Blood Serum Uric Acid Levels Research Articles

The Ethanol Extract Fractionation (Peperomia Pellucida (L.) Kunth) On Uric Acid Levels Blood Serum Of Male White Mice

Research has been carried out on the effect of fractionating the ethanol extract of the messenger herbs (Peperomia pellucida (L.) Kunth) to reduce blood serum uric acid levels in male white mice. Ordered herbs containing flavonoid compounds are thought to be used as lowering uric acid levels in the blood. The purpose of this study was to determine the effect of giving the ethanol extract fraction (Peperomia pellucida (L.) Kunth) on blood serum uric acid levels of male white mice. Simplicia extraction was carried out with 96% ethanol and extract fractionation was carried out using n-hexane, ethyl acetate, and water as solvents. The chicken liver inductor was used using experimental methods in vivo. Uric acid levels in mice were measured using a test-strip out. The results of the analysis using statistical tests on the decrease in uric acid levels in the blood were significant with a value (p 0.05) on the 14th day of the ethyl acetate fraction. This study concludes that there are compounds in the messenger herbs that have the potential to reduce uric acid levels in the blood.

EFEK PEMBERIAN SEDUHAN SERBUK HERBA SELEDRI (Apium graviolens L.) TERHADAP KADAR ASAM URAT SERUM DARAH AYAM LEGHORN JANTAN HIPERURIKEMIA

Apium graviolens L. is a medicinal plant that is useful for treating gout. Flavonoids are components of chemical compounds found in celery because they can work as antioxidants and inhibit the action of the xanthine oxidase enzyme to form uric acid. This study aims to determine the effect of giving celery herb powder on the blood serum uric acid levels of hyperuricemia male leghorn chickens. This study used twenty-five male leghorn chickens which were randomly divided into 5 groups. All groups were made hyperuricemia by being given 100% chicken liver juice 5 mL/l kg BW once a day orally during treatment. Group 1 was given 0.5% CMC suspension solution as a negative control group. Group 2 was treated with allopurinol 14 mg/1.5 kg BW in CMC 0.5% as a positive control. Groups 3, 4, 5 received infusion of celery herb powder in the order of doses (0.6 g/1.5 kg BW), (1.2 g/1.5 kg BW), (1.8 g/1.5 kg BW). Examination of uric acid levels was carried out on days 0, 4, 8, 12. The results showed that steeping celery could reduce uric acid levels in proportion to the dose. The greater the dose given, the greater the decrease in uric acid levels. The dose of celery herb group 3 (1.8 g/1.5 kg BW) was the most effective doses because it had the same value as the positive control.

Relationship Between Serum Uric Acid Levels and Cognitive Functions in Bipolar Disorder

Objective: There are many studies showing that cognitive impairment persisted during the remission period in bipolar disorder type 1(BPD1). The end-product of purine catabolism, uric acid, is a natural antioxidant. The purinergic system has a role in the regulation of mood, sleep, energy, cognitive function, and behavior. Several studies have indicated that malfunctioning of the purinergic system might have an impact on the pathophysiology of BPD1. We aimed to compare differences in cognitive functions and serum urate levels between patients with BPD1and healthy controls (HC), and to evaluate the relationship between serum uric acid levels and cognitive functions in the patient group. Methods: This study included 75 euthymic patients with BPD1 and 75 healthy age- and sex-matched individuals. All participants completed a sociodemographic form, the Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), and Montreal Cognitive Assessment Scale (MoCA), and underwent a neuropsychometric battery; blood serum uric acid levels were also measured. Clinical interviews for Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) (SCID-I) and Young Mania Rating Scale (YMRS) scores were obtained for the patients; the HC group was investigated using the SCID non-patient version. Results: All of the neurocognitive domains, patients showed worse performance than healthy controls (p

Uric acid and factors of cardiometabolic risk in adolescents with arterial hypertension

To elucidate links of blood serum uric acid level (SUAL) with cardiometabolic risk factors (CMR) in adolescent boys with arterial hypertension (AH). We examined 261 adolescent boys (mean age 15.8+/-1.3 years) with primary AH. Examination included 24-hour blood pressure (BP) monitoring, and measurement of office BP, BMI Z-score, levels of serum glucose, uric acid, total cholesterol (TC), high density lipoprotein cholesterol (HDL) and triglycerides (TG). Low density lipoprotein cholesterol (LDL) was calculated using Friedwald equation. SUAL was significantly and independently of patient age related to BMI Z-score (=0.0000001) and TG level (=0.01). There were no correlation between SUAL and glucose level. According to logistic regression analysis highest tertile of SUAL was regardless of age significantly associated with excess body mass and obesity (odds ratio [OR] 3.5 [95% confidence interval [CI] 1.9-6.7; =0.0001]), and dyslipidemia (OR 3.05, 95%CI 1.3-6.9; =0,007]). Significant relationship was also found between elevated SUAL and clasterization of 2-3 CMR (OR 3.2, CI 1.3-7.7; =0.01]). Hyperuricemia in adolescent boys with AH is a marker of high cardiometabolic risk. This justifies screening for high SUA levels among boys with elevated BP with subsequent estimation of individual risk and timely initiation of preventive measures.