Status Of Blood Supply Research Articles

Experimental study of contrast-enhanced ultrasound in the evaluation of random-pattern flap blood supply in the early postoperative stage in rats.

This study aims to investigate whether contrast-enhanced ultrasound (CEUS) could be used to reveal the status of blood supply of the superficial flap of rat model in the early postoperative stage. One viable and one ischemic random-pattern flap were prepared on the left and right back of the same rat respectively with a number of 40. CEUS examinations were applied within 12 h and 7 days postoperatively, and the quantitative measurements of microvascular blood volume (BV) of the base and the end of both flaps were expressed using acoustic intensity as a ratio to that of the healthy skin. Within 12 h post operation, there was a smaller BV value of the ischemic ends than that of both the ischemic bases and viable ends (p < 0.001), while no difference was indicated between ischemic bases and viable bases or between viable bases and viable ends. The same result was provided 7 days post operation. Microcirculation of superficial tissues such as random-pattern flaps in this rat model can be assessed quantitatively by CEUS. It could sensitively and accurately reveal the objective status of tissue perfusion in the early postoperative stage.

Postoperative hemorrhages in vestibular schwannoma surgery pontine hemorrhage. Clinical case report

Vestibular schwannoma (acoustic neuroma) is a benign tumor that develops from Schwann cells and can be life-threatening. Nowadays, surgical treatment is the method of choice in the management of patients with this type of tumor. We present a clinical case report of 71 y.o. patient with vestibular schwannoma (Koos grade IV, Samii grade 4B) with severe compression of the pons and the left cerebellar hemisphere. Microsurgical removal of the tumor was performed via the retrosigmoid approach. Starting from postoperative day 1, signs of respiratory distress developed. Control multislice spiral computed tomography (MSCT) of the brain revealed the area of hemorrhage in the left regions of the pons. On postoperative day 24 the patient's condition rapidly worsened progressing to coma with pronounced arterial hypotonia and cardiac arrest. Hemorrhage in the brain stem structures is a rare and life-threatening postoperative complication in vestibular schwannoma surgery. The incidence of postoperative hemorrhage is 2–11% of cases. Vascular complications are the leading cause of mortality. The key predisposing factors are older age, large and giant size of the tumor, tumor invasion into the pia mater of the brainstem, and vascularization of the tumor stroma. Comprehensive assessment of the tumor blood supply status, the state of the brainstem, intra- and postoperative clinical and neurophysiological monitoring, careful and thorough dissection of the tumor capsule and strict control of blood pressure in the postoperative period are the basis for the prevention of these complications.

The status of blood supply in sub-Saharan Africa: barriers and health impact

The status of blood supply in sub-Saharan Africa: barriers and health impact

Portable flexible probe for detecting blood supply status in clinical surgery

In the medical field, it is important to monitor and evaluate the blood supply status of organs and tissues during the clinical surgery. However, this largely depends on the surgeon’s experience and naked eye, which is easy to misjudge due to the interference of blood stains or other factors. A portable and flexible photoplethysmographic (PPG) detection probe is developed in this paper. And a new evaluation methodology of blood supply status is proposed based on this probe. Three typical indicators based on PPG is proposed to comprehensively evaluate the blood supply status, which are the blood oxygen saturation and its pulsation, differential characteristics of different lights, and time-frequency energy spectral characteristic. The probe and its evaluation methodology are verified using the brain of rats as a model.

Imaging Findings From Different Pathological Types of Oral and Maxillofacial Intramuscular Hemangiomas for Selecting Optimum Management.

