Book reviewed in this article: Blood Transfusion in Clinical Medicine, 9th edn. By P. L. Mollison, C. P. Engelfriet and Marcela Contreras. Acute Leukemias. Pharmacokinetics and Management of Relapsed and Refractory Disease. Edited by W. Hiddemann, T. Buchner, W. Plunkett, M. Keating, B. Wormann and M. Andreeff. Hemopoietic Growth Factors and Mononuclear Phagocytes. Edited by R. Van Furth. The Myelodysplastic Syndromes. Edited by G. J. Mufti and D. A. G. Galton.

Blood Transfusion in Clinical Medicine, 8th Edition

Blood Transfusion in Clinical Medicine, 8th Edition

Book Reviews

Book Reviewed in this article: Blood Transfusion in Clinical Medicine, 8th edn. By P. L. Mollison, C. P. Engelfriet and Marcela Contreras. Developmental Control of Globin Gene Expression. Edited by G. Stamatoyannopoulos and A. W. Nienhuis. Progress in Clinical and Biological Research. Blood, Blood Products and AIDS. Edited by R. Madhok, C. D. Forbes and B. Evatt.