ObjectivesTo assess computed tomography (CT) and magnetic resonance imaging (MRI) findings of intramuscular hemangiomas (IMHs) in oral and maxillofacial region and correlate them with the histopathological classifications for selecting optimum management.MethodsThe clinical data and pretreatment findings of 32 patients with pathologically proven IMHs on CT (n = 10), MRI (n = 27), or both (n = 5) were analyzed retrospectively. Correspondence of clinical and imaging characters with 3 different pathological classifications (cavernous, capillary, and mixed) of IMHs was studied. A number of pitfalls and overlap of imaging features can result in misdiagnosis of different IMHs lesions.ResultsFour patients had multi-muscular lesions, and 28 had single-muscular lesions. The predilection site were the tongue (11 cases, 34.4%) and the masseter muscle (10 cases, 31.2%). Cavernous type (17 cases, 53.1%) was the most common IMHs type. All patients showed slightly hypointense or isointense on T1-weighted imaging, 3 patients showed hyperintense on T2-weighted imaging and the others showed slightly hyperintense. The most common enhancement pattern was progressive (29 cases, 90.6%). The capillary type (9 cases, 28.1%) and mixed type (6 cases, 28.1%) of IMHs on imaging indicated characteristics of lesions with rich blood supply status, the cavernous type (17cases, 53.1%) of IMHs belonged to relatively poor blood supply lesions. A total of 5 patients (15.6%) were initially misdiagnosed, there were recurrences in 4 IMHs patients. Extra functional MRI (fMRI) was performed on these 5 misdiagnosed patients, the average ADC of the 5 patients was 1.50 × 10−3 mm2/s. The presence of vermicular vessels was different among these three types of IMHs.ConclusionsThe reason for the misdiagnosis in localized IMHs may be the obvious border of mass-like lesions and the lack of enlarged vessels. Combined evaluation of presence of vermicular vessels and fMRI might be more accurately for determining the IMHs and create a preoperative plan.

Measurement of blood flow reserve fraction in coronary intervention in evidence-based nursing

Objective To investigate the method and effect of evidence-based nursing in percutaneous coronary intervention (PCI) by flow reserve fraction(FFR). Methods A total of 106 patients who underwent coronary intervention(PCI) from May 2015 to May 2017 were selected as research objects.According to the random number table method, they were divided into observation group(53 cases)and control group(53 cases). Patients in the control group underwent PCI after evidence-based nursing combined with coronary angiography (CAG), while patients in the observation group underwent PCI after evidence-based nursing combined with FFR.The two groups of patients were compared in operation related conditions and the incidence of surgical complications, and statistical analysis was performed. Results The number of stents per capita, hospitalization expense per capita, material expense per capita and dosage of contrast agent per capita in the observation group were significantly lower than those in the control group, the incidence of postoperative complications in the observation group was significantly lower than that in the control group, and the differences were statistically significant(P<0.05). Conclusions Evidence-based nursing combined with FFR can more directly and accurately evaluate the cardiac blood supply status of patients undergoing coronary intervention, enhance the surgical effect and reduce postoperative complications. Key words: Blood flow reserve score; Coronary intervention; Evidence-based nursing; Coronary angiography

Assessing the Blood Supply Status of the Focal Ground-Glass Opacity in Lungs Using Spectral Computed Tomography.

ObjectiveTo exploit material decomposition analysis in dual-energy spectral computed tomography (CT) to assess the blood supply status of the ground-glass opacity (GGO) in lungs.Materials and MethodsThis retrospective study included 48 patients with lung adenocarcinoma, who underwent a contrast-enhanced dual-energy spectral CT scan before treatment (53 GGOs in total). The iodine concentration (IC) and water content (WC) of the GGO, the contralateral and ipsilateral normal lung tissues were measured in the arterial phase (AP) and their differences were analyzed. IC, normalized IC (NIC), and WC values were compared between the pure ground-glass opacity (pGGO) and the mixed ground-glass opacity (mGGO), and between the group of preinvasive lesions and the minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IA) groups.ResultsThe values of pGGO (IC = 20.9 ± 6.2 mg/mL and WC = 345.1 ± 87.1 mg/mL) and mGGO (IC = 23.8 ± 8.3 mg/mL and WC = 606.8 ± 124.5 mg/mL) in the AP were significantly higher than those of the contralateral normal lung tissues (IC = 15.0 ± 4.9 mg/mL and WC = 156.4 ± 36.8 mg/mL; IC = 16.2 ± 5.7 mg/mL and WC = 169.4 ± 41.0 mg/mL) and ipsilateral normal lung tissues (IC = 15.1 ± 6.2 mg/mL and WC = 156.3 ± 38.8 mg/mL; IC = 15.9 ± 6.0 mg/mL and WC = 174.7 ± 39.2 mg/mL; all p < 0.001). After normalizing the data according to the values of the artery, pGGO (NIC = 0.1 and WC = 345.1 ± 87.1 mg/mL) and mGGO (NIC = 0.2 and WC = 606.8 ± 124.5 mg/mL) were statistically different (p = 0.049 and p < 0.001, respectively), but not for the IC value (p = 0.161). The WC values of the group with preinvasive lesions and MIA (345.4 ± 96.1 mg/mL) and IA (550.1 ± 158.2 mg/mL) were statistically different (p < 0.001).ConclusionUsing dual-energy spectral CT and material decomposition analysis, the IC in GGO can be quantitatively measured which can be an indicator of the blood supply status in the GGO.

Diagnostic Value of High Frequency Ultrasound on Pilomatricoma

To analyze the characteristics of high-frequency ultrasonography of pilomatricoma and discuss the value of high-frequency ultrasonography in the diagnosis of pilomatricoma, ultrasonographic data of 71 cases (77 patients) with pilomatricoma diagnosed by high-frequency ultrasonography and pathology in our hospital from June 2013 to June 2017 were retrospectively analyzed. The location, size, shape, border, echo and blood supply status of the sonographic images were summarized. As a Result, among the 71 patients (77), there were 62 cases located at the head and neck, 11 at limbs and 4 at the trunk. 66 cases were single and 5 cases were multiple. All the tumors were subcutaneously located. The typical characteristics of pilomatricoma: it is more common in young people. They are hypoechoic nodules on hypodermatic parts of head and neck. The boundary is clear. The shape is regular, accompanied by calcification within the visible dot-like blood flow signal. There is inner calcification within the visible dot-like blood flow signal. It is concluded that ilomatricoma has certain sonographic features. High-frequency ultrasonography has a significant impact in the diagnosis.

Obstetric hemorrhage and safe blood for transfusion in Ethiopia: the challenges of bridging the gap.

Obstetric hemorrhage is a leading cause of maternal death in sub-Saharan Africa, and the shortage of blood for transfusion is a contributory factor. In Ethiopia, the National Blood Bank Service continues to be confronted with challenges in its efforts to ensure the availability of blood for health care facilities. This paper reviews the available data on the contribution of obstetric hemorrhage to maternal mortality and examines the current status of the blood supply in Ethiopia. We reviewed the published literature and data from the Ethiopian Federal Ministry of Health. To assess the status of the current blood supply, we applied the five cornerstones of a safe and effective blood donor service advocated by the World Health Organization. Our review indicates that there are insufficient national data on the prevalence of obstetric hemorrhage and the contribution of blood supply shortage to maternal death. Also, transfusion safety may be compromised by inadequate testing of donated blood and ineffective hospital transfusion policies. To overcome the shortage of blood to treat obstetric hemorrhage, the first step is to evaluate the demand and supply gap by acquiring comprehensive data on the current status of the blood supply and the prevalence of obstetric hemorrhage in Ethiopia. Subsequent steps would include the implementation of transfusion policies, the optimization of whole blood collection, ensuring quality-assured testing of donated blood, and the implementation of transfusion guidelines for the appropriate use of blood products. Strategies for long-term, viable solutions to maintain an adequate blood supply should be simultaneously developed.

Three-dimensional hemodynamics analysis of the circle of Willis in the patient-specific nonintegral arterial structures

The hemodynamic alteration in the cerebral circulation caused by the geometric variations in the cerebral circulation arterial network of the circle of Wills (CoW) can lead to fatal ischemic attacks in the brain. The geometric variations due to impairment in the arterial network result in incomplete cerebral arterial structure of CoW and inadequate blood supply to the brain. Therefore, it is of great importance to understand the hemodynamics of the CoW, for efficiently and precisely evaluating the status of blood supply to the brain. In this paper, three-dimensional computational fluid dynamics of the main CoW vasculature coupled with zero-dimensional lumped parameter model boundary condition for the CoW outflow boundaries is developed for analysis of the blood flow distribution in the incomplete CoW cerebral arterial structures. The geometric models in our study cover the arterial segments from the aorta to the cerebral arteries, which can allow us to take into account the innate patient-specific resistance of the arterial trees. Numerical simulations of the governing fluid mechanics are performed to determine the CoW arterial structural hemodynamics, for illustrating the redistribution of the blood flow in CoW due to the structural variations. We have evaluated our coupling methodology in five patient-specific cases that were diagnosed with the absence of efferent vessels or impairment in the connective arteries in their CoWs. The velocity profiles calculated by our approach in the segments of the patient-specific arterial structures are found to be very close to the Doppler ultrasound measurements. The accuracy and consistency of our hemodynamic results have been improved (to [Formula: see text]%) compared to that of the pure-resistance boundary conditions (of 43.5 [Formula: see text] 28%). Based on our grouping of the five cases according to the occurrence of unilateral occlusion in vertebral arteries, the inter-comparison has shown that (i) the flow reduction in posterior cerebral arteries is the consequence of the unilateral vertebral arterial occlusion, and (ii) the flow rate in the anterior cerebral arteries is correlated with the posterior structural variations. This study shows that our coupling approach is capable of providing comprehensive information of the hemodynamic alterations in the pathological CoW arterial structures. The information generated by our methodology can enable evaluation of both the functional and structural status of the clinically significant symptoms, for assisting the treatment decision-making.

Relationship between the Status of Blood Supply in the Non-hypervascular Hepatocellular Nodules among Chronic Liver Diseases and the Hypervascular Change

Relationship between the Status of Blood Supply in the Non-hypervascular Hepatocellular Nodules among Chronic Liver Diseases and the Hypervascular Change

Genistein Produces Hepatoprotection through Modulating EGFR Expression and Phosphorylation in Experimental Fibrosis

Objectives: We observed the time-course changes of blood flow in non-hypervascular hepatocellular nodules that showed hypointensity in the hepatobiliary phase on Gd-EOB-DTPA-enhanced magnetic resonance imaging (EOB-MRI), and evaluated the relationship between hypervascular change and the status of blood supply in the nodules. Methods: The study included 69 hepatocellular nodules in 33 patients demonstrating hypointensity in the hepatobiliary phase on EOB-MRI and showing non-hypervascular features on CT during hepatic arteriography (CTHA) performed during the same period. Results: In relation to blood flow on CTHA/ CT during arterial portography (CTAP), the cumulative rate of hypervascular change at 52 weeks was 0.0% for iso/iso, 29.7% for hypo/iso, 61.5% for iso/hypo, and 55.0% for hypo/hypo. Multivariate analysis using COX proportional hazards regression showed that CTAP findings (hypodensity) and CTHA findings (hypo-density) were significant variables for hypervascular change. Conclusions: In cases of non-hypervascular hepatocellular tumors, nodules with decreased arterial or portal blood flow that show hypointensity in the hepatobiliary phase on EOB-MRI are likely to develop into typical hepatocellular carcinoma in a shorter time.

Analysis of facial far-infrared thermogram of patients with acute facial neuritis

In order to provide an objective observational index for facial neuritis, the authors monitored the changes of facial far-infrared thermogram in patients with acute facial neuritis. A total of 23 patients with acute facial neuritis were enrolled from Department of Acupuncture and Moxibustion, Chinese PLA General Hospital. Another 21 healthy participants were selected as the control group. Focal plane thermal imaging system (thermal sensitivity 0.05 degrees centigrade) was applied to collect facial far-infrared thermogram. Temperature differences in the thermogram of both sides of the cheeks, inner canthus, supraorbitals and forehead of the same patient were compared separately and statistically and analyzed by software provided by the imaging system. Results of far-infrared thermography of the patients displayed obvious temperature differences ranging from 0.01 to 0.26 degrees centigrade between two sides of the cheeks, inner canthus, supraorbitals and forehead areas. In the control group, far-infrared thermogram showed that there were no obvious temperature differences between two sides of the cheeks, inner canthus, supraorbitals and forehead. There were significant differences in temperature difference in the four monitoring areas between the two groups (P<0.01). Among the 23 patients, there were 14 patients with congestive change, 7 with ischemic change and 2 with both congestive and ischemic changes. The facial far-infrared thermogram of patients with acute facial neuritis is characterized mainly by congestive changes. Far-infrared thermography can objectively reflect the changes of blood-supply status in patients with facial neuritis.

Measurements of capillary dimensions and blood volume in rapidly frozen lungs.

Measurements of capillary dimensions and blood volume in rapidly frozen lungs